YMR270C / RRN9

Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR270C / RRN9

Click on Significant Values for Screen Details ID:SGTC_127|Compound:0180-0333|FD-Score:-4.99|P-value:2.47E-8 ID:SGTC_141|Compound:0443-0274|FD-Score:-2.94|P-value:6.94E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.17|P-value:2.06E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.05|P-value:4.53E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-3.09|P-value:3.80E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-2.90|P-value:8.03E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.78|P-value:1.86E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:-3.07|P-value:4.05E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.21|P-value:2.06E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:-2.99|P-value:5.62E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:2.93|P-value:5.55E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.52|P-value:4.49E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.51|P-value:6.32E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.04|P-value:3.60E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.15|P-value:3.05E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.79|P-value:9.53E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.06|P-value:4.32E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:-2.97|P-value:6.01E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-4.13|P-value:3.15E-6 ID:SGTC_1554|Compound:st069299|FD-Score:-2.85|P-value:9.63E-4 ID:SGTC_1617|Compound:st002906|FD-Score:2.86|P-value:7.25E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.02|P-value:5.07E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.34|P-value:1.36E-4 ID:SGTC_1690|Compound:st023502|FD-Score:4.52|P-value:2.64E-7 ID:SGTC_1742|Compound:st038235|FD-Score:3.99|P-value:4.62E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:2.89|P-value:6.32E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.91|P-value:7.58E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.11|P-value:2.73E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.23|P-value:2.15E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-3.01|P-value:5.21E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-2.87|P-value:8.91E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.91|P-value:7.04E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-4.55|P-value:3.24E-7 ID:SGTC_3035|Compound:9091303|FD-Score:-2.90|P-value:7.83E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.91|P-value:9.94E-6 ID:SGTC_127|Compound:0180-0333|FD-Score:-4.99|P-value:2.47E-8 ID:SGTC_141|Compound:0443-0274|FD-Score:-2.94|P-value:6.94E-4 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:3.17|P-value:2.06E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.05|P-value:4.53E-4 ID:SGTC_448|Compound:monastrol|FD-Score:-3.09|P-value:3.80E-4 ID:SGTC_573|Compound:3702-0553|FD-Score:-2.90|P-value:8.03E-4 ID:SGTC_640|Compound:3381-0960|FD-Score:-3.78|P-value:1.86E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:-3.07|P-value:4.05E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.21|P-value:2.06E-6 ID:SGTC_787|Compound:4152-0075|FD-Score:-2.99|P-value:5.62E-4 ID:SGTC_790|Compound:1575-0012|FD-Score:2.93|P-value:5.55E-4 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.52|P-value:4.49E-5 ID:SGTC_1056|Compound:3448-1962|FD-Score:-3.51|P-value:6.32E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.04|P-value:3.60E-4 ID:SGTC_1131|Compound:3454-3128|FD-Score:-3.15|P-value:3.05E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.79|P-value:9.53E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:-3.06|P-value:4.32E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:-2.97|P-value:6.01E-4 ID:SGTC_1549|Compound:4'-methoxyflavonol|FD-Score:-4.13|P-value:3.15E-6 ID:SGTC_1554|Compound:st069299|FD-Score:-2.85|P-value:9.63E-4 ID:SGTC_1617|Compound:st002906|FD-Score:2.86|P-value:7.25E-4 ID:SGTC_1629|Compound:st005085|FD-Score:-3.02|P-value:5.07E-4 ID:SGTC_1648|Compound:st011736|FD-Score:-3.34|P-value:1.36E-4 ID:SGTC_1690|Compound:st023502|FD-Score:4.52|P-value:2.64E-7 ID:SGTC_1742|Compound:st038235|FD-Score:3.99|P-value:4.62E-6 ID:SGTC_2129|Compound:girgensonine|FD-Score:2.89|P-value:6.32E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-2.91|P-value:7.58E-4 ID:SGTC_2444|Compound:5485484|FD-Score:3.11|P-value:2.73E-4 ID:SGTC_2478|Compound:5763493|FD-Score:-3.23|P-value:2.15E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:-3.01|P-value:5.21E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-2.87|P-value:8.91E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:3.91|P-value:7.04E-6 ID:SGTC_2965|Compound:9082772|FD-Score:-4.55|P-value:3.24E-7 ID:SGTC_3035|Compound:9091303|FD-Score:-2.90|P-value:7.83E-4 ID:SGTC_3062|Compound:9077494|FD-Score:-3.91|P-value:9.94E-6

Top fitness defect scores for YMR270C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1690 st023502 4.52 41.2 µM 2.64E-7 calcium & mitochondrial duress 1 3.08E-6 0.65
2 SGTC_1742 st038235 3.99 28.9 µM 4.62E-6 mitochondrial stress 9 3.26E-5 0.02
3 SGTC_2773 thioridazine 3.91 9.1 µM 7.04E-6 1 4.62E-5 0.35
4 SGTC_1041 0206-0046 3.52 107.0 µM 4.49E-5 7 2.13E-4 0.42
5 SGTC_402 epigallocatechin gallate 3.17 10.0 µM 2.06E-4 13 7.52E-4 0.08
6 SGTC_2444 5485484 3.11 36.4 µM 2.73E-4 16 9.49E-4 0.01
7 SGTC_1117 retinoic acid 3.04 1.1 µM 3.60E-4 5 0.00119 0.09
8 SGTC_790 1575-0012 2.93 79.1 µM 5.55E-4 TSC3-RPN4 17 0.00171 0.06
9 SGTC_2129 girgensonine 2.89 121.0 µM 6.32E-4 heme biosynthesis & mitochondrial translocase 42 0.00190 0.01
10 SGTC_1617 st002906 2.86 78.0 µM 7.25E-4 11 0.00213 0.01
11 SGTC_1134 3477-0009 2.79 42.5 µM 9.53E-4 35 0.00267 0.05
12 SGTC_3033 9090887 2.72 49.5 µM 0.00121 fatty acid desaturase (OLE1) 45 0.00326 0.03
13 SGTC_2879 9041815 2.71 71.4 µM 0.00124 7 0.00333 0.25
14 SGTC_412 gemfibrozil 2.70 100.0 µM 0.00133 DNA intercalators 25 0.00351 0.03
15 SGTC_293 4049-0273 2.67 38.5 µM 0.00146 20 0.00382 0.03
16 SGTC_1248 0469-0687 2.65 58.6 µM 0.00155 26 0.00401 0.06
17 SGTC_1527 coumarin 2.59 137.0 µM 0.00191 25 0.00475 0.18
18 SGTC_2125 5246583 2.59 200.0 µM 0.00193 tubulin folding & SWR complex 26 0.00480 0.01
19 SGTC_1192 1488-0095 2.58 21.4 µM 0.00198 16 0.00491 0.01
20 SGTC_547 1120-0019 2.57 610.0 nM 0.00207 azole & statin 21 0.00507 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.178 2.24E-25 YGL018C JAC1 het Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
0.165 5.83E-22 YBL020W RFT1 het Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein
0.163 1.96E-21 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.159 2.39E-20 YCR013C_d YCR013C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant
0.150 2.72E-18 YCR054C CTR86 het Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
0.148 6.72E-18 YAR008W SEN34 het Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease
0.146 1.65E-17 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.146 1.82E-17 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.135 5.21E-15 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.134 6.42E-15 YOR335C ALA1 het Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog
0.131 3.08E-14 YHR166C CDC23 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition
0.129 6.24E-14 YJR057W CDC8 het Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p
0.128 8.43E-14 YML046W PRP39 het U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats
0.128 1.04E-13 YDR397C NCB2 het Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta
0.127 1.49E-13 YJL047C-A_p YJL047C-A_p hom Putative protein of unknown function