YMR252C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR252C / YMR252C

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-2.86|P-value:7.73E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:2.96|P-value:6.08E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:2.83|P-value:9.73E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.33|P-value:1.08E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:3.89|P-value:1.04E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:2.96|P-value:5.94E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.64|P-value:2.93E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.11|P-value:3.33E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-2.84|P-value:8.36E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.16|P-value:2.72E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.52|P-value:5.78E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.25|P-value:1.89E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.54|P-value:5.40E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:3.33|P-value:1.36E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.27|P-value:1.72E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.81|P-value:1.49E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.63|P-value:3.48E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:3.59|P-value:4.18E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:2.99|P-value:5.41E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:2.85|P-value:9.11E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.36|P-value:1.17E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.30|P-value:1.51E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-2.95|P-value:5.49E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.22|P-value:2.10E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.16|P-value:2.79E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.44|P-value:5.73E-7 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.81|P-value:6.66E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:-4.74|P-value:8.34E-8 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.44|P-value:8.31E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.14|P-value:2.97E-4 ID:SGTC_1703|Compound:st026983|FD-Score:2.93|P-value:6.71E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.90|P-value:6.66E-4 ID:SGTC_1972|Compound:st070201|FD-Score:6.74|P-value:7.45E-14 ID:SGTC_1988|Compound:st071872|FD-Score:2.89|P-value:7.82E-4 ID:SGTC_2093|Compound:5331342|FD-Score:2.88|P-value:8.20E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.00|P-value:5.97E-6 ID:SGTC_2148|Compound:5546263|FD-Score:3.60|P-value:4.03E-5 ID:SGTC_2166|Compound:5933061|FD-Score:3.72|P-value:2.37E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.56|P-value:4.29E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.66|P-value:3.10E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:2.96|P-value:6.12E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.32|P-value:1.23E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.17|P-value:2.05E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.58|P-value:4.36E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.39|P-value:8.89E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:3.03|P-value:4.66E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.08|P-value:3.79E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.06|P-value:4.14E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.37|P-value:9.82E-5 ID:SGTC_2824|Compound:7998404|FD-Score:-3.05|P-value:3.81E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.05|P-value:3.75E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.40|P-value:9.98E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.47|P-value:7.41E-5 ID:SGTC_3012|Compound:9080433|FD-Score:3.87|P-value:1.13E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:-2.86|P-value:7.73E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:2.96|P-value:6.08E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:2.83|P-value:9.73E-4 ID:SGTC_130|Compound:0136-0219|FD-Score:4.33|P-value:1.08E-6 ID:SGTC_135|Compound:0933-0004|FD-Score:3.89|P-value:1.04E-5 ID:SGTC_308|Compound:4092-1169|FD-Score:2.96|P-value:5.94E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.64|P-value:2.93E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.11|P-value:3.33E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-2.84|P-value:8.36E-4 ID:SGTC_461|Compound:N-acetylfarnesylcysteine|FD-Score:3.16|P-value:2.72E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.52|P-value:5.78E-5 ID:SGTC_632|Compound:0781-2353|FD-Score:3.25|P-value:1.89E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:3.54|P-value:5.40E-5 ID:SGTC_663|Compound:1486-0733|FD-Score:3.33|P-value:1.36E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:3.27|P-value:1.72E-4 ID:SGTC_760|Compound:0568-0725|FD-Score:3.81|P-value:1.49E-5 ID:SGTC_766|Compound:1391-0721|FD-Score:3.63|P-value:3.48E-5 ID:SGTC_845|Compound:0330-0138|FD-Score:3.59|P-value:4.18E-5 ID:SGTC_864|Compound:0469-0573|FD-Score:2.99|P-value:5.41E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:2.85|P-value:9.11E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:3.36|P-value:1.17E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.30|P-value:1.51E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-2.95|P-value:5.49E-4 ID:SGTC_1194|Compound:1488-0194|FD-Score:3.22|P-value:2.10E-4 ID:SGTC_1292|Compound:0kpi-0043|FD-Score:3.16|P-value:2.79E-4 ID:SGTC_1311|Compound:1190-0148|FD-Score:4.44|P-value:5.73E-7 ID:SGTC_1313|Compound:1220-0047|FD-Score:4.81|P-value:6.66E-8 ID:SGTC_1317|Compound:1273-0028|FD-Score:-4.74|P-value:8.34E-8 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:3.44|P-value:8.31E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.14|P-value:2.97E-4 ID:SGTC_1703|Compound:st026983|FD-Score:2.93|P-value:6.71E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-2.90|P-value:6.66E-4 ID:SGTC_1972|Compound:st070201|FD-Score:6.74|P-value:7.45E-14 ID:SGTC_1988|Compound:st071872|FD-Score:2.89|P-value:7.82E-4 ID:SGTC_2093|Compound:5331342|FD-Score:2.88|P-value:8.20E-4 ID:SGTC_2126|Compound:5251174|FD-Score:4.00|P-value:5.97E-6 ID:SGTC_2148|Compound:5546263|FD-Score:3.60|P-value:4.03E-5 ID:SGTC_2166|Compound:5933061|FD-Score:3.72|P-value:2.37E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:-3.56|P-value:4.29E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.66|P-value:3.10E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:2.96|P-value:6.12E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.32|P-value:1.23E-4 ID:SGTC_2581|Compound:avocatin a|FD-Score:-4.17|P-value:2.05E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.58|P-value:4.36E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.39|P-value:8.89E-5 ID:SGTC_2740|Compound:felodipine|FD-Score:3.03|P-value:4.66E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.08|P-value:3.79E-4 ID:SGTC_2747|Compound:doxorubicin|FD-Score:3.06|P-value:4.14E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-3.37|P-value:9.82E-5 ID:SGTC_2824|Compound:7998404|FD-Score:-3.05|P-value:3.81E-4 ID:SGTC_2826|Compound:7992541|FD-Score:-3.05|P-value:3.75E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.40|P-value:9.98E-5 ID:SGTC_2976|Compound:9009005|FD-Score:3.47|P-value:7.41E-5 ID:SGTC_3012|Compound:9080433|FD-Score:3.87|P-value:1.13E-5

Top fitness defect scores for YMR252C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1972 st070201 6.74 17.4 µM 7.45E-14 7 8.14E-12
2 SGTC_1313 1220-0047 4.81 237.0 µM 6.66E-8 21 7.42E-7
3 SGTC_1311 1190-0148 4.44 100.0 µM 5.73E-7 azole & statin 19 4.48E-6
4 SGTC_130 0136-0219 4.33 337.7 µM 1.08E-6 15 7.59E-6
5 SGTC_2126 5251174 4.00 33.9 µM 5.97E-6 33 3.18E-5
6 SGTC_135 0933-0004 3.89 26.4 µM 1.04E-5 60S ribosome export 28 5.08E-5
7 SGTC_3012 9080433 3.87 71.4 µM 1.13E-5 15 5.42E-5
8 SGTC_760 0568-0725 3.81 82.9 µM 1.49E-5 13 6.86E-5
9 SGTC_2166 5933061 3.72 31.5 µM 2.37E-5 tubulin folding & SWR complex 50 1.01E-4
10 SGTC_2478 5763493 3.66 32.3 µM 3.10E-5 29 1.27E-4
11 SGTC_766 1391-0721 3.63 126.0 µM 3.48E-5 21 1.40E-4
12 SGTC_2148 5546263 3.60 113.6 µM 4.03E-5 29 1.58E-4
13 SGTC_845 0330-0138 3.59 4.5 µM 4.18E-5 28 1.63E-4
14 SGTC_2648 atorvastatin 3.58 78.7 µM 4.36E-5 azole & statin 26 1.69E-4
15 SGTC_640 3381-0960 3.54 37.1 µM 5.40E-5 24 2.02E-4
16 SGTC_618 k072-0232 3.52 33.2 µM 5.78E-5 60S ribosome export 17 2.14E-4
17 SGTC_2976 9009005 3.47 19.5 µM 7.41E-5 40 2.63E-4
18 SGTC_1544 7-methoxy-4-methylcoumarin 3.44 105.0 µM 8.31E-5 32 2.90E-4
19 SGTC_2852 9023854 3.40 52.0 µM 9.98E-5 43 3.38E-4
20 SGTC_1123 mangostin 3.36 811.3 nM 1.17E-4 mitochondrial response to ROS 59 3.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.118 7.33E-12 YBR067C TIP1 hom Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins
0.116 1.60E-11 YNL274C GOR1 hom Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.108 4.04E-10 YJL119C_d YJL119C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.09E-8 YIR036C_p IRC24_p hom Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci
0.092 1.10E-7 YHR080C YHR080C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication
0.088 3.29E-7 YDR499W LCD1 het Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP; forms nuclear foci upon DNA replication stress
0.086 5.56E-7 YMR223W UBP8 hom Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B
0.081 2.72E-6 YLL053C_p YLL053C_p hom Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin
0.079 4.03E-6 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.079 4.86E-6 YML074C FPR3 hom Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
0.077 8.22E-6 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)
0.077 8.40E-6 YBL064C PRX1 hom Mitochondrial peroxiredoxin with thioredoxin peroxidase activity; has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated; protein abundance increases in response to DNA replication stress
0.076 1.06E-5 YEL052W AFG1 hom Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain
0.075 1.28E-5 YOR124C UBP2 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity
0.073 2.54E-5 YLR312W-A MRPL15 hom Mitochondrial ribosomal protein of the large subunit