YMR244W_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR244W / YMR244W

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:3.58|P-value:6.43E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:2.88|P-value:9.68E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:4.30|P-value:2.48E-6 ID:SGTC_251|Compound:melphalan|FD-Score:3.27|P-value:2.28E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.15|P-value:3.64E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.15|P-value:3.62E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.50|P-value:8.73E-7 ID:SGTC_944|Compound:3370-0224|FD-Score:-5.20|P-value:7.71E-8 ID:SGTC_986|Compound:1493-0483|FD-Score:3.34|P-value:1.73E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.62|P-value:5.60E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:-5.82|P-value:1.88E-9 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.36|P-value:4.00E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.09|P-value:4.48E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.01|P-value:6.04E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.19|P-value:3.10E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.76|P-value:8.27E-5 ID:SGTC_1863|Compound:st057641|FD-Score:3.73|P-value:3.48E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.94|P-value:1.37E-5 ID:SGTC_1871|Compound:st057448|FD-Score:6.20|P-value:3.16E-11 ID:SGTC_1887|Compound:st057648|FD-Score:3.03|P-value:5.68E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.26|P-value:2.91E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-3.64|P-value:1.37E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-4.61|P-value:1.73E-6 ID:SGTC_2106|Compound:5357045|FD-Score:2.92|P-value:8.35E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.51|P-value:8.67E-5 ID:SGTC_2143|Compound:5623677|FD-Score:2.90|P-value:8.97E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.11|P-value:4.22E-4 ID:SGTC_2208|Compound:7283366|FD-Score:5.56|P-value:2.11E-9 ID:SGTC_2236|Compound:dapsone|FD-Score:4.11|P-value:6.20E-6 ID:SGTC_2273|Compound:7815444|FD-Score:5.20|P-value:1.86E-8 ID:SGTC_2382|Compound:9035899|FD-Score:3.02|P-value:5.80E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.72|P-value:3.61E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.27|P-value:2.30E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.47|P-value:1.03E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:6.55|P-value:2.66E-12 ID:SGTC_2691|Compound:st077356|FD-Score:-3.99|P-value:3.09E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.87|P-value:1.88E-5 ID:SGTC_2695|Compound:st077686|FD-Score:3.57|P-value:6.77E-5 ID:SGTC_2786|Compound:7743617|FD-Score:4.75|P-value:2.34E-7 ID:SGTC_2814|Compound:7977482|FD-Score:4.03|P-value:8.90E-6 ID:SGTC_2988|Compound:9073640|FD-Score:4.22|P-value:3.54E-6 ID:SGTC_3003|Compound:9075612|FD-Score:-3.19|P-value:7.61E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.04|P-value:5.44E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.22|P-value:2.77E-4 ID:SGTC_3339|Compound:9145883|FD-Score:2.92|P-value:8.49E-4 ID:SGTC_26|Compound:0302-0163|FD-Score:3.58|P-value:6.43E-5 ID:SGTC_175|Compound:3793-3120|FD-Score:2.88|P-value:9.68E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:4.30|P-value:2.48E-6 ID:SGTC_251|Compound:melphalan|FD-Score:3.27|P-value:2.28E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:3.15|P-value:3.64E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:3.15|P-value:3.62E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.50|P-value:8.73E-7 ID:SGTC_944|Compound:3370-0224|FD-Score:-5.20|P-value:7.71E-8 ID:SGTC_986|Compound:1493-0483|FD-Score:3.34|P-value:1.73E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.62|P-value:5.60E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:-5.82|P-value:1.88E-9 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.36|P-value:4.00E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:3.09|P-value:4.48E-4 ID:SGTC_1495|Compound:4469-0029|FD-Score:3.01|P-value:6.04E-4 ID:SGTC_1726|Compound:st035556|FD-Score:3.19|P-value:3.10E-4 ID:SGTC_1728|Compound:st035614|FD-Score:-3.76|P-value:8.27E-5 ID:SGTC_1863|Compound:st057641|FD-Score:3.73|P-value:3.48E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.94|P-value:1.37E-5 ID:SGTC_1871|Compound:st057448|FD-Score:6.20|P-value:3.16E-11 ID:SGTC_1887|Compound:st057648|FD-Score:3.03|P-value:5.68E-4 ID:SGTC_1950|Compound:st077106|FD-Score:4.26|P-value:2.91E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-3.64|P-value:1.37E-4 ID:SGTC_2001|Compound:4023502|FD-Score:-4.61|P-value:1.73E-6 ID:SGTC_2106|Compound:5357045|FD-Score:2.92|P-value:8.35E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.51|P-value:8.67E-5 ID:SGTC_2143|Compound:5623677|FD-Score:2.90|P-value:8.97E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.11|P-value:4.22E-4 ID:SGTC_2208|Compound:7283366|FD-Score:5.56|P-value:2.11E-9 ID:SGTC_2236|Compound:dapsone|FD-Score:4.11|P-value:6.20E-6 ID:SGTC_2273|Compound:7815444|FD-Score:5.20|P-value:1.86E-8 ID:SGTC_2382|Compound:9035899|FD-Score:3.02|P-value:5.80E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.72|P-value:3.61E-5 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:3.27|P-value:2.30E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.47|P-value:1.03E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:6.55|P-value:2.66E-12 ID:SGTC_2691|Compound:st077356|FD-Score:-3.99|P-value:3.09E-5 ID:SGTC_2694|Compound:st077685|FD-Score:3.87|P-value:1.88E-5 ID:SGTC_2695|Compound:st077686|FD-Score:3.57|P-value:6.77E-5 ID:SGTC_2786|Compound:7743617|FD-Score:4.75|P-value:2.34E-7 ID:SGTC_2814|Compound:7977482|FD-Score:4.03|P-value:8.90E-6 ID:SGTC_2988|Compound:9073640|FD-Score:4.22|P-value:3.54E-6 ID:SGTC_3003|Compound:9075612|FD-Score:-3.19|P-value:7.61E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.04|P-value:5.44E-4 ID:SGTC_3298|Compound:9116858|FD-Score:3.22|P-value:2.77E-4 ID:SGTC_3339|Compound:9145883|FD-Score:2.92|P-value:8.49E-4

Top fitness defect scores for YMR244W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2581 avocatin a 6.55 64.0 µM 2.66E-12 sphingolipid biosynthesis & PDR1 14 2.85E-11
2 SGTC_1871 st057448 6.20 67.3 µM 3.16E-11 3 2.79E-10
3 SGTC_2208 7283366 5.56 200.0 µM 2.11E-9 2 1.33E-8
4 SGTC_2273 7815444 5.20 169.1 µM 1.86E-8 5 9.79E-8
5 SGTC_2786 7743617 4.75 45.5 µM 2.34E-7 11 9.96E-7
6 SGTC_687 k029-0044 4.50 34.9 µM 8.73E-7 PDR1 12 3.33E-6
7 SGTC_176 1486-1328 4.30 72.8 µM 2.48E-6 43 8.66E-6
8 SGTC_1950 st077106 4.26 7.2 µM 2.91E-6 RNA processing & uracil transport 21 1.00E-5
9 SGTC_2988 9073640 4.22 71.4 µM 3.54E-6 18 1.20E-5
10 SGTC_2236 dapsone 4.11 200.0 µM 6.20E-6 8 2.00E-5
11 SGTC_2814 7977482 4.03 43.0 µM 8.90E-6 50 2.78E-5
12 SGTC_1868 st057644 3.94 42.7 µM 1.37E-5 38 4.12E-5
13 SGTC_2694 st077685 3.87 81.9 µM 1.88E-5 endomembrane recycling 33 5.51E-5
14 SGTC_1863 st057641 3.73 20.1 µM 3.48E-5 17 9.67E-5
15 SGTC_2395 5646831 3.72 180.2 µM 3.61E-5 29 9.99E-5
16 SGTC_1051 3253-3903 3.62 78.0 µM 5.60E-5 32 1.49E-4
17 SGTC_26 0302-0163 3.58 425.2 µM 6.43E-5 heme biosynthesis & mitochondrial translocase 15 1.69E-4
18 SGTC_2695 st077686 3.57 52.0 µM 6.77E-5 49 1.77E-4
19 SGTC_2129 girgensonine 3.51 121.0 µM 8.67E-5 heme biosynthesis & mitochondrial translocase 47 2.22E-4
20 SGTC_2438 5259590 3.47 200.0 µM 1.03E-4 24 2.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.148 7.87E-18 YER093C-A AIM11 hom Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron; YER093C-A has a paralog, YBL059W, that arose from the whole genome duplication
0.120 2.67E-12 YGR017W_p YGR017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
0.102 3.26E-9 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.098 1.37E-8 YKL043W PHD1 hom Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental regulator; potential Cdc28p substrate; PHD1 has a paralog, SOK2, that arose from the whole genome duplication
0.092 9.13E-8 YML051W GAL80 hom Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding
0.083 1.57E-6 YOL049W GSH2 hom Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock
0.082 1.96E-6 YLR428C_d YLR428C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1
0.081 2.37E-6 YBR012C_d YBR012C_d hom Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p
0.081 2.49E-6 YLR323C CWC24 het Spliceosome assembly factor, essential for the first step of splicing; component of the pre-catalytic spliceosome complex containing Cef1p; has similarity to S. pombe Cwf24p
0.078 6.48E-6 YGL164C YRB30 hom RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
0.076 1.10E-5 YBR214W SDS24 hom Protein involved in cell separation during budding; one of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; may play an indirect role in fluid-phase endocytosis; protein abundance increases in response to DNA replication stress; SDS24 has a paralog, SDS23, that arose from the whole genome duplication
0.076 1.17E-5 YOR359W VTS1 hom Flap-structured DNA-binding and RNA-binding protein; stimulates deadenylation-dependent mRNA degradation mediated by the CCR4-NOT deadenylase complex; member of the Smaug (Smg) family of post-transcriptional regulators which bind RNA through a conserved sterile alpha motif (SAM) domain that interacts with Smg recognition element (SREs) containing transcripts; stimulates Dna2p endonuclease activity
0.074 2.03E-5 YHL001W RPL14B hom Ribosomal 60S subunit protein L14B; homologous to mammalian ribosomal protein L14, no bacterial homolog; RPL14B has a paralog, RPL14A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.071 3.97E-5 YER091C MET6 hom Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs
0.071 4.14E-5 YOL048C RRT8 hom Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress