YMR261C / TPS3

Regulatory subunit of trehalose-6-phosphate synthase/phosphatase; involved in synthesis of storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway; TPS3 has a paralog, TSL1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR261C / TPS3

Click on Significant Values for Screen Details ID:SGTC_69|Compound:0096-0274|FD-Score:-3.11|P-value:7.90E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.15|P-value:6.81E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.29|P-value:3.76E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.34|P-value:3.15E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.04|P-value:9.38E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:6.07|P-value:2.72E-10 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.30|P-value:3.99E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.57|P-value:1.26E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.84|P-value:4.30E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:4.45|P-value:2.63E-6 ID:SGTC_891|Compound:0929-0073|FD-Score:5.25|P-value:3.92E-8 ID:SGTC_893|Compound:0958-0369|FD-Score:5.17|P-value:6.06E-8 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.14|P-value:7.13E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.44|P-value:2.17E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-5.01|P-value:1.66E-7 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.36|P-value:2.92E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.36|P-value:2.86E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:5.33|P-value:2.51E-8 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.42|P-value:2.35E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.74|P-value:6.58E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.44|P-value:2.13E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.89|P-value:3.41E-5 ID:SGTC_1754|Compound:st042065|FD-Score:6.91|P-value:8.12E-13 ID:SGTC_1757|Compound:st041620|FD-Score:5.65|P-value:3.87E-9 ID:SGTC_1766|Compound:st045414|FD-Score:-3.71|P-value:7.85E-5 ID:SGTC_1767|Compound:st044992|FD-Score:-4.17|P-value:1.10E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.02|P-value:9.91E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.66|P-value:9.07E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.72|P-value:7.06E-5 ID:SGTC_1824|Compound:st053723|FD-Score:4.98|P-value:1.77E-7 ID:SGTC_2013|Compound:4024628|FD-Score:3.56|P-value:1.36E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.79|P-value:5.76E-5 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.09|P-value:8.23E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.62|P-value:1.05E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.20|P-value:5.18E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.42|P-value:3.00E-6 ID:SGTC_2746|Compound:daunorubicin|FD-Score:3.85|P-value:4.01E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.28|P-value:4.23E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.13|P-value:6.83E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.26|P-value:4.25E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.77|P-value:5.69E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.37|P-value:2.82E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.98|P-value:2.28E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.07|P-value:8.39E-4 ID:SGTC_3084|Compound:9116877|FD-Score:3.23|P-value:4.76E-4 ID:SGTC_69|Compound:0096-0274|FD-Score:-3.11|P-value:7.90E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.15|P-value:6.81E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.29|P-value:3.76E-4 ID:SGTC_172|Compound:1112-0046|FD-Score:3.34|P-value:3.15E-4 ID:SGTC_279|Compound:1273-0055|FD-Score:3.04|P-value:9.38E-4 ID:SGTC_735|Compound:3076-0345|FD-Score:6.07|P-value:2.72E-10 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.30|P-value:3.99E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:3.57|P-value:1.26E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.84|P-value:4.30E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:4.45|P-value:2.63E-6 ID:SGTC_891|Compound:0929-0073|FD-Score:5.25|P-value:3.92E-8 ID:SGTC_893|Compound:0958-0369|FD-Score:5.17|P-value:6.06E-8 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.14|P-value:7.13E-4 ID:SGTC_987|Compound:1497-1013|FD-Score:3.44|P-value:2.17E-4 ID:SGTC_1046|Compound:2001-0062|FD-Score:-5.01|P-value:1.66E-7 ID:SGTC_1048|Compound:3161-0300|FD-Score:3.36|P-value:2.92E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.36|P-value:2.86E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:5.33|P-value:2.51E-8 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.42|P-value:2.35E-4 ID:SGTC_1625|Compound:st003711|FD-Score:3.74|P-value:6.58E-5 ID:SGTC_1630|Compound:st005209|FD-Score:3.44|P-value:2.13E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.89|P-value:3.41E-5 ID:SGTC_1754|Compound:st042065|FD-Score:6.91|P-value:8.12E-13 ID:SGTC_1757|Compound:st041620|FD-Score:5.65|P-value:3.87E-9 ID:SGTC_1766|Compound:st045414|FD-Score:-3.71|P-value:7.85E-5 ID:SGTC_1767|Compound:st044992|FD-Score:-4.17|P-value:1.10E-5 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.02|P-value:9.91E-4 ID:SGTC_1800|Compound:st050079|FD-Score:3.66|P-value:9.07E-5 ID:SGTC_1806|Compound:st050005|FD-Score:3.72|P-value:7.06E-5 ID:SGTC_1824|Compound:st053723|FD-Score:4.98|P-value:1.77E-7 ID:SGTC_2013|Compound:4024628|FD-Score:3.56|P-value:1.36E-4 ID:SGTC_2022|Compound:5136654|FD-Score:-3.79|P-value:5.76E-5 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.09|P-value:8.23E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.62|P-value:1.05E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:3.20|P-value:5.18E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:4.42|P-value:3.00E-6 ID:SGTC_2746|Compound:daunorubicin|FD-Score:3.85|P-value:4.01E-5 ID:SGTC_2769|Compound:toremifene|FD-Score:-3.28|P-value:4.23E-4 ID:SGTC_2831|Compound:7999036|FD-Score:3.13|P-value:6.83E-4 ID:SGTC_2902|Compound:5787006|FD-Score:3.26|P-value:4.25E-4 ID:SGTC_2907|Compound:7721985|FD-Score:3.77|P-value:5.69E-5 ID:SGTC_2935|Compound:9038016|FD-Score:3.37|P-value:2.82E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.98|P-value:2.28E-5 ID:SGTC_2993|Compound:9054257|FD-Score:3.07|P-value:8.39E-4 ID:SGTC_3084|Compound:9116877|FD-Score:3.23|P-value:4.76E-4

Top fitness defect scores for YMR261C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1754 st042065 6.91 16.1 µM 8.12E-13 NEO1-PIK1 74 2.42E-12
2 SGTC_735 3076-0345 6.07 636.0 µM 2.72E-10 2 6.40E-10
3 SGTC_1757 st041620 5.65 31.8 µM 3.87E-9 15 8.18E-9
4 SGTC_1220 1838-0075 5.33 193.0 µM 2.51E-8 4 4.93E-8
5 SGTC_891 0929-0073 5.25 133.0 µM 3.92E-8 3 7.55E-8
6 SGTC_893 0958-0369 5.17 48.9 µM 6.06E-8 10 1.15E-7
7 SGTC_1824 st053723 4.98 68.6 µM 1.77E-7 13 3.20E-7
8 SGTC_890 0929-0006 4.45 47.2 µM 2.63E-6 11 4.27E-6
9 SGTC_2633 5,7-dihydroxyisoflavone 4.42 100.0 µM 3.00E-6 24 4.84E-6
10 SGTC_2991 9074669 3.98 71.4 µM 2.28E-5 azole & statin 61 3.39E-5
11 SGTC_1656 st012921 3.89 11.0 µM 3.41E-5 32 4.99E-5
12 SGTC_2746 daunorubicin 3.85 9.9 µM 4.01E-5 anthracycline transcription coupled DNA repair 4 5.82E-5
13 SGTC_881 0833-0569 3.84 170.0 µM 4.30E-5 33 6.23E-5
14 SGTC_2907 7721985 3.77 69.9 µM 5.69E-5 28 8.16E-5
15 SGTC_1625 st003711 3.74 30.1 µM 6.58E-5 calcium & mitochondrial duress 42 9.37E-5
16 SGTC_1806 st050005 3.72 60.3 µM 7.06E-5 14 1.00E-4
17 SGTC_1800 st050079 3.66 29.1 µM 9.07E-5 NEO1-PIK1 141 1.27E-4
18 SGTC_2583 asiatic acid 3.62 100.0 µM 1.05E-4 45 1.46E-4
19 SGTC_864 0469-0573 3.57 172.0 µM 1.26E-4 31 1.75E-4
20 SGTC_2013 4024628 3.56 200.0 µM 1.36E-4 61 1.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.145 2.62E-17 YNL183C NPR1 hom Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.111 1.02E-10 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.108 2.97E-10 YHL014C YLF2 hom Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.103 2.60E-9 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.094 5.18E-8 YML106W URA5 hom Major orotate phosphoribosyltransferase (OPRTase) isozyme; catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; URA5 has a paralog, URA10, that arose from the whole genome duplication
0.094 5.19E-8 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.089 2.45E-7 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.088 3.30E-7 YJR124C_p YJR124C_p hom Putative protein of unknown function; expression induced under calcium shortage
0.086 5.88E-7 YLR360W VPS38 hom Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity; required for overflow degradation of misfolded proteins when ERAD is saturated
0.086 6.90E-7 YDR190C RVB1 het ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly
0.085 9.04E-7 YNL251C NRD1 het RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex interacts with the exosome to mediate 3′ end formation of some mRNAs, snRNAs, snoRNAs, and CUTs; interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially at phosphorylated Ser5, to direct transcription termination of non-polyadenylated transcripts; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites
0.084 1.05E-6 YML097C VPS9 hom A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.084 1.13E-6 YDR491C_d YDR491C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.51E-6 YNL056W OCA2 hom Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene
0.082 1.83E-6 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism