YMR260C / TIF11

Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR260C / TIF11

Click on Significant Values for Screen Details ID:SGTC_11|Compound:0438-0307|FD-Score:3.57|P-value:2.78E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:5.43|P-value:7.10E-8 ID:SGTC_69|Compound:0096-0274|FD-Score:4.37|P-value:1.18E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.89|P-value:8.31E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:14.90|P-value:1.68E-47 ID:SGTC_86|Compound:0417-1630|FD-Score:7.19|P-value:1.66E-12 ID:SGTC_168|Compound:3970-0862|FD-Score:4.31|P-value:1.52E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:7.88|P-value:1.18E-14 ID:SGTC_263|Compound:alizarin|FD-Score:-4.61|P-value:4.04E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:3.47|P-value:3.97E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.03|P-value:4.70E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:4.22|P-value:2.16E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.22|P-value:9.14E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:9.01|P-value:1.29E-18 ID:SGTC_717|Compound:1532-0246|FD-Score:-4.14|P-value:3.04E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.31|P-value:6.83E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.53|P-value:3.14E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.26|P-value:8.11E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:4.28|P-value:1.70E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.26|P-value:1.83E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:3.92|P-value:7.50E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.39|P-value:5.10E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.19|P-value:9.97E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.31|P-value:1.47E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.23|P-value:8.71E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.62|P-value:3.79E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:3.53|P-value:3.15E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.94|P-value:6.93E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-6.78|P-value:2.51E-11 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.77|P-value:1.27E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.26|P-value:7.96E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:-3.24|P-value:8.38E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.62|P-value:3.90E-6 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.49|P-value:6.95E-6 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.50|P-value:3.53E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.62|P-value:2.29E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:5.34|P-value:1.17E-7 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.96|P-value:3.82E-9 ID:SGTC_1520|Compound:flindersine|FD-Score:4.76|P-value:2.00E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.53|P-value:4.40E-8 ID:SGTC_1634|Compound:st006576|FD-Score:3.66|P-value:1.99E-4 ID:SGTC_1658|Compound:st012944|FD-Score:7.42|P-value:3.28E-13 ID:SGTC_1720|Compound:st037298|FD-Score:4.57|P-value:4.92E-6 ID:SGTC_1747|Compound:st037496|FD-Score:5.47|P-value:5.90E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.00|P-value:5.43E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.47|P-value:3.87E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.84|P-value:1.00E-4 ID:SGTC_2004|Compound:4023728|FD-Score:12.80|P-value:1.22E-35 ID:SGTC_2245|Compound:6637752|FD-Score:3.31|P-value:6.71E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-4.16|P-value:2.74E-5 ID:SGTC_2396|Compound:5342950|FD-Score:-3.47|P-value:3.86E-4 ID:SGTC_2487|Compound:5918373|FD-Score:5.14|P-value:3.27E-7 ID:SGTC_2488|Compound:5268135|FD-Score:-4.24|P-value:1.97E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.19|P-value:2.45E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.21|P-value:2.22E-7 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.47|P-value:3.87E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.58|P-value:4.58E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.32|P-value:6.49E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.00|P-value:5.35E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:4.79|P-value:1.77E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.35|P-value:5.98E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.28|P-value:7.40E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.09|P-value:3.78E-5 ID:SGTC_2872|Compound:9044037|FD-Score:3.48|P-value:3.80E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.90|P-value:7.94E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.91|P-value:7.64E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-3.28|P-value:7.30E-4 ID:SGTC_2953|Compound:9074162|FD-Score:4.25|P-value:1.96E-5 ID:SGTC_2962|Compound:9082311|FD-Score:3.85|P-value:9.65E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.59|P-value:2.58E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.29|P-value:1.61E-5 ID:SGTC_3014|Compound:9081533|FD-Score:3.49|P-value:3.60E-4 ID:SGTC_3045|Compound:9092950|FD-Score:4.26|P-value:1.89E-5 ID:SGTC_3141|Compound:9094609|FD-Score:5.20|P-value:2.44E-7 ID:SGTC_3142|Compound:9086498|FD-Score:9.48|P-value:2.12E-20 ID:SGTC_3161|Compound:9100388|FD-Score:4.40|P-value:1.02E-5 ID:SGTC_3175|Compound:9106517|FD-Score:4.31|P-value:1.49E-5 ID:SGTC_3188|Compound:9110789|FD-Score:4.64|P-value:3.47E-6 ID:SGTC_3207|Compound:9114163|FD-Score:3.47|P-value:3.87E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.65|P-value:2.02E-4 ID:SGTC_11|Compound:0438-0307|FD-Score:3.57|P-value:2.78E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:5.43|P-value:7.10E-8 ID:SGTC_69|Compound:0096-0274|FD-Score:4.37|P-value:1.18E-5 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.89|P-value:8.31E-5 ID:SGTC_81|Compound:0411-0046|FD-Score:14.90|P-value:1.68E-47 ID:SGTC_86|Compound:0417-1630|FD-Score:7.19|P-value:1.66E-12 ID:SGTC_168|Compound:3970-0862|FD-Score:4.31|P-value:1.52E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:7.88|P-value:1.18E-14 ID:SGTC_263|Compound:alizarin|FD-Score:-4.61|P-value:4.04E-6 ID:SGTC_309|Compound:k408-0051|FD-Score:3.47|P-value:3.97E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.03|P-value:4.70E-5 ID:SGTC_525|Compound:k781-2675|FD-Score:4.22|P-value:2.16E-5 ID:SGTC_553|Compound:k007-0256|FD-Score:3.22|P-value:9.14E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:9.01|P-value:1.29E-18 ID:SGTC_717|Compound:1532-0246|FD-Score:-4.14|P-value:3.04E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.31|P-value:6.83E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.53|P-value:3.14E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.26|P-value:8.11E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:4.28|P-value:1.70E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.26|P-value:1.83E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:3.92|P-value:7.50E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.39|P-value:5.10E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.19|P-value:9.97E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:4.31|P-value:1.47E-5 ID:SGTC_1020|Compound:4335-0961|FD-Score:-3.23|P-value:8.71E-4 ID:SGTC_1022|Compound:4477-0945|FD-Score:-4.62|P-value:3.79E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:3.53|P-value:3.15E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:3.94|P-value:6.93E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:-6.78|P-value:2.51E-11 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.77|P-value:1.27E-4 ID:SGTC_1224|Compound:0823-0416|FD-Score:-3.26|P-value:7.96E-4 ID:SGTC_1229|Compound:0139-0193|FD-Score:-3.24|P-value:8.38E-4 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.62|P-value:3.90E-6 ID:SGTC_1358|Compound:1509-0022|FD-Score:4.49|P-value:6.95E-6 ID:SGTC_1411|Compound:3909-8223|FD-Score:3.50|P-value:3.53E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:3.62|P-value:2.29E-4 ID:SGTC_1438|Compound:4092-1045|FD-Score:5.34|P-value:1.17E-7 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.96|P-value:3.82E-9 ID:SGTC_1520|Compound:flindersine|FD-Score:4.76|P-value:2.00E-6 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:5.53|P-value:4.40E-8 ID:SGTC_1634|Compound:st006576|FD-Score:3.66|P-value:1.99E-4 ID:SGTC_1658|Compound:st012944|FD-Score:7.42|P-value:3.28E-13 ID:SGTC_1720|Compound:st037298|FD-Score:4.57|P-value:4.92E-6 ID:SGTC_1747|Compound:st037496|FD-Score:5.47|P-value:5.90E-8 ID:SGTC_1844|Compound:rapamycin|FD-Score:4.00|P-value:5.43E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.47|P-value:3.87E-4 ID:SGTC_1934|Compound:st074720|FD-Score:3.84|P-value:1.00E-4 ID:SGTC_2004|Compound:4023728|FD-Score:12.80|P-value:1.22E-35 ID:SGTC_2245|Compound:6637752|FD-Score:3.31|P-value:6.71E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-4.16|P-value:2.74E-5 ID:SGTC_2396|Compound:5342950|FD-Score:-3.47|P-value:3.86E-4 ID:SGTC_2487|Compound:5918373|FD-Score:5.14|P-value:3.27E-7 ID:SGTC_2488|Compound:5268135|FD-Score:-4.24|P-value:1.97E-5 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.19|P-value:2.45E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.21|P-value:2.22E-7 ID:SGTC_2544|Compound:sphondin|FD-Score:-3.47|P-value:3.87E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.58|P-value:4.58E-6 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.32|P-value:6.49E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:4.00|P-value:5.35E-5 ID:SGTC_2720|Compound:fluspirilene|FD-Score:4.79|P-value:1.77E-6 ID:SGTC_2724|Compound:maprotiline|FD-Score:3.35|P-value:5.98E-4 ID:SGTC_2830|Compound:7992007|FD-Score:3.28|P-value:7.40E-4 ID:SGTC_2867|Compound:9039098|FD-Score:4.09|P-value:3.78E-5 ID:SGTC_2872|Compound:9044037|FD-Score:3.48|P-value:3.80E-4 ID:SGTC_2874|Compound:9043904|FD-Score:3.90|P-value:7.94E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.91|P-value:7.64E-5 ID:SGTC_2935|Compound:9038016|FD-Score:-3.28|P-value:7.30E-4 ID:SGTC_2953|Compound:9074162|FD-Score:4.25|P-value:1.96E-5 ID:SGTC_2962|Compound:9082311|FD-Score:3.85|P-value:9.65E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.59|P-value:2.58E-4 ID:SGTC_2975|Compound:9084847|FD-Score:4.29|P-value:1.61E-5 ID:SGTC_3014|Compound:9081533|FD-Score:3.49|P-value:3.60E-4 ID:SGTC_3045|Compound:9092950|FD-Score:4.26|P-value:1.89E-5 ID:SGTC_3141|Compound:9094609|FD-Score:5.20|P-value:2.44E-7 ID:SGTC_3142|Compound:9086498|FD-Score:9.48|P-value:2.12E-20 ID:SGTC_3161|Compound:9100388|FD-Score:4.40|P-value:1.02E-5 ID:SGTC_3175|Compound:9106517|FD-Score:4.31|P-value:1.49E-5 ID:SGTC_3188|Compound:9110789|FD-Score:4.64|P-value:3.47E-6 ID:SGTC_3207|Compound:9114163|FD-Score:3.47|P-value:3.87E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.65|P-value:2.02E-4

Top fitness defect scores for YMR260C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_81 0411-0046 14.90 10.0 µM 1.68E-47 3 1.69E-50 2.84
2 SGTC_2004 4023728 12.80 41.9 µM 1.22E-35 4 7.36E-38 0.62
3 SGTC_3142 9086498 9.48 49.5 µM 2.12E-20 iron homeostasis 8 1.26E-21 0.26
4 SGTC_690 glyoxal 9.01 20.3 µM 1.29E-18 5 1.01E-19 1.12
5 SGTC_184 1494-0393 7.88 24.7 µM 1.18E-14 4 1.66E-15 0.43
6 SGTC_1658 st012944 7.42 20.0 µM 3.28E-13 iron homeostasis 2 5.73E-14 0.51
7 SGTC_86 0417-1630 7.19 471.9 µM 1.66E-12 ubiquinone biosynthesis & proteasome 6 3.23E-13 0.10
8 SGTC_1469 k284-2957 5.96 126.0 µM 3.82E-9 3 1.22E-9 0.01
9 SGTC_1597 7-benzyloxygramine 5.53 47.5 µM 4.40E-8 calcium & mitochondrial duress 39 1.65E-8 0.18
10 SGTC_1747 st037496 5.47 66.6 µM 5.90E-8 2 2.25E-8 0.17
11 SGTC_67 0335-0847 5.43 266.0 µM 7.10E-8 ubiquinone biosynthesis & proteasome 11 2.74E-8 0.01
12 SGTC_1438 4092-1045 5.34 4.0 µM 1.17E-7 1 4.67E-8 0.69
13 SGTC_2541 muurolladie-3-one 5.21 83.1 µM 2.22E-7 excess fatty acid 8 9.22E-8 0.10
14 SGTC_3141 9094609 5.20 49.5 µM 2.44E-7 iron homeostasis 7 1.02E-7 0.17
15 SGTC_2487 5918373 5.14 44.0 µM 3.27E-7 2 1.39E-7 0.71
16 SGTC_2720 fluspirilene 4.79 36.9 µM 1.77E-6 ERG2 1 8.41E-7 0.41
17 SGTC_1520 flindersine 4.76 88.0 µM 2.00E-6 5 9.55E-7 0.13
18 SGTC_3188 9110789 4.64 49.5 µM 3.47E-6 iron homeostasis 7 1.72E-6 0.01
19 SGTC_1250 0485-0349 4.62 40.2 µM 3.90E-6 7 1.94E-6 0.35
20 SGTC_2567 aureobasidin a 4.58 60.0 nM 4.58E-6 34 2.31E-6 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.347 8.50E-96 YDR041W RSM10 het Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins
0.303 4.16E-72 YNL112W DBP2 het ATP-dependent RNA helicase of the DEAD-box protein family; has a strong preference for dsRNA; involved mRNA decay and rRNA processing; may be involved in suppression of transcription from cryptic initiation sites
0.240 2.31E-45 YNL114C_d YNL114C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit
0.211 4.37E-35 YNL075W IMP4 het Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs
0.167 2.06E-22 YDR189W SLY1 het Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex
0.145 2.44E-17 YJL019W MPS3 het Nuclear envelope protein required for SPB insertion; initiation of SPB duplication and nuclear fusion; acetylation of Mps3p by Eco1p regulates its role in nuclear organization; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement; N-terminal acetylated by Eco1p
0.137 1.58E-15 YNL131W TOM22 het Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes
0.136 2.12E-15 YNR031C SSK2 hom MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress
0.136 2.30E-15 YPR105C COG4 het Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
0.135 4.65E-15 YDR272W GLO2 hom Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate
0.134 6.03E-15 YMR211W DML1 het Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family
0.134 8.42E-15 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.128 9.24E-14 YDR527W RBA50 het Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1
0.124 6.68E-13 YJR139C HOM6 hom Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions
0.124 6.62E-13 YGR077C PEX8 hom Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p