YMR251W / GTO3

Omega class glutathione transferase; putative cytosolic localization

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR251W / GTO3

Click on Significant Values for Screen Details ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.85|P-value:9.53E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.12|P-value:3.26E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.45|P-value:3.61E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.59|P-value:2.52E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:5.23|P-value:1.96E-7 ID:SGTC_972|Compound:1319-0219|FD-Score:3.41|P-value:4.85E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.49|P-value:3.62E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.27|P-value:7.87E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.37|P-value:5.55E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.71|P-value:1.39E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.42|P-value:4.07E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.60|P-value:2.48E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.22|P-value:9.11E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.04|P-value:4.53E-5 ID:SGTC_2052|Compound:5265182|FD-Score:-4.04|P-value:3.80E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.98|P-value:5.85E-5 ID:SGTC_2087|Compound:5276107|FD-Score:6.04|P-value:2.34E-9 ID:SGTC_2098|Compound:5376439|FD-Score:4.68|P-value:2.85E-6 ID:SGTC_2100|Compound:5377183|FD-Score:3.98|P-value:5.72E-5 ID:SGTC_2199|Compound:6590217|FD-Score:-3.45|P-value:3.60E-4 ID:SGTC_2212|Compound:7123476|FD-Score:-3.36|P-value:5.03E-4 ID:SGTC_2227|Compound:7312221|FD-Score:3.82|P-value:1.07E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.75|P-value:1.40E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:6.55|P-value:1.05E-10 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.52|P-value:2.88E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.51|P-value:4.45E-8 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.31|P-value:1.48E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.25|P-value:8.27E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.63|P-value:2.31E-8 ID:SGTC_2767|Compound:sibutramine|FD-Score:5.34|P-value:1.11E-7 ID:SGTC_2777|Compound:climbazole|FD-Score:4.09|P-value:3.76E-5 ID:SGTC_2954|Compound:9074818|FD-Score:-3.26|P-value:7.09E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-4.59|P-value:3.66E-6 ID:SGTC_265|Compound:mycophenolic acid|FD-Score:3.85|P-value:9.53E-5 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.12|P-value:3.26E-5 ID:SGTC_370|Compound:0180-0345|FD-Score:-3.45|P-value:3.61E-4 ID:SGTC_423|Compound:5-fluorouracil|FD-Score:3.59|P-value:2.52E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:5.23|P-value:1.96E-7 ID:SGTC_972|Compound:1319-0219|FD-Score:3.41|P-value:4.85E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.49|P-value:3.62E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.27|P-value:7.87E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.37|P-value:5.55E-4 ID:SGTC_1379|Compound:2144-0755|FD-Score:-3.71|P-value:1.39E-4 ID:SGTC_1521|Compound:st012942|FD-Score:-3.42|P-value:4.07E-4 ID:SGTC_1713|Compound:st033146|FD-Score:3.60|P-value:2.48E-4 ID:SGTC_1962|Compound:st076595|FD-Score:3.22|P-value:9.11E-4 ID:SGTC_2005|Compound:4024620|FD-Score:4.04|P-value:4.53E-5 ID:SGTC_2052|Compound:5265182|FD-Score:-4.04|P-value:3.80E-5 ID:SGTC_2059|Compound:5238311|FD-Score:3.98|P-value:5.85E-5 ID:SGTC_2087|Compound:5276107|FD-Score:6.04|P-value:2.34E-9 ID:SGTC_2098|Compound:5376439|FD-Score:4.68|P-value:2.85E-6 ID:SGTC_2100|Compound:5377183|FD-Score:3.98|P-value:5.72E-5 ID:SGTC_2199|Compound:6590217|FD-Score:-3.45|P-value:3.60E-4 ID:SGTC_2212|Compound:7123476|FD-Score:-3.36|P-value:5.03E-4 ID:SGTC_2227|Compound:7312221|FD-Score:3.82|P-value:1.07E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:3.75|P-value:1.40E-4 ID:SGTC_2546|Compound:rhodinyl acetate|FD-Score:6.55|P-value:1.05E-10 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.52|P-value:2.88E-4 ID:SGTC_2563|Compound:tomatine|FD-Score:5.51|P-value:4.45E-8 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.31|P-value:1.48E-5 ID:SGTC_2668|Compound:2',4'-dihydroxychalcone|FD-Score:3.25|P-value:8.27E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.63|P-value:2.31E-8 ID:SGTC_2767|Compound:sibutramine|FD-Score:5.34|P-value:1.11E-7 ID:SGTC_2777|Compound:climbazole|FD-Score:4.09|P-value:3.76E-5 ID:SGTC_2954|Compound:9074818|FD-Score:-3.26|P-value:7.09E-4 ID:SGTC_3305|Compound:9127027|FD-Score:-4.59|P-value:3.66E-6

Top fitness defect scores for YMR251W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2546 rhodinyl acetate 6.55 100.0 µM 1.05E-10 1 2.97E-11
2 SGTC_2087 5276107 6.04 200.0 µM 2.34E-9 1 7.89E-10
3 SGTC_2762 leflunomide 5.63 42.1 µM 2.31E-8 7 8.88E-9
4 SGTC_2563 tomatine 5.51 8.5 µM 4.45E-8 15 1.77E-8
5 SGTC_2767 sibutramine 5.34 71.5 µM 1.11E-7 6 4.66E-8
6 SGTC_827 3253-0474 5.23 693.0 µM 1.96E-7 5 8.49E-8
7 SGTC_2098 5376439 4.68 882.5 nM 2.85E-6 4 1.44E-6
8 SGTC_2564 betulinic acid 4.31 100.0 µM 1.48E-5 25 8.18E-6
9 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 4.12 44.4 nM 3.26E-5 DNA damage response 27 1.89E-5
10 SGTC_2777 climbazole 4.09 1.5 µM 3.76E-5 iron homeostasis 43 2.19E-5
11 SGTC_2005 4024620 4.04 188.0 µM 4.53E-5 18 2.67E-5
12 SGTC_2100 5377183 3.98 190.0 µM 5.72E-5 60S ribosome export 11 3.42E-5
13 SGTC_2059 5238311 3.98 157.0 µM 5.85E-5 26 3.50E-5
14 SGTC_265 mycophenolic acid 3.85 32.9 µM 9.53E-5 RPP1 & pyrimidine depletion 21 5.87E-5
15 SGTC_2227 7312221 3.82 64.1 µM 1.07E-4 3 6.66E-5
16 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 3.75 100.0 µM 1.40E-4 27 8.83E-5
17 SGTC_1713 st033146 3.60 12.8 µM 2.48E-4 37 1.61E-4
18 SGTC_423 5-fluorouracil 3.59 457.0 µM 2.52E-4 exosome 33 1.64E-4
19 SGTC_1042 0350-0096 3.49 82.0 µM 3.62E-4 TSC3-RPN4 41 2.40E-4
20 SGTC_972 1319-0219 3.41 195.0 µM 4.85E-4 54 3.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.159 2.47E-20 YIR010W DSN1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation
0.142 1.07E-16 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.136 3.09E-15 YGL242C_p YGL242C_p hom Putative protein of unknown function; deletion mutant is viable
0.136 3.23E-15 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.130 4.63E-14 YOR169C_d YOR169C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W
0.128 9.87E-14 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.112 8.34E-11 YPL022W RAD1 hom Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
0.109 2.79E-10 YLR105C SEN2 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease
0.107 4.54E-10 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.107 4.62E-10 YER162C RAD4 hom Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
0.106 6.10E-10 YNR032C-A HUB1 hom Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear
0.105 1.17E-9 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.102 2.70E-9 YOL052C SPE2 hom S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically
0.101 4.31E-9 YBL063W KIP1 hom Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions
0.092 8.67E-8 YDR514C YDR514C hom Protein of unknown function that localizes to mitochondria; overexpression affects endocytic protein trafficking; YDR514C has a paralog, GFD2, that arose from the whole genome duplication