YMR273C / ZDS1

Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR273C / ZDS1

Click on Significant Values for Screen Details ID:SGTC_55|Compound:0767-0285|FD-Score:3.34|P-value:8.00E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.34|P-value:7.92E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:8.96|P-value:7.43E-18 ID:SGTC_140|Compound:0062-0056|FD-Score:4.49|P-value:1.05E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:3.40|P-value:6.54E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-3.27|P-value:8.05E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:6.03|P-value:5.11E-9 ID:SGTC_377|Compound:3970-0964|FD-Score:3.69|P-value:2.39E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.77|P-value:3.00E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.62|P-value:2.40E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.32|P-value:8.37E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.46|P-value:1.15E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:3.63|P-value:2.96E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.46|P-value:1.15E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:4.20|P-value:3.49E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:5.69|P-value:3.19E-8 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.28|P-value:9.48E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.34|P-value:6.34E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.85|P-value:1.33E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.32|P-value:8.49E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.33|P-value:2.13E-7 ID:SGTC_1727|Compound:st034309|FD-Score:3.74|P-value:1.98E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.73|P-value:3.59E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.50|P-value:4.66E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.00|P-value:7.43E-5 ID:SGTC_1896|Compound:st058441|FD-Score:3.73|P-value:2.08E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.53|P-value:4.22E-4 ID:SGTC_1917|Compound:st066507|FD-Score:6.90|P-value:2.74E-11 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.46|P-value:5.31E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.34|P-value:7.80E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.87|P-value:9.62E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.51|P-value:4.55E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.80|P-value:1.61E-4 ID:SGTC_2441|Compound:5730946|FD-Score:4.24|P-value:2.89E-5 ID:SGTC_2442|Compound:5158906|FD-Score:5.44|P-value:1.20E-7 ID:SGTC_2481|Compound:5478948|FD-Score:3.42|P-value:6.11E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.85|P-value:1.38E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:3.97|P-value:8.53E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.62|P-value:3.05E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.69|P-value:2.40E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.20|P-value:1.96E-9 ID:SGTC_2827|Compound:7993847|FD-Score:3.98|P-value:8.12E-5 ID:SGTC_2912|Compound:7964298|FD-Score:4.79|P-value:2.69E-6 ID:SGTC_2932|Compound:9016711|FD-Score:3.65|P-value:2.77E-4 ID:SGTC_2939|Compound:9044578|FD-Score:5.15|P-value:5.14E-7 ID:SGTC_3143|Compound:9086658|FD-Score:3.73|P-value:2.05E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.14|P-value:4.43E-5 ID:SGTC_3321|Compound:9137793|FD-Score:7.26|P-value:2.45E-12 ID:SGTC_55|Compound:0767-0285|FD-Score:3.34|P-value:8.00E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:3.34|P-value:7.92E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:8.96|P-value:7.43E-18 ID:SGTC_140|Compound:0062-0056|FD-Score:4.49|P-value:1.05E-5 ID:SGTC_314|Compound:1671-0008|FD-Score:3.40|P-value:6.54E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:-3.27|P-value:8.05E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:6.03|P-value:5.11E-9 ID:SGTC_377|Compound:3970-0964|FD-Score:3.69|P-value:2.39E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.77|P-value:3.00E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:-3.62|P-value:2.40E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:3.32|P-value:8.37E-4 ID:SGTC_796|Compound:1234-0020|FD-Score:4.46|P-value:1.15E-5 ID:SGTC_807|Compound:1315-0151|FD-Score:3.63|P-value:2.96E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:4.46|P-value:1.15E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:4.20|P-value:3.49E-5 ID:SGTC_1060|Compound:3448-7350|FD-Score:5.69|P-value:3.19E-8 ID:SGTC_1311|Compound:1190-0148|FD-Score:3.28|P-value:9.48E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.34|P-value:6.34E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:3.85|P-value:1.33E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.32|P-value:8.49E-4 ID:SGTC_1712|Compound:st032288|FD-Score:5.33|P-value:2.13E-7 ID:SGTC_1727|Compound:st034309|FD-Score:3.74|P-value:1.98E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.73|P-value:3.59E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:3.50|P-value:4.66E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.00|P-value:7.43E-5 ID:SGTC_1896|Compound:st058441|FD-Score:3.73|P-value:2.08E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.53|P-value:4.22E-4 ID:SGTC_1917|Compound:st066507|FD-Score:6.90|P-value:2.74E-11 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:3.46|P-value:5.31E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.34|P-value:7.80E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.87|P-value:9.62E-5 ID:SGTC_2430|Compound:5571206|FD-Score:3.51|P-value:4.55E-4 ID:SGTC_2431|Compound:5490079|FD-Score:3.80|P-value:1.61E-4 ID:SGTC_2441|Compound:5730946|FD-Score:4.24|P-value:2.89E-5 ID:SGTC_2442|Compound:5158906|FD-Score:5.44|P-value:1.20E-7 ID:SGTC_2481|Compound:5478948|FD-Score:3.42|P-value:6.11E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:5.85|P-value:1.38E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:3.97|P-value:8.53E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.62|P-value:3.05E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:3.69|P-value:2.40E-4 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.20|P-value:1.96E-9 ID:SGTC_2827|Compound:7993847|FD-Score:3.98|P-value:8.12E-5 ID:SGTC_2912|Compound:7964298|FD-Score:4.79|P-value:2.69E-6 ID:SGTC_2932|Compound:9016711|FD-Score:3.65|P-value:2.77E-4 ID:SGTC_2939|Compound:9044578|FD-Score:5.15|P-value:5.14E-7 ID:SGTC_3143|Compound:9086658|FD-Score:3.73|P-value:2.05E-4 ID:SGTC_3214|Compound:9129694|FD-Score:4.14|P-value:4.43E-5 ID:SGTC_3321|Compound:9137793|FD-Score:7.26|P-value:2.45E-12

Top fitness defect scores for YMR273C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 8.96 40.9 µM 7.43E-18 cell wall 56 1.64E-19
2 SGTC_3321 9137793 7.26 26.8 µM 2.45E-12 cell wall 16 1.89E-13
3 SGTC_1917 st066507 6.90 28.5 µM 2.74E-11 Golgi 9 2.67E-12
4 SGTC_2697 mebhydrolin 6.20 72.4 µM 1.96E-9 NEO1 25 2.91E-10
5 SGTC_351 caspofungin 6.03 25.0 nM 5.11E-9 cell wall 39 8.34E-10
6 SGTC_2584 androsterone 5.85 48.7 µM 1.38E-8 cell wall 63 2.49E-9
7 SGTC_1060 3448-7350 5.69 82.0 µM 3.19E-8 Golgi 15 6.23E-9
8 SGTC_2442 5158906 5.44 48.5 µM 1.20E-7 4 2.67E-8
9 SGTC_1712 st032288 5.33 53.4 µM 2.13E-7 calcium & mitochondrial duress 100 5.02E-8
10 SGTC_2939 9044578 5.15 71.4 µM 5.14E-7 21 1.32E-7
11 SGTC_2912 7964298 4.79 10.9 µM 2.69E-6 cell wall 71 8.14E-7
12 SGTC_514 4466-0038 4.77 2.6 nM 3.00E-6 cell wall 117 9.16E-7
13 SGTC_1754 st042065 4.73 16.1 µM 3.59E-6 NEO1-PIK1 140 1.12E-6
14 SGTC_140 0062-0056 4.49 502.5 µM 1.05E-5 12 3.63E-6
15 SGTC_796 1234-0020 4.46 70.7 µM 1.15E-5 SWF1 & branched chain AA biosynthesis 16 4.03E-6
16 SGTC_839 0122-0028 4.46 230.0 µM 1.15E-5 RSC complex & mRNA processing 24 4.03E-6
17 SGTC_2441 5730946 4.24 39.1 µM 2.89E-5 11 1.11E-5
18 SGTC_863 0466-0191 4.20 129.0 µM 3.49E-5 cell wall 61 1.36E-5
19 SGTC_3214 9129694 4.14 49.5 µM 4.43E-5 22 1.77E-5
20 SGTC_1800 st050079 4.00 29.1 µM 7.43E-5 NEO1-PIK1 116 3.12E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.333 1.08E-87 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.280 2.53E-61 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.278 1.05E-60 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.273 1.28E-58 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.265 5.34E-55 YLR330W CHS5 hom Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane
0.263 4.37E-54 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.261 1.84E-53 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.257 7.37E-52 YKL035W UGP1 het UDP-glucose pyrophosphorylase (UGPase); catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p; UGP1 has a paralog, YHL012W, that arose from the whole genome duplication
0.251 1.97E-49 YDR348C PAL1 hom Protein of unknown function thought to be involved in endocytosis; Pal1p physically interacts with Ede1p and is found at endocytic sites at the cell periphery during the early stages of endocytosis; green fluorescent protein (GFP)-fusion protein also localizes to the bud neck; potential Cdc28p substrate; similar to the S. pombe Pal1 protein; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.244 7.76E-47 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.239 5.39E-45 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.233 1.69E-42 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.231 4.91E-42 YNL283C WSC2 hom Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
0.230 1.87E-41 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.224 2.00E-39 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication