YMR251W-A / HOR7

Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor; HOR7 has a paralog, DDR2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR251W-A / HOR7

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.05|P-value:7.34E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.28|P-value:3.22E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.50|P-value:1.34E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:2.98|P-value:9.44E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.71|P-value:7.56E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.80|P-value:5.31E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:4.70|P-value:5.33E-7 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.33|P-value:2.64E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.63|P-value:7.52E-7 ID:SGTC_634|Compound:1611-4317|FD-Score:4.16|P-value:7.84E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:4.55|P-value:1.17E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.36|P-value:2.37E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:4.55|P-value:1.18E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:3.31|P-value:2.88E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.14|P-value:5.38E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.31|P-value:3.83E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.87|P-value:2.90E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.29|P-value:3.07E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.81|P-value:3.72E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.75|P-value:4.85E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:2.99|P-value:9.18E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.47|P-value:1.55E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.43|P-value:1.78E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.94|P-value:2.11E-5 ID:SGTC_1590|Compound:st077108|FD-Score:5.78|P-value:1.04E-9 ID:SGTC_1632|Compound:st005650|FD-Score:3.27|P-value:3.33E-4 ID:SGTC_1648|Compound:st011736|FD-Score:4.17|P-value:7.43E-6 ID:SGTC_1684|Compound:st024538|FD-Score:3.35|P-value:2.47E-4 ID:SGTC_1689|Compound:st020265|FD-Score:4.84|P-value:2.48E-7 ID:SGTC_1726|Compound:st035556|FD-Score:3.22|P-value:3.97E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.10|P-value:6.12E-4 ID:SGTC_1828|Compound:st055811|FD-Score:5.32|P-value:1.76E-8 ID:SGTC_1832|Compound:st054113|FD-Score:3.46|P-value:1.61E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.15|P-value:5.22E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.44|P-value:1.74E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.49|P-value:1.38E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.49|P-value:1.41E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.31|P-value:2.79E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.14|P-value:6.89E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.01|P-value:8.47E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.08|P-value:6.70E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.66|P-value:7.12E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.86|P-value:3.03E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.61|P-value:8.46E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.04|P-value:9.66E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.21|P-value:5.30E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.34|P-value:3.22E-6 ID:SGTC_2878|Compound:9043973|FD-Score:3.06|P-value:7.02E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.28|P-value:3.22E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.23|P-value:5.46E-6 ID:SGTC_3305|Compound:9127027|FD-Score:3.44|P-value:1.69E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.85|P-value:3.16E-5 ID:SGTC_3333|Compound:9141820|FD-Score:3.88|P-value:2.73E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:3.05|P-value:7.34E-4 ID:SGTC_92|Compound:0063-0024|FD-Score:3.28|P-value:3.22E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.50|P-value:1.34E-4 ID:SGTC_497|Compound:capsazepine|FD-Score:2.98|P-value:9.44E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:-3.71|P-value:7.56E-5 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.80|P-value:5.31E-5 ID:SGTC_554|Compound:4483-2211|FD-Score:4.70|P-value:5.33E-7 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.33|P-value:2.64E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.63|P-value:7.52E-7 ID:SGTC_634|Compound:1611-4317|FD-Score:4.16|P-value:7.84E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:4.55|P-value:1.17E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:3.36|P-value:2.37E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:4.55|P-value:1.18E-6 ID:SGTC_970|Compound:1315-0089|FD-Score:3.31|P-value:2.88E-4 ID:SGTC_981|Compound:1488-1094|FD-Score:3.14|P-value:5.38E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:4.31|P-value:3.83E-6 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.87|P-value:2.90E-5 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.29|P-value:3.07E-4 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:3.81|P-value:3.72E-5 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.75|P-value:4.85E-5 ID:SGTC_1220|Compound:1838-0075|FD-Score:2.99|P-value:9.18E-4 ID:SGTC_1273|Compound:0849-0096|FD-Score:3.47|P-value:1.55E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:3.43|P-value:1.78E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.94|P-value:2.11E-5 ID:SGTC_1590|Compound:st077108|FD-Score:5.78|P-value:1.04E-9 ID:SGTC_1632|Compound:st005650|FD-Score:3.27|P-value:3.33E-4 ID:SGTC_1648|Compound:st011736|FD-Score:4.17|P-value:7.43E-6 ID:SGTC_1684|Compound:st024538|FD-Score:3.35|P-value:2.47E-4 ID:SGTC_1689|Compound:st020265|FD-Score:4.84|P-value:2.48E-7 ID:SGTC_1726|Compound:st035556|FD-Score:3.22|P-value:3.97E-4 ID:SGTC_1768|Compound:st044301|FD-Score:3.10|P-value:6.12E-4 ID:SGTC_1828|Compound:st055811|FD-Score:5.32|P-value:1.76E-8 ID:SGTC_1832|Compound:st054113|FD-Score:3.46|P-value:1.61E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.15|P-value:5.22E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.44|P-value:1.74E-4 ID:SGTC_1912|Compound:st060209|FD-Score:3.49|P-value:1.38E-4 ID:SGTC_1949|Compound:st076024|FD-Score:3.49|P-value:1.41E-4 ID:SGTC_2191|Compound:5911152|FD-Score:3.31|P-value:2.79E-4 ID:SGTC_2279|Compound:7948423|FD-Score:-3.14|P-value:6.89E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.01|P-value:8.47E-4 ID:SGTC_2473|Compound:5854593|FD-Score:3.08|P-value:6.70E-4 ID:SGTC_2474|Compound:5321570|FD-Score:3.66|P-value:7.12E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.86|P-value:3.03E-5 ID:SGTC_2570|Compound:licareol|FD-Score:3.61|P-value:8.46E-5 ID:SGTC_2607|Compound:solasodine|FD-Score:-3.04|P-value:9.66E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:-3.21|P-value:5.30E-4 ID:SGTC_2800|Compound:7887935|FD-Score:4.34|P-value:3.22E-6 ID:SGTC_2878|Compound:9043973|FD-Score:3.06|P-value:7.02E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.28|P-value:3.22E-4 ID:SGTC_3202|Compound:9113761|FD-Score:4.23|P-value:5.46E-6 ID:SGTC_3305|Compound:9127027|FD-Score:3.44|P-value:1.69E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.85|P-value:3.16E-5 ID:SGTC_3333|Compound:9141820|FD-Score:3.88|P-value:2.73E-5

Top fitness defect scores for YMR251W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1590 st077108 5.78 57.8 µM 1.04E-9 1 3.76E-9
2 SGTC_1828 st055811 5.32 49.0 µM 1.76E-8 1 5.33E-8
3 SGTC_1689 st020265 4.84 53.5 µM 2.48E-7 10 6.35E-7
4 SGTC_554 4483-2211 4.70 187.0 µM 5.33E-7 7 1.30E-6
5 SGTC_579 4491-1009 4.63 110.0 µM 7.52E-7 60S ribosome export 11 1.80E-6
6 SGTC_637 1181-0519 4.55 7.3 µM 1.17E-6 fatty acid desaturase (OLE1) 80 2.73E-6
7 SGTC_937 3122-0005 4.55 46.7 µM 1.18E-6 14 2.74E-6
8 SGTC_2800 7887935 4.34 81.8 µM 3.22E-6 RPP1 & pyrimidine depletion 20 7.02E-6
9 SGTC_991 3996-0057 4.31 64.7 µM 3.83E-6 15 8.26E-6
10 SGTC_3202 9113761 4.23 49.5 µM 5.46E-6 39 1.15E-5
11 SGTC_1648 st011736 4.17 69.8 µM 7.43E-6 PDR1 12 1.54E-5
12 SGTC_634 1611-4317 4.16 11.2 µM 7.84E-6 ERG2 11 1.62E-5
13 SGTC_1505 k297-0037 3.94 20.6 µM 2.11E-5 18 4.08E-5
14 SGTC_3333 9141820 3.88 12.1 µM 2.73E-5 14 5.20E-5
15 SGTC_1017 4239-0030 3.87 168.0 µM 2.90E-5 32 5.50E-5
16 SGTC_2531 methyl deoxycholate 3.86 70.1 µM 3.03E-5 27 5.74E-5
17 SGTC_3326 9140064 3.85 16.4 µM 3.16E-5 21 5.97E-5
18 SGTC_1065 prochlorperazine maleate 3.81 2.5 µM 3.72E-5 16 6.95E-5
19 SGTC_1173 0443-0020 3.75 122.0 µM 4.85E-5 TSC3-RPN4 40 8.91E-5
20 SGTC_2474 5321570 3.66 43.3 µM 7.12E-5 21 1.28E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.100 6.15E-9 YKL071W_p YKL071W_p hom Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.099 9.93E-9 YGR047C TFC4 het One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
0.096 2.78E-8 YDR266C HEL2 hom RING finger ubiquitin ligase (E3); involved in ubiquitylation and degradation of excess histones; interacts with Ubc4p and Rad53p; null mutant sensitive to hydroxyurea (HU); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; computational analysis suggests a role as a transcription factor
0.088 3.87E-7 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.086 6.91E-7 YPL277C_p YPL277C_p hom Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels
0.083 1.46E-6 YER039C HVG1 hom Protein of unknown function, has homology to Vrg4p
0.083 1.72E-6 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.081 2.44E-6 YOR377W ATF1 hom Alcohol acetyltransferase; responsible for the major part of volatile acetate ester production during fermentation; main enzyme involved in terpenyl acetate synthesis; potential roles in lipid and sterol metabolism
0.080 3.17E-6 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.078 5.49E-6 YGR094W VAS1 het Mitochondrial and cytoplasmic valyl-tRNA synthetase
0.077 8.88E-6 YML002W_p YML002W_p hom Putative protein of unknown function; expression induced by heat and by calcium shortage
0.077 9.13E-6 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.069 7.12E-5 YKL095W YJU2 het Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing
0.068 7.48E-5 YBL106C SRO77 hom Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p; SRO77 has a paralog, SRO7, that arose from the whole genome duplication
0.067 1.12E-4 YPL203W TPK2 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase