YMR256C / COX7

Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR256C / COX7

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.68|P-value:5.45E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:4.16|P-value:1.11E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.81|P-value:3.46E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.94|P-value:2.41E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.37|P-value:5.37E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:14.00|P-value:8.18E-36 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.66|P-value:1.73E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:-4.14|P-value:1.14E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.58|P-value:7.29E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:15.40|P-value:5.56E-43 ID:SGTC_264|Compound:promethazine|FD-Score:8.18|P-value:1.93E-13 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.38|P-value:9.17E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:3.55|P-value:8.31E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.45|P-value:5.25E-9 ID:SGTC_386|Compound:1509-0011|FD-Score:18.20|P-value:5.52E-59 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.62|P-value:2.10E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:4.90|P-value:6.83E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:3.82|P-value:3.55E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.63|P-value:6.24E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.68|P-value:5.44E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.67|P-value:5.75E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.63|P-value:6.49E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:5.13|P-value:2.67E-6 ID:SGTC_891|Compound:0929-0073|FD-Score:4.54|P-value:2.80E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.93|P-value:2.41E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.97|P-value:2.12E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:-5.32|P-value:1.12E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:4.29|P-value:6.97E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.74|P-value:4.43E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.88|P-value:2.88E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.93|P-value:2.42E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:4.69|P-value:1.56E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.69|P-value:5.32E-4 ID:SGTC_1635|Compound:st007035|FD-Score:10.10|P-value:1.76E-19 ID:SGTC_1744|Compound:st037937|FD-Score:3.64|P-value:6.18E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.19|P-value:1.02E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.78|P-value:1.04E-5 ID:SGTC_1832|Compound:st054113|FD-Score:3.83|P-value:3.36E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.62|P-value:2.07E-5 ID:SGTC_1938|Compound:st074717|FD-Score:4.04|P-value:1.70E-4 ID:SGTC_2002|Compound:4023503|FD-Score:9.29|P-value:7.94E-17 ID:SGTC_2282|Compound:7944268|FD-Score:3.53|P-value:8.66E-4 ID:SGTC_2624|Compound:nerol|FD-Score:4.20|P-value:9.61E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.61|P-value:2.17E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:8.46|P-value:2.84E-14 ID:SGTC_2690|Compound:usnic acid|FD-Score:-5.54|P-value:4.11E-7 ID:SGTC_2692|Compound:st077426|FD-Score:7.79|P-value:2.38E-12 ID:SGTC_2693|Compound:st077581|FD-Score:6.92|P-value:3.94E-10 ID:SGTC_2695|Compound:st077686|FD-Score:9.63|P-value:6.00E-18 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-9.71|P-value:2.94E-18 ID:SGTC_2713|Compound:st079149|FD-Score:-3.51|P-value:8.99E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.81|P-value:3.67E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.53|P-value:8.38E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-4.66|P-value:1.67E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.14|P-value:1.16E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.50|P-value:9.22E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.89|P-value:2.79E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.78|P-value:4.05E-4 ID:SGTC_3351|Compound:9150312|FD-Score:5.09|P-value:3.15E-6 ID:SGTC_11|Compound:0438-0307|FD-Score:3.68|P-value:5.45E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:4.16|P-value:1.11E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.81|P-value:3.46E-4 ID:SGTC_34|Compound:0469-0683|FD-Score:3.94|P-value:2.41E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.37|P-value:5.37E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:14.00|P-value:8.18E-36 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.66|P-value:1.73E-5 ID:SGTC_153|Compound:4077-0274|FD-Score:-4.14|P-value:1.14E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.58|P-value:7.29E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:15.40|P-value:5.56E-43 ID:SGTC_264|Compound:promethazine|FD-Score:8.18|P-value:1.93E-13 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.38|P-value:9.17E-7 ID:SGTC_279|Compound:1273-0055|FD-Score:3.55|P-value:8.31E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.45|P-value:5.25E-9 ID:SGTC_386|Compound:1509-0011|FD-Score:18.20|P-value:5.52E-59 ID:SGTC_407|Compound:eburnamonine|FD-Score:4.62|P-value:2.10E-5 ID:SGTC_520|Compound:3584-0023|FD-Score:4.90|P-value:6.83E-6 ID:SGTC_541|Compound:4513-1321|FD-Score:3.82|P-value:3.55E-4 ID:SGTC_621|Compound:3584-0052|FD-Score:-3.63|P-value:6.24E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.68|P-value:5.44E-4 ID:SGTC_786|Compound:4544-0069|FD-Score:3.67|P-value:5.75E-4 ID:SGTC_818|Compound:4072-2707|FD-Score:3.63|P-value:6.49E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:5.13|P-value:2.67E-6 ID:SGTC_891|Compound:0929-0073|FD-Score:4.54|P-value:2.80E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.93|P-value:2.41E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:3.97|P-value:2.12E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:-5.32|P-value:1.12E-6 ID:SGTC_980|Compound:1473-0395|FD-Score:4.29|P-value:6.97E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:-3.74|P-value:4.43E-4 ID:SGTC_1096|Compound:rimcazole|FD-Score:3.88|P-value:2.88E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:3.93|P-value:2.42E-4 ID:SGTC_1303|Compound:1160-0052|FD-Score:4.69|P-value:1.56E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:3.69|P-value:5.32E-4 ID:SGTC_1635|Compound:st007035|FD-Score:10.10|P-value:1.76E-19 ID:SGTC_1744|Compound:st037937|FD-Score:3.64|P-value:6.18E-4 ID:SGTC_1771|Compound:st048882|FD-Score:4.19|P-value:1.02E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.78|P-value:1.04E-5 ID:SGTC_1832|Compound:st054113|FD-Score:3.83|P-value:3.36E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.62|P-value:2.07E-5 ID:SGTC_1938|Compound:st074717|FD-Score:4.04|P-value:1.70E-4 ID:SGTC_2002|Compound:4023503|FD-Score:9.29|P-value:7.94E-17 ID:SGTC_2282|Compound:7944268|FD-Score:3.53|P-value:8.66E-4 ID:SGTC_2624|Compound:nerol|FD-Score:4.20|P-value:9.61E-5 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.61|P-value:2.17E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:8.46|P-value:2.84E-14 ID:SGTC_2690|Compound:usnic acid|FD-Score:-5.54|P-value:4.11E-7 ID:SGTC_2692|Compound:st077426|FD-Score:7.79|P-value:2.38E-12 ID:SGTC_2693|Compound:st077581|FD-Score:6.92|P-value:3.94E-10 ID:SGTC_2695|Compound:st077686|FD-Score:9.63|P-value:6.00E-18 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:-9.71|P-value:2.94E-18 ID:SGTC_2713|Compound:st079149|FD-Score:-3.51|P-value:8.99E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:3.81|P-value:3.67E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:-3.53|P-value:8.38E-4 ID:SGTC_2880|Compound:9042983|FD-Score:-4.66|P-value:1.67E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-4.14|P-value:1.16E-4 ID:SGTC_3334|Compound:9142812|FD-Score:-3.50|P-value:9.22E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.89|P-value:2.79E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.78|P-value:4.05E-4 ID:SGTC_3351|Compound:9150312|FD-Score:5.09|P-value:3.15E-6

Top fitness defect scores for YMR256C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_386 1509-0011 18.20 3.1 µM 5.52E-59 12 3.36E-74
2 SGTC_236 1509-0011 15.40 5.3 µM 5.56E-43 95 6.14E-54
3 SGTC_134 0269-0018 14.00 6.9 µM 8.18E-36 23 7.26E-45
4 SGTC_1635 st007035 10.10 42.4 µM 1.76E-19 72 3.36E-24
5 SGTC_2695 st077686 9.63 52.0 µM 6.00E-18 2 2.91E-22
6 SGTC_2002 4023503 9.29 131.0 µM 7.94E-17 mitochondrial processes 1 7.62E-21
7 SGTC_2686 alizarin 8.46 95.4 µM 2.84E-14 RPP1 & pyrimidine depletion 1 1.29E-17
8 SGTC_264 promethazine 8.18 12.5 mM 1.93E-13 DNA intercalators 11 1.45E-16
9 SGTC_2692 st077426 7.79 47.7 µM 2.38E-12 2 3.44E-15
10 SGTC_2693 st077581 6.92 40.7 µM 3.94E-10 4 2.18E-12
11 SGTC_310 1273-0058 6.45 1.1 µM 5.25E-9 mitochondrial stress 132 5.70E-11
12 SGTC_275 trichlorophene 5.38 5.7 µM 9.17E-7 mitochondrial stress 143 3.81E-8
13 SGTC_867 0518-0118 5.13 155.0 µM 2.67E-6 DNA intercalators 8 1.46E-7
14 SGTC_3351 9150312 5.09 21.6 µM 3.15E-6 cell wall 17 1.80E-7
15 SGTC_520 3584-0023 4.90 682.0 µM 6.83E-6 11 4.76E-7
16 SGTC_1303 1160-0052 4.69 261.0 µM 1.56E-5 5 1.35E-6
17 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.62 70.1 µM 2.07E-5 10 1.91E-6
18 SGTC_407 eburnamonine 4.62 100.0 µM 2.10E-5 7 1.95E-6
19 SGTC_2626 ethyl orsellinate 4.61 100.0 µM 2.17E-5 20 2.04E-6
20 SGTC_891 0929-0073 4.54 133.0 µM 2.80E-5 11 2.80E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.520 2.91E-231 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.510 1.04E-221 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.506 8.16E-218 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.500 5.80E-211 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.493 9.35E-205 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.490 3.87E-202 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.487 3.80E-199 YDL067C COX9 hom Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.486 1.68E-198 YJL209W CBP1 hom Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress
0.484 2.34E-196 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.471 1.16E-184 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.471 1.33E-184 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.471 2.78E-184 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.468 1.65E-181 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.467 1.40E-180 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.463 3.26E-177 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p