YMR265C_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR265C / YMR265C

Click on Significant Values for Screen Details ID:SGTC_46|Compound:0329-0187a|FD-Score:3.64|P-value:1.37E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:4.46|P-value:4.33E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:4.00|P-value:3.18E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:3.12|P-value:8.96E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.90|P-value:4.88E-5 ID:SGTC_277|Compound:nystatin|FD-Score:4.42|P-value:5.18E-6 ID:SGTC_324|Compound:1315-0088|FD-Score:3.12|P-value:9.20E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.27|P-value:5.95E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.44|P-value:3.29E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:5.19|P-value:1.12E-7 ID:SGTC_624|Compound:k048-0052|FD-Score:3.72|P-value:1.03E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.38|P-value:6.14E-6 ID:SGTC_803|Compound:4488-1585|FD-Score:3.32|P-value:4.53E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.81|P-value:7.10E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:3.64|P-value:1.36E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.46|P-value:2.72E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.43|P-value:4.82E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:3.87|P-value:5.66E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.17|P-value:7.57E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.25|P-value:5.76E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.21|P-value:6.79E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.60|P-value:1.64E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.77|P-value:8.45E-5 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.96|P-value:3.76E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.83|P-value:6.49E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.43|P-value:3.05E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.72|P-value:1.00E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.60|P-value:2.17E-6 ID:SGTC_1657|Compound:st012939|FD-Score:5.86|P-value:2.53E-9 ID:SGTC_1736|Compound:st036774|FD-Score:3.76|P-value:8.62E-5 ID:SGTC_1819|Compound:st053448|FD-Score:4.48|P-value:3.86E-6 ID:SGTC_1889|Compound:st059080|FD-Score:5.09|P-value:1.90E-7 ID:SGTC_1899|Compound:st063254|FD-Score:4.74|P-value:1.11E-6 ID:SGTC_1919|Compound:st067113|FD-Score:3.60|P-value:1.63E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.29|P-value:5.59E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.32|P-value:4.47E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.86|P-value:6.16E-7 ID:SGTC_2222|Compound:6885208|FD-Score:3.62|P-value:1.47E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.77|P-value:9.60E-7 ID:SGTC_2319|Compound:6033012|FD-Score:-3.15|P-value:9.09E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.22|P-value:7.26E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.10|P-value:9.79E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.55|P-value:2.82E-6 ID:SGTC_2379|Compound:9035213|FD-Score:4.37|P-value:6.51E-6 ID:SGTC_2380|Compound:9035439|FD-Score:-4.41|P-value:6.19E-6 ID:SGTC_2382|Compound:9035899|FD-Score:3.30|P-value:4.87E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.70|P-value:1.25E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.57|P-value:1.78E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.26|P-value:5.71E-4 ID:SGTC_2625|Compound:euphol|FD-Score:4.68|P-value:1.50E-6 ID:SGTC_2684|Compound:capsaicin|FD-Score:5.81|P-value:3.39E-9 ID:SGTC_2712|Compound:st079126|FD-Score:4.73|P-value:1.19E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:3.63|P-value:1.45E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.26|P-value:1.05E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.36|P-value:3.91E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.84|P-value:6.38E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-4.05|P-value:3.05E-5 ID:SGTC_2998|Compound:9066762|FD-Score:3.64|P-value:1.40E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.56|P-value:1.90E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-3.36|P-value:4.44E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.32|P-value:7.94E-6 ID:SGTC_3088|Compound:9117578|FD-Score:3.81|P-value:7.05E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.41|P-value:3.28E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:3.64|P-value:1.37E-4 ID:SGTC_139|Compound:0099-0334|FD-Score:4.46|P-value:4.33E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:4.00|P-value:3.18E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:3.12|P-value:8.96E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.90|P-value:4.88E-5 ID:SGTC_277|Compound:nystatin|FD-Score:4.42|P-value:5.18E-6 ID:SGTC_324|Compound:1315-0088|FD-Score:3.12|P-value:9.20E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-3.27|P-value:5.95E-4 ID:SGTC_449|Compound:xestospongin c|FD-Score:-3.44|P-value:3.29E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:5.19|P-value:1.12E-7 ID:SGTC_624|Compound:k048-0052|FD-Score:3.72|P-value:1.03E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.38|P-value:6.14E-6 ID:SGTC_803|Compound:4488-1585|FD-Score:3.32|P-value:4.53E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.81|P-value:7.10E-5 ID:SGTC_993|Compound:3909-8757|FD-Score:3.64|P-value:1.36E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:3.46|P-value:2.72E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:4.43|P-value:4.82E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:3.87|P-value:5.66E-5 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.17|P-value:7.57E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.25|P-value:5.76E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.21|P-value:6.79E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:3.60|P-value:1.64E-4 ID:SGTC_1391|Compound:3442-0225|FD-Score:3.77|P-value:8.45E-5 ID:SGTC_1486|Compound:3970-0793|FD-Score:3.96|P-value:3.76E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.83|P-value:6.49E-5 ID:SGTC_1522|Compound:st012842|FD-Score:3.43|P-value:3.05E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.72|P-value:1.00E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.60|P-value:2.17E-6 ID:SGTC_1657|Compound:st012939|FD-Score:5.86|P-value:2.53E-9 ID:SGTC_1736|Compound:st036774|FD-Score:3.76|P-value:8.62E-5 ID:SGTC_1819|Compound:st053448|FD-Score:4.48|P-value:3.86E-6 ID:SGTC_1889|Compound:st059080|FD-Score:5.09|P-value:1.90E-7 ID:SGTC_1899|Compound:st063254|FD-Score:4.74|P-value:1.11E-6 ID:SGTC_1919|Compound:st067113|FD-Score:3.60|P-value:1.63E-4 ID:SGTC_1938|Compound:st074717|FD-Score:-3.29|P-value:5.59E-4 ID:SGTC_2135|Compound:5326629|FD-Score:3.32|P-value:4.47E-4 ID:SGTC_2149|Compound:5554786|FD-Score:4.86|P-value:6.16E-7 ID:SGTC_2222|Compound:6885208|FD-Score:3.62|P-value:1.47E-4 ID:SGTC_2265|Compound:7929201|FD-Score:4.77|P-value:9.60E-7 ID:SGTC_2319|Compound:6033012|FD-Score:-3.15|P-value:9.09E-4 ID:SGTC_2328|Compound:6201408|FD-Score:-3.22|P-value:7.26E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.10|P-value:9.79E-4 ID:SGTC_2370|Compound:9071495|FD-Score:4.55|P-value:2.82E-6 ID:SGTC_2379|Compound:9035213|FD-Score:4.37|P-value:6.51E-6 ID:SGTC_2380|Compound:9035439|FD-Score:-4.41|P-value:6.19E-6 ID:SGTC_2382|Compound:9035899|FD-Score:3.30|P-value:4.87E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.70|P-value:1.25E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:3.57|P-value:1.78E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.26|P-value:5.71E-4 ID:SGTC_2625|Compound:euphol|FD-Score:4.68|P-value:1.50E-6 ID:SGTC_2684|Compound:capsaicin|FD-Score:5.81|P-value:3.39E-9 ID:SGTC_2712|Compound:st079126|FD-Score:4.73|P-value:1.19E-6 ID:SGTC_2739|Compound:tacrine|FD-Score:3.63|P-value:1.45E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.26|P-value:1.05E-5 ID:SGTC_2779|Compound:methotrexate|FD-Score:3.36|P-value:3.91E-4 ID:SGTC_2788|Compound:5282734|FD-Score:3.84|P-value:6.38E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-4.05|P-value:3.05E-5 ID:SGTC_2998|Compound:9066762|FD-Score:3.64|P-value:1.40E-4 ID:SGTC_3008|Compound:9078912|FD-Score:3.56|P-value:1.90E-4 ID:SGTC_3010|Compound:9080089|FD-Score:-3.36|P-value:4.44E-4 ID:SGTC_3083|Compound:9117465|FD-Score:4.32|P-value:7.94E-6 ID:SGTC_3088|Compound:9117578|FD-Score:3.81|P-value:7.05E-5 ID:SGTC_3340|Compound:9146634|FD-Score:3.41|P-value:3.28E-4

Top fitness defect scores for YMR265C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1657 st012939 5.86 43.4 µM 2.53E-9 2 2.30E-9
2 SGTC_2684 capsaicin 5.81 100.0 µM 3.39E-9 5 3.10E-9
3 SGTC_529 4076-0302 5.19 30.3 µM 1.12E-7 mitochondrial processes 5 1.05E-7
4 SGTC_1889 st059080 5.09 5.2 µM 1.90E-7 4 1.79E-7
5 SGTC_2149 5554786 4.86 194.8 µM 6.16E-7 cell wall signaling 18 5.85E-7
6 SGTC_2265 7929201 4.77 200.0 µM 9.60E-7 13 9.15E-7
7 SGTC_1899 st063254 4.74 59.6 µM 1.11E-6 3 1.06E-6
8 SGTC_2712 st079126 4.73 47.7 µM 1.19E-6 5 1.13E-6
9 SGTC_2625 euphol 4.68 100.0 µM 1.50E-6 19 1.43E-6
10 SGTC_1599 8-chlro-1-tetrahydronorharmanone 4.60 90.6 µM 2.17E-6 19 2.08E-6
11 SGTC_2370 9071495 4.55 200.0 µM 2.82E-6 mitochondrial processes 16 2.71E-6
12 SGTC_1819 st053448 4.48 58.6 µM 3.86E-6 amide catabolism 11 3.71E-6
13 SGTC_139 0099-0334 4.46 718.6 µM 4.33E-6 15 4.17E-6
14 SGTC_1034 k072-0165 4.43 12.7 µM 4.82E-6 Golgi 12 4.64E-6
15 SGTC_277 nystatin 4.42 15.5 µM 5.18E-6 6 4.99E-6
16 SGTC_796 1234-0020 4.38 70.7 µM 6.14E-6 SWF1 & branched chain AA biosynthesis 18 5.92E-6
17 SGTC_2379 9035213 4.37 200.0 µM 6.51E-6 12 6.29E-6
18 SGTC_3083 9117465 4.32 49.5 µM 7.94E-6 11 7.68E-6
19 SGTC_2770 toltrazuril 4.26 17.5 µM 1.05E-5 18 1.02E-5
20 SGTC_207 4185-0010 4.00 4.5 µM 3.18E-5 endomembrane recycling 85 3.11E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.094 5.37E-8 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.090 1.66E-7 YGR267C FOL2 het GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway
0.076 9.71E-6 YPL218W SAR1 het GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport
0.075 1.22E-5 YLR220W CCC1 hom Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation; relative distribution to the vacuole decreases upon DNA replication stress
0.072 2.64E-5 YNL122C_p YNL122C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene
0.072 2.92E-5 YIL143C SSL2 het Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site selection and in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3
0.071 4.18E-5 YLR112W_d YLR112W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.070 5.00E-5 YLR045C STU2 het Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p
0.068 7.43E-5 YLR178C TFS1 hom Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase; protein abundance increases in response to DNA replication stress
0.067 1.11E-4 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.066 1.27E-4 YHR152W SPO12 hom Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis
0.066 1.49E-4 YDR029W_d YDR029W_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data
0.065 1.57E-4 YHR048W_p YHK8_p hom Presumed antiporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
0.065 1.66E-4 YNL125C ESBP6 hom Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
0.064 2.08E-4 YNL332W THI12 hom Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13