YMR244C-A / COA6

Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR244C-A / COA6

Click on Significant Values for Screen Details

Top fitness defect scores for YMR244C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3137 9097352 7.04 49.5 µM 1.21E-14 2 9.67E-13
2 SGTC_3016 9080866 5.03 49.5 µM 2.61E-8 10 2.47E-7
3 SGTC_392 N-ethylmaleimide 4.74 8.3 µM 1.45E-7 RNA pol III & RNase P/MRP 6 1.07E-6
4 SGTC_2093 5331342 4.57 194.4 µM 3.72E-7 21 2.40E-6
5 SGTC_1508 1080-0625 4.43 72.9 µM 8.15E-7 11 4.71E-6
6 SGTC_3203 9113543 4.39 49.5 µM 9.88E-7 23 5.55E-6
7 SGTC_353 1988-1175 3.86 58.3 µM 1.47E-5 unfolded protein response 27 5.63E-5
8 SGTC_716 1683-5115 3.73 658.0 µM 2.74E-5 28 9.61E-5
9 SGTC_3200 9114385 3.72 49.5 µM 2.80E-5 42 9.77E-5
10 SGTC_1520 flindersine 3.66 88.0 µM 3.78E-5 38 1.27E-4
11 SGTC_2494 18-aminoabieta-8,11,13-triene sulfate 3.64 3.7 µM 4.06E-5 108 1.35E-4
12 SGTC_3332 9141069 3.59 11.2 µM 5.07E-5 27 1.63E-4
13 SGTC_3126 9127922 3.44 49.5 µM 1.02E-4 fatty acid desaturase (OLE1) 56 2.96E-4
14 SGTC_2103 5378138 3.36 10.0 µM 1.41E-4 38 3.91E-4
15 SGTC_1072 oxiconazole 3.35 14.9 nM 1.48E-4 ergosterol depletion effects on membrane 70 4.08E-4
16 SGTC_2582 agaric acid 3.27 100.0 µM 2.07E-4 redox potentiating 392 5.45E-4
17 SGTC_75 0159-0059 3.27 199.0 µM 2.07E-4 fatty acid desaturase (OLE1) 44 5.46E-4
18 SGTC_3136 9095672 3.19 49.5 µM 2.77E-4 56 7.02E-4
19 SGTC_1384 3089-0840 3.19 101.0 µM 2.81E-4 40 7.10E-4
20 SGTC_1369 1866-0067 3.14 208.0 µM 3.48E-4 RPP1 & pyrimidine depletion 76 8.55E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.63E-19 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.151 2.13E-18 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.143 1.09E-16 YML053C_p YML053C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene
0.139 8.01E-16 YMR096W SNZ1 hom Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins
0.131 2.64E-14 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.126 2.64E-13 YKL122C SRP21 het Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
0.124 6.01E-13 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.124 7.58E-13 YFL008W SMC1 het Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure
0.115 2.36E-11 YKL171W NNK1 hom Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm
0.114 3.70E-11 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.114 4.76E-11 YJR019C TES1 hom Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids
0.114 5.01E-11 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.111 1.24E-10 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.110 1.84E-10 YGL089C MF(ALPHA)2 hom Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
0.109 2.66E-10 YMR007W_d YMR007W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data