YMR243C / ZRC1

Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR243C / ZRC1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:-6.38|P-value:3.12E-11 ID:SGTC_20|Compound:0481-0013|FD-Score:-3.17|P-value:5.48E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:4.05|P-value:1.92E-5 ID:SGTC_27|Compound:0485-0001|FD-Score:-3.88|P-value:3.31E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:3.56|P-value:1.48E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.69|P-value:8.81E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.58|P-value:1.34E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:8.40|P-value:5.21E-18 ID:SGTC_232|Compound:clozapine|FD-Score:3.10|P-value:8.03E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.67|P-value:9.41E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:4.38|P-value:4.16E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:4.53|P-value:2.00E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:6.38|P-value:3.98E-11 ID:SGTC_406|Compound:estrone|FD-Score:-3.12|P-value:6.60E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.85|P-value:4.52E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:5.17|P-value:6.96E-8 ID:SGTC_533|Compound:1222-0222|FD-Score:3.29|P-value:4.15E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.70|P-value:8.22E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:3.13|P-value:7.25E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.59|P-value:1.51E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.80|P-value:4.69E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:5.01|P-value:1.69E-7 ID:SGTC_702|Compound:1488-0190|FD-Score:4.59|P-value:1.51E-6 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.09|P-value:7.41E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.78|P-value:6.03E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.81|P-value:5.36E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.38|P-value:2.94E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.82|P-value:5.10E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.98|P-value:2.60E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-3.49|P-value:1.64E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:7.41|P-value:2.00E-14 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.34|P-value:3.36E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.81|P-value:5.32E-5 ID:SGTC_2015|Compound:5119600|FD-Score:4.33|P-value:5.22E-6 ID:SGTC_2018|Compound:5133068|FD-Score:3.15|P-value:6.86E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.33|P-value:3.50E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.67|P-value:8.12E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.49|P-value:1.95E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.85|P-value:4.46E-5 ID:SGTC_2244|Compound:6635614|FD-Score:3.16|P-value:6.71E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.18|P-value:6.15E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.90|P-value:3.68E-5 ID:SGTC_2310|Compound:7668677|FD-Score:5.13|P-value:8.55E-8 ID:SGTC_2312|Compound:7706453|FD-Score:3.27|P-value:4.45E-4 ID:SGTC_2440|Compound:5628896|FD-Score:3.87|P-value:4.08E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.85|P-value:4.55E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.85|P-value:4.46E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.10|P-value:8.21E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.14|P-value:7.02E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.06|P-value:9.31E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.07|P-value:9.06E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.85|P-value:4.46E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.39|P-value:2.50E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.71|P-value:6.76E-5 ID:SGTC_2811|Compound:7967822|FD-Score:-4.12|P-value:1.14E-5 ID:SGTC_2850|Compound:9015429|FD-Score:5.16|P-value:7.25E-8 ID:SGTC_2856|Compound:9022925|FD-Score:-7.14|P-value:1.29E-13 ID:SGTC_2989|Compound:9073649|FD-Score:-4.88|P-value:2.72E-7 ID:SGTC_2996|Compound:9066192|FD-Score:-4.75|P-value:5.30E-7 ID:SGTC_3027|Compound:9089541|FD-Score:4.14|P-value:1.27E-5 ID:SGTC_3038|Compound:9091290|FD-Score:6.96|P-value:6.31E-13 ID:SGTC_3044|Compound:9093193|FD-Score:3.08|P-value:8.63E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.32|P-value:3.63E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.47|P-value:2.11E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.57|P-value:1.60E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.40|P-value:2.74E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:-6.38|P-value:3.12E-11 ID:SGTC_20|Compound:0481-0013|FD-Score:-3.17|P-value:5.48E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:4.05|P-value:1.92E-5 ID:SGTC_27|Compound:0485-0001|FD-Score:-3.88|P-value:3.31E-5 ID:SGTC_48|Compound:0382-0018|FD-Score:3.56|P-value:1.48E-4 ID:SGTC_154|Compound:3389-1638|FD-Score:3.69|P-value:8.81E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.58|P-value:1.34E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:8.40|P-value:5.21E-18 ID:SGTC_232|Compound:clozapine|FD-Score:3.10|P-value:8.03E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.67|P-value:9.41E-5 ID:SGTC_288|Compound:1315-0019|FD-Score:4.38|P-value:4.16E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:4.53|P-value:2.00E-6 ID:SGTC_391|Compound:gliotoxin|FD-Score:6.38|P-value:3.98E-11 ID:SGTC_406|Compound:estrone|FD-Score:-3.12|P-value:6.60E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.85|P-value:4.52E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:5.17|P-value:6.96E-8 ID:SGTC_533|Compound:1222-0222|FD-Score:3.29|P-value:4.15E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.70|P-value:8.22E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:3.13|P-value:7.25E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.59|P-value:1.51E-6 ID:SGTC_695|Compound:3505-6186|FD-Score:-3.80|P-value:4.69E-5 ID:SGTC_700|Compound:3453-2283|FD-Score:5.01|P-value:1.69E-7 ID:SGTC_702|Compound:1488-0190|FD-Score:4.59|P-value:1.51E-6 ID:SGTC_705|Compound:1124-0212|FD-Score:-3.09|P-value:7.41E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.78|P-value:6.03E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:3.81|P-value:5.36E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.38|P-value:2.94E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.82|P-value:5.10E-5 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.98|P-value:2.60E-5 ID:SGTC_1533|Compound:dihydroergotamine mesylate|FD-Score:-3.49|P-value:1.64E-4 ID:SGTC_1540|Compound:guanosine|FD-Score:7.41|P-value:2.00E-14 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.34|P-value:3.36E-4 ID:SGTC_1945|Compound:st075991|FD-Score:3.81|P-value:5.32E-5 ID:SGTC_2015|Compound:5119600|FD-Score:4.33|P-value:5.22E-6 ID:SGTC_2018|Compound:5133068|FD-Score:3.15|P-value:6.86E-4 ID:SGTC_2020|Compound:4017018|FD-Score:3.33|P-value:3.50E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-3.67|P-value:8.12E-5 ID:SGTC_2083|Compound:5306046|FD-Score:3.49|P-value:1.95E-4 ID:SGTC_2155|Compound:5570423|FD-Score:3.85|P-value:4.46E-5 ID:SGTC_2244|Compound:6635614|FD-Score:3.16|P-value:6.71E-4 ID:SGTC_2265|Compound:7929201|FD-Score:3.18|P-value:6.15E-4 ID:SGTC_2279|Compound:7948423|FD-Score:3.90|P-value:3.68E-5 ID:SGTC_2310|Compound:7668677|FD-Score:5.13|P-value:8.55E-8 ID:SGTC_2312|Compound:7706453|FD-Score:3.27|P-value:4.45E-4 ID:SGTC_2440|Compound:5628896|FD-Score:3.87|P-value:4.08E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:3.85|P-value:4.55E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.85|P-value:4.46E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.10|P-value:8.21E-4 ID:SGTC_2661|Compound:dactinomycin|FD-Score:3.14|P-value:7.02E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.06|P-value:9.31E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:3.07|P-value:9.06E-4 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.85|P-value:4.46E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:-3.39|P-value:2.50E-4 ID:SGTC_2804|Compound:7954240|FD-Score:-3.71|P-value:6.76E-5 ID:SGTC_2811|Compound:7967822|FD-Score:-4.12|P-value:1.14E-5 ID:SGTC_2850|Compound:9015429|FD-Score:5.16|P-value:7.25E-8 ID:SGTC_2856|Compound:9022925|FD-Score:-7.14|P-value:1.29E-13 ID:SGTC_2989|Compound:9073649|FD-Score:-4.88|P-value:2.72E-7 ID:SGTC_2996|Compound:9066192|FD-Score:-4.75|P-value:5.30E-7 ID:SGTC_3027|Compound:9089541|FD-Score:4.14|P-value:1.27E-5 ID:SGTC_3038|Compound:9091290|FD-Score:6.96|P-value:6.31E-13 ID:SGTC_3044|Compound:9093193|FD-Score:3.08|P-value:8.63E-4 ID:SGTC_3052|Compound:9092717|FD-Score:3.32|P-value:3.63E-4 ID:SGTC_3103|Compound:9120822|FD-Score:3.47|P-value:2.11E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.57|P-value:1.60E-6 ID:SGTC_3306|Compound:9127676|FD-Score:3.40|P-value:2.74E-4

Top fitness defect scores for YMR243C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_207 4185-0010 8.40 4.5 µM 5.21E-18 endomembrane recycling 23 2.23E-17
2 SGTC_1540 guanosine 7.41 70.6 µM 2.00E-14 1 6.13E-14
3 SGTC_3038 9091290 6.96 49.5 µM 6.31E-13 2 1.68E-12
4 SGTC_391 gliotoxin 6.38 8.3 µM 3.98E-11 19 9.00E-11
5 SGTC_515 4092-1064 5.17 102.0 µM 6.96E-8 plasma membrane duress 34 1.17E-7
6 SGTC_2850 9015429 5.16 58.4 µM 7.25E-8 2 1.22E-7
7 SGTC_2310 7668677 5.13 200.0 µM 8.55E-8 12 1.43E-7
8 SGTC_700 3453-2283 5.01 142.0 µM 1.69E-7 amide catabolism 8 2.75E-7
9 SGTC_702 1488-0190 4.59 94.0 µM 1.51E-6 amide catabolism 6 2.26E-6
10 SGTC_687 k029-0044 4.59 34.9 µM 1.51E-6 PDR1 11 2.26E-6
11 SGTC_3218 9131285 4.57 49.5 µM 1.60E-6 endomembrane recycling 25 2.39E-6
12 SGTC_384 k007-0144 4.53 5.2 µM 2.00E-6 ERAD & cell cycle 44 2.96E-6
13 SGTC_288 1315-0019 4.38 35.1 µM 4.16E-6 RSC & ERG11 14 5.99E-6
14 SGTC_2015 5119600 4.33 184.0 µM 5.22E-6 22 7.46E-6
15 SGTC_3027 9089541 4.14 49.5 µM 1.27E-5 fatty acid desaturase (OLE1) 19 1.76E-5
16 SGTC_24 0417-1663 4.05 219.0 µM 1.92E-5 15 2.61E-5
17 SGTC_1511 0906-3109 3.98 28.5 µM 2.60E-5 excess fatty acid 46 3.50E-5
18 SGTC_2279 7948423 3.90 32.9 µM 3.68E-5 13 4.89E-5
19 SGTC_2440 5628896 3.87 157.8 µM 4.08E-5 27 5.40E-5
20 SGTC_2155 5570423 3.85 76.0 µM 4.46E-5 ergosterol biosynthesis 11 5.87E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.129 6.39E-14 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.117 8.47E-12 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.117 1.13E-11 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.081 2.60E-6 YCR017C CWH43 hom Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion
0.081 2.92E-6 YBR044C TCM62 hom Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone
0.080 3.52E-6 YHR209W CRG1 hom S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin
0.080 3.57E-6 YER132C PMD1 hom Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions
0.079 5.11E-6 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.073 2.43E-5 YPR170C_d YPR170C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
0.073 2.53E-5 YDL026W_d YDL026W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.072 3.08E-5 YOL123W HRP1 het Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
0.070 4.47E-5 YER180C-A SLO1 hom Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
0.070 5.21E-5 YGR179C OKP1 het Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7
0.069 6.02E-5 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.069 6.93E-5 YDR080W VPS41 hom Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport