YMR268C / PRP24

Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR268C / PRP24

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:5.27|P-value:2.51E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:10.60|P-value:1.63E-20 ID:SGTC_64|Compound:000l-0018|FD-Score:11.70|P-value:1.74E-24 ID:SGTC_86|Compound:0417-1630|FD-Score:3.63|P-value:8.16E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.89|P-value:1.15E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:7.33|P-value:1.08E-10 ID:SGTC_137|Compound:0438-0332|FD-Score:5.88|P-value:1.74E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:4.72|P-value:2.17E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:7.85|P-value:5.39E-12 ID:SGTC_157|Compound:1348-1695|FD-Score:6.31|P-value:2.30E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:6.64|P-value:4.59E-9 ID:SGTC_159|Compound:3970-0959|FD-Score:6.70|P-value:3.25E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:4.32|P-value:9.01E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:5.42|P-value:1.35E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:5.49|P-value:9.91E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:4.44|P-value:5.88E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:5.84|P-value:2.13E-7 ID:SGTC_248|Compound:streptozotocin|FD-Score:8.21|P-value:6.00E-13 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.69|P-value:6.85E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.61|P-value:8.81E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:4.51|P-value:4.63E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:4.08|P-value:2.05E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.47|P-value:5.79E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-9.48|P-value:1.36E-16 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.73|P-value:6.55E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.67|P-value:7.79E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.35|P-value:1.76E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.86|P-value:4.06E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.08|P-value:7.77E-8 ID:SGTC_539|Compound:4859-0462|FD-Score:4.17|P-value:1.53E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:7.75|P-value:9.64E-12 ID:SGTC_660|Compound:4031-1742|FD-Score:3.89|P-value:3.69E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:12.00|P-value:2.18E-25 ID:SGTC_733|Compound:4069-0007|FD-Score:5.28|P-value:2.42E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:4.98|P-value:8.02E-6 ID:SGTC_857|Compound:0438-0306|FD-Score:4.35|P-value:8.28E-5 ID:SGTC_918|Compound:glabranin|FD-Score:4.06|P-value:2.14E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:4.53|P-value:4.27E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:4.03|P-value:2.40E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.06|P-value:2.35E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.81|P-value:4.82E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-5.31|P-value:2.31E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:10.50|P-value:4.15E-20 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.24|P-value:2.85E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.60|P-value:9.53E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.08|P-value:7.13E-8 ID:SGTC_1635|Compound:st007035|FD-Score:3.73|P-value:6.07E-4 ID:SGTC_1719|Compound:st032227|FD-Score:4.11|P-value:1.86E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.86|P-value:4.15E-4 ID:SGTC_1750|Compound:st081859|FD-Score:7.73|P-value:1.07E-11 ID:SGTC_1754|Compound:st042065|FD-Score:-3.68|P-value:7.61E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.43|P-value:6.13E-5 ID:SGTC_1766|Compound:st045414|FD-Score:7.25|P-value:1.68E-10 ID:SGTC_1950|Compound:st077106|FD-Score:3.86|P-value:4.10E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.82|P-value:4.71E-4 ID:SGTC_2026|Compound:5148700|FD-Score:4.36|P-value:7.80E-5 ID:SGTC_2041|Compound:5107442|FD-Score:3.76|P-value:5.63E-4 ID:SGTC_2086|Compound:5274770|FD-Score:5.51|P-value:8.95E-7 ID:SGTC_2089|Compound:5281248|FD-Score:6.10|P-value:6.40E-8 ID:SGTC_2125|Compound:5246583|FD-Score:5.39|P-value:1.52E-6 ID:SGTC_2320|Compound:7373003|FD-Score:5.49|P-value:1.01E-6 ID:SGTC_2338|Compound:7999974|FD-Score:3.85|P-value:4.28E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.40|P-value:1.51E-8 ID:SGTC_2436|Compound:5633522|FD-Score:-5.60|P-value:6.78E-7 ID:SGTC_2437|Compound:5741531|FD-Score:-4.41|P-value:7.15E-5 ID:SGTC_2440|Compound:5628896|FD-Score:5.63|P-value:5.49E-7 ID:SGTC_2511|Compound:berberine|FD-Score:5.33|P-value:1.93E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.47|P-value:5.30E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.58|P-value:3.58E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-6.22|P-value:4.02E-8 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:5.01|P-value:7.05E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.60|P-value:6.64E-7 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.58|P-value:9.99E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-4.35|P-value:8.61E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-6.32|P-value:2.42E-8 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.99|P-value:2.69E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.60|P-value:9.64E-4 ID:SGTC_2821|Compound:7996764|FD-Score:7.03|P-value:5.62E-10 ID:SGTC_2823|Compound:7987624|FD-Score:8.08|P-value:1.32E-12 ID:SGTC_2856|Compound:9022925|FD-Score:3.62|P-value:8.53E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-4.27|P-value:1.14E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.73|P-value:6.51E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.95|P-value:3.26E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-4.10|P-value:2.04E-4 ID:SGTC_3065|Compound:9113888|FD-Score:4.69|P-value:2.45E-5 ID:SGTC_3100|Compound:9120536|FD-Score:-5.02|P-value:7.27E-6 ID:SGTC_3111|Compound:9122088|FD-Score:4.18|P-value:1.45E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.82|P-value:4.60E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-5.23|P-value:3.13E-6 ID:SGTC_3257|Compound:9139206|FD-Score:3.63|P-value:8.15E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.87|P-value:3.95E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.90|P-value:3.61E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.21|P-value:1.33E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.74|P-value:5.86E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.64|P-value:8.02E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:5.27|P-value:2.51E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:10.60|P-value:1.63E-20 ID:SGTC_64|Compound:000l-0018|FD-Score:11.70|P-value:1.74E-24 ID:SGTC_86|Compound:0417-1630|FD-Score:3.63|P-value:8.16E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.89|P-value:1.15E-5 ID:SGTC_122|Compound:0236-0016|FD-Score:7.33|P-value:1.08E-10 ID:SGTC_137|Compound:0438-0332|FD-Score:5.88|P-value:1.74E-7 ID:SGTC_142|Compound:0335-0849|FD-Score:4.72|P-value:2.17E-5 ID:SGTC_150|Compound:3970-0969|FD-Score:7.85|P-value:5.39E-12 ID:SGTC_157|Compound:1348-1695|FD-Score:6.31|P-value:2.30E-8 ID:SGTC_158|Compound:k038-0087|FD-Score:6.64|P-value:4.59E-9 ID:SGTC_159|Compound:3970-0959|FD-Score:6.70|P-value:3.25E-9 ID:SGTC_163|Compound:1327-0036|FD-Score:4.32|P-value:9.01E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:5.42|P-value:1.35E-6 ID:SGTC_188|Compound:3229-0966|FD-Score:5.49|P-value:9.91E-7 ID:SGTC_212|Compound:3807-4682|FD-Score:4.44|P-value:5.88E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:5.84|P-value:2.13E-7 ID:SGTC_248|Compound:streptozotocin|FD-Score:8.21|P-value:6.00E-13 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:3.69|P-value:6.85E-4 ID:SGTC_274|Compound:sirtinol|FD-Score:3.61|P-value:8.81E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:4.51|P-value:4.63E-5 ID:SGTC_340|Compound:k038-0059|FD-Score:4.08|P-value:2.05E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:-4.47|P-value:5.79E-5 ID:SGTC_372|Compound:0155-0182|FD-Score:-9.48|P-value:1.36E-16 ID:SGTC_431|Compound:k089-0097|FD-Score:-3.73|P-value:6.55E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.67|P-value:7.79E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:5.35|P-value:1.76E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.86|P-value:4.06E-4 ID:SGTC_490|Compound:phenamil|FD-Score:-6.08|P-value:7.77E-8 ID:SGTC_539|Compound:4859-0462|FD-Score:4.17|P-value:1.53E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:7.75|P-value:9.64E-12 ID:SGTC_660|Compound:4031-1742|FD-Score:3.89|P-value:3.69E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:12.00|P-value:2.18E-25 ID:SGTC_733|Compound:4069-0007|FD-Score:5.28|P-value:2.42E-6 ID:SGTC_839|Compound:0122-0028|FD-Score:4.98|P-value:8.02E-6 ID:SGTC_857|Compound:0438-0306|FD-Score:4.35|P-value:8.28E-5 ID:SGTC_918|Compound:glabranin|FD-Score:4.06|P-value:2.14E-4 ID:SGTC_959|Compound:1222-0044|FD-Score:4.53|P-value:4.27E-5 ID:SGTC_975|Compound:1335-0046|FD-Score:4.03|P-value:2.40E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:-4.06|P-value:2.35E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:3.81|P-value:4.82E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:-5.31|P-value:2.31E-6 ID:SGTC_1133|Compound:3473-0247|FD-Score:10.50|P-value:4.15E-20 ID:SGTC_1161|Compound:k007-0610|FD-Score:5.24|P-value:2.85E-6 ID:SGTC_1469|Compound:k284-2957|FD-Score:-3.60|P-value:9.53E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.08|P-value:7.13E-8 ID:SGTC_1635|Compound:st007035|FD-Score:3.73|P-value:6.07E-4 ID:SGTC_1719|Compound:st032227|FD-Score:4.11|P-value:1.86E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.86|P-value:4.15E-4 ID:SGTC_1750|Compound:st081859|FD-Score:7.73|P-value:1.07E-11 ID:SGTC_1754|Compound:st042065|FD-Score:-3.68|P-value:7.61E-4 ID:SGTC_1765|Compound:st044815|FD-Score:4.43|P-value:6.13E-5 ID:SGTC_1766|Compound:st045414|FD-Score:7.25|P-value:1.68E-10 ID:SGTC_1950|Compound:st077106|FD-Score:3.86|P-value:4.10E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.82|P-value:4.71E-4 ID:SGTC_2026|Compound:5148700|FD-Score:4.36|P-value:7.80E-5 ID:SGTC_2041|Compound:5107442|FD-Score:3.76|P-value:5.63E-4 ID:SGTC_2086|Compound:5274770|FD-Score:5.51|P-value:8.95E-7 ID:SGTC_2089|Compound:5281248|FD-Score:6.10|P-value:6.40E-8 ID:SGTC_2125|Compound:5246583|FD-Score:5.39|P-value:1.52E-6 ID:SGTC_2320|Compound:7373003|FD-Score:5.49|P-value:1.01E-6 ID:SGTC_2338|Compound:7999974|FD-Score:3.85|P-value:4.28E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.40|P-value:1.51E-8 ID:SGTC_2436|Compound:5633522|FD-Score:-5.60|P-value:6.78E-7 ID:SGTC_2437|Compound:5741531|FD-Score:-4.41|P-value:7.15E-5 ID:SGTC_2440|Compound:5628896|FD-Score:5.63|P-value:5.49E-7 ID:SGTC_2511|Compound:berberine|FD-Score:5.33|P-value:1.93E-6 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.47|P-value:5.30E-5 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:4.58|P-value:3.58E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:-6.22|P-value:4.02E-8 ID:SGTC_2558|Compound:carylophyllene oxide|FD-Score:5.01|P-value:7.05E-6 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:-5.60|P-value:6.64E-7 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.58|P-value:9.99E-4 ID:SGTC_2736|Compound:butenafine|FD-Score:-4.35|P-value:8.61E-5 ID:SGTC_2739|Compound:tacrine|FD-Score:-6.32|P-value:2.42E-8 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.99|P-value:2.69E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:-3.60|P-value:9.64E-4 ID:SGTC_2821|Compound:7996764|FD-Score:7.03|P-value:5.62E-10 ID:SGTC_2823|Compound:7987624|FD-Score:8.08|P-value:1.32E-12 ID:SGTC_2856|Compound:9022925|FD-Score:3.62|P-value:8.53E-4 ID:SGTC_2905|Compound:7799065|FD-Score:-4.27|P-value:1.14E-4 ID:SGTC_2968|Compound:9090663|FD-Score:-3.73|P-value:6.51E-4 ID:SGTC_3054|Compound:9094397|FD-Score:-3.95|P-value:3.26E-4 ID:SGTC_3056|Compound:9094900|FD-Score:-4.10|P-value:2.04E-4 ID:SGTC_3065|Compound:9113888|FD-Score:4.69|P-value:2.45E-5 ID:SGTC_3100|Compound:9120536|FD-Score:-5.02|P-value:7.27E-6 ID:SGTC_3111|Compound:9122088|FD-Score:4.18|P-value:1.45E-4 ID:SGTC_3152|Compound:9099253|FD-Score:3.82|P-value:4.60E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-5.23|P-value:3.13E-6 ID:SGTC_3257|Compound:9139206|FD-Score:3.63|P-value:8.15E-4 ID:SGTC_3272|Compound:9137413|FD-Score:3.87|P-value:3.95E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.90|P-value:3.61E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.21|P-value:1.33E-4 ID:SGTC_3316|Compound:9136639|FD-Score:3.74|P-value:5.86E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.64|P-value:8.02E-4

Top fitness defect scores for YMR268C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_673 1082-0474 12.00 110.0 µM 2.18E-25 RSC complex & mRNA processing 6 3.00E-33 0.17
2 SGTC_64 000l-0018 11.70 272.1 µM 1.74E-24 ubiquinone biosynthesis & proteasome 11 4.80E-32 2.27
3 SGTC_36 0335-0881 10.60 14.2 µM 1.63E-20 ubiquinone biosynthesis & proteasome 3 9.39E-27 1.14
4 SGTC_1133 3473-0247 10.50 50.0 µM 4.15E-20 RSC complex & mRNA processing 6 3.28E-26 0.61
5 SGTC_248 streptozotocin 8.21 5.2 mM 6.00E-13 DNA damage response 3 1.12E-16 0.06
6 SGTC_2823 7987624 8.08 58.4 µM 1.32E-12 2 3.21E-16 2.30
7 SGTC_150 3970-0969 7.85 77.2 µM 5.39E-12 4 2.08E-15 1.62
8 SGTC_568 1193-0097 7.75 7.5 µM 9.64E-12 ERAD & cell cycle 5 4.50E-15 0.11
9 SGTC_1750 st081859 7.73 2.4 µM 1.07E-11 endomembrane recycling 11 5.20E-15 0.68
10 SGTC_122 0236-0016 7.33 402.4 µM 1.08E-10 RNA processing & uracil transport 2 1.11E-13 1.84
11 SGTC_1766 st045414 7.25 44.8 µM 1.68E-10 RPP1 & pyrimidine depletion 4 2.01E-13 0.95
12 SGTC_2821 7996764 7.03 71.4 µM 5.62E-10 2 9.97E-13 1.12
13 SGTC_159 3970-0959 6.70 50.0 µM 3.25E-9 8 1.03E-11 1.12
14 SGTC_158 k038-0087 6.64 26.4 µM 4.59E-9 ubiquinone biosynthesis & proteasome 12 1.62E-11 0.27
15 SGTC_2348 9022543 6.40 33.4 µM 1.51E-8 mitochondrial processes 17 7.86E-11 0.09
16 SGTC_157 1348-1695 6.31 65.8 µM 2.30E-8 iron homeostasis 18 1.37E-10 0.37
17 SGTC_2089 5281248 6.10 129.7 µM 6.40E-8 superoxide 5 5.34E-10 1.17
18 SGTC_1493 4348-0038 6.08 111.0 µM 7.13E-8 RSC complex & mRNA processing 17 6.15E-10 0.10
19 SGTC_137 0438-0332 5.88 85.4 µM 1.74E-7 ubiquinone biosynthesis & proteasome 19 2.00E-9 0.31
20 SGTC_214 4373-3496 5.84 70.0 µM 2.13E-7 5 2.62E-9 0.83

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.263 3.93E-54 YER019C-A SBH2 hom Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p
0.257 6.39E-52 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)
0.253 2.66E-50 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.249 1.07E-48 YMR067C UBX4 hom UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress
0.248 2.57E-48 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex
0.246 2.68E-47 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.243 1.98E-46 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.241 1.95E-45 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.240 2.65E-45 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.240 4.35E-45 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.230 1.90E-41 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.230 2.19E-41 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.226 6.07E-40 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.225 1.14E-39 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.214 5.70E-36 YJL072C PSF2 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery