Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate
Zygosity: Homozygous strain
fixedexpanded
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Top fitness defect scores for YMR267W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.434 | 1.83E-154 | YGR215W | RSM27 | hom | Mitochondrial ribosomal protein of the small subunit |
0.433 | 9.69E-154 | YPL183W-A | RTC6 | hom | Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress |
0.431 | 2.19E-151 | YMR287C | DSS1 | hom | 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs |
0.421 | 5.38E-144 | YER087W | AIM10 | hom | Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss |
0.419 | 2.17E-142 | YGR102C | GTF1 | hom | Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria |
0.410 | 7.46E-136 | YDR114C_p | YDR114C_p | hom | Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium |
0.408 | 1.50E-134 | YNL177C | MRPL22 | hom | Mitochondrial ribosomal protein of the large subunit |
0.403 | 1.93E-131 | YGR171C | MSM1 | hom | Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p |
0.401 | 1.08E-129 | YDR298C | ATP5 | hom | Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated |
0.400 | 3.18E-129 | YDR347W | MRP1 | hom | Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein |
0.398 | 2.16E-127 | YNL081C | SWS2 | hom | Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency |
0.394 | 3.78E-125 | YLR069C | MEF1 | hom | Mitochondrial elongation factor involved in translational elongation |
0.394 | 4.32E-125 | YDR296W | MHR1 | hom | Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress |
0.392 | 2.31E-123 | YPR100W | MRPL51 | hom | Mitochondrial ribosomal protein of the large subunit |
0.389 | 9.20E-122 | YMR228W | MTF1 | hom | Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation |