YMR262W_p

Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR262W / YMR262W

Click on Significant Values for Screen Details ID:SGTC_101|Compound:0490-5701|FD-Score:-3.19|P-value:5.75E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:5.60|P-value:4.77E-9 ID:SGTC_125|Compound:0133-0007|FD-Score:3.21|P-value:5.00E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:7.24|P-value:6.44E-14 ID:SGTC_144|Compound:4161-2749|FD-Score:6.49|P-value:1.55E-11 ID:SGTC_145|Compound:3737-0113|FD-Score:8.16|P-value:3.33E-17 ID:SGTC_160|Compound:3453-0671|FD-Score:3.07|P-value:8.25E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.53|P-value:1.71E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.56|P-value:1.33E-4 ID:SGTC_264|Compound:promethazine|FD-Score:10.10|P-value:1.66E-25 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.64|P-value:1.04E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.11|P-value:7.10E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:3.26|P-value:4.11E-4 ID:SGTC_442|Compound:cape|FD-Score:-3.74|P-value:6.90E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.20|P-value:5.53E-4 ID:SGTC_446|Compound:go6976|FD-Score:-3.22|P-value:5.15E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.69|P-value:7.81E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:-6.02|P-value:4.13E-10 ID:SGTC_577|Compound:r071-0003|FD-Score:6.93|P-value:6.33E-13 ID:SGTC_579|Compound:4491-1009|FD-Score:4.23|P-value:7.15E-6 ID:SGTC_585|Compound:0kpi-0023|FD-Score:5.69|P-value:2.74E-9 ID:SGTC_588|Compound:3970-1144|FD-Score:7.24|P-value:6.08E-14 ID:SGTC_663|Compound:1486-0733|FD-Score:3.82|P-value:4.52E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.41|P-value:2.33E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.23|P-value:4.95E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:-3.26|P-value:4.54E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.11|P-value:7.21E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.32|P-value:3.26E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.16|P-value:5.89E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.69|P-value:7.58E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.04|P-value:9.07E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.03|P-value:9.39E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.92|P-value:2.34E-7 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.39|P-value:2.55E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.10|P-value:7.34E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.35|P-value:2.94E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.18|P-value:6.10E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.38|P-value:3.59E-6 ID:SGTC_1773|Compound:st048542|FD-Score:3.14|P-value:6.29E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.11|P-value:7.06E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.04|P-value:9.73E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-4.13|P-value:1.28E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.08|P-value:2.45E-10 ID:SGTC_1998|Compound:st075797|FD-Score:-4.61|P-value:1.33E-6 ID:SGTC_2254|Compound:7938975|FD-Score:3.60|P-value:1.13E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.52|P-value:1.56E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.28|P-value:3.80E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.04|P-value:9.72E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.37|P-value:3.83E-6 ID:SGTC_2691|Compound:st077356|FD-Score:-3.32|P-value:3.62E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.05|P-value:8.69E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.33|P-value:4.58E-6 ID:SGTC_2834|Compound:9001755|FD-Score:6.52|P-value:1.21E-11 ID:SGTC_2884|Compound:9058502|FD-Score:4.26|P-value:6.31E-6 ID:SGTC_2906|Compound:7926292|FD-Score:3.73|P-value:6.55E-5 ID:SGTC_2977|Compound:9011197|FD-Score:3.33|P-value:3.16E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.35|P-value:3.21E-4 ID:SGTC_3040|Compound:9091894|FD-Score:5.93|P-value:6.49E-10 ID:SGTC_3093|Compound:9117344|FD-Score:3.46|P-value:1.95E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.18|P-value:5.49E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.06|P-value:8.60E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.24|P-value:4.38E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.33|P-value:3.17E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.32|P-value:3.28E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:-3.19|P-value:5.75E-4 ID:SGTC_112|Compound:phenothiazine|FD-Score:5.60|P-value:4.77E-9 ID:SGTC_125|Compound:0133-0007|FD-Score:3.21|P-value:5.00E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:7.24|P-value:6.44E-14 ID:SGTC_144|Compound:4161-2749|FD-Score:6.49|P-value:1.55E-11 ID:SGTC_145|Compound:3737-0113|FD-Score:8.16|P-value:3.33E-17 ID:SGTC_160|Compound:3453-0671|FD-Score:3.07|P-value:8.25E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.53|P-value:1.71E-6 ID:SGTC_257|Compound:daunorubicin|FD-Score:3.56|P-value:1.33E-4 ID:SGTC_264|Compound:promethazine|FD-Score:10.10|P-value:1.66E-25 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.64|P-value:1.04E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:3.11|P-value:7.10E-4 ID:SGTC_347|Compound:4534-1311|FD-Score:3.26|P-value:4.11E-4 ID:SGTC_442|Compound:cape|FD-Score:-3.74|P-value:6.90E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.20|P-value:5.53E-4 ID:SGTC_446|Compound:go6976|FD-Score:-3.22|P-value:5.15E-4 ID:SGTC_569|Compound:4130-2812|FD-Score:3.69|P-value:7.81E-5 ID:SGTC_571|Compound:k831-0106|FD-Score:-6.02|P-value:4.13E-10 ID:SGTC_577|Compound:r071-0003|FD-Score:6.93|P-value:6.33E-13 ID:SGTC_579|Compound:4491-1009|FD-Score:4.23|P-value:7.15E-6 ID:SGTC_585|Compound:0kpi-0023|FD-Score:5.69|P-value:2.74E-9 ID:SGTC_588|Compound:3970-1144|FD-Score:7.24|P-value:6.08E-14 ID:SGTC_663|Compound:1486-0733|FD-Score:3.82|P-value:4.52E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.41|P-value:2.33E-4 ID:SGTC_696|Compound:1560-0013|FD-Score:-3.23|P-value:4.95E-4 ID:SGTC_709|Compound:3807-1509|FD-Score:-3.26|P-value:4.54E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.11|P-value:7.21E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:3.32|P-value:3.26E-4 ID:SGTC_840|Compound:0245-0196|FD-Score:3.16|P-value:5.89E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:3.69|P-value:7.58E-5 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.04|P-value:9.07E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.03|P-value:9.39E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.92|P-value:2.34E-7 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.39|P-value:2.55E-4 ID:SGTC_1519|Compound:esterone|FD-Score:3.10|P-value:7.34E-4 ID:SGTC_1604|Compound:st002052|FD-Score:3.35|P-value:2.94E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.18|P-value:6.10E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.38|P-value:3.59E-6 ID:SGTC_1773|Compound:st048542|FD-Score:3.14|P-value:6.29E-4 ID:SGTC_1803|Compound:st050068|FD-Score:3.11|P-value:7.06E-4 ID:SGTC_1915|Compound:st067105|FD-Score:-3.04|P-value:9.73E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:-4.13|P-value:1.28E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.08|P-value:2.45E-10 ID:SGTC_1998|Compound:st075797|FD-Score:-4.61|P-value:1.33E-6 ID:SGTC_2254|Compound:7938975|FD-Score:3.60|P-value:1.13E-4 ID:SGTC_2351|Compound:9026858|FD-Score:3.52|P-value:1.56E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.28|P-value:3.80E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.04|P-value:9.72E-4 ID:SGTC_2628|Compound:lathosterol|FD-Score:4.37|P-value:3.83E-6 ID:SGTC_2691|Compound:st077356|FD-Score:-3.32|P-value:3.62E-4 ID:SGTC_2710|Compound:st078562|FD-Score:3.05|P-value:8.69E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:4.33|P-value:4.58E-6 ID:SGTC_2834|Compound:9001755|FD-Score:6.52|P-value:1.21E-11 ID:SGTC_2884|Compound:9058502|FD-Score:4.26|P-value:6.31E-6 ID:SGTC_2906|Compound:7926292|FD-Score:3.73|P-value:6.55E-5 ID:SGTC_2977|Compound:9011197|FD-Score:3.33|P-value:3.16E-4 ID:SGTC_2994|Compound:9053520|FD-Score:-3.35|P-value:3.21E-4 ID:SGTC_3040|Compound:9091894|FD-Score:5.93|P-value:6.49E-10 ID:SGTC_3093|Compound:9117344|FD-Score:3.46|P-value:1.95E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.18|P-value:5.49E-4 ID:SGTC_3208|Compound:9114115|FD-Score:3.06|P-value:8.60E-4 ID:SGTC_3216|Compound:9129716|FD-Score:3.24|P-value:4.38E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.33|P-value:3.17E-4 ID:SGTC_3337|Compound:9144342|FD-Score:3.32|P-value:3.28E-4

Top fitness defect scores for YMR262W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_264 promethazine 10.10 12.5 mM 1.66E-25 DNA intercalators 10 1.90E-24
2 SGTC_145 3737-0113 8.16 38.4 µM 3.33E-17 DNA intercalators 7 1.66E-16
3 SGTC_588 3970-1144 7.24 52.9 µM 6.08E-14 3 2.19E-13
4 SGTC_126 0417-1624 7.24 672.5 µM 6.44E-14 DNA intercalators 1 2.31E-13
5 SGTC_577 r071-0003 6.93 38.6 µM 6.33E-13 fatty acid desaturase (OLE1) 8 2.06E-12
6 SGTC_2834 9001755 6.52 58.4 µM 1.21E-11 8 3.46E-11
7 SGTC_144 4161-2749 6.49 112.4 µM 1.55E-11 DNA intercalators 6 4.38E-11
8 SGTC_1926 methyl fluorone black 6.08 53.6 µM 2.45E-10 DNA intercalators 19 6.14E-10
9 SGTC_3040 9091894 5.93 49.5 µM 6.49E-10 DNA intercalators 9 1.56E-9
10 SGTC_585 0kpi-0023 5.69 191.0 µM 2.74E-9 6 6.19E-9
11 SGTC_112 phenothiazine 5.60 287.2 µM 4.77E-9 unfolded protein response 5 1.05E-8
12 SGTC_1337 1486-1011 4.92 40.3 µM 2.34E-7 4 4.35E-7
13 SGTC_219 mitoxanthrone 4.53 164.4 µM 1.71E-6 DNA intercalators 38 2.93E-6
14 SGTC_1750 st081859 4.38 2.4 µM 3.59E-6 endomembrane recycling 159 5.95E-6
15 SGTC_2628 lathosterol 4.37 100.0 µM 3.83E-6 22 6.32E-6
16 SGTC_2757 clomiphene 4.33 4.2 µM 4.58E-6 fatty acid desaturase (OLE1) 27 7.50E-6
17 SGTC_2884 9058502 4.26 52.0 µM 6.31E-6 22 1.02E-5
18 SGTC_579 4491-1009 4.23 110.0 µM 7.15E-6 60S ribosome export 17 1.15E-5
19 SGTC_663 1486-0733 3.82 13.9 µM 4.52E-5 cell wall signaling 55 6.70E-5
20 SGTC_2906 7926292 3.73 26.4 µM 6.55E-5 31 9.56E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.430 7.14E-151 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.410 4.04E-136 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.396 2.57E-126 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.383 1.06E-117 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.344 8.07E-94 YMR289W ABZ2 hom Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis
0.329 2.71E-85 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.289 2.69E-65 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.286 3.80E-64 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.282 2.86E-62 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.273 1.53E-58 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.267 7.85E-56 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.238 1.44E-44 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.230 1.82E-41 YDL102W POL3 het Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER)
0.230 2.73E-41 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.222 1.34E-38 YNL101W AVT4 hom Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters