YMR264W / CUE1

Ubiquitin-binding protein; endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination; CUE1 has a paralog, CUE4, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR264W / CUE1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:9.84|P-value:5.48E-20 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.65|P-value:3.90E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.65|P-value:3.58E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.96|P-value:1.32E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.62|P-value:4.36E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:14.60|P-value:1.65E-41 ID:SGTC_86|Compound:0417-1630|FD-Score:3.56|P-value:5.23E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:8.17|P-value:2.46E-14 ID:SGTC_137|Compound:0438-0332|FD-Score:8.16|P-value:2.72E-14 ID:SGTC_138|Compound:0850-0259|FD-Score:4.27|P-value:4.23E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.16|P-value:6.34E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:4.15|P-value:6.65E-5 ID:SGTC_230|Compound:MPP+|FD-Score:4.25|P-value:4.62E-5 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.62|P-value:4.28E-4 ID:SGTC_252|Compound:miconazole|FD-Score:4.21|P-value:5.25E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:5.37|P-value:3.73E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.49|P-value:1.59E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:4.01|P-value:1.10E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.41|P-value:8.53E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.62|P-value:4.29E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.36|P-value:9.90E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.40|P-value:8.84E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.08|P-value:8.52E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:5.03|P-value:1.83E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:4.27|P-value:4.14E-5 ID:SGTC_594|Compound:1487-1584|FD-Score:3.83|P-value:2.09E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.84|P-value:4.17E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:12.10|P-value:4.90E-29 ID:SGTC_656|Compound:4090-1979|FD-Score:3.51|P-value:6.13E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.78|P-value:2.49E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.15|P-value:6.71E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:8.04|P-value:6.00E-14 ID:SGTC_791|Compound:1348-1292|FD-Score:3.41|P-value:8.64E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.10|P-value:8.09E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.64|P-value:1.03E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.39|P-value:9.19E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:9.07|P-value:3.02E-17 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.62|P-value:4.34E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.93|P-value:1.50E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.56|P-value:1.52E-7 ID:SGTC_1165|Compound:k072-0275|FD-Score:9.20|P-value:1.06E-17 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.40|P-value:8.68E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.64|P-value:4.05E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.78|P-value:2.53E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.07|P-value:9.04E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.35|P-value:3.06E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.66|P-value:3.78E-4 ID:SGTC_1663|Compound:st014140|FD-Score:5.17|P-value:9.58E-7 ID:SGTC_1708|Compound:st033234|FD-Score:3.51|P-value:6.24E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.16|P-value:6.37E-5 ID:SGTC_1767|Compound:st044992|FD-Score:5.18|P-value:9.21E-7 ID:SGTC_1791|Compound:st048313|FD-Score:4.96|P-value:2.44E-6 ID:SGTC_1833|Compound:st055984|FD-Score:6.84|P-value:1.46E-10 ID:SGTC_1838|Compound:st055369|FD-Score:3.81|P-value:2.30E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.95|P-value:1.40E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.59|P-value:4.70E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.94|P-value:1.43E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.89|P-value:1.71E-4 ID:SGTC_1962|Compound:st076595|FD-Score:5.43|P-value:2.78E-7 ID:SGTC_1995|Compound:st072814|FD-Score:4.40|P-value:2.58E-5 ID:SGTC_2067|Compound:5224629|FD-Score:5.47|P-value:2.29E-7 ID:SGTC_2137|Compound:5261020|FD-Score:7.48|P-value:2.59E-12 ID:SGTC_2322|Compound:7413319|FD-Score:10.30|P-value:6.99E-22 ID:SGTC_2385|Compound:9074692|FD-Score:4.25|P-value:4.56E-5 ID:SGTC_2428|Compound:5615643|FD-Score:6.46|P-value:1.32E-9 ID:SGTC_2429|Compound:5902844|FD-Score:3.52|P-value:5.91E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.64|P-value:9.43E-6 ID:SGTC_2467|Compound:5474540|FD-Score:4.03|P-value:1.05E-4 ID:SGTC_2477|Compound:5967686|FD-Score:5.15|P-value:1.07E-6 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.37|P-value:9.66E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:7.86|P-value:2.16E-13 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.98|P-value:2.29E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.93|P-value:1.51E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:8.76|P-value:3.28E-16 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:7.46|P-value:2.94E-12 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.97|P-value:1.02E-13 ID:SGTC_2780|Compound:5215298|FD-Score:9.05|P-value:3.63E-17 ID:SGTC_2781|Compound:5567276|FD-Score:3.84|P-value:2.01E-4 ID:SGTC_2831|Compound:7999036|FD-Score:5.06|P-value:1.56E-6 ID:SGTC_2885|Compound:9057732|FD-Score:4.93|P-value:2.84E-6 ID:SGTC_2943|Compound:9068529|FD-Score:3.55|P-value:5.52E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-5.16|P-value:8.98E-7 ID:SGTC_2953|Compound:9074162|FD-Score:-6.78|P-value:1.76E-10 ID:SGTC_2970|Compound:9090938|FD-Score:4.72|P-value:6.93E-6 ID:SGTC_2988|Compound:9073640|FD-Score:4.19|P-value:5.71E-5 ID:SGTC_3186|Compound:9110464|FD-Score:4.63|P-value:1.02E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:9.84|P-value:5.48E-20 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:3.65|P-value:3.90E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-3.65|P-value:3.58E-4 ID:SGTC_55|Compound:0767-0285|FD-Score:3.96|P-value:1.32E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.62|P-value:4.36E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:14.60|P-value:1.65E-41 ID:SGTC_86|Compound:0417-1630|FD-Score:3.56|P-value:5.23E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:8.17|P-value:2.46E-14 ID:SGTC_137|Compound:0438-0332|FD-Score:8.16|P-value:2.72E-14 ID:SGTC_138|Compound:0850-0259|FD-Score:4.27|P-value:4.23E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:4.16|P-value:6.34E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:4.15|P-value:6.65E-5 ID:SGTC_230|Compound:MPP+|FD-Score:4.25|P-value:4.62E-5 ID:SGTC_250|Compound:brefeldin a|FD-Score:3.62|P-value:4.28E-4 ID:SGTC_252|Compound:miconazole|FD-Score:4.21|P-value:5.25E-5 ID:SGTC_274|Compound:sirtinol|FD-Score:5.37|P-value:3.73E-7 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.49|P-value:1.59E-5 ID:SGTC_352|Compound:k048-0007|FD-Score:4.01|P-value:1.10E-4 ID:SGTC_362|Compound:0310-0100|FD-Score:3.41|P-value:8.53E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:3.62|P-value:4.29E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:3.36|P-value:9.90E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:3.40|P-value:8.84E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.08|P-value:8.52E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:5.03|P-value:1.83E-6 ID:SGTC_581|Compound:0958-0271|FD-Score:4.27|P-value:4.14E-5 ID:SGTC_594|Compound:1487-1584|FD-Score:3.83|P-value:2.09E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:4.84|P-value:4.17E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:12.10|P-value:4.90E-29 ID:SGTC_656|Compound:4090-1979|FD-Score:3.51|P-value:6.13E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:3.78|P-value:2.49E-4 ID:SGTC_700|Compound:3453-2283|FD-Score:4.15|P-value:6.71E-5 ID:SGTC_733|Compound:4069-0007|FD-Score:8.04|P-value:6.00E-14 ID:SGTC_791|Compound:1348-1292|FD-Score:3.41|P-value:8.64E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:4.10|P-value:8.09E-5 ID:SGTC_1003|Compound:4049-0218|FD-Score:5.64|P-value:1.03E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.39|P-value:9.19E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:9.07|P-value:3.02E-17 ID:SGTC_1098|Compound:clofazimine|FD-Score:3.62|P-value:4.34E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:3.93|P-value:1.50E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.56|P-value:1.52E-7 ID:SGTC_1165|Compound:k072-0275|FD-Score:9.20|P-value:1.06E-17 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.40|P-value:8.68E-4 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.64|P-value:4.05E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.78|P-value:2.53E-4 ID:SGTC_1506|Compound:4226-2149|FD-Score:4.07|P-value:9.04E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:4.35|P-value:3.06E-5 ID:SGTC_1648|Compound:st011736|FD-Score:3.66|P-value:3.78E-4 ID:SGTC_1663|Compound:st014140|FD-Score:5.17|P-value:9.58E-7 ID:SGTC_1708|Compound:st033234|FD-Score:3.51|P-value:6.24E-4 ID:SGTC_1750|Compound:st081859|FD-Score:4.16|P-value:6.37E-5 ID:SGTC_1767|Compound:st044992|FD-Score:5.18|P-value:9.21E-7 ID:SGTC_1791|Compound:st048313|FD-Score:4.96|P-value:2.44E-6 ID:SGTC_1833|Compound:st055984|FD-Score:6.84|P-value:1.46E-10 ID:SGTC_1838|Compound:st055369|FD-Score:3.81|P-value:2.30E-4 ID:SGTC_1860|Compound:st056228|FD-Score:3.95|P-value:1.40E-4 ID:SGTC_1901|Compound:st060216|FD-Score:3.59|P-value:4.70E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.94|P-value:1.43E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.89|P-value:1.71E-4 ID:SGTC_1962|Compound:st076595|FD-Score:5.43|P-value:2.78E-7 ID:SGTC_1995|Compound:st072814|FD-Score:4.40|P-value:2.58E-5 ID:SGTC_2067|Compound:5224629|FD-Score:5.47|P-value:2.29E-7 ID:SGTC_2137|Compound:5261020|FD-Score:7.48|P-value:2.59E-12 ID:SGTC_2322|Compound:7413319|FD-Score:10.30|P-value:6.99E-22 ID:SGTC_2385|Compound:9074692|FD-Score:4.25|P-value:4.56E-5 ID:SGTC_2428|Compound:5615643|FD-Score:6.46|P-value:1.32E-9 ID:SGTC_2429|Compound:5902844|FD-Score:3.52|P-value:5.91E-4 ID:SGTC_2450|Compound:5739737|FD-Score:4.64|P-value:9.43E-6 ID:SGTC_2467|Compound:5474540|FD-Score:4.03|P-value:1.05E-4 ID:SGTC_2477|Compound:5967686|FD-Score:5.15|P-value:1.07E-6 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:3.37|P-value:9.66E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:7.86|P-value:2.16E-13 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:4.98|P-value:2.29E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.93|P-value:1.51E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:8.76|P-value:3.28E-16 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:7.46|P-value:2.94E-12 ID:SGTC_2651|Compound:1327-0036|FD-Score:7.97|P-value:1.02E-13 ID:SGTC_2780|Compound:5215298|FD-Score:9.05|P-value:3.63E-17 ID:SGTC_2781|Compound:5567276|FD-Score:3.84|P-value:2.01E-4 ID:SGTC_2831|Compound:7999036|FD-Score:5.06|P-value:1.56E-6 ID:SGTC_2885|Compound:9057732|FD-Score:4.93|P-value:2.84E-6 ID:SGTC_2943|Compound:9068529|FD-Score:3.55|P-value:5.52E-4 ID:SGTC_2951|Compound:9072950|FD-Score:-5.16|P-value:8.98E-7 ID:SGTC_2953|Compound:9074162|FD-Score:-6.78|P-value:1.76E-10 ID:SGTC_2970|Compound:9090938|FD-Score:4.72|P-value:6.93E-6 ID:SGTC_2988|Compound:9073640|FD-Score:4.19|P-value:5.71E-5 ID:SGTC_3186|Compound:9110464|FD-Score:4.63|P-value:1.02E-5

Top fitness defect scores for YMR264W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_64 000l-0018 14.60 272.1 µM 1.65E-41 ubiquinone biosynthesis & proteasome 21 2.24E-48
2 SGTC_637 1181-0519 12.10 7.3 µM 4.90E-29 fatty acid desaturase (OLE1) 13 9.27E-34
3 SGTC_2322 7413319 10.30 38.2 µM 6.99E-22 ERAD & cell cycle 17 2.24E-25
4 SGTC_16 erodoxin 9.84 22.8 µM 5.48E-20 unfolded protein response 11 3.71E-23
5 SGTC_1165 k072-0275 9.20 30.3 µM 1.06E-17 3 1.77E-20
6 SGTC_1026 k007-1105 9.07 30.6 µM 3.02E-17 ERAD & cell cycle 14 6.02E-20
7 SGTC_2780 5215298 9.05 71.4 µM 3.63E-17 2 7.47E-20
8 SGTC_2584 androsterone 8.76 48.7 µM 3.28E-16 cell wall 23 9.85E-19
9 SGTC_103 0844-0104 8.17 51.8 µM 2.46E-14 ERAD & cell cycle 47 1.55E-16
10 SGTC_137 0438-0332 8.16 85.4 µM 2.72E-14 ubiquinone biosynthesis & proteasome 36 1.74E-16
11 SGTC_733 4069-0007 8.04 56.1 µM 6.00E-14 ERAD & cell cycle 21 4.40E-16
12 SGTC_2651 1327-0036 7.97 5.0 µM 1.02E-13 38 8.16E-16
13 SGTC_2573 2',4'-dihydroxychalcone 7.86 15.0 µM 2.16E-13 7 1.97E-15
14 SGTC_2137 5261020 7.48 140.0 µM 2.59E-12 7 3.60E-14
15 SGTC_2634 4'-methoxyflavone 7.46 100.0 µM 2.94E-12 3 4.18E-14
16 SGTC_1833 st055984 6.84 71.0 µM 1.46E-10 3 4.06E-12
17 SGTC_2428 5615643 6.46 7.8 µM 1.32E-9 7 5.31E-11
18 SGTC_1003 4049-0218 5.64 100.0 µM 1.03E-7 4 8.64E-9
19 SGTC_1161 k007-0610 5.56 110.0 µM 1.52E-7 ERAD & cell cycle 65 1.37E-8
20 SGTC_2067 5224629 5.47 34.1 µM 2.29E-7 7 2.21E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.511 5.05E-223 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.339 3.05E-91 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.330 7.15E-86 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.329 2.10E-85 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.287 1.57E-64 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.283 1.87E-62 YDL020C RPN4 hom Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses; relative distribution to the nucleus increases upon DNA replication stress
0.270 3.70E-57 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.268 1.88E-56 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.253 3.29E-50 YBR106W PHO88 hom Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations
0.249 1.44E-48 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.238 2.26E-44 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.238 3.01E-44 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.235 3.41E-43 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.232 2.74E-42 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.231 9.02E-42 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data