YMR245W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR245W / YMR245W

Click on Significant Values for Screen Details ID:SGTC_104|Compound:0074-0074|FD-Score:-3.63|P-value:1.91E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.44|P-value:9.02E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:4.35|P-value:3.42E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:4.24|P-value:5.30E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:3.99|P-value:1.38E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.26|P-value:6.81E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.37|P-value:3.93E-7 ID:SGTC_530|Compound:4358-1714|FD-Score:4.54|P-value:1.58E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.31|P-value:5.82E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:4.03|P-value:1.16E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:4.28|P-value:4.61E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:3.89|P-value:1.95E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.42|P-value:9.62E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.74|P-value:3.30E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.11|P-value:8.71E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.43|P-value:9.42E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.95|P-value:1.60E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.64|P-value:4.65E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.27|P-value:4.68E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:5.51|P-value:1.90E-7 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.86|P-value:2.15E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.74|P-value:3.32E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.02|P-value:1.20E-4 ID:SGTC_1676|Compound:st018489|FD-Score:5.61|P-value:1.19E-7 ID:SGTC_1732|Compound:st034308|FD-Score:4.82|P-value:4.77E-6 ID:SGTC_1771|Compound:st048882|FD-Score:6.18|P-value:5.89E-9 ID:SGTC_1778|Compound:st046819|FD-Score:4.94|P-value:2.80E-6 ID:SGTC_1804|Compound:st050076|FD-Score:5.24|P-value:7.09E-7 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.57|P-value:5.84E-4 ID:SGTC_1851|Compound:st056236|FD-Score:4.77|P-value:6.12E-6 ID:SGTC_2024|Compound:5144227|FD-Score:3.80|P-value:2.66E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.73|P-value:3.46E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-4.03|P-value:4.23E-5 ID:SGTC_2112|Compound:5488546|FD-Score:5.47|P-value:2.39E-7 ID:SGTC_2313|Compound:7726885|FD-Score:5.06|P-value:1.70E-6 ID:SGTC_2411|Compound:st077133|FD-Score:3.88|P-value:2.00E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.17|P-value:6.87E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.49|P-value:7.71E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.59|P-value:5.57E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.06|P-value:1.05E-4 ID:SGTC_2681|Compound:menadione|FD-Score:4.40|P-value:2.85E-5 ID:SGTC_2781|Compound:5567276|FD-Score:4.10|P-value:9.15E-5 ID:SGTC_2820|Compound:7989630|FD-Score:3.88|P-value:2.05E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.26|P-value:6.86E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.39|P-value:2.96E-5 ID:SGTC_2967|Compound:9089538|FD-Score:-3.53|P-value:2.68E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.57|P-value:5.97E-4 ID:SGTC_2976|Compound:9009005|FD-Score:5.94|P-value:2.12E-8 ID:SGTC_2995|Compound:9067767|FD-Score:3.56|P-value:6.02E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.57|P-value:5.85E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.86|P-value:2.15E-4 ID:SGTC_3195|Compound:9113082|FD-Score:4.25|P-value:5.12E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.54|P-value:6.58E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.74|P-value:3.34E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.78|P-value:1.09E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.63|P-value:1.91E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:3.44|P-value:9.02E-4 ID:SGTC_192|Compound:3455-0609|FD-Score:4.35|P-value:3.42E-5 ID:SGTC_286|Compound:k060-0067|FD-Score:4.24|P-value:5.30E-5 ID:SGTC_368|Compound:fentichlor|FD-Score:3.99|P-value:1.38E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:-3.26|P-value:6.81E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:5.37|P-value:3.93E-7 ID:SGTC_530|Compound:4358-1714|FD-Score:4.54|P-value:1.58E-5 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.31|P-value:5.82E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:4.03|P-value:1.16E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:4.28|P-value:4.61E-5 ID:SGTC_853|Compound:0419-0306|FD-Score:3.89|P-value:1.95E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.42|P-value:9.62E-4 ID:SGTC_910|Compound:3454-3003|FD-Score:3.74|P-value:3.30E-4 ID:SGTC_931|Compound:2812-0076|FD-Score:4.11|P-value:8.71E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.43|P-value:9.42E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.95|P-value:1.60E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.64|P-value:4.65E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.27|P-value:4.68E-5 ID:SGTC_1583|Compound:clindamycin|FD-Score:5.51|P-value:1.90E-7 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.86|P-value:2.15E-4 ID:SGTC_1592|Compound:4',5'-dihydroxyflavone|FD-Score:3.74|P-value:3.32E-4 ID:SGTC_1593|Compound:justicidin b . 9-(1,3-benzodioxol-5-yl)- 6,7-dimethoxynaphtho[2,3-c]furan-1(3h)-one|FD-Score:4.02|P-value:1.20E-4 ID:SGTC_1676|Compound:st018489|FD-Score:5.61|P-value:1.19E-7 ID:SGTC_1732|Compound:st034308|FD-Score:4.82|P-value:4.77E-6 ID:SGTC_1771|Compound:st048882|FD-Score:6.18|P-value:5.89E-9 ID:SGTC_1778|Compound:st046819|FD-Score:4.94|P-value:2.80E-6 ID:SGTC_1804|Compound:st050076|FD-Score:5.24|P-value:7.09E-7 ID:SGTC_1823|Compound:3-hydroxy-2-naphthoic acid|FD-Score:3.57|P-value:5.84E-4 ID:SGTC_1851|Compound:st056236|FD-Score:4.77|P-value:6.12E-6 ID:SGTC_2024|Compound:5144227|FD-Score:3.80|P-value:2.66E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.73|P-value:3.46E-4 ID:SGTC_2081|Compound:5214970|FD-Score:-4.03|P-value:4.23E-5 ID:SGTC_2112|Compound:5488546|FD-Score:5.47|P-value:2.39E-7 ID:SGTC_2313|Compound:7726885|FD-Score:5.06|P-value:1.70E-6 ID:SGTC_2411|Compound:st077133|FD-Score:3.88|P-value:2.00E-4 ID:SGTC_2479|Compound:5617353|FD-Score:4.17|P-value:6.87E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.49|P-value:7.71E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.59|P-value:5.57E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:4.06|P-value:1.05E-4 ID:SGTC_2681|Compound:menadione|FD-Score:4.40|P-value:2.85E-5 ID:SGTC_2781|Compound:5567276|FD-Score:4.10|P-value:9.15E-5 ID:SGTC_2820|Compound:7989630|FD-Score:3.88|P-value:2.05E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.26|P-value:6.86E-4 ID:SGTC_2931|Compound:9014674|FD-Score:4.39|P-value:2.96E-5 ID:SGTC_2967|Compound:9089538|FD-Score:-3.53|P-value:2.68E-4 ID:SGTC_2973|Compound:9094665|FD-Score:3.57|P-value:5.97E-4 ID:SGTC_2976|Compound:9009005|FD-Score:5.94|P-value:2.12E-8 ID:SGTC_2995|Compound:9067767|FD-Score:3.56|P-value:6.02E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.57|P-value:5.85E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.86|P-value:2.15E-4 ID:SGTC_3195|Compound:9113082|FD-Score:4.25|P-value:5.12E-5 ID:SGTC_3233|Compound:9132340|FD-Score:3.54|P-value:6.58E-4 ID:SGTC_3269|Compound:9137823|FD-Score:3.74|P-value:3.34E-4 ID:SGTC_3293|Compound:9120939|FD-Score:-3.78|P-value:1.09E-4

Top fitness defect scores for YMR245W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1771 st048882 6.18 4.2 µM 5.89E-9 RPP1 & pyrimidine depletion 2 3.29E-10
2 SGTC_2976 9009005 5.94 19.5 µM 2.12E-8 12 1.42E-9
3 SGTC_1676 st018489 5.61 23.4 µM 1.19E-7 60S ribosome export 8 1.03E-8
4 SGTC_1583 clindamycin 5.51 39.6 µM 1.90E-7 mitochondrial processes 1 1.75E-8
5 SGTC_2112 5488546 5.47 200.0 µM 2.39E-7 TSC3-RPN4 6 2.28E-8
6 SGTC_386 1509-0011 5.37 3.1 µM 3.93E-7 100 4.02E-8
7 SGTC_1804 st050076 5.24 49.1 µM 7.09E-7 2 7.89E-8
8 SGTC_2313 7726885 5.06 200.0 µM 1.70E-6 RPP1 & pyrimidine depletion 14 2.15E-7
9 SGTC_1778 st046819 4.94 58.9 µM 2.80E-6 12 3.81E-7
10 SGTC_1732 st034308 4.82 51.8 µM 4.77E-6 15 7.03E-7
11 SGTC_1851 st056236 4.77 18.9 µM 6.12E-6 5 9.35E-7
12 SGTC_530 4358-1714 4.54 28.0 µM 1.58E-5 29 2.78E-6
13 SGTC_2681 menadione 4.40 3.2 µM 2.85E-5 superoxide 26 5.46E-6
14 SGTC_2931 9014674 4.39 55.7 µM 2.96E-5 13 5.70E-6
15 SGTC_192 3455-0609 4.35 60.9 µM 3.42E-5 7 6.74E-6
16 SGTC_757 1066-0008 4.28 322.0 µM 4.61E-5 Golgi 14 9.49E-6
17 SGTC_1567 st069303 4.27 68.4 µM 4.68E-5 mitochondrial processes 11 9.65E-6
18 SGTC_3195 9113082 4.25 49.5 µM 5.12E-5 14 1.07E-5
19 SGTC_286 k060-0067 4.24 22.9 µM 5.30E-5 tubulin folding & SWR complex 21 1.11E-5
20 SGTC_2479 5617353 4.17 43.9 µM 6.87E-5 31 1.50E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.112 7.49E-11 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.085 7.14E-7 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.083 1.33E-6 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.082 2.01E-6 YDR340W_d YDR340W_d hom Putative protein of unknown function
0.080 3.11E-6 YNL160W YGP1 hom Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p
0.079 4.01E-6 YDR019C GCV1 hom T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm
0.079 4.80E-6 YPL188W POS5 hom Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress
0.077 7.28E-6 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.077 8.97E-6 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.076 9.15E-6 YFR032C-A RPL29 hom Ribosomal 60S subunit protein L29; not essential for translation, but required for proper joining of large and small ribosomal subunits and for normal translation rate; homologous to mammalian ribosomal protein L29, no bacterial homolog
0.075 1.36E-5 YPL011C TAF3 het TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation
0.074 1.64E-5 YKL206C ADD66 hom Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly
0.074 1.70E-5 YML007W YAP1 hom Basic leucine zipper (bZIP) transcription factor; required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; Yap1p is degraded in the nucleus after the oxidative stress has passed; mediates resistance to cadmium; YAP1 has a paralog, CAD1, that arose from the whole genome duplication; relative distribution to the nucleus increases upon DNA replication stress
0.074 1.86E-5 YIL140W AXL2 hom Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate
0.072 2.94E-5 YHL036W MUP3 hom Low affinity methionine permease, similar to Mup1p