YMR278W / PGM3

Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR278W / PGM3

Click on Significant Values for Screen Details ID:SGTC_206|Compound:4546-0025|FD-Score:2.91|P-value:8.61E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.44|P-value:1.06E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.26|P-value:2.76E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.04|P-value:5.16E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:2.98|P-value:6.53E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.26|P-value:2.26E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.28|P-value:2.01E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.26|P-value:2.29E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.86|P-value:1.64E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.12|P-value:3.81E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.14|P-value:4.14E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.65|P-value:4.36E-5 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.07|P-value:4.68E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.11|P-value:3.98E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.53|P-value:7.21E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.03|P-value:7.12E-6 ID:SGTC_1252|Compound:0493-0875|FD-Score:2.94|P-value:7.70E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.38|P-value:1.34E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.07|P-value:5.58E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.16|P-value:3.32E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:2.93|P-value:7.82E-4 ID:SGTC_1516|Compound:st013856|FD-Score:-3.20|P-value:3.51E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.96|P-value:1.00E-5 ID:SGTC_1605|Compound:st000082|FD-Score:3.03|P-value:5.49E-4 ID:SGTC_1838|Compound:st055369|FD-Score:3.02|P-value:5.72E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.18|P-value:3.52E-6 ID:SGTC_1935|Compound:st074532|FD-Score:3.69|P-value:3.60E-5 ID:SGTC_1958|Compound:st076513|FD-Score:2.94|P-value:7.52E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.46|P-value:9.93E-5 ID:SGTC_2204|Compound:7233102|FD-Score:3.58|P-value:5.84E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-3.42|P-value:1.45E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.02|P-value:5.74E-4 ID:SGTC_2330|Compound:7979373|FD-Score:8.00|P-value:4.58E-18 ID:SGTC_2336|Compound:9001819|FD-Score:5.76|P-value:3.02E-10 ID:SGTC_2361|Compound:9034121|FD-Score:-3.22|P-value:3.15E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.53|P-value:5.48E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.35|P-value:1.55E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.21|P-value:2.69E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.41|P-value:1.48E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.22|P-value:2.77E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.59|P-value:5.52E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.54|P-value:7.05E-5 ID:SGTC_2785|Compound:7756463|FD-Score:4.77|P-value:1.47E-7 ID:SGTC_2823|Compound:7987624|FD-Score:2.93|P-value:8.02E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.48|P-value:1.09E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.64|P-value:4.43E-5 ID:SGTC_2958|Compound:9077254|FD-Score:3.23|P-value:2.46E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-3.11|P-value:4.81E-4 ID:SGTC_3137|Compound:9097352|FD-Score:2.99|P-value:6.35E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.57|P-value:5.95E-5 ID:SGTC_3176|Compound:9106582|FD-Score:3.06|P-value:4.94E-4 ID:SGTC_3177|Compound:9107506|FD-Score:4.14|P-value:4.21E-6 ID:SGTC_3190|Compound:9110366|FD-Score:3.55|P-value:6.71E-5 ID:SGTC_3195|Compound:9113082|FD-Score:2.92|P-value:8.24E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.46|P-value:9.75E-5 ID:SGTC_206|Compound:4546-0025|FD-Score:2.91|P-value:8.61E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:3.44|P-value:1.06E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.26|P-value:2.76E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.04|P-value:5.16E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:2.98|P-value:6.53E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.26|P-value:2.26E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.28|P-value:2.01E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.26|P-value:2.29E-6 ID:SGTC_1045|Compound:1348-1485|FD-Score:3.86|P-value:1.64E-5 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.12|P-value:3.81E-4 ID:SGTC_1077|Compound:5-fluorocytosine|FD-Score:4.14|P-value:4.14E-6 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.65|P-value:4.36E-5 ID:SGTC_1158|Compound:4092-0494|FD-Score:3.07|P-value:4.68E-4 ID:SGTC_1196|Compound:1588-0294|FD-Score:3.11|P-value:3.98E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.53|P-value:7.21E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:4.03|P-value:7.12E-6 ID:SGTC_1252|Compound:0493-0875|FD-Score:2.94|P-value:7.70E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.38|P-value:1.34E-4 ID:SGTC_1460|Compound:k062-0059|FD-Score:-3.07|P-value:5.58E-4 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.16|P-value:3.32E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:2.93|P-value:7.82E-4 ID:SGTC_1516|Compound:st013856|FD-Score:-3.20|P-value:3.51E-4 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.96|P-value:1.00E-5 ID:SGTC_1605|Compound:st000082|FD-Score:3.03|P-value:5.49E-4 ID:SGTC_1838|Compound:st055369|FD-Score:3.02|P-value:5.72E-4 ID:SGTC_1934|Compound:st074720|FD-Score:4.18|P-value:3.52E-6 ID:SGTC_1935|Compound:st074532|FD-Score:3.69|P-value:3.60E-5 ID:SGTC_1958|Compound:st076513|FD-Score:2.94|P-value:7.52E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.46|P-value:9.93E-5 ID:SGTC_2204|Compound:7233102|FD-Score:3.58|P-value:5.84E-5 ID:SGTC_2244|Compound:6635614|FD-Score:-3.42|P-value:1.45E-4 ID:SGTC_2309|Compound:7664088|FD-Score:3.02|P-value:5.74E-4 ID:SGTC_2330|Compound:7979373|FD-Score:8.00|P-value:4.58E-18 ID:SGTC_2336|Compound:9001819|FD-Score:5.76|P-value:3.02E-10 ID:SGTC_2361|Compound:9034121|FD-Score:-3.22|P-value:3.15E-4 ID:SGTC_2365|Compound:9042475|FD-Score:4.53|P-value:5.48E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.35|P-value:1.55E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.21|P-value:2.69E-4 ID:SGTC_2618|Compound:avocadyne|FD-Score:-3.41|P-value:1.48E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:4.22|P-value:2.77E-6 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.59|P-value:5.52E-5 ID:SGTC_2781|Compound:5567276|FD-Score:3.54|P-value:7.05E-5 ID:SGTC_2785|Compound:7756463|FD-Score:4.77|P-value:1.47E-7 ID:SGTC_2823|Compound:7987624|FD-Score:2.93|P-value:8.02E-4 ID:SGTC_2848|Compound:9016370|FD-Score:-3.48|P-value:1.09E-4 ID:SGTC_2933|Compound:9026794|FD-Score:3.64|P-value:4.43E-5 ID:SGTC_2958|Compound:9077254|FD-Score:3.23|P-value:2.46E-4 ID:SGTC_3019|Compound:9081971|FD-Score:-3.11|P-value:4.81E-4 ID:SGTC_3137|Compound:9097352|FD-Score:2.99|P-value:6.35E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.57|P-value:5.95E-5 ID:SGTC_3176|Compound:9106582|FD-Score:3.06|P-value:4.94E-4 ID:SGTC_3177|Compound:9107506|FD-Score:4.14|P-value:4.21E-6 ID:SGTC_3190|Compound:9110366|FD-Score:3.55|P-value:6.71E-5 ID:SGTC_3195|Compound:9113082|FD-Score:2.92|P-value:8.24E-4 ID:SGTC_3240|Compound:9133527|FD-Score:3.46|P-value:9.75E-5

Top fitness defect scores for YMR278W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2330 7979373 8.00 200.0 µM 4.58E-18 60S ribosome export 5 6.02E-16
2 SGTC_2336 9001819 5.76 198.7 µM 3.02E-10 heme biosynthesis & mitochondrial translocase 11 4.11E-9
3 SGTC_2785 7756463 4.77 72.7 µM 1.47E-7 11 9.18E-7
4 SGTC_2365 9042475 4.53 200.0 µM 5.48E-7 21 2.90E-6
5 SGTC_1019 4262-0212 4.26 3.4 µM 2.29E-6 ergosterol depletion effects on membrane 54 1.01E-5
6 SGTC_2626 ethyl orsellinate 4.22 100.0 µM 2.77E-6 28 1.20E-5
7 SGTC_1934 st074720 4.18 32.6 µM 3.52E-6 46 1.48E-5
8 SGTC_1077 5-fluorocytosine 4.14 377.0 nM 4.14E-6 exosome 13 1.70E-5
9 SGTC_3177 9107506 4.14 49.5 µM 4.21E-6 ERG2 7 1.73E-5
10 SGTC_1248 0469-0687 4.03 58.6 µM 7.12E-6 26 2.74E-5
11 SGTC_1535 tetrahydropapaveroline hydrobromide 3.96 54.3 µM 1.00E-5 RPP1 & pyrimidine depletion 11 3.69E-5
12 SGTC_1045 1348-1485 3.86 165.0 µM 1.64E-5 34 5.69E-5
13 SGTC_1935 st074532 3.69 41.6 µM 3.60E-5 41 1.13E-4
14 SGTC_1087 pterostilbene 3.65 9.1 µM 4.36E-5 34 1.34E-4
15 SGTC_2933 9026794 3.64 32.5 µM 4.43E-5 34 1.36E-4
16 SGTC_2753 fluvastatin 3.59 17.1 µM 5.52E-5 azole & statin 52 1.64E-4
17 SGTC_2204 7233102 3.58 200.0 µM 5.84E-5 60S ribosome export 6 1.73E-4
18 SGTC_3170 9103054 3.57 49.5 µM 5.95E-5 60S ribosome export 24 1.76E-4
19 SGTC_3190 9110366 3.55 49.5 µM 6.71E-5 17 1.95E-4
20 SGTC_2781 5567276 3.54 71.4 µM 7.05E-5 71 2.04E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.31E-11 YDR454C GUK1 het Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
0.111 1.01E-10 YPR079W MRL1 hom Membrane protein; has similarity to mammalian mannose-6-phosphate receptors; possibly functions as a sorting receptor in the delivery of vacuolar hydrolases; protein abundance increases in response to DNA replication stress
0.102 3.57E-9 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.098 1.12E-8 YDL221W_d YDL221W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13
0.096 2.75E-8 YOL109W ZEO1 hom Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
0.090 1.69E-7 YGL051W MST27 hom Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles
0.089 2.66E-7 YDL120W YFH1 het Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia
0.084 9.82E-7 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.084 9.95E-7 YOR230W WTM1 hom Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
0.084 9.94E-7 YOL107W_p YOL107W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein
0.082 1.73E-6 YLR082C SRL2 hom Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation
0.082 1.82E-6 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.081 2.53E-6 YPL101W ELP4 hom Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity
0.079 5.28E-6 YML029W USA1 hom Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p
0.078 6.21E-6 YBL009W ALK2 hom Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins