YMR242W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR242W-A / YMR242W-A

Click on Significant Values for Screen Details ID:SGTC_23|Compound:0213-0011|FD-Score:-3.49|P-value:2.96E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.52|P-value:2.21E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.00|P-value:3.32E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:3.24|P-value:6.03E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.55|P-value:1.57E-8 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.71|P-value:1.32E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.16|P-value:9.46E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:3.34|P-value:4.22E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:5.67|P-value:8.17E-9 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.52|P-value:4.19E-6 ID:SGTC_587|Compound:k089-0003|FD-Score:3.50|P-value:2.40E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:-3.78|P-value:9.88E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.66|P-value:1.27E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.93|P-value:1.73E-9 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.59|P-value:2.04E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.41|P-value:3.23E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.20|P-value:8.36E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:4.24|P-value:1.17E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.25|P-value:1.12E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:11.50|P-value:1.51E-30 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.63|P-value:1.76E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:-3.79|P-value:9.65E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.48|P-value:3.14E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:6.99|P-value:1.78E-12 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.21|P-value:6.63E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.00|P-value:3.34E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:3.10|P-value:9.57E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.80|P-value:7.42E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:7.32|P-value:1.68E-13 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.12|P-value:9.01E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:6.54|P-value:3.72E-11 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.46|P-value:2.73E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.11|P-value:9.28E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.17|P-value:7.74E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.12|P-value:8.97E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.07|P-value:2.45E-5 ID:SGTC_1603|Compound:st002045|FD-Score:-3.28|P-value:6.39E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.05|P-value:2.65E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.34|P-value:4.29E-4 ID:SGTC_1947|Compound:st076332|FD-Score:4.17|P-value:1.57E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-4.17|P-value:2.04E-5 ID:SGTC_2015|Compound:5119600|FD-Score:4.01|P-value:3.17E-5 ID:SGTC_2017|Compound:5132927|FD-Score:4.38|P-value:6.16E-6 ID:SGTC_2203|Compound:7227154|FD-Score:3.11|P-value:9.49E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.14|P-value:1.81E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.33|P-value:7.65E-6 ID:SGTC_2431|Compound:5490079|FD-Score:4.37|P-value:6.55E-6 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.25|P-value:6.91E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.37|P-value:6.63E-6 ID:SGTC_2802|Compound:7925815|FD-Score:6.47|P-value:6.12E-11 ID:SGTC_2805|Compound:7950783|FD-Score:4.08|P-value:2.35E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.30|P-value:4.86E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.65|P-value:1.34E-4 ID:SGTC_2874|Compound:9043904|FD-Score:4.53|P-value:3.05E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.25|P-value:5.73E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.12|P-value:9.13E-4 ID:SGTC_3028|Compound:9087778|FD-Score:4.23|P-value:1.23E-5 ID:SGTC_3033|Compound:9090887|FD-Score:4.46|P-value:4.31E-6 ID:SGTC_3196|Compound:9111891|FD-Score:3.36|P-value:3.99E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.45|P-value:3.50E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.87|P-value:5.66E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.29|P-value:4.98E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.48|P-value:2.50E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.40|P-value:3.36E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:-3.49|P-value:2.96E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.52|P-value:2.21E-4 ID:SGTC_60|Compound:0986-0278|FD-Score:4.00|P-value:3.32E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:3.24|P-value:6.03E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:5.55|P-value:1.57E-8 ID:SGTC_156|Compound:3474-0145|FD-Score:-3.71|P-value:1.32E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.16|P-value:9.46E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:3.34|P-value:4.22E-4 ID:SGTC_366|Compound:0181-0206|FD-Score:5.67|P-value:8.17E-9 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.52|P-value:4.19E-6 ID:SGTC_587|Compound:k089-0003|FD-Score:3.50|P-value:2.40E-4 ID:SGTC_642|Compound:0335-0876|FD-Score:-3.78|P-value:9.88E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.66|P-value:1.27E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:5.93|P-value:1.73E-9 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.59|P-value:2.04E-4 ID:SGTC_697|Compound:0508-1955|FD-Score:3.41|P-value:3.23E-4 ID:SGTC_763|Compound:3453-1109|FD-Score:-3.20|P-value:8.36E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:4.24|P-value:1.17E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.25|P-value:1.12E-5 ID:SGTC_808|Compound:0711-0032|FD-Score:11.50|P-value:1.51E-30 ID:SGTC_810|Compound:3825-7150|FD-Score:-3.63|P-value:1.76E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:-3.79|P-value:9.65E-5 ID:SGTC_944|Compound:3370-0224|FD-Score:-3.48|P-value:3.14E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:6.99|P-value:1.78E-12 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.21|P-value:6.63E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:4.00|P-value:3.34E-5 ID:SGTC_1070|Compound:indatraline|FD-Score:3.10|P-value:9.57E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.80|P-value:7.42E-5 ID:SGTC_1136|Compound:pergolide|FD-Score:7.32|P-value:1.68E-13 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.12|P-value:9.01E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:6.54|P-value:3.72E-11 ID:SGTC_1380|Compound:2291-0730|FD-Score:3.46|P-value:2.73E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.11|P-value:9.28E-4 ID:SGTC_1466|Compound:k213-0079|FD-Score:3.17|P-value:7.74E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.12|P-value:8.97E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:4.07|P-value:2.45E-5 ID:SGTC_1603|Compound:st002045|FD-Score:-3.28|P-value:6.39E-4 ID:SGTC_1632|Compound:st005650|FD-Score:4.05|P-value:2.65E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.34|P-value:4.29E-4 ID:SGTC_1947|Compound:st076332|FD-Score:4.17|P-value:1.57E-5 ID:SGTC_2006|Compound:4011487|FD-Score:-4.17|P-value:2.04E-5 ID:SGTC_2015|Compound:5119600|FD-Score:4.01|P-value:3.17E-5 ID:SGTC_2017|Compound:5132927|FD-Score:4.38|P-value:6.16E-6 ID:SGTC_2203|Compound:7227154|FD-Score:3.11|P-value:9.49E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.14|P-value:1.81E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.33|P-value:7.65E-6 ID:SGTC_2431|Compound:5490079|FD-Score:4.37|P-value:6.55E-6 ID:SGTC_2676|Compound:harmalol|FD-Score:-3.25|P-value:6.91E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.37|P-value:6.63E-6 ID:SGTC_2802|Compound:7925815|FD-Score:6.47|P-value:6.12E-11 ID:SGTC_2805|Compound:7950783|FD-Score:4.08|P-value:2.35E-5 ID:SGTC_2817|Compound:7995342|FD-Score:3.30|P-value:4.86E-4 ID:SGTC_2864|Compound:9034755|FD-Score:3.65|P-value:1.34E-4 ID:SGTC_2874|Compound:9043904|FD-Score:4.53|P-value:3.05E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.25|P-value:5.73E-4 ID:SGTC_2903|Compound:5923464|FD-Score:3.12|P-value:9.13E-4 ID:SGTC_3028|Compound:9087778|FD-Score:4.23|P-value:1.23E-5 ID:SGTC_3033|Compound:9090887|FD-Score:4.46|P-value:4.31E-6 ID:SGTC_3196|Compound:9111891|FD-Score:3.36|P-value:3.99E-4 ID:SGTC_3197|Compound:9113331|FD-Score:-3.45|P-value:3.50E-4 ID:SGTC_3299|Compound:9121982|FD-Score:3.87|P-value:5.66E-5 ID:SGTC_3305|Compound:9127027|FD-Score:3.29|P-value:4.98E-4 ID:SGTC_3309|Compound:9129340|FD-Score:3.48|P-value:2.50E-4 ID:SGTC_3314|Compound:9135860|FD-Score:3.40|P-value:3.36E-4

Top fitness defect scores for YMR242W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_808 0711-0032 11.50 135.0 µM 1.51E-30 1 6.47E-31
2 SGTC_1136 pergolide 7.32 1.1 µM 1.68E-13 3 1.28E-13
3 SGTC_1010 4112-3296 6.99 15.2 µM 1.78E-12 2 1.40E-12
4 SGTC_1374 2889-5571 6.54 141.0 µM 3.72E-11 RSC complex & mRNA processing 10 3.05E-11
5 SGTC_2802 7925815 6.47 54.5 µM 6.12E-11 5 5.05E-11
6 SGTC_691 1548-0686 5.93 185.0 µM 1.73E-9 4 1.49E-9
7 SGTC_366 0181-0206 5.67 4.3 µM 8.17E-9 Golgi 11 7.19E-9
8 SGTC_118 0083-0097 5.55 135.3 µM 1.57E-8 translation 35 1.40E-8
9 SGTC_2874 9043904 4.53 71.4 µM 3.05E-6 3 2.88E-6
10 SGTC_3033 9090887 4.46 49.5 µM 4.31E-6 fatty acid desaturase (OLE1) 15 4.08E-6
11 SGTC_2017 5132927 4.38 60.6 µM 6.16E-6 21 5.86E-6
12 SGTC_2431 5490079 4.37 200.0 µM 6.55E-6 21 6.23E-6
13 SGTC_2688 kanamycin b 4.37 96.7 µM 6.63E-6 calcium & mitochondrial duress 314 6.31E-6
14 SGTC_2405 ticlatone 4.33 3.5 µM 7.65E-6 55 7.29E-6
15 SGTC_800 3448-7362 4.25 155.0 µM 1.12E-5 translation 137 1.08E-5
16 SGTC_797 k781-0471 4.24 270.0 µM 1.17E-5 RPP1 & pyrimidine depletion 13 1.12E-5
17 SGTC_3028 9087778 4.23 49.5 µM 1.23E-5 10 1.18E-5
18 SGTC_1947 st076332 4.17 61.6 µM 1.57E-5 13 1.51E-5
19 SGTC_2320 7373003 4.14 200.0 µM 1.81E-5 23 1.74E-5
20 SGTC_2805 7950783 4.08 58.4 µM 2.35E-5 28 2.27E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.124 6.22E-13 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.123 7.21E-13 YLL035W GRC3 het Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
0.117 1.07E-11 YKR057W RPS21A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21A has a paralog, RPS21B, that arose from the whole genome duplication
0.110 1.46E-10 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.108 4.11E-10 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.106 6.79E-10 YBL071C-B_p YBL071C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.106 7.26E-10 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.105 1.07E-9 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.104 1.77E-9 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.103 1.99E-9 YDL061C RPS29B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S29 and bacterial S14; RPS29B has a paralog, RPS29A, that arose from the whole genome duplication
0.103 2.01E-9 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.103 2.64E-9 YKR094C RPL40B hom Ubiquitin-ribosomal 60S subunit protein L40B fusion protein; cleaved to yield ubiquitin and ribosomal protein L40B; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; homologous to mammalian ribosomal protein L40, no bacterial homolog; RPL40B has a paralog, RPL40A, that arose from the whole genome duplication
0.102 3.04E-9 YLR061W RPL22A hom Ribosomal 60S subunit protein L22A; required for the oxidative stress response in yeast; homologous to mammalian ribosomal protein L22, no bacterial homolog; RPL22A has a paralog, RPL22B, that arose from the whole genome duplication
0.102 3.79E-9 YGR071C ENV11 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.098 1.22E-8 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication