YMR272C / SCS7

Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR272C / SCS7

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.10|P-value:3.02E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:4.24|P-value:1.60E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.82|P-value:9.22E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:3.35|P-value:5.38E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:4.09|P-value:3.08E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:3.97|P-value:5.07E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:3.75|P-value:1.21E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:4.19|P-value:2.00E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:4.77|P-value:1.47E-6 ID:SGTC_559|Compound:1550-0661|FD-Score:4.35|P-value:1.01E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.22|P-value:6.19E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.24|P-value:7.76E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.54|P-value:2.66E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:-3.80|P-value:7.09E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:3.26|P-value:7.21E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.72|P-value:1.36E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:4.13|P-value:2.66E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.90|P-value:4.80E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.43|P-value:3.95E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.02|P-value:4.19E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.45|P-value:3.69E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:5.87|P-value:3.98E-9 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.33|P-value:5.79E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:-4.00|P-value:3.15E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:5.28|P-value:1.09E-7 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.39|P-value:4.66E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.05|P-value:3.62E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.83|P-value:4.93E-9 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.94|P-value:5.76E-5 ID:SGTC_1901|Compound:st060216|FD-Score:3.17|P-value:9.86E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.80|P-value:9.97E-5 ID:SGTC_1932|Compound:st074806|FD-Score:3.51|P-value:2.97E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.22|P-value:8.44E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.39|P-value:4.57E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.92|P-value:6.15E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.25|P-value:7.58E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.51|P-value:2.18E-4 ID:SGTC_2288|Compound:7946289|FD-Score:9.22|P-value:5.03E-20 ID:SGTC_2312|Compound:7706453|FD-Score:3.32|P-value:5.92E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.80|P-value:1.01E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.26|P-value:5.41E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.75|P-value:1.04E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.42|P-value:4.15E-4 ID:SGTC_2780|Compound:5215298|FD-Score:6.16|P-value:7.22E-10 ID:SGTC_2782|Compound:7736369|FD-Score:6.14|P-value:8.05E-10 ID:SGTC_2828|Compound:7998861|FD-Score:5.49|P-value:3.49E-8 ID:SGTC_3236|Compound:9132701|FD-Score:3.96|P-value:5.27E-5 ID:SGTC_9|Compound:0092-0002|FD-Score:4.10|P-value:3.02E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:4.24|P-value:1.60E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.82|P-value:9.22E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:3.35|P-value:5.38E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:4.09|P-value:3.08E-5 ID:SGTC_404|Compound:fumagillin|FD-Score:3.97|P-value:5.07E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:3.75|P-value:1.21E-4 ID:SGTC_544|Compound:k015-0020|FD-Score:4.19|P-value:2.00E-5 ID:SGTC_552|Compound:k242-0005|FD-Score:4.77|P-value:1.47E-6 ID:SGTC_559|Compound:1550-0661|FD-Score:4.35|P-value:1.01E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.22|P-value:6.19E-4 ID:SGTC_650|Compound:1328-0195|FD-Score:3.24|P-value:7.76E-4 ID:SGTC_651|Compound:3253-0966|FD-Score:3.54|P-value:2.66E-4 ID:SGTC_654|Compound:1124-0271|FD-Score:-3.80|P-value:7.09E-5 ID:SGTC_671|Compound:0560-0003|FD-Score:3.26|P-value:7.21E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:3.72|P-value:1.36E-4 ID:SGTC_780|Compound:0109-0199|FD-Score:4.13|P-value:2.66E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:-3.90|P-value:4.80E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.43|P-value:3.95E-4 ID:SGTC_953|Compound:1188-0045|FD-Score:4.02|P-value:4.19E-5 ID:SGTC_967|Compound:1306-0166|FD-Score:3.45|P-value:3.69E-4 ID:SGTC_977|Compound:1348-1378|FD-Score:5.87|P-value:3.98E-9 ID:SGTC_1041|Compound:0206-0046|FD-Score:3.33|P-value:5.79E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:-4.00|P-value:3.15E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:5.28|P-value:1.09E-7 ID:SGTC_1223|Compound:0764-0573|FD-Score:3.39|P-value:4.66E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:4.05|P-value:3.62E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:5.83|P-value:4.93E-9 ID:SGTC_1869|Compound:3',7'-dimethoxyflavone|FD-Score:3.94|P-value:5.76E-5 ID:SGTC_1901|Compound:st060216|FD-Score:3.17|P-value:9.86E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:3.80|P-value:9.97E-5 ID:SGTC_1932|Compound:st074806|FD-Score:3.51|P-value:2.97E-4 ID:SGTC_1959|Compound:st077091|FD-Score:3.22|P-value:8.44E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.39|P-value:4.57E-4 ID:SGTC_2178|Compound:5812956|FD-Score:3.92|P-value:6.15E-5 ID:SGTC_2261|Compound:9010538|FD-Score:3.25|P-value:7.58E-4 ID:SGTC_2287|Compound:7945887|FD-Score:-3.51|P-value:2.18E-4 ID:SGTC_2288|Compound:7946289|FD-Score:9.22|P-value:5.03E-20 ID:SGTC_2312|Compound:7706453|FD-Score:3.32|P-value:5.92E-4 ID:SGTC_2396|Compound:5342950|FD-Score:3.80|P-value:1.01E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-3.26|P-value:5.41E-4 ID:SGTC_2433|Compound:5607874|FD-Score:-4.75|P-value:1.04E-6 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.78|P-value:1.10E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.42|P-value:4.15E-4 ID:SGTC_2780|Compound:5215298|FD-Score:6.16|P-value:7.22E-10 ID:SGTC_2782|Compound:7736369|FD-Score:6.14|P-value:8.05E-10 ID:SGTC_2828|Compound:7998861|FD-Score:5.49|P-value:3.49E-8 ID:SGTC_3236|Compound:9132701|FD-Score:3.96|P-value:5.27E-5

Top fitness defect scores for YMR272C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2288 7946289 9.22 167.3 µM 5.03E-20 3 1.43E-20
2 SGTC_2780 5215298 6.16 71.4 µM 7.22E-10 8 3.75E-10
3 SGTC_2782 7736369 6.14 71.4 µM 8.05E-10 5 4.19E-10
4 SGTC_977 1348-1378 5.87 135.0 µM 3.98E-9 4 2.16E-9
5 SGTC_1459 k035-0031 5.83 35.7 µM 4.93E-9 DNA intercalators 3 2.69E-9
6 SGTC_2828 7998861 5.49 71.4 µM 3.49E-8 6 2.01E-8
7 SGTC_1206 3978-0017 5.28 132.0 µM 1.09E-7 ERG2 14 6.48E-8
8 SGTC_552 k242-0005 4.77 476.0 µM 1.47E-6 6 9.44E-7
9 SGTC_559 1550-0661 4.35 158.0 µM 1.01E-5 3 6.80E-6
10 SGTC_184 1494-0393 4.24 24.7 µM 1.60E-5 50 1.10E-5
11 SGTC_544 k015-0020 4.19 52.4 µM 2.00E-5 9 1.38E-5
12 SGTC_780 0109-0199 4.13 192.0 µM 2.66E-5 9 1.85E-5
13 SGTC_9 0092-0002 4.10 10.4 µM 3.02E-5 24 2.11E-5
14 SGTC_354 2783-3500 4.09 4.9 µM 3.08E-5 cell wall 45 2.15E-5
15 SGTC_1337 1486-1011 4.05 40.3 µM 3.62E-5 14 2.54E-5
16 SGTC_953 1188-0045 4.02 9.7 µM 4.19E-5 60S ribosome export 24 2.95E-5
17 SGTC_404 fumagillin 3.97 50.0 µM 5.07E-5 19 3.59E-5
18 SGTC_3236 9132701 3.96 49.5 µM 5.27E-5 TSC3-RPN4 27 3.74E-5
19 SGTC_1869 3',7'-dimethoxyflavone 3.94 40.3 µM 5.76E-5 26 4.10E-5
20 SGTC_2178 5812956 3.92 200.0 µM 6.15E-5 19 4.39E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.144 5.25E-17 YEL004W YEA4 hom Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER
0.105 1.18E-9 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.103 2.06E-9 YMR013C SEC59 het Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation
0.102 2.96E-9 YHL017W_p YHL017W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles; YHL017W has a paralog, PTM1, that arose from the whole genome duplication
0.097 1.99E-8 YPL035C_d YPL035C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene
0.096 2.46E-8 YFL013W-A_d YFL013W-A_d hom Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching
0.095 4.04E-8 YPR059C_d YPR059C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W
0.094 4.48E-8 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.094 4.80E-8 YCR015C_p YCR015C_p hom Putative protein of unknown function; YCR015C is not an essential gene
0.092 9.20E-8 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.091 1.33E-7 YGR051C_d YGR051C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
0.088 3.54E-7 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.087 4.14E-7 YGR179C OKP1 het Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7
0.087 4.48E-7 YIL144W TID3 het Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering
0.085 8.14E-7 YML080W DUS1 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17