YMR253C_p

Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR253C / YMR253C

Click on Significant Values for Screen Details ID:SGTC_202|Compound:3594-0513|FD-Score:3.92|P-value:2.46E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.43|P-value:1.90E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.53|P-value:1.38E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.20|P-value:4.64E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.21|P-value:4.17E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.33|P-value:2.87E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.76|P-value:4.95E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:4.05|P-value:1.35E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:6.73|P-value:1.52E-12 ID:SGTC_891|Compound:0929-0073|FD-Score:3.37|P-value:2.39E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:4.40|P-value:2.55E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.01|P-value:9.16E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.74|P-value:5.27E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.57|P-value:1.11E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.01|P-value:9.28E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.18|P-value:5.05E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.31|P-value:3.92E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.00|P-value:9.53E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.22|P-value:6.18E-6 ID:SGTC_1625|Compound:st003711|FD-Score:3.53|P-value:1.30E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.71|P-value:6.00E-5 ID:SGTC_1629|Compound:st005085|FD-Score:8.46|P-value:8.68E-19 ID:SGTC_1634|Compound:st006576|FD-Score:3.51|P-value:1.40E-4 ID:SGTC_1636|Compound:st007707|FD-Score:13.50|P-value:4.17E-45 ID:SGTC_1713|Compound:st033146|FD-Score:3.48|P-value:1.55E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.10|P-value:6.65E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.28|P-value:3.36E-4 ID:SGTC_1975|Compound:st070967|FD-Score:5.70|P-value:1.74E-9 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.28|P-value:3.23E-4 ID:SGTC_2104|Compound:5389443|FD-Score:7.30|P-value:1.86E-14 ID:SGTC_2114|Compound:5491910|FD-Score:3.51|P-value:1.40E-4 ID:SGTC_2141|Compound:5621638|FD-Score:3.55|P-value:1.16E-4 ID:SGTC_2143|Compound:5623677|FD-Score:4.81|P-value:3.07E-7 ID:SGTC_2166|Compound:5933061|FD-Score:-6.28|P-value:3.53E-11 ID:SGTC_2195|Compound:6536160|FD-Score:4.43|P-value:2.23E-6 ID:SGTC_2197|Compound:6588183|FD-Score:3.25|P-value:3.76E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.02|P-value:8.95E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.56|P-value:1.11E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.13|P-value:5.88E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.37|P-value:2.92E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:3.08|P-value:7.07E-4 ID:SGTC_2692|Compound:st077426|FD-Score:4.45|P-value:1.99E-6 ID:SGTC_2694|Compound:st077685|FD-Score:3.30|P-value:3.19E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.28|P-value:3.29E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.89|P-value:2.80E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.64|P-value:7.77E-7 ID:SGTC_2812|Compound:7970281|FD-Score:3.51|P-value:1.36E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.79|P-value:3.52E-7 ID:SGTC_2860|Compound:9025725|FD-Score:4.23|P-value:5.90E-6 ID:SGTC_2866|Compound:9034245|FD-Score:3.91|P-value:2.54E-5 ID:SGTC_2873|Compound:9040596|FD-Score:3.96|P-value:2.03E-5 ID:SGTC_2910|Compound:7948405|FD-Score:3.52|P-value:1.32E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.09|P-value:6.62E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.08|P-value:7.04E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.26|P-value:3.72E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.55|P-value:1.19E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.03|P-value:8.68E-4 ID:SGTC_202|Compound:3594-0513|FD-Score:3.92|P-value:2.46E-5 ID:SGTC_342|Compound:k048-0088|FD-Score:3.43|P-value:1.90E-4 ID:SGTC_419|Compound:nsc-638432|FD-Score:4.53|P-value:1.38E-6 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:3.20|P-value:4.64E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:-3.21|P-value:4.17E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:3.33|P-value:2.87E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.76|P-value:4.95E-5 ID:SGTC_648|Compound:0375-0473|FD-Score:4.05|P-value:1.35E-5 ID:SGTC_798|Compound:1287-0182|FD-Score:6.73|P-value:1.52E-12 ID:SGTC_891|Compound:0929-0073|FD-Score:3.37|P-value:2.39E-4 ID:SGTC_979|Compound:1426-2828|FD-Score:4.40|P-value:2.55E-6 ID:SGTC_1043|Compound:0916-0009|FD-Score:3.01|P-value:9.16E-4 ID:SGTC_1080|Compound:nisoldipine|FD-Score:3.74|P-value:5.27E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:3.57|P-value:1.11E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:3.01|P-value:9.28E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:3.18|P-value:5.05E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:4.31|P-value:3.92E-6 ID:SGTC_1361|Compound:1608-0041|FD-Score:3.00|P-value:9.53E-4 ID:SGTC_1573|Compound:oleylamine|FD-Score:4.22|P-value:6.18E-6 ID:SGTC_1625|Compound:st003711|FD-Score:3.53|P-value:1.30E-4 ID:SGTC_1628|Compound:st004252|FD-Score:3.71|P-value:6.00E-5 ID:SGTC_1629|Compound:st005085|FD-Score:8.46|P-value:8.68E-19 ID:SGTC_1634|Compound:st006576|FD-Score:3.51|P-value:1.40E-4 ID:SGTC_1636|Compound:st007707|FD-Score:13.50|P-value:4.17E-45 ID:SGTC_1713|Compound:st033146|FD-Score:3.48|P-value:1.55E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.10|P-value:6.65E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.28|P-value:3.36E-4 ID:SGTC_1975|Compound:st070967|FD-Score:5.70|P-value:1.74E-9 ID:SGTC_2091|Compound:4-phenylthiadiazole|FD-Score:-3.28|P-value:3.23E-4 ID:SGTC_2104|Compound:5389443|FD-Score:7.30|P-value:1.86E-14 ID:SGTC_2114|Compound:5491910|FD-Score:3.51|P-value:1.40E-4 ID:SGTC_2141|Compound:5621638|FD-Score:3.55|P-value:1.16E-4 ID:SGTC_2143|Compound:5623677|FD-Score:4.81|P-value:3.07E-7 ID:SGTC_2166|Compound:5933061|FD-Score:-6.28|P-value:3.53E-11 ID:SGTC_2195|Compound:6536160|FD-Score:4.43|P-value:2.23E-6 ID:SGTC_2197|Compound:6588183|FD-Score:3.25|P-value:3.76E-4 ID:SGTC_2201|Compound:6605497|FD-Score:3.02|P-value:8.95E-4 ID:SGTC_2342|Compound:7990637|FD-Score:3.56|P-value:1.11E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.13|P-value:5.88E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:4.37|P-value:2.92E-6 ID:SGTC_2610|Compound:ononetin|FD-Score:3.08|P-value:7.07E-4 ID:SGTC_2692|Compound:st077426|FD-Score:4.45|P-value:1.99E-6 ID:SGTC_2694|Compound:st077685|FD-Score:3.30|P-value:3.19E-4 ID:SGTC_2695|Compound:st077686|FD-Score:-3.28|P-value:3.29E-4 ID:SGTC_2704|Compound:st078022|FD-Score:3.89|P-value:2.80E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:4.64|P-value:7.77E-7 ID:SGTC_2812|Compound:7970281|FD-Score:3.51|P-value:1.36E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.79|P-value:3.52E-7 ID:SGTC_2860|Compound:9025725|FD-Score:4.23|P-value:5.90E-6 ID:SGTC_2866|Compound:9034245|FD-Score:3.91|P-value:2.54E-5 ID:SGTC_2873|Compound:9040596|FD-Score:3.96|P-value:2.03E-5 ID:SGTC_2910|Compound:7948405|FD-Score:3.52|P-value:1.32E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-3.09|P-value:6.62E-4 ID:SGTC_2997|Compound:9067075|FD-Score:3.08|P-value:7.04E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.26|P-value:3.72E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.55|P-value:1.19E-4 ID:SGTC_3328|Compound:9140624|FD-Score:3.03|P-value:8.68E-4

Top fitness defect scores for YMR253C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1636 st007707 13.50 68.9 µM 4.17E-45 5 4.44E-42
2 SGTC_1629 st005085 8.46 44.9 µM 8.68E-19 RPP1 & pyrimidine depletion 2 1.32E-17
3 SGTC_2104 5389443 7.30 200.0 µM 1.86E-14 1 1.41E-13
4 SGTC_798 1287-0182 6.73 476.0 µM 1.52E-12 3 8.53E-12
5 SGTC_1975 st070967 5.70 30.8 µM 1.74E-9 11 6.00E-9
6 SGTC_2143 5623677 4.81 140.5 µM 3.07E-7 1 7.45E-7
7 SGTC_2814 7977482 4.79 43.0 µM 3.52E-7 26 8.47E-7
8 SGTC_2779 methotrexate 4.64 400.0 µM 7.77E-7 20 1.77E-6
9 SGTC_419 nsc-638432 4.53 893.0 µM 1.38E-6 DNA damage response 7 3.02E-6
10 SGTC_2692 st077426 4.45 47.7 µM 1.99E-6 16 4.26E-6
11 SGTC_2195 6536160 4.43 144.2 µM 2.23E-6 60S ribosome export 6 4.73E-6
12 SGTC_979 1426-2828 4.40 121.0 µM 2.55E-6 14 5.37E-6
13 SGTC_2575 plumbagin 4.37 510.0 nM 2.92E-6 superoxide 30 6.08E-6
14 SGTC_1360 1598-0022 4.31 39.8 µM 3.92E-6 ERG2 23 8.01E-6
15 SGTC_2860 9025725 4.23 39.0 µM 5.90E-6 RPP1 & pyrimidine depletion 5 1.17E-5
16 SGTC_1573 oleylamine 4.22 1.1 µM 6.18E-6 22 1.23E-5
17 SGTC_648 0375-0473 4.05 33.3 µM 1.35E-5 14 2.54E-5
18 SGTC_2873 9040596 3.96 71.4 µM 2.03E-5 46 3.72E-5
19 SGTC_202 3594-0513 3.92 34.8 µM 2.46E-5 PDR1 9 4.45E-5
20 SGTC_2866 9034245 3.91 58.4 µM 2.54E-5 8 4.59E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.161 5.42E-21 YPL236C ENV7 hom Vacuolar membrane protein kinase; negatively regulates membrane fusion; associates with vacuolar membrane through palmitoylation of one or more cysteines in consensus sequence; vacuolar membrane association is essential to its kinase activity; mutant shows defect in CPY processing; ortholog of human serine/threonine kinase 16 (STK16)
0.141 2.18E-16 YJL034W KAR2 het ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p
0.129 6.25E-14 YLL058W_p YLL058W_p hom Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene
0.125 4.12E-13 YOR032C HMS1 hom Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant
0.124 5.67E-13 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.114 4.12E-11 YLR097C HRT3 hom Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies
0.110 1.95E-10 YGR133W PEX4 hom Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis
0.109 2.15E-10 YMR283C RIT1 hom 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
0.109 2.11E-10 YHR103W SBE22 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth
0.102 3.43E-9 YGR247W CPD1 hom Cyclic nucleotide phosphodiesterase; hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression; protein abundance increases in response to DNA replication stress
0.102 3.84E-9 YGR256W GND2 hom 6-phosphogluconate dehydrogenase (decarboxylating); catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone; GND2 has a paralog, GND1, that arose from the whole genome duplication
0.101 5.29E-9 YEL051W VMA8 hom Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis
0.101 5.36E-9 YMR002W MIC17 hom Mitochondrial intermembrane space protein; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.100 6.13E-9 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.099 7.85E-9 YGR238C KEL2 hom Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate