Vacuolar membrane zinc transporter; transports zinc from cytosol to vacuole for storage; also has role in resistance to zinc shock resulting from sudden influx of zinc into cytoplasm; human ortholog SLC30A10 functions as a Mn transporter and mutations in SLC30A10 cause neurotoxic accumulation of Mn in liver and brain; ZRC1 has a paralog, COT1, that arose from the whole genome duplication
Zygosity: Homozygous strain
fixedexpanded
![]() ![]() Click on Significant Values for Screen Details |
Top fitness defect scores for YMR243C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.129 | 6.39E-14 | YHL019C | APM2 | hom | Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport |
0.117 | 8.47E-12 | YLR170C | APS1 | hom | Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex |
0.117 | 1.13E-11 | YFL034W_p | YFL034W_p | hom | Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk |
0.081 | 2.60E-6 | YCR017C | CWH43 | hom | Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion |
0.081 | 2.92E-6 | YBR044C | TCM62 | hom | Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone |
0.080 | 3.52E-6 | YHR209W | CRG1 | hom | S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin |
0.080 | 3.57E-6 | YER132C | PMD1 | hom | Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions |
0.079 | 5.11E-6 | YDR213W | UPC2 | hom | Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication |
0.073 | 2.43E-5 | YPR170C_d | YPR170C_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B |
0.073 | 2.53E-5 | YDL026W_d | YDL026W_d | hom | Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data |
0.072 | 3.08E-5 | YOL123W | HRP1 | het | Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences |
0.070 | 4.47E-5 | YER180C-A | SLO1 | hom | Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO |
0.070 | 5.21E-5 | YGR179C | OKP1 | het | Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7 |
0.069 | 6.02E-5 | YLR171W_d | YLR171W_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
0.069 | 6.93E-5 | YDR080W | VPS41 | hom | Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport |