HIPHOP chemogenomics database

YMR267W / PPA2

Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR267W / PPA2

Click on Significant Values for Screen Details

Top fitness defect scores for YMR267W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_310	1273-0058	16.60	1.1 µM	2.52E-47	mitochondrial stress	3	5.88E-62
2	SGTC_173	1273-0061	12.40	2.7 µM	3.29E-27	mitochondrial stress	24	2.41E-35
3	SGTC_236	1509-0011	11.40	5.3 µM	1.62E-23		162	1.82E-30
4	SGTC_1188	1403-0014	7.86	4.6 µM	3.87E-12	mitochondrial stress	5	1.89E-15
5	SGTC_63	0099-0242	7.72	26.7 µM	9.04E-12	mitochondrial stress	13	5.76E-15
6	SGTC_2812	7970281	7.33	58.4 µM	8.90E-11		1	1.17E-13
7	SGTC_2232	chlorophetanol	6.64	41.5 µM	3.63E-9	TRP & mitochondrial translation	29	1.54E-11
8	SGTC_2250	alverine citrate	6.43	130.0 µM	1.06E-8		42	6.28E-11
9	SGTC_2373	9071805	6.28	200.0 µM	2.27E-8		1	1.70E-10
10	SGTC_908	3448-7491	6.11	47.7 µM	5.24E-8	mitochondrial stress	45	5.11E-10
11	SGTC_1912	st060209	5.78	90.8 µM	2.33E-7		10	3.63E-9
12	SGTC_2378	9074213	5.75	121.4 µM	2.79E-7	RSC complex & mRNA processing	1	4.59E-9
13	SGTC_10	0279-0212	5.40	42.6 µM	1.24E-6	TRP & mitochondrial translation	44	3.24E-8
14	SGTC_2809	7964133	5.35	13.0 µM	1.55E-6	60S ribosome export	10	4.35E-8
15	SGTC_614	0462-0418	5.33	107.0 µM	1.70E-6		10	4.91E-8
16	SGTC_1426	4048-4480	5.31	71.7 µM	1.89E-6	60S ribosome export	4	5.63E-8
17	SGTC_2807	7945238	5.18	52.0 µM	3.22E-6		8	1.13E-7
18	SGTC_1538	2',3',6-trimethoxyflavanone	5.14	63.6 µM	3.75E-6		6	1.38E-7
19	SGTC_275	trichlorophene	5.12	5.7 µM	4.11E-6	mitochondrial stress	162	1.55E-7
20	SGTC_2526	patulin	4.98	37.6 µM	7.16E-6		46	3.21E-7

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.434	1.83E-154	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.433	9.69E-154	YPL183W-A	RTC6	hom	Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.431	2.19E-151	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.421	5.38E-144	YER087W	AIM10	hom	Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.419	2.17E-142	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.410	7.46E-136	YDR114C_p	YDR114C_p	hom	Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium
0.408	1.50E-134	YNL177C	MRPL22	hom	Mitochondrial ribosomal protein of the large subunit
0.403	1.93E-131	YGR171C	MSM1	hom	Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.401	1.08E-129	YDR298C	ATP5	hom	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.400	3.18E-129	YDR347W	MRP1	hom	Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein
0.398	2.16E-127	YNL081C	SWS2	hom	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency
0.394	3.78E-125	YLR069C	MEF1	hom	Mitochondrial elongation factor involved in translational elongation
0.394	4.32E-125	YDR296W	MHR1	hom	Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.392	2.31E-123	YPR100W	MRPL51	hom	Mitochondrial ribosomal protein of the large subunit
0.389	9.20E-122	YMR228W	MTF1	hom	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation