YMR277W / FCP1

Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR277W / FCP1

Click on Significant Values for Screen Details ID:SGTC_5|Compound:0352-0601|FD-Score:-3.71|P-value:8.42E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-8.07|P-value:4.07E-12 ID:SGTC_57|Compound:miconazole|FD-Score:8.86|P-value:3.08E-14 ID:SGTC_58|Compound:0957-0393|FD-Score:5.73|P-value:6.10E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:3.90|P-value:4.79E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.88|P-value:5.07E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:14.10|P-value:2.50E-33 ID:SGTC_150|Compound:3970-0969|FD-Score:3.69|P-value:8.94E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:6.44|P-value:2.37E-8 ID:SGTC_208|Compound:k072-0098|FD-Score:6.10|P-value:1.19E-7 ID:SGTC_256|Compound:clotrimazole|FD-Score:8.40|P-value:5.49E-13 ID:SGTC_268|Compound:camptothecin|FD-Score:3.72|P-value:8.08E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:5.74|P-value:5.68E-7 ID:SGTC_302|Compound:1094-0063|FD-Score:3.97|P-value:3.88E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.69|P-value:8.97E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.92|P-value:4.53E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.67|P-value:9.39E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-7.04|P-value:1.19E-9 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.79|P-value:6.65E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.74|P-value:7.59E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.74|P-value:7.76E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.08|P-value:1.29E-7 ID:SGTC_483|Compound:fpl-64176|FD-Score:4.29|P-value:1.38E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:4.20|P-value:1.89E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.92|P-value:4.51E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.53|P-value:6.29E-5 ID:SGTC_759|Compound:3486-0358|FD-Score:4.20|P-value:1.87E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-4.09|P-value:2.61E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.04|P-value:3.14E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:7.88|P-value:1.23E-11 ID:SGTC_839|Compound:0122-0028|FD-Score:7.80|P-value:1.92E-11 ID:SGTC_854|Compound:0422-0053|FD-Score:4.36|P-value:1.09E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.32|P-value:1.25E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.89|P-value:4.95E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.09|P-value:2.67E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.93|P-value:1.48E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.35|P-value:2.95E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:6.82|P-value:3.78E-9 ID:SGTC_1124|Compound:fisetin|FD-Score:4.76|P-value:2.75E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.62|P-value:4.51E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.98|P-value:3.72E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.62|P-value:4.56E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.69|P-value:8.87E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:4.39|P-value:9.98E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.22|P-value:1.77E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.72|P-value:8.04E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.00|P-value:3.50E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.81|P-value:6.28E-4 ID:SGTC_1652|Compound:st011932|FD-Score:7.32|P-value:2.86E-10 ID:SGTC_1672|Compound:st016598|FD-Score:4.96|P-value:1.30E-5 ID:SGTC_1683|Compound:st010134|FD-Score:4.25|P-value:1.58E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.45|P-value:8.26E-5 ID:SGTC_1745|Compound:st081495|FD-Score:4.14|P-value:2.28E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.42|P-value:9.09E-5 ID:SGTC_1772|Compound:st048439|FD-Score:-3.94|P-value:4.20E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.84|P-value:5.72E-4 ID:SGTC_1934|Compound:st074720|FD-Score:5.66|P-value:8.23E-7 ID:SGTC_1980|Compound:st071811|FD-Score:4.24|P-value:1.65E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.77|P-value:7.03E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-3.83|P-value:5.79E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.01|P-value:3.41E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-4.04|P-value:3.13E-4 ID:SGTC_2140|Compound:5586273|FD-Score:4.46|P-value:7.90E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.84|P-value:5.74E-4 ID:SGTC_2285|Compound:7945142|FD-Score:5.66|P-value:7.98E-7 ID:SGTC_2311|Compound:7694451|FD-Score:3.72|P-value:8.18E-4 ID:SGTC_2348|Compound:9022543|FD-Score:14.70|P-value:4.20E-36 ID:SGTC_2396|Compound:5342950|FD-Score:3.99|P-value:3.57E-4 ID:SGTC_2439|Compound:5492030|FD-Score:4.45|P-value:8.15E-5 ID:SGTC_2471|Compound:5466956|FD-Score:4.20|P-value:1.85E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.35|P-value:1.12E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:5.95|P-value:2.33E-7 ID:SGTC_2625|Compound:euphol|FD-Score:4.14|P-value:2.29E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.19|P-value:7.86E-8 ID:SGTC_2657|Compound:nystatin|FD-Score:3.73|P-value:7.95E-4 ID:SGTC_2695|Compound:st077686|FD-Score:5.15|P-value:6.32E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:9.28|P-value:1.93E-15 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.75|P-value:7.32E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.77|P-value:6.97E-4 ID:SGTC_2789|Compound:5281112|FD-Score:6.02|P-value:1.68E-7 ID:SGTC_2806|Compound:7952793|FD-Score:3.98|P-value:3.76E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.51|P-value:6.70E-5 ID:SGTC_2816|Compound:7982706|FD-Score:8.79|P-value:4.85E-14 ID:SGTC_2823|Compound:7987624|FD-Score:10.20|P-value:2.67E-18 ID:SGTC_2846|Compound:9008642|FD-Score:4.94|P-value:1.44E-5 ID:SGTC_2858|Compound:9025781|FD-Score:5.31|P-value:3.35E-6 ID:SGTC_2912|Compound:7964298|FD-Score:5.14|P-value:6.73E-6 ID:SGTC_2917|Compound:7979103|FD-Score:-6.95|P-value:1.95E-9 ID:SGTC_2923|Compound:7992654|FD-Score:-4.09|P-value:2.63E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-3.86|P-value:5.32E-4 ID:SGTC_3009|Compound:9080819|FD-Score:6.82|P-value:3.76E-9 ID:SGTC_3015|Compound:9080845|FD-Score:6.23|P-value:6.56E-8 ID:SGTC_3019|Compound:9081971|FD-Score:4.27|P-value:1.50E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.84|P-value:2.08E-5 ID:SGTC_3298|Compound:9116858|FD-Score:4.22|P-value:1.77E-4 ID:SGTC_5|Compound:0352-0601|FD-Score:-3.71|P-value:8.42E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:-8.07|P-value:4.07E-12 ID:SGTC_57|Compound:miconazole|FD-Score:8.86|P-value:3.08E-14 ID:SGTC_58|Compound:0957-0393|FD-Score:5.73|P-value:6.10E-7 ID:SGTC_64|Compound:000l-0018|FD-Score:3.90|P-value:4.79E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:3.88|P-value:5.07E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:14.10|P-value:2.50E-33 ID:SGTC_150|Compound:3970-0969|FD-Score:3.69|P-value:8.94E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:6.44|P-value:2.37E-8 ID:SGTC_208|Compound:k072-0098|FD-Score:6.10|P-value:1.19E-7 ID:SGTC_256|Compound:clotrimazole|FD-Score:8.40|P-value:5.49E-13 ID:SGTC_268|Compound:camptothecin|FD-Score:3.72|P-value:8.08E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:5.74|P-value:5.68E-7 ID:SGTC_302|Compound:1094-0063|FD-Score:3.97|P-value:3.88E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:3.69|P-value:8.97E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:3.92|P-value:4.53E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.67|P-value:9.39E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-7.04|P-value:1.19E-9 ID:SGTC_364|Compound:0083-0097|FD-Score:-3.79|P-value:6.65E-4 ID:SGTC_393|Compound:acivicin|FD-Score:3.74|P-value:7.59E-4 ID:SGTC_395|Compound:anisomycin|FD-Score:3.74|P-value:7.76E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:6.08|P-value:1.29E-7 ID:SGTC_483|Compound:fpl-64176|FD-Score:4.29|P-value:1.38E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:4.20|P-value:1.89E-4 ID:SGTC_631|Compound:k072-0230|FD-Score:3.92|P-value:4.51E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.53|P-value:6.29E-5 ID:SGTC_759|Compound:3486-0358|FD-Score:4.20|P-value:1.87E-4 ID:SGTC_768|Compound:0384-0033|FD-Score:-4.09|P-value:2.61E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.04|P-value:3.14E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:7.88|P-value:1.23E-11 ID:SGTC_839|Compound:0122-0028|FD-Score:7.80|P-value:1.92E-11 ID:SGTC_854|Compound:0422-0053|FD-Score:4.36|P-value:1.09E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:4.32|P-value:1.25E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.89|P-value:4.95E-4 ID:SGTC_945|Compound:3381-0768|FD-Score:4.09|P-value:2.67E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.93|P-value:1.48E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:5.35|P-value:2.95E-6 ID:SGTC_1072|Compound:oxiconazole|FD-Score:6.82|P-value:3.78E-9 ID:SGTC_1124|Compound:fisetin|FD-Score:4.76|P-value:2.75E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.62|P-value:4.51E-5 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.98|P-value:3.72E-4 ID:SGTC_1234|Compound:0326-0494|FD-Score:4.62|P-value:4.56E-5 ID:SGTC_1340|Compound:1486-1359|FD-Score:3.69|P-value:8.87E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:4.39|P-value:9.98E-5 ID:SGTC_1493|Compound:4348-0038|FD-Score:4.22|P-value:1.77E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:3.72|P-value:8.04E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.00|P-value:3.50E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.81|P-value:6.28E-4 ID:SGTC_1652|Compound:st011932|FD-Score:7.32|P-value:2.86E-10 ID:SGTC_1672|Compound:st016598|FD-Score:4.96|P-value:1.30E-5 ID:SGTC_1683|Compound:st010134|FD-Score:4.25|P-value:1.58E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.45|P-value:8.26E-5 ID:SGTC_1745|Compound:st081495|FD-Score:4.14|P-value:2.28E-4 ID:SGTC_1754|Compound:st042065|FD-Score:4.42|P-value:9.09E-5 ID:SGTC_1772|Compound:st048439|FD-Score:-3.94|P-value:4.20E-4 ID:SGTC_1907|Compound:st060210|FD-Score:3.84|P-value:5.72E-4 ID:SGTC_1934|Compound:st074720|FD-Score:5.66|P-value:8.23E-7 ID:SGTC_1980|Compound:st071811|FD-Score:4.24|P-value:1.65E-4 ID:SGTC_2056|Compound:5235370|FD-Score:3.77|P-value:7.03E-4 ID:SGTC_2088|Compound:5278280|FD-Score:-3.83|P-value:5.79E-4 ID:SGTC_2109|Compound:5483026|FD-Score:4.01|P-value:3.41E-4 ID:SGTC_2138|Compound:5575593|FD-Score:-4.04|P-value:3.13E-4 ID:SGTC_2140|Compound:5586273|FD-Score:4.46|P-value:7.90E-5 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-3.84|P-value:5.74E-4 ID:SGTC_2285|Compound:7945142|FD-Score:5.66|P-value:7.98E-7 ID:SGTC_2311|Compound:7694451|FD-Score:3.72|P-value:8.18E-4 ID:SGTC_2348|Compound:9022543|FD-Score:14.70|P-value:4.20E-36 ID:SGTC_2396|Compound:5342950|FD-Score:3.99|P-value:3.57E-4 ID:SGTC_2439|Compound:5492030|FD-Score:4.45|P-value:8.15E-5 ID:SGTC_2471|Compound:5466956|FD-Score:4.20|P-value:1.85E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.35|P-value:1.12E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:5.95|P-value:2.33E-7 ID:SGTC_2625|Compound:euphol|FD-Score:4.14|P-value:2.29E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:6.19|P-value:7.86E-8 ID:SGTC_2657|Compound:nystatin|FD-Score:3.73|P-value:7.95E-4 ID:SGTC_2695|Compound:st077686|FD-Score:5.15|P-value:6.32E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:9.28|P-value:1.93E-15 ID:SGTC_2779|Compound:methotrexate|FD-Score:-3.75|P-value:7.32E-4 ID:SGTC_2784|Compound:7567673|FD-Score:-3.77|P-value:6.97E-4 ID:SGTC_2789|Compound:5281112|FD-Score:6.02|P-value:1.68E-7 ID:SGTC_2806|Compound:7952793|FD-Score:3.98|P-value:3.76E-4 ID:SGTC_2814|Compound:7977482|FD-Score:4.51|P-value:6.70E-5 ID:SGTC_2816|Compound:7982706|FD-Score:8.79|P-value:4.85E-14 ID:SGTC_2823|Compound:7987624|FD-Score:10.20|P-value:2.67E-18 ID:SGTC_2846|Compound:9008642|FD-Score:4.94|P-value:1.44E-5 ID:SGTC_2858|Compound:9025781|FD-Score:5.31|P-value:3.35E-6 ID:SGTC_2912|Compound:7964298|FD-Score:5.14|P-value:6.73E-6 ID:SGTC_2917|Compound:7979103|FD-Score:-6.95|P-value:1.95E-9 ID:SGTC_2923|Compound:7992654|FD-Score:-4.09|P-value:2.63E-4 ID:SGTC_3003|Compound:9075612|FD-Score:-3.86|P-value:5.32E-4 ID:SGTC_3009|Compound:9080819|FD-Score:6.82|P-value:3.76E-9 ID:SGTC_3015|Compound:9080845|FD-Score:6.23|P-value:6.56E-8 ID:SGTC_3019|Compound:9081971|FD-Score:4.27|P-value:1.50E-4 ID:SGTC_3207|Compound:9114163|FD-Score:4.84|P-value:2.08E-5 ID:SGTC_3298|Compound:9116858|FD-Score:4.22|P-value:1.77E-4

Top fitness defect scores for YMR277W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2348 9022543 14.70 33.4 µM 4.20E-36 mitochondrial processes 3 1.76E-49 1.27
2 SGTC_138 0850-0259 14.10 40.9 µM 2.50E-33 cell wall 7 1.27E-45 1.97
3 SGTC_2823 7987624 10.20 58.4 µM 2.67E-18 1 9.55E-25 2.30
4 SGTC_2778 tioconazole 9.28 65.1 nM 1.93E-15 ergosterol depletion effects on membrane 4 8.81E-21 0.43
5 SGTC_57 miconazole 8.86 162.5 nM 3.08E-14 ergosterol depletion effects on membrane 9 4.11E-19 1.03
6 SGTC_2816 7982706 8.79 58.4 µM 4.85E-14 azole & statin 2 7.71E-19 4.19
7 SGTC_256 clotrimazole 8.40 625.0 nM 5.49E-13 ergosterol depletion effects on membrane 3 2.23E-17 0.91
8 SGTC_829 1635-0120 7.88 117.0 µM 1.23E-11 DNA damage response 18 1.65E-15 0.25
9 SGTC_839 0122-0028 7.80 230.0 µM 1.92E-11 RSC complex & mRNA processing 2 3.07E-15 0.15
10 SGTC_1652 st011932 7.32 78.0 µM 2.86E-10 RSC complex & mRNA processing 17 1.29E-13 0.40
11 SGTC_3009 9080819 6.82 71.4 µM 3.76E-9 1 4.54E-12 1.62
12 SGTC_1072 oxiconazole 6.82 14.9 nM 3.78E-9 ergosterol depletion effects on membrane 8 4.57E-12 0.72
13 SGTC_181 1447-1644 6.44 8.1 µM 2.37E-8 endomembrane recycling 6 5.79E-11 0.28
14 SGTC_3015 9080845 6.23 49.5 µM 6.56E-8 1 2.36E-10 1.31
15 SGTC_2651 1327-0036 6.19 5.0 µM 7.86E-8 32 3.03E-10 0.30
16 SGTC_208 k072-0098 6.10 12.4 µM 1.19E-7 heme biosynthesis & mitochondrial translocase 8 5.38E-10 0.56
17 SGTC_453 enantio-paf c16 6.08 10.0 µM 1.29E-7 4 5.97E-10 0.03
18 SGTC_2789 5281112 6.02 71.4 µM 1.68E-7 2 8.63E-10 0.82
19 SGTC_2617 dihydrotanshinone i 5.95 20.8 µM 2.33E-7 copper-dependent oxidative stress 8 1.36E-9 0.25
20 SGTC_287 k060-0039 5.74 29.6 µM 5.68E-7 1 4.64E-9 0.45

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.289 2.24E-65 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.265 5.85E-55 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.248 2.97E-48 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.245 3.14E-47 YDL140C RPO21 het RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime
0.244 1.63E-46 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.234 5.86E-43 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.233 9.87E-43 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.225 1.21E-39 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.221 2.43E-38 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.219 9.95E-38 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.210 6.50E-35 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.207 1.09E-33 YLR033W RSC58 het Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance
0.200 1.45E-31 YLR424W SPP382 het Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation
0.200 1.65E-31 YGL093W SPC105 het Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components
0.195 5.24E-30 YNL271C BNI1 hom Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1