YMR279C

Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; YMR279C has a paralog, ATR1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR279C / YMR279C

Click on Significant Values for Screen Details ID:SGTC_161|Compound:4065-0411|FD-Score:3.47|P-value:7.82E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.42|P-value:9.35E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.81|P-value:3.06E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:4.23|P-value:6.06E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.31|P-value:4.39E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:6.14|P-value:1.21E-8 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.04|P-value:1.19E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:-3.52|P-value:7.72E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.40|P-value:3.19E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:-4.17|P-value:8.72E-5 ID:SGTC_1604|Compound:st002052|FD-Score:3.96|P-value:1.58E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.40|P-value:9.79E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.66|P-value:4.32E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.84|P-value:2.36E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.77|P-value:3.05E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.73|P-value:3.39E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.88|P-value:2.39E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.74|P-value:3.30E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.04|P-value:1.20E-4 ID:SGTC_2128|Compound:5255449|FD-Score:5.19|P-value:1.22E-6 ID:SGTC_2133|Compound:5320837|FD-Score:-3.55|P-value:7.08E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.43|P-value:8.81E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.74|P-value:8.10E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:-4.01|P-value:1.52E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.63|P-value:1.57E-7 ID:SGTC_2839|Compound:9003951|FD-Score:-4.53|P-value:2.28E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-7.60|P-value:3.44E-12 ID:SGTC_2846|Compound:9008642|FD-Score:-3.69|P-value:4.49E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.47|P-value:7.87E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.66|P-value:4.95E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.14|P-value:8.39E-5 ID:SGTC_2971|Compound:9092186|FD-Score:4.85|P-value:5.29E-6 ID:SGTC_3038|Compound:9091290|FD-Score:3.75|P-value:3.25E-4 ID:SGTC_3185|Compound:9108267|FD-Score:4.63|P-value:1.31E-5 ID:SGTC_3208|Compound:9114115|FD-Score:3.58|P-value:5.62E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-4.31|P-value:5.17E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.40|P-value:9.91E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.47|P-value:7.82E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.42|P-value:9.35E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.81|P-value:3.06E-4 ID:SGTC_1169|Compound:aniline yellow|FD-Score:4.23|P-value:6.06E-5 ID:SGTC_1211|Compound:1056-0033|FD-Score:4.31|P-value:4.39E-5 ID:SGTC_1318|Compound:1280-3875|FD-Score:6.14|P-value:1.21E-8 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.04|P-value:1.19E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:-3.52|P-value:7.72E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.40|P-value:3.19E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:-4.17|P-value:8.72E-5 ID:SGTC_1604|Compound:st002052|FD-Score:3.96|P-value:1.58E-4 ID:SGTC_1780|Compound:st038448|FD-Score:3.40|P-value:9.79E-4 ID:SGTC_1820|Compound:st053765|FD-Score:3.66|P-value:4.32E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.84|P-value:2.36E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.77|P-value:3.05E-4 ID:SGTC_2013|Compound:4024628|FD-Score:3.73|P-value:3.39E-4 ID:SGTC_2017|Compound:5132927|FD-Score:-3.88|P-value:2.39E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.74|P-value:3.30E-4 ID:SGTC_2065|Compound:5221596|FD-Score:4.04|P-value:1.20E-4 ID:SGTC_2128|Compound:5255449|FD-Score:5.19|P-value:1.22E-6 ID:SGTC_2133|Compound:5320837|FD-Score:-3.55|P-value:7.08E-4 ID:SGTC_2376|Compound:9072922|FD-Score:3.43|P-value:8.81E-4 ID:SGTC_2426|Compound:5582046|FD-Score:4.74|P-value:8.10E-6 ID:SGTC_2557|Compound:derrustone|FD-Score:-4.01|P-value:1.52E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:5.63|P-value:1.57E-7 ID:SGTC_2839|Compound:9003951|FD-Score:-4.53|P-value:2.28E-5 ID:SGTC_2844|Compound:9010103|FD-Score:-7.60|P-value:3.44E-12 ID:SGTC_2846|Compound:9008642|FD-Score:-3.69|P-value:4.49E-4 ID:SGTC_2848|Compound:9016370|FD-Score:3.47|P-value:7.87E-4 ID:SGTC_2943|Compound:9068529|FD-Score:-3.66|P-value:4.95E-4 ID:SGTC_2967|Compound:9089538|FD-Score:4.14|P-value:8.39E-5 ID:SGTC_2971|Compound:9092186|FD-Score:4.85|P-value:5.29E-6 ID:SGTC_3038|Compound:9091290|FD-Score:3.75|P-value:3.25E-4 ID:SGTC_3185|Compound:9108267|FD-Score:4.63|P-value:1.31E-5 ID:SGTC_3208|Compound:9114115|FD-Score:3.58|P-value:5.62E-4 ID:SGTC_3264|Compound:9137442|FD-Score:-4.31|P-value:5.17E-5 ID:SGTC_3326|Compound:9140064|FD-Score:3.40|P-value:9.91E-4

Top fitness defect scores for YMR279C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1318 1280-3875 6.14 124.0 µM 1.21E-8 2 4.04E-10
2 SGTC_2615 purpurogallin-4-carboxylic acid 5.63 100.0 µM 1.57E-7 redox potentiating 29 9.00E-9
3 SGTC_2128 5255449 5.19 168.5 µM 1.22E-6 9 1.07E-7
4 SGTC_2971 9092186 4.85 9.9 µM 5.29E-6 ergosterol biosynthesis 13 6.29E-7
5 SGTC_2426 5582046 4.74 32.2 µM 8.10E-6 13 1.05E-6
6 SGTC_3185 9108267 4.63 49.5 µM 1.31E-5 60S ribosome export 6 1.87E-6
7 SGTC_1357 1503-1303 4.40 39.5 µM 3.19E-5 20 5.49E-6
8 SGTC_1211 1056-0033 4.31 32.3 µM 4.39E-5 5 8.07E-6
9 SGTC_1169 aniline yellow 4.23 25.8 µM 6.06E-5 6 1.19E-5
10 SGTC_2967 9089538 4.14 49.9 µM 8.39E-5 28 1.76E-5
11 SGTC_1341 1486-1360 4.04 280.0 µM 1.19E-4 23 2.67E-5
12 SGTC_2065 5221596 4.04 34.3 µM 1.20E-4 13 2.69E-5
13 SGTC_1604 st002052 3.96 72.4 µM 1.58E-4 TSC3-RPN4 31 3.76E-5
14 SGTC_1879 gemcitabine 3.84 100.0 µM 2.36E-4 17 6.10E-5
15 SGTC_2005 4024620 3.77 188.0 µM 3.05E-4 25 8.29E-5
16 SGTC_3038 9091290 3.75 49.5 µM 3.25E-4 19 8.96E-5
17 SGTC_2062 5245942 3.74 200.0 µM 3.30E-4 27 9.11E-5
18 SGTC_2013 4024628 3.73 200.0 µM 3.39E-4 50 9.41E-5
19 SGTC_1820 st053765 3.66 18.6 µM 4.32E-4 RPP1 & pyrimidine depletion 26 1.26E-4
20 SGTC_3208 9114115 3.58 49.5 µM 5.62E-4 54 1.73E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.16E-11 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.095 3.39E-8 YBL059W_p YBL059W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YBL059W has a paralog, YER093C-A, that arose from the whole genome duplication
0.087 4.97E-7 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.080 3.72E-6 YPL222W_p FMP40_p hom Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.079 5.21E-6 YGL168W HUR1 hom Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene
0.075 1.24E-5 YOR382W FIT2 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.073 2.65E-5 YNL047C SLM2 hom Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex; SLM2 has a paralog, SLM1, that arose from the whole genome duplication
0.072 2.66E-5 YJL205C NCE101 hom Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences
0.069 5.74E-5 YGR086C PIL1 hom Primary protein component of eisosomes; eisosomes are large immobile cell cortex structures associated with endocytosis; null mutant shows activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR domain family; protein increases in abundance and relocalizes from plasma membrane to cytoplasm upon DNA replication stress
0.068 8.06E-5 YHR104W GRE3 hom Aldose reductase; involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway; protein abundance increases in response to DNA replication stress
0.068 8.79E-5 YKL083W_d YKL083W_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified essential gene RRP14
0.068 9.15E-5 YOR038C HIR2 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
0.067 1.07E-4 YAR015W ADE1 hom N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress
0.065 1.47E-4 YDR438W THI74 hom Mitochondrial transporter repressible by thiamine; THI74 has a paralog, YML018C, that arose from the whole genome duplication
0.065 1.70E-4 YER169W RPH1 hom JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as its substrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway; RPH1 has a paralog, GIS1, that arose from the whole genome duplication