YMR269W / TMA23

Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR269W / TMA23

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:4.50|P-value:3.34E-6 ID:SGTC_48|Compound:0382-0018|FD-Score:3.79|P-value:7.63E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:3.93|P-value:4.17E-5 ID:SGTC_191|Compound:3914-0123|FD-Score:-3.48|P-value:2.54E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:9.09|P-value:5.07E-20 ID:SGTC_271|Compound:rotenone|FD-Score:3.82|P-value:6.53E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:4.23|P-value:1.17E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:3.83|P-value:6.28E-5 ID:SGTC_446|Compound:go6976|FD-Score:5.37|P-value:3.95E-8 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.37|P-value:3.70E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.54|P-value:1.97E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.98|P-value:3.10E-7 ID:SGTC_869|Compound:0564-0080|FD-Score:3.40|P-value:3.42E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.38|P-value:3.63E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.85|P-value:6.01E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-6.37|P-value:9.35E-11 ID:SGTC_922|Compound:1866-0035|FD-Score:3.11|P-value:9.42E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.72|P-value:9.96E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:4.28|P-value:9.39E-6 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.51|P-value:2.24E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.58|P-value:1.73E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.60|P-value:1.62E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.34|P-value:7.09E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.55|P-value:1.95E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.44|P-value:2.86E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.50|P-value:2.31E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.34|P-value:4.16E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.28|P-value:5.20E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.56|P-value:1.87E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.72|P-value:9.84E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.04|P-value:2.70E-5 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.92|P-value:4.47E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.07|P-value:2.36E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:8.52|P-value:7.90E-18 ID:SGTC_1740|Compound:st038286|FD-Score:-3.29|P-value:5.02E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.44|P-value:2.94E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.68|P-value:1.14E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.52|P-value:2.16E-4 ID:SGTC_1992|Compound:st073643|FD-Score:4.64|P-value:1.75E-6 ID:SGTC_1995|Compound:st072814|FD-Score:4.25|P-value:1.08E-5 ID:SGTC_1996|Compound:st072960|FD-Score:-3.46|P-value:2.71E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.12|P-value:8.97E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.16|P-value:7.85E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.57|P-value:2.48E-6 ID:SGTC_2323|Compound:6148992|FD-Score:3.68|P-value:1.15E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.39|P-value:5.73E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.94|P-value:1.43E-9 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.13|P-value:8.81E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.11|P-value:9.32E-4 ID:SGTC_2432|Compound:5630864|FD-Score:-4.42|P-value:4.81E-6 ID:SGTC_2485|Compound:5633444|FD-Score:5.31|P-value:5.54E-8 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.66|P-value:1.27E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.44|P-value:2.88E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.12|P-value:9.01E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.29|P-value:5.05E-4 ID:SGTC_3034|Compound:9090421|FD-Score:4.29|P-value:8.82E-6 ID:SGTC_3088|Compound:9117578|FD-Score:3.77|P-value:8.15E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-5.82|P-value:2.94E-9 ID:SGTC_3199|Compound:9111318|FD-Score:-3.71|P-value:1.02E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.10|P-value:9.80E-4 ID:SGTC_3210|Compound:9128157|FD-Score:5.36|P-value:4.06E-8 ID:SGTC_3322|Compound:9139058|FD-Score:5.34|P-value:4.72E-8 ID:SGTC_3324|Compound:9138759|FD-Score:-3.49|P-value:2.41E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:4.50|P-value:3.34E-6 ID:SGTC_48|Compound:0382-0018|FD-Score:3.79|P-value:7.63E-5 ID:SGTC_59|Compound:0330-0160|FD-Score:3.93|P-value:4.17E-5 ID:SGTC_191|Compound:3914-0123|FD-Score:-3.48|P-value:2.54E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:9.09|P-value:5.07E-20 ID:SGTC_271|Compound:rotenone|FD-Score:3.82|P-value:6.53E-5 ID:SGTC_297|Compound:0986-0032|FD-Score:4.23|P-value:1.17E-5 ID:SGTC_385|Compound:1494-0393|FD-Score:3.83|P-value:6.28E-5 ID:SGTC_446|Compound:go6976|FD-Score:5.37|P-value:3.95E-8 ID:SGTC_825|Compound:1988-2224|FD-Score:-3.37|P-value:3.70E-4 ID:SGTC_830|Compound:4076-0286|FD-Score:3.54|P-value:1.97E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:4.98|P-value:3.10E-7 ID:SGTC_869|Compound:0564-0080|FD-Score:3.40|P-value:3.42E-4 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.38|P-value:3.63E-4 ID:SGTC_882|Compound:0843-0131|FD-Score:3.85|P-value:6.01E-5 ID:SGTC_893|Compound:0958-0369|FD-Score:-6.37|P-value:9.35E-11 ID:SGTC_922|Compound:1866-0035|FD-Score:3.11|P-value:9.42E-4 ID:SGTC_958|Compound:1222-0007|FD-Score:3.72|P-value:9.96E-5 ID:SGTC_990|Compound:3985-0011|FD-Score:4.28|P-value:9.39E-6 ID:SGTC_991|Compound:3996-0057|FD-Score:-3.51|P-value:2.24E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:3.58|P-value:1.73E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:3.60|P-value:1.62E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.34|P-value:7.09E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.55|P-value:1.95E-4 ID:SGTC_1191|Compound:1487-1166|FD-Score:3.44|P-value:2.86E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.50|P-value:2.31E-4 ID:SGTC_1208|Compound:2323-2347|FD-Score:3.34|P-value:4.16E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:3.28|P-value:5.20E-4 ID:SGTC_1268|Compound:0828-0275|FD-Score:3.56|P-value:1.87E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.72|P-value:9.84E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.04|P-value:2.70E-5 ID:SGTC_1440|Compound:4100-1550|FD-Score:3.92|P-value:4.47E-5 ID:SGTC_1470|Compound:k295-0292|FD-Score:4.07|P-value:2.36E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:8.52|P-value:7.90E-18 ID:SGTC_1740|Compound:st038286|FD-Score:-3.29|P-value:5.02E-4 ID:SGTC_1769|Compound:st044406|FD-Score:3.44|P-value:2.94E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.68|P-value:1.14E-4 ID:SGTC_1939|Compound:st074455|FD-Score:-3.52|P-value:2.16E-4 ID:SGTC_1992|Compound:st073643|FD-Score:4.64|P-value:1.75E-6 ID:SGTC_1995|Compound:st072814|FD-Score:4.25|P-value:1.08E-5 ID:SGTC_1996|Compound:st072960|FD-Score:-3.46|P-value:2.71E-4 ID:SGTC_2008|Compound:4012253|FD-Score:3.12|P-value:8.97E-4 ID:SGTC_2177|Compound:5811945|FD-Score:3.16|P-value:7.85E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.57|P-value:2.48E-6 ID:SGTC_2323|Compound:6148992|FD-Score:3.68|P-value:1.15E-4 ID:SGTC_2339|Compound:9000433|FD-Score:4.39|P-value:5.73E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:5.94|P-value:1.43E-9 ID:SGTC_2406|Compound:ethylparaben|FD-Score:3.13|P-value:8.81E-4 ID:SGTC_2413|Compound:inermin|FD-Score:3.11|P-value:9.32E-4 ID:SGTC_2432|Compound:5630864|FD-Score:-4.42|P-value:4.81E-6 ID:SGTC_2485|Compound:5633444|FD-Score:5.31|P-value:5.54E-8 ID:SGTC_2553|Compound:4-methylesculetin|FD-Score:3.66|P-value:1.27E-4 ID:SGTC_2557|Compound:derrustone|FD-Score:3.44|P-value:2.88E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.12|P-value:9.01E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.29|P-value:5.05E-4 ID:SGTC_3034|Compound:9090421|FD-Score:4.29|P-value:8.82E-6 ID:SGTC_3088|Compound:9117578|FD-Score:3.77|P-value:8.15E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-5.82|P-value:2.94E-9 ID:SGTC_3199|Compound:9111318|FD-Score:-3.71|P-value:1.02E-4 ID:SGTC_3205|Compound:9113483|FD-Score:-3.10|P-value:9.80E-4 ID:SGTC_3210|Compound:9128157|FD-Score:5.36|P-value:4.06E-8 ID:SGTC_3322|Compound:9139058|FD-Score:5.34|P-value:4.72E-8 ID:SGTC_3324|Compound:9138759|FD-Score:-3.49|P-value:2.41E-4

Top fitness defect scores for YMR269W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_258 haloperidol 9.09 50.8 µM 5.07E-20 fatty acid desaturase (OLE1) 3 5.17E-20
2 SGTC_1514 1189-1591 8.52 158.0 µM 7.90E-18 3 8.03E-18
3 SGTC_2405 ticlatone 5.94 3.5 µM 1.43E-9 30 1.44E-9
4 SGTC_446 go6976 5.37 132.0 µM 3.95E-8 5 3.98E-8
5 SGTC_3210 9128157 5.36 49.5 µM 4.06E-8 22 4.08E-8
6 SGTC_3322 9139058 5.34 2.1 µM 4.72E-8 cell wall 12 4.75E-8
7 SGTC_2485 5633444 5.31 17.8 µM 5.54E-8 redox potentiating 20 5.57E-8
8 SGTC_832 4083-0019 4.98 164.0 µM 3.10E-7 translation 40 3.12E-7
9 SGTC_1992 st073643 4.64 23.3 µM 1.75E-6 mitochondrial processes 6 1.75E-6
10 SGTC_2296 7971656 4.57 126.5 µM 2.48E-6 30 2.49E-6
11 SGTC_47 0149-0135 4.50 24.2 µM 3.34E-6 TSC3-RPN4 12 3.35E-6
12 SGTC_2339 9000433 4.39 200.0 µM 5.73E-6 24 5.75E-6
13 SGTC_1155 4088-0394 4.34 48.2 µM 7.09E-6 19 7.11E-6
14 SGTC_3034 9090421 4.29 49.5 µM 8.82E-6 60S ribosome export 7 8.85E-6
15 SGTC_990 3985-0011 4.28 41.3 µM 9.39E-6 amide catabolism 13 9.42E-6
16 SGTC_1995 st072814 4.25 61.1 µM 1.08E-5 11 1.09E-5
17 SGTC_297 0986-0032 4.23 24.0 µM 1.17E-5 60S ribosome export 3 1.17E-5
18 SGTC_1470 k295-0292 4.07 231.0 µM 2.36E-5 10 2.37E-5
19 SGTC_1423 4048-0112 4.04 5.6 µM 2.70E-5 24 2.71E-5
20 SGTC_59 0330-0160 3.93 1.3 µM 4.17E-5 113 4.18E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 3.49E-18 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.118 6.69E-12 YKL181W PRS1 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
0.099 9.92E-9 YOR080W DIA2 hom Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, and correct nucleosome positioning; involved in invasive and pseudohyphal growth; required to target Cdc6p for ubiquitin-mediated destruction during G1 phase
0.099 9.95E-9 YOR211C MGM1 hom Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy
0.098 1.18E-8 YGL246C RAI1 hom Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z
0.095 3.29E-8 YLL017W YLL017W hom Non-essential Ras guanine nucleotide exchange factor (GEF); localized to the membrane; expressed in poor nutrient conditions and on nonfermentable carbon sources; contains a stop codon in S288C, full-length gene includes YLL016W; SDC25 has a paralog, CDC25, that arose from the whole genome duplication
0.095 3.64E-8 YDL082W RPL13A hom Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication
0.092 8.28E-8 YNL069C RPL16B hom Ribosomal 60S subunit protein L16B; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16B has a paralog, RPL16A, that arose from the whole genome duplication
0.091 1.16E-7 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.091 1.44E-7 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.087 5.02E-7 YGL038C OCH1 hom Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins
0.085 8.05E-7 YOR222W ODC2 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
0.085 8.56E-7 YPL235W RVB2 het ATP-dependent DNA helicase, also known as reptin; member of the AAA+ and RuvB protein families, similar to Rvb1p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly
0.084 9.96E-7 YMR013W-A_d YMR013W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73
0.083 1.42E-6 YIL133C RPL16A hom Ribosomal 60S subunit protein L16A; N-terminally acetylated, binds 5.8 S rRNA; transcriptionally regulated by Rap1p; homologous to mammalian ribosomal protein L13A and bacterial L13; RPL16A has a paralog, RPL16B, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress