Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YMR256C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.520 | 2.91E-231 | YJL022W_d | YJL022W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130 |
0.510 | 1.04E-221 | YPL132W | COX11 | hom | Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p |
0.506 | 8.16E-218 | YDR231C | COX20 | hom | Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase |
0.500 | 5.80E-211 | YDR230W_d | YDR230W_d | hom | Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20 |
0.493 | 9.35E-205 | YNR045W | PET494 | hom | Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane |
0.490 | 3.87E-202 | YJL062W-A | COA3 | hom | Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly |
0.487 | 3.80E-199 | YDL067C | COX9 | hom | Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain |
0.486 | 1.68E-198 | YJL209W | CBP1 | hom | Mitochondrial protein, regulator of COB mRNA stability and translation; interacts with the 5'-untranslated region of the COB mRNA; found in a complex at the inner membrane along with Pet309p; localizes to mitochondrial foci upon DNA replication stress |
0.484 | 2.34E-196 | YPL013C | MRPS16 | hom | Mitochondrial ribosomal protein of the small subunit |
0.471 | 1.16E-184 | YER058W | PET117 | hom | Protein required for assembly of cytochrome c oxidase |
0.471 | 1.33E-184 | YHR116W | COX23 | hom | Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs |
0.471 | 2.78E-184 | YML129C | COX14 | hom | Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes |
0.468 | 1.65E-181 | YKL194C | MST1 | hom | Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro |
0.467 | 1.40E-180 | YOR330C | MIP1 | hom | Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit |
0.463 | 3.26E-177 | YJL166W | QCR8 | hom | Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p |