HIPHOP chemogenomics database

YMR243C / ZRC1

Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR243C / ZRC1

Click on Significant Values for Screen Details

Top fitness defect scores for YMR243C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_207	4185-0010	8.40	4.5 µM	5.21E-18	endomembrane recycling	23	2.23E-17
2	SGTC_1540	guanosine	7.41	70.6 µM	2.00E-14		1	6.13E-14
3	SGTC_3038	9091290	6.96	49.5 µM	6.31E-13		2	1.68E-12
4	SGTC_391	gliotoxin	6.38	8.3 µM	3.98E-11		19	9.00E-11
5	SGTC_515	4092-1064	5.17	102.0 µM	6.96E-8	plasma membrane duress	34	1.17E-7
6	SGTC_2850	9015429	5.16	58.4 µM	7.25E-8		2	1.22E-7
7	SGTC_2310	7668677	5.13	200.0 µM	8.55E-8		12	1.43E-7
8	SGTC_700	3453-2283	5.01	142.0 µM	1.69E-7	amide catabolism	8	2.75E-7
9	SGTC_702	1488-0190	4.59	94.0 µM	1.51E-6	amide catabolism	6	2.26E-6
10	SGTC_687	k029-0044	4.59	34.9 µM	1.51E-6	PDR1	11	2.26E-6
11	SGTC_3218	9131285	4.57	49.5 µM	1.60E-6	endomembrane recycling	25	2.39E-6
12	SGTC_384	k007-0144	4.53	5.2 µM	2.00E-6	ERAD & cell cycle	44	2.96E-6
13	SGTC_288	1315-0019	4.38	35.1 µM	4.16E-6	RSC & ERG11	14	5.99E-6
14	SGTC_2015	5119600	4.33	184.0 µM	5.22E-6		22	7.46E-6
15	SGTC_3027	9089541	4.14	49.5 µM	1.27E-5	fatty acid desaturase (OLE1)	19	1.76E-5
16	SGTC_24	0417-1663	4.05	219.0 µM	1.92E-5		15	2.61E-5
17	SGTC_1511	0906-3109	3.98	28.5 µM	2.60E-5	excess fatty acid	46	3.50E-5
18	SGTC_2279	7948423	3.90	32.9 µM	3.68E-5		13	4.89E-5
19	SGTC_2440	5628896	3.87	157.8 µM	4.08E-5		27	5.40E-5
20	SGTC_2155	5570423	3.85	76.0 µM	4.46E-5	ergosterol biosynthesis	11	5.87E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.129	6.39E-14	YHL019C	APM2	hom	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.117	8.47E-12	YLR170C	APS1	hom	Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.117	1.13E-11	YFL034W_p	YFL034W_p	hom	Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.081	2.60E-6	YCR017C	CWH43	hom	Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion
0.081	2.92E-6	YBR044C	TCM62	hom	Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
0.080	3.52E-6	YHR209W	CRG1	hom	S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.080	3.57E-6	YER132C	PMD1	hom	Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions
0.079	5.11E-6	YDR213W	UPC2	hom	Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.073	2.43E-5	YPR170C_d	YPR170C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
0.073	2.53E-5	YDL026W_d	YDL026W_d	hom	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.072	3.08E-5	YOL123W	HRP1	het	Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
0.070	4.47E-5	YER180C-A	SLO1	hom	Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
0.070	5.21E-5	YGR179C	OKP1	het	Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7
0.069	6.02E-5	YLR171W_d	YLR171W_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.069	6.93E-5	YDR080W	VPS41	hom	Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport