YMR247W-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR247W-A / YMR247W-A

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:4.11|P-value:1.60E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:3.94|P-value:3.44E-5 ID:SGTC_82|Compound:0054-0107|FD-Score:5.79|P-value:2.47E-9 ID:SGTC_83|Compound:0170-0301|FD-Score:4.59|P-value:1.75E-6 ID:SGTC_85|Compound:0868-0259|FD-Score:3.08|P-value:9.03E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.12|P-value:8.89E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.15|P-value:7.15E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.38|P-value:3.16E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.09|P-value:8.64E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.46|P-value:2.33E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:4.36|P-value:5.27E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:3.11|P-value:8.22E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.74|P-value:8.67E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:-6.58|P-value:1.84E-11 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.38|P-value:3.52E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:5.83|P-value:1.96E-9 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.93|P-value:4.03E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:4.07|P-value:1.90E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:3.05|P-value:9.96E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.95|P-value:2.78E-7 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.87|P-value:4.50E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.14|P-value:7.48E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.54|P-value:1.95E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:4.52|P-value:2.41E-6 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.85|P-value:4.93E-5 ID:SGTC_1603|Compound:st002045|FD-Score:3.16|P-value:6.82E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.71|P-value:9.97E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.78|P-value:7.59E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.64|P-value:1.15E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.11|P-value:1.62E-5 ID:SGTC_1753|Compound:st043925|FD-Score:3.20|P-value:5.97E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.32|P-value:4.34E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.34|P-value:5.70E-6 ID:SGTC_1919|Compound:st067113|FD-Score:-3.92|P-value:4.28E-5 ID:SGTC_1942|Compound:st076330|FD-Score:3.98|P-value:2.81E-5 ID:SGTC_1989|Compound:st071868|FD-Score:-3.27|P-value:5.25E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.88|P-value:4.43E-5 ID:SGTC_2206|Compound:7254556|FD-Score:3.28|P-value:4.45E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.56|P-value:1.77E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.23|P-value:5.97E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.78|P-value:7.56E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-4.42|P-value:4.55E-6 ID:SGTC_2943|Compound:9068529|FD-Score:-3.75|P-value:8.32E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-4.42|P-value:4.54E-6 ID:SGTC_2952|Compound:9073731|FD-Score:-4.08|P-value:2.16E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-8.13|P-value:1.53E-16 ID:SGTC_2969|Compound:9091408|FD-Score:-3.91|P-value:4.42E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.61|P-value:1.31E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.92|P-value:4.12E-5 ID:SGTC_3274|Compound:9138298|FD-Score:-3.41|P-value:3.17E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-3.42|P-value:2.97E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.30|P-value:4.13E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.75|P-value:8.51E-5 ID:SGTC_5|Compound:0352-0601|FD-Score:4.11|P-value:1.60E-5 ID:SGTC_34|Compound:0469-0683|FD-Score:3.94|P-value:3.44E-5 ID:SGTC_82|Compound:0054-0107|FD-Score:5.79|P-value:2.47E-9 ID:SGTC_83|Compound:0170-0301|FD-Score:4.59|P-value:1.75E-6 ID:SGTC_85|Compound:0868-0259|FD-Score:3.08|P-value:9.03E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:-3.12|P-value:8.89E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.15|P-value:7.15E-4 ID:SGTC_155|Compound:k072-0202|FD-Score:3.38|P-value:3.16E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.09|P-value:8.64E-4 ID:SGTC_382|Compound:3229-0966|FD-Score:3.46|P-value:2.33E-4 ID:SGTC_486|Compound:niguldipine|FD-Score:4.36|P-value:5.27E-6 ID:SGTC_536|Compound:3852-0578|FD-Score:3.11|P-value:8.22E-4 ID:SGTC_777|Compound:1315-0167|FD-Score:-3.74|P-value:8.67E-5 ID:SGTC_784|Compound:4579-0127|FD-Score:-6.58|P-value:1.84E-11 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.38|P-value:3.52E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:5.83|P-value:1.96E-9 ID:SGTC_947|Compound:3447-0010|FD-Score:-3.93|P-value:4.03E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:4.07|P-value:1.90E-5 ID:SGTC_1078|Compound:idebenone|FD-Score:3.05|P-value:9.96E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:4.95|P-value:2.78E-7 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.87|P-value:4.50E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.14|P-value:7.48E-4 ID:SGTC_1483|Compound:3453-0561|FD-Score:-3.54|P-value:1.95E-4 ID:SGTC_1488|Compound:4013-0813|FD-Score:4.52|P-value:2.41E-6 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.85|P-value:4.93E-5 ID:SGTC_1603|Compound:st002045|FD-Score:3.16|P-value:6.82E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.71|P-value:9.97E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.78|P-value:7.59E-5 ID:SGTC_1713|Compound:st033146|FD-Score:3.64|P-value:1.15E-4 ID:SGTC_1716|Compound:st033144|FD-Score:4.11|P-value:1.62E-5 ID:SGTC_1753|Compound:st043925|FD-Score:3.20|P-value:5.97E-4 ID:SGTC_1912|Compound:st060209|FD-Score:-3.32|P-value:4.34E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.34|P-value:5.70E-6 ID:SGTC_1919|Compound:st067113|FD-Score:-3.92|P-value:4.28E-5 ID:SGTC_1942|Compound:st076330|FD-Score:3.98|P-value:2.81E-5 ID:SGTC_1989|Compound:st071868|FD-Score:-3.27|P-value:5.25E-4 ID:SGTC_2010|Compound:4012422|FD-Score:3.88|P-value:4.43E-5 ID:SGTC_2206|Compound:7254556|FD-Score:3.28|P-value:4.45E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.56|P-value:1.77E-4 ID:SGTC_2315|Compound:7733312|FD-Score:-3.23|P-value:5.97E-4 ID:SGTC_2347|Compound:9049783|FD-Score:-3.78|P-value:7.56E-5 ID:SGTC_2922|Compound:7999257|FD-Score:-4.42|P-value:4.55E-6 ID:SGTC_2943|Compound:9068529|FD-Score:-3.75|P-value:8.32E-5 ID:SGTC_2949|Compound:9072542|FD-Score:-4.42|P-value:4.54E-6 ID:SGTC_2952|Compound:9073731|FD-Score:-4.08|P-value:2.16E-5 ID:SGTC_2966|Compound:9084041|FD-Score:-8.13|P-value:1.53E-16 ID:SGTC_2969|Compound:9091408|FD-Score:-3.91|P-value:4.42E-5 ID:SGTC_3266|Compound:9136860|FD-Score:3.61|P-value:1.31E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-3.92|P-value:4.12E-5 ID:SGTC_3274|Compound:9138298|FD-Score:-3.41|P-value:3.17E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-3.42|P-value:2.97E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.30|P-value:4.13E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.75|P-value:8.51E-5

Top fitness defect scores for YMR247W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_894 0960-0238 5.83 55.9 µM 1.96E-9 2 2.79E-9
2 SGTC_82 0054-0107 5.79 293.8 µM 2.47E-9 4 3.50E-9
3 SGTC_1135 dihydrocapsaicin 4.95 536.7 nM 2.78E-7 13 3.64E-7
4 SGTC_83 0170-0301 4.59 39.0 µM 1.75E-6 endomembrane recycling 5 2.22E-6
5 SGTC_1488 4013-0813 4.52 75.9 µM 2.41E-6 RPP1 & pyrimidine depletion 4 3.05E-6
6 SGTC_486 niguldipine 4.36 82.0 µM 5.27E-6 amide catabolism 12 6.57E-6
7 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.34 70.1 µM 5.70E-6 15 7.10E-6
8 SGTC_5 0352-0601 4.11 109.9 µM 1.60E-5 ERG2 14 1.96E-5
9 SGTC_1716 st033144 4.11 30.6 µM 1.62E-5 18 1.98E-5
10 SGTC_998 3996-0085 4.07 177.0 µM 1.90E-5 15 2.32E-5
11 SGTC_1942 st076330 3.98 65.2 µM 2.81E-5 30 3.40E-5
12 SGTC_34 0469-0683 3.94 81.8 µM 3.44E-5 SWF1 & branched chain AA biosynthesis 27 4.15E-5
13 SGTC_2010 4012422 3.88 159.0 µM 4.43E-5 23 5.32E-5
14 SGTC_1277 0873-0036 3.87 22.0 µM 4.50E-5 PDR1 26 5.40E-5
15 SGTC_1504 k297-0033 3.85 30.0 µM 4.93E-5 15 5.91E-5
16 SGTC_1713 st033146 3.64 12.8 µM 1.15E-4 35 1.35E-4
17 SGTC_3266 9136860 3.61 49.5 µM 1.31E-4 cell wall 58 1.54E-4
18 SGTC_382 3229-0966 3.46 23.2 µM 2.33E-4 38 2.72E-4
19 SGTC_155 k072-0202 3.38 43.6 µM 3.16E-4 34 3.67E-4
20 SGTC_3311 9131146 3.30 2.9 µM 4.13E-4 cell wall 153 4.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.095 4.02E-8 YLR152C_p YLR152C_p hom Putative protein of unknown function; YLR152C is not an essential gene
0.085 8.62E-7 YLR214W FRE1 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels
0.076 1.20E-5 YDL113C ATG20 hom Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate
0.075 1.31E-5 YLL016W SDC25 hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL017W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.075 1.36E-5 YNL078W NIS1 hom Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network
0.075 1.56E-5 YDR249C_p YDR249C_p hom Putative protein of unknown function
0.074 1.95E-5 YER072W VTC1 hom Subunit of the vacuolar transporter chaperone (VTC) complex; VTC complex is involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.074 2.00E-5 YPR046W MCM16 hom Component of the Ctf19 complex and the COMA subcomplex; involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-H and fission yeast fta3
0.072 2.77E-5 YDR209C_d YDR209C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.
0.072 2.85E-5 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.072 2.91E-5 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
0.071 3.95E-5 YDR317W HIM1 hom Protein of unknown function involved in DNA repair
0.070 5.28E-5 YLR054C OSW2 hom Protein of unknown function proposed to be involved in the assembly of the spore wall
0.069 6.55E-5 YDR253C MET32 hom Zinc-finger DNA-binding transcription factor; involved in transcriptional regulation of the methionine biosynthetic genes; MET32 has a paralog, MET31, that arose from the whole genome duplication
0.068 8.59E-5 YDL012C YDL012C hom Tail-anchored plasma membrane protein with a conserved CYSTM module; possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype; YDL012C has a paralog, YBR016W, that arose from the whole genome duplication