YMR280C / CAT8

Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR280C / CAT8

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:4.43|P-value:1.02E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:3.59|P-value:5.50E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:3.09|P-value:4.13E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.51|P-value:1.57E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.20|P-value:5.31E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:4.63|P-value:3.47E-7 ID:SGTC_667|Compound:1498-1044|FD-Score:3.20|P-value:2.70E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.81|P-value:2.05E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:4.36|P-value:1.50E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.04|P-value:9.44E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.90|P-value:8.48E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:2.93|P-value:7.71E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.19|P-value:2.91E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.33|P-value:1.66E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.41|P-value:1.16E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.49|P-value:8.59E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.03|P-value:5.23E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.65|P-value:4.22E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.79|P-value:1.48E-7 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.82|P-value:4.32E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.07|P-value:8.61E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:2.89|P-value:8.74E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.81|P-value:2.14E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:4.38|P-value:1.30E-6 ID:SGTC_1531|Compound:st059297|FD-Score:3.41|P-value:1.18E-4 ID:SGTC_1571|Compound:st070080|FD-Score:2.94|P-value:7.38E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-4.31|P-value:4.36E-6 ID:SGTC_1683|Compound:st010134|FD-Score:3.46|P-value:9.43E-5 ID:SGTC_1727|Compound:st034309|FD-Score:3.11|P-value:3.92E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-3.45|P-value:2.04E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.00|P-value:5.89E-4 ID:SGTC_1835|Compound:st008666|FD-Score:4.20|P-value:3.22E-6 ID:SGTC_1972|Compound:st070201|FD-Score:3.03|P-value:5.21E-4 ID:SGTC_2231|Compound:micatex|FD-Score:2.93|P-value:7.57E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.35|P-value:1.54E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.32|P-value:1.72E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.02|P-value:5.52E-4 ID:SGTC_2402|Compound:5553605|FD-Score:4.06|P-value:6.57E-6 ID:SGTC_2404|Compound:5161160|FD-Score:2.86|P-value:9.69E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.01|P-value:5.74E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.99|P-value:2.04E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.14|P-value:6.49E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.68|P-value:3.68E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.13|P-value:6.93E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:2.89|P-value:8.66E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.99|P-value:9.09E-6 ID:SGTC_2897|Compound:9048598|FD-Score:-3.27|P-value:4.05E-4 ID:SGTC_2919|Compound:7978188|FD-Score:2.89|P-value:8.75E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.86|P-value:3.59E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.69|P-value:3.51E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:4.43|P-value:1.02E-6 ID:SGTC_41|Compound:0478-0632|FD-Score:3.59|P-value:5.50E-5 ID:SGTC_333|Compound:3486-0131|FD-Score:3.09|P-value:4.13E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.51|P-value:1.57E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:-3.20|P-value:5.31E-4 ID:SGTC_622|Compound:1348-1566|FD-Score:4.63|P-value:3.47E-7 ID:SGTC_667|Compound:1498-1044|FD-Score:3.20|P-value:2.70E-4 ID:SGTC_728|Compound:3030-5151|FD-Score:3.81|P-value:2.05E-5 ID:SGTC_828|Compound:2074-0507|FD-Score:4.36|P-value:1.50E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:-3.04|P-value:9.44E-4 ID:SGTC_922|Compound:1866-0035|FD-Score:2.90|P-value:8.48E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:2.93|P-value:7.71E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.19|P-value:2.91E-4 ID:SGTC_1066|Compound:ketoconazole|FD-Score:3.33|P-value:1.66E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.41|P-value:1.16E-4 ID:SGTC_1127|Compound:asiatic acid|FD-Score:3.49|P-value:8.59E-5 ID:SGTC_1169|Compound:aniline yellow|FD-Score:3.03|P-value:5.23E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.65|P-value:4.22E-5 ID:SGTC_1202|Compound:1988-0068|FD-Score:4.79|P-value:1.48E-7 ID:SGTC_1204|Compound:4049-0315|FD-Score:-3.82|P-value:4.32E-5 ID:SGTC_1241|Compound:0364-0022|FD-Score:-3.07|P-value:8.61E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:2.89|P-value:8.74E-4 ID:SGTC_1383|Compound:3049-0032|FD-Score:3.81|P-value:2.14E-5 ID:SGTC_1435|Compound:4092-0789|FD-Score:4.38|P-value:1.30E-6 ID:SGTC_1531|Compound:st059297|FD-Score:3.41|P-value:1.18E-4 ID:SGTC_1571|Compound:st070080|FD-Score:2.94|P-value:7.38E-4 ID:SGTC_1632|Compound:st005650|FD-Score:-4.31|P-value:4.36E-6 ID:SGTC_1683|Compound:st010134|FD-Score:3.46|P-value:9.43E-5 ID:SGTC_1727|Compound:st034309|FD-Score:3.11|P-value:3.92E-4 ID:SGTC_1734|Compound:st037168|FD-Score:-3.45|P-value:2.04E-4 ID:SGTC_1737|Compound:st035557|FD-Score:3.00|P-value:5.89E-4 ID:SGTC_1835|Compound:st008666|FD-Score:4.20|P-value:3.22E-6 ID:SGTC_1972|Compound:st070201|FD-Score:3.03|P-value:5.21E-4 ID:SGTC_2231|Compound:micatex|FD-Score:2.93|P-value:7.57E-4 ID:SGTC_2264|Compound:7948757|FD-Score:3.35|P-value:1.54E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.32|P-value:1.72E-4 ID:SGTC_2401|Compound:5128683|FD-Score:3.02|P-value:5.52E-4 ID:SGTC_2402|Compound:5553605|FD-Score:4.06|P-value:6.57E-6 ID:SGTC_2404|Compound:5161160|FD-Score:2.86|P-value:9.69E-4 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:3.01|P-value:5.74E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-3.99|P-value:2.04E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-3.14|P-value:6.49E-4 ID:SGTC_2590|Compound:3,4',5',6',7'-pentamethoxyflavone|FD-Score:3.68|P-value:3.68E-5 ID:SGTC_2611|Compound:pyromycin|FD-Score:-3.13|P-value:6.93E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:2.89|P-value:8.66E-4 ID:SGTC_2815|Compound:7968870|FD-Score:3.99|P-value:9.09E-6 ID:SGTC_2897|Compound:9048598|FD-Score:-3.27|P-value:4.05E-4 ID:SGTC_2919|Compound:7978188|FD-Score:2.89|P-value:8.75E-4 ID:SGTC_3045|Compound:9092950|FD-Score:-3.86|P-value:3.59E-5 ID:SGTC_3083|Compound:9117465|FD-Score:3.69|P-value:3.51E-5

Top fitness defect scores for YMR280C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1202 1988-0068 4.79 29.6 µM 1.48E-7 RNA processing & uracil transport 9 8.37E-7
2 SGTC_622 1348-1566 4.63 26.3 µM 3.47E-7 12 1.79E-6
3 SGTC_38 0929-0051 4.43 58.3 µM 1.02E-6 14 4.70E-6
4 SGTC_1435 4092-0789 4.38 56.7 µM 1.30E-6 plasma membrane duress 10 5.85E-6
5 SGTC_828 2074-0507 4.36 139.0 µM 1.50E-6 RPP1 & pyrimidine depletion 17 6.62E-6
6 SGTC_1835 st008666 4.20 49.2 µM 3.22E-6 21 1.31E-5
7 SGTC_2402 5553605 4.06 200.0 µM 6.57E-6 23 2.47E-5
8 SGTC_2815 7968870 3.99 71.4 µM 9.09E-6 22 3.30E-5
9 SGTC_728 3030-5151 3.81 22.5 µM 2.05E-5 17 6.82E-5
10 SGTC_1383 3049-0032 3.81 20.7 µM 2.14E-5 60S ribosome export 22 7.08E-5
11 SGTC_3083 9117465 3.69 49.5 µM 3.51E-5 27 1.10E-4
12 SGTC_2590 3,4',5',6',7'-pentamethoxyflavone 3.68 100.0 µM 3.68E-5 60S ribosome export 26 1.15E-4
13 SGTC_1193 1488-0126 3.65 41.5 µM 4.22E-5 32 1.30E-4
14 SGTC_41 0478-0632 3.59 82.6 µM 5.50E-5 40 1.64E-4
15 SGTC_1127 asiatic acid 3.49 681.4 nM 8.59E-5 38 2.44E-4
16 SGTC_1683 st010134 3.46 710.0 nM 9.43E-5 50 2.65E-4
17 SGTC_1067 clotrimazole 3.41 1.4 µM 1.16E-4 azole & statin 58 3.19E-4
18 SGTC_1531 st059297 3.41 52.4 µM 1.18E-4 36 3.23E-4
19 SGTC_2264 7948757 3.35 110.8 µM 1.54E-4 36 4.09E-4
20 SGTC_1066 ketoconazole 3.33 628.0 nM 1.66E-4 45 4.40E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 4.12E-11 YBR294W SUL1 hom High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates
0.109 2.28E-10 YKL066W_d YKL066W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene YNK1
0.105 1.09E-9 YOR084W LPX1 hom Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction
0.101 4.97E-9 YLL041C SDH2 hom Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain
0.099 9.64E-9 YDR078C SHU2 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.094 5.57E-8 YMR184W ADD37 hom Protein of unknown function; involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene; protein abundance increases in response to DNA replication stress
0.084 1.21E-6 YEL059W_d HHY1_d hom Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking
0.081 2.85E-6 YAL028W FRT2 hom Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication
0.081 3.00E-6 YGL098W USE1 het Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p
0.080 3.41E-6 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.080 3.91E-6 YMR272W-B_p YMR272W-B_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.079 4.12E-6 YKL001C MET14 hom Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism
0.076 1.01E-5 YHR190W ERG9 het Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway
0.075 1.47E-5 YLR347C KAP95 het Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p
0.073 2.21E-5 YIL089W YIL089W hom Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking