YMR267W / PPA2

Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR267W / PPA2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:5.40|P-value:1.24E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.11|P-value:1.70E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:7.72|P-value:9.04E-12 ID:SGTC_87|Compound:0100-0052|FD-Score:3.98|P-value:2.54E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.18|P-value:1.33E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:12.40|P-value:3.29E-27 ID:SGTC_236|Compound:1509-0011|FD-Score:11.40|P-value:1.62E-23 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.12|P-value:4.11E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:16.60|P-value:2.52E-47 ID:SGTC_330|Compound:1488-0319|FD-Score:3.80|P-value:4.55E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.62|P-value:8.87E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.61|P-value:9.10E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.04|P-value:2.10E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:5.33|P-value:1.70E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:4.13|P-value:1.59E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.93|P-value:3.02E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.62|P-value:8.92E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.11|P-value:5.24E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.94|P-value:2.90E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.70|P-value:6.12E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:7.86|P-value:3.87E-12 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.39|P-value:6.53E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:-4.58|P-value:3.81E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:-4.42|P-value:6.59E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:5.31|P-value:1.89E-6 ID:SGTC_1506|Compound:4226-2149|FD-Score:-4.32|P-value:9.51E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:-4.16|P-value:1.60E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:5.14|P-value:3.75E-6 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.71|P-value:6.84E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.14|P-value:1.55E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.29|P-value:9.27E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-3.70|P-value:7.03E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.26|P-value:1.01E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-5.06|P-value:6.04E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.71|P-value:2.01E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-7.74|P-value:1.00E-11 ID:SGTC_1898|Compound:st060199|FD-Score:4.12|P-value:1.63E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.93|P-value:3.00E-4 ID:SGTC_1912|Compound:st060209|FD-Score:5.78|P-value:2.33E-7 ID:SGTC_2036|Compound:5160441|FD-Score:-3.87|P-value:4.12E-4 ID:SGTC_2094|Compound:5332512|FD-Score:4.67|P-value:2.37E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.64|P-value:3.63E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.43|P-value:1.06E-8 ID:SGTC_2358|Compound:9037157|FD-Score:3.64|P-value:7.39E-4 ID:SGTC_2373|Compound:9071805|FD-Score:6.28|P-value:2.27E-8 ID:SGTC_2376|Compound:9072922|FD-Score:4.96|P-value:7.68E-6 ID:SGTC_2378|Compound:9074213|FD-Score:5.75|P-value:2.79E-7 ID:SGTC_2382|Compound:9035899|FD-Score:-4.44|P-value:6.15E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-3.96|P-value:3.11E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.59|P-value:8.70E-4 ID:SGTC_2411|Compound:st077133|FD-Score:4.10|P-value:1.72E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:4.50|P-value:4.41E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.98|P-value:7.16E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.39|P-value:6.38E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-3.76|P-value:5.83E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.64|P-value:8.48E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.81|P-value:4.47E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:4.22|P-value:1.17E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.06|P-value:1.98E-4 ID:SGTC_2807|Compound:7945238|FD-Score:5.18|P-value:3.22E-6 ID:SGTC_2809|Compound:7964133|FD-Score:5.35|P-value:1.55E-6 ID:SGTC_2812|Compound:7970281|FD-Score:7.33|P-value:8.90E-11 ID:SGTC_2896|Compound:9052656|FD-Score:-3.59|P-value:9.67E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.67|P-value:7.72E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.63|P-value:8.54E-4 ID:SGTC_3128|Compound:9127691|FD-Score:4.94|P-value:8.44E-6 ID:SGTC_10|Compound:0279-0212|FD-Score:5.40|P-value:1.24E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.11|P-value:1.70E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:7.72|P-value:9.04E-12 ID:SGTC_87|Compound:0100-0052|FD-Score:3.98|P-value:2.54E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:4.18|P-value:1.33E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:12.40|P-value:3.29E-27 ID:SGTC_236|Compound:1509-0011|FD-Score:11.40|P-value:1.62E-23 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.12|P-value:4.11E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:16.60|P-value:2.52E-47 ID:SGTC_330|Compound:1488-0319|FD-Score:3.80|P-value:4.55E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.62|P-value:8.87E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.61|P-value:9.10E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.04|P-value:2.10E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:5.33|P-value:1.70E-6 ID:SGTC_767|Compound:0929-0023|FD-Score:4.13|P-value:1.59E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.93|P-value:3.02E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-3.62|P-value:8.92E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.11|P-value:5.24E-8 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.94|P-value:2.90E-4 ID:SGTC_1167|Compound:k781-0610|FD-Score:3.70|P-value:6.12E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:7.86|P-value:3.87E-12 ID:SGTC_1189|Compound:1431-2119|FD-Score:4.39|P-value:6.53E-5 ID:SGTC_1209|Compound:2323-2347|FD-Score:-4.58|P-value:3.81E-5 ID:SGTC_1283|Compound:0922-0125|FD-Score:-4.42|P-value:6.59E-5 ID:SGTC_1426|Compound:4048-4480|FD-Score:5.31|P-value:1.89E-6 ID:SGTC_1506|Compound:4226-2149|FD-Score:-4.32|P-value:9.51E-5 ID:SGTC_1510|Compound:1123-0200|FD-Score:-4.16|P-value:1.60E-4 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:5.14|P-value:3.75E-6 ID:SGTC_1556|Compound:plumbagin|FD-Score:-3.71|P-value:6.84E-4 ID:SGTC_1627|Compound:st003713|FD-Score:4.14|P-value:1.55E-4 ID:SGTC_1695|Compound:st026914|FD-Score:4.29|P-value:9.27E-5 ID:SGTC_1707|Compound:st032323|FD-Score:-3.70|P-value:7.03E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.26|P-value:1.01E-4 ID:SGTC_1880|Compound:MG-132|FD-Score:-5.06|P-value:6.04E-6 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:4.71|P-value:2.01E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-7.74|P-value:1.00E-11 ID:SGTC_1898|Compound:st060199|FD-Score:4.12|P-value:1.63E-4 ID:SGTC_1902|Compound:st060212|FD-Score:3.93|P-value:3.00E-4 ID:SGTC_1912|Compound:st060209|FD-Score:5.78|P-value:2.33E-7 ID:SGTC_2036|Compound:5160441|FD-Score:-3.87|P-value:4.12E-4 ID:SGTC_2094|Compound:5332512|FD-Score:4.67|P-value:2.37E-5 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:6.64|P-value:3.63E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:6.43|P-value:1.06E-8 ID:SGTC_2358|Compound:9037157|FD-Score:3.64|P-value:7.39E-4 ID:SGTC_2373|Compound:9071805|FD-Score:6.28|P-value:2.27E-8 ID:SGTC_2376|Compound:9072922|FD-Score:4.96|P-value:7.68E-6 ID:SGTC_2378|Compound:9074213|FD-Score:5.75|P-value:2.79E-7 ID:SGTC_2382|Compound:9035899|FD-Score:-4.44|P-value:6.15E-5 ID:SGTC_2395|Compound:5646831|FD-Score:-3.96|P-value:3.11E-4 ID:SGTC_2402|Compound:5553605|FD-Score:3.59|P-value:8.70E-4 ID:SGTC_2411|Compound:st077133|FD-Score:4.10|P-value:1.72E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:4.50|P-value:4.41E-5 ID:SGTC_2526|Compound:patulin|FD-Score:4.98|P-value:7.16E-6 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:4.39|P-value:6.38E-5 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-3.76|P-value:5.83E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.64|P-value:8.48E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.81|P-value:4.47E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:4.22|P-value:1.17E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.06|P-value:1.98E-4 ID:SGTC_2807|Compound:7945238|FD-Score:5.18|P-value:3.22E-6 ID:SGTC_2809|Compound:7964133|FD-Score:5.35|P-value:1.55E-6 ID:SGTC_2812|Compound:7970281|FD-Score:7.33|P-value:8.90E-11 ID:SGTC_2896|Compound:9052656|FD-Score:-3.59|P-value:9.67E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.67|P-value:7.72E-4 ID:SGTC_3063|Compound:1327-0034|FD-Score:-3.63|P-value:8.54E-4 ID:SGTC_3128|Compound:9127691|FD-Score:4.94|P-value:8.44E-6

Top fitness defect scores for YMR267W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 16.60 1.1 µM 2.52E-47 mitochondrial stress 3 5.88E-62
2 SGTC_173 1273-0061 12.40 2.7 µM 3.29E-27 mitochondrial stress 24 2.41E-35
3 SGTC_236 1509-0011 11.40 5.3 µM 1.62E-23 162 1.82E-30
4 SGTC_1188 1403-0014 7.86 4.6 µM 3.87E-12 mitochondrial stress 5 1.89E-15
5 SGTC_63 0099-0242 7.72 26.7 µM 9.04E-12 mitochondrial stress 13 5.76E-15
6 SGTC_2812 7970281 7.33 58.4 µM 8.90E-11 1 1.17E-13
7 SGTC_2232 chlorophetanol 6.64 41.5 µM 3.63E-9 TRP & mitochondrial translation 29 1.54E-11
8 SGTC_2250 alverine citrate 6.43 130.0 µM 1.06E-8 42 6.28E-11
9 SGTC_2373 9071805 6.28 200.0 µM 2.27E-8 1 1.70E-10
10 SGTC_908 3448-7491 6.11 47.7 µM 5.24E-8 mitochondrial stress 45 5.11E-10
11 SGTC_1912 st060209 5.78 90.8 µM 2.33E-7 10 3.63E-9
12 SGTC_2378 9074213 5.75 121.4 µM 2.79E-7 RSC complex & mRNA processing 1 4.59E-9
13 SGTC_10 0279-0212 5.40 42.6 µM 1.24E-6 TRP & mitochondrial translation 44 3.24E-8
14 SGTC_2809 7964133 5.35 13.0 µM 1.55E-6 60S ribosome export 10 4.35E-8
15 SGTC_614 0462-0418 5.33 107.0 µM 1.70E-6 10 4.91E-8
16 SGTC_1426 4048-4480 5.31 71.7 µM 1.89E-6 60S ribosome export 4 5.63E-8
17 SGTC_2807 7945238 5.18 52.0 µM 3.22E-6 8 1.13E-7
18 SGTC_1538 2',3',6-trimethoxyflavanone 5.14 63.6 µM 3.75E-6 6 1.38E-7
19 SGTC_275 trichlorophene 5.12 5.7 µM 4.11E-6 mitochondrial stress 162 1.55E-7
20 SGTC_2526 patulin 4.98 37.6 µM 7.16E-6 46 3.21E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.434 1.83E-154 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.433 9.69E-154 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.431 2.19E-151 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.421 5.38E-144 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.419 2.17E-142 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.410 7.46E-136 YDR114C_p YDR114C_p hom Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
0.408 1.50E-134 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.403 1.93E-131 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.401 1.08E-129 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.400 3.18E-129 YDR347W MRP1 hom Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
0.398 2.16E-127 YNL081C SWS2 hom Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.394 3.78E-125 YLR069C MEF1 hom Mitochondrial elongation factor involved in translational elongation
0.394 4.32E-125 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.392 2.31E-123 YPR100W MRPL51 hom Mitochondrial ribosomal protein of the large subunit
0.389 9.20E-122 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation