YMR282C / AEP2

Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR282C / AEP2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.94|P-value:3.74E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.33|P-value:1.03E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:5.42|P-value:1.72E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:7.58|P-value:4.19E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:10.60|P-value:4.80E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.68|P-value:2.99E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:15.90|P-value:9.49E-43 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.85|P-value:1.59E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-4.80|P-value:1.96E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.40|P-value:1.86E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:5.90|P-value:2.18E-7 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.00|P-value:3.03E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.23|P-value:1.43E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.41|P-value:7.86E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:4.77|P-value:2.19E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.63|P-value:9.44E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.42|P-value:7.52E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:4.05|P-value:2.61E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.66|P-value:8.69E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:8.10|P-value:1.90E-12 ID:SGTC_908|Compound:3448-7491|FD-Score:4.60|P-value:3.99E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.69|P-value:2.98E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:7.59|P-value:3.89E-11 ID:SGTC_990|Compound:3985-0011|FD-Score:5.39|P-value:1.96E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:4.08|P-value:2.36E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.09|P-value:2.28E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.95|P-value:3.61E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.76|P-value:6.28E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.94|P-value:3.67E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.23|P-value:1.43E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-4.95|P-value:1.12E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.93|P-value:3.80E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.61|P-value:9.91E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.94|P-value:3.65E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.57|P-value:4.56E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.01|P-value:2.99E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.21|P-value:1.53E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.63|P-value:9.44E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.95|P-value:3.62E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.96|P-value:1.09E-5 ID:SGTC_1624|Compound:st003710|FD-Score:5.81|P-value:3.21E-7 ID:SGTC_1707|Compound:st032323|FD-Score:-3.94|P-value:3.69E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.89|P-value:1.42E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-4.62|P-value:3.74E-5 ID:SGTC_1758|Compound:st042942|FD-Score:6.88|P-value:1.89E-9 ID:SGTC_1765|Compound:st044815|FD-Score:5.43|P-value:1.68E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.77|P-value:6.19E-4 ID:SGTC_1856|Compound:st057054|FD-Score:6.13|P-value:7.68E-8 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.35|P-value:9.62E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-4.04|P-value:2.64E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-5.01|P-value:8.74E-6 ID:SGTC_2041|Compound:5107442|FD-Score:4.56|P-value:4.71E-5 ID:SGTC_2139|Compound:5578692|FD-Score:4.21|P-value:1.55E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.10|P-value:2.25E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.35|P-value:2.26E-6 ID:SGTC_2285|Compound:7945142|FD-Score:3.99|P-value:3.12E-4 ID:SGTC_2288|Compound:7946289|FD-Score:5.94|P-value:1.79E-7 ID:SGTC_2290|Compound:7904846|FD-Score:4.83|P-value:1.75E-5 ID:SGTC_2345|Compound:9052315|FD-Score:5.26|P-value:3.33E-6 ID:SGTC_2347|Compound:9049783|FD-Score:4.10|P-value:2.20E-4 ID:SGTC_2433|Compound:5607874|FD-Score:4.27|P-value:1.26E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.49|P-value:5.93E-5 ID:SGTC_2526|Compound:patulin|FD-Score:3.81|P-value:5.47E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-5.05|P-value:7.37E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.54|P-value:5.34E-11 ID:SGTC_2777|Compound:climbazole|FD-Score:-8.10|P-value:1.88E-12 ID:SGTC_2778|Compound:tioconazole|FD-Score:-5.32|P-value:2.59E-6 ID:SGTC_2854|Compound:9024559|FD-Score:5.58|P-value:8.82E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-6.19|P-value:5.48E-8 ID:SGTC_2866|Compound:9034245|FD-Score:4.51|P-value:5.64E-5 ID:SGTC_2887|Compound:9044784|FD-Score:-3.60|P-value:9.97E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-10.50|P-value:1.07E-19 ID:SGTC_3266|Compound:9136860|FD-Score:-4.83|P-value:1.74E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-4.08|P-value:2.33E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.40|P-value:8.06E-5 ID:SGTC_10|Compound:0279-0212|FD-Score:3.94|P-value:3.74E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.33|P-value:1.03E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:5.42|P-value:1.72E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:7.58|P-value:4.19E-11 ID:SGTC_236|Compound:1509-0011|FD-Score:10.60|P-value:4.80E-20 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.68|P-value:2.99E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:15.90|P-value:9.49E-43 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.85|P-value:1.59E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-4.80|P-value:1.96E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.40|P-value:1.86E-6 ID:SGTC_502|Compound:l-744,832|FD-Score:5.90|P-value:2.18E-7 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:4.00|P-value:3.03E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.23|P-value:1.43E-4 ID:SGTC_581|Compound:0958-0271|FD-Score:4.41|P-value:7.86E-5 ID:SGTC_596|Compound:1155-0152|FD-Score:4.77|P-value:2.19E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:3.63|P-value:9.44E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:4.42|P-value:7.52E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:4.05|P-value:2.61E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:3.66|P-value:8.69E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:8.10|P-value:1.90E-12 ID:SGTC_908|Compound:3448-7491|FD-Score:4.60|P-value:3.99E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.69|P-value:2.98E-5 ID:SGTC_932|Compound:2857-0803|FD-Score:7.59|P-value:3.89E-11 ID:SGTC_990|Compound:3985-0011|FD-Score:5.39|P-value:1.96E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:4.08|P-value:2.36E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:4.09|P-value:2.28E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:3.95|P-value:3.61E-4 ID:SGTC_1015|Compound:4130-4525|FD-Score:-3.76|P-value:6.28E-4 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.94|P-value:3.67E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:4.23|P-value:1.43E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:-4.95|P-value:1.12E-5 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.93|P-value:3.80E-4 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.61|P-value:9.91E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.94|P-value:3.65E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:4.57|P-value:4.56E-5 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.01|P-value:2.99E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:4.21|P-value:1.53E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.63|P-value:9.44E-4 ID:SGTC_1622|Compound:st003707|FD-Score:3.95|P-value:3.62E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.96|P-value:1.09E-5 ID:SGTC_1624|Compound:st003710|FD-Score:5.81|P-value:3.21E-7 ID:SGTC_1707|Compound:st032323|FD-Score:-3.94|P-value:3.69E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.89|P-value:1.42E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-4.62|P-value:3.74E-5 ID:SGTC_1758|Compound:st042942|FD-Score:6.88|P-value:1.89E-9 ID:SGTC_1765|Compound:st044815|FD-Score:5.43|P-value:1.68E-6 ID:SGTC_1844|Compound:rapamycin|FD-Score:-3.77|P-value:6.19E-4 ID:SGTC_1856|Compound:st057054|FD-Score:6.13|P-value:7.68E-8 ID:SGTC_1880|Compound:MG-132|FD-Score:-4.35|P-value:9.62E-5 ID:SGTC_1884|Compound:5633444|FD-Score:-4.04|P-value:2.64E-4 ID:SGTC_2021|Compound:4019055|FD-Score:-5.01|P-value:8.74E-6 ID:SGTC_2041|Compound:5107442|FD-Score:4.56|P-value:4.71E-5 ID:SGTC_2139|Compound:5578692|FD-Score:4.21|P-value:1.55E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.10|P-value:2.25E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:5.35|P-value:2.26E-6 ID:SGTC_2285|Compound:7945142|FD-Score:3.99|P-value:3.12E-4 ID:SGTC_2288|Compound:7946289|FD-Score:5.94|P-value:1.79E-7 ID:SGTC_2290|Compound:7904846|FD-Score:4.83|P-value:1.75E-5 ID:SGTC_2345|Compound:9052315|FD-Score:5.26|P-value:3.33E-6 ID:SGTC_2347|Compound:9049783|FD-Score:4.10|P-value:2.20E-4 ID:SGTC_2433|Compound:5607874|FD-Score:4.27|P-value:1.26E-4 ID:SGTC_2444|Compound:5485484|FD-Score:4.49|P-value:5.93E-5 ID:SGTC_2526|Compound:patulin|FD-Score:3.81|P-value:5.47E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-5.05|P-value:7.37E-6 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.54|P-value:5.34E-11 ID:SGTC_2777|Compound:climbazole|FD-Score:-8.10|P-value:1.88E-12 ID:SGTC_2778|Compound:tioconazole|FD-Score:-5.32|P-value:2.59E-6 ID:SGTC_2854|Compound:9024559|FD-Score:5.58|P-value:8.82E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-6.19|P-value:5.48E-8 ID:SGTC_2866|Compound:9034245|FD-Score:4.51|P-value:5.64E-5 ID:SGTC_2887|Compound:9044784|FD-Score:-3.60|P-value:9.97E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-10.50|P-value:1.07E-19 ID:SGTC_3266|Compound:9136860|FD-Score:-4.83|P-value:1.74E-5 ID:SGTC_3280|Compound:9140961|FD-Score:-4.08|P-value:2.33E-4 ID:SGTC_3307|Compound:9126885|FD-Score:4.40|P-value:8.06E-5

Top fitness defect scores for YMR282C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 15.90 1.1 µM 9.49E-43 mitochondrial stress 5 1.85E-57
2 SGTC_236 1509-0011 10.60 5.3 µM 4.80E-20 184 1.31E-26
3 SGTC_832 4083-0019 8.10 164.0 µM 1.90E-12 translation 9 2.64E-16
4 SGTC_932 2857-0803 7.59 154.0 µM 3.89E-11 2 1.58E-14
5 SGTC_173 1273-0061 7.58 2.7 µM 4.19E-11 mitochondrial stress 78 1.74E-14
6 SGTC_2688 kanamycin b 7.54 96.7 µM 5.34E-11 calcium & mitochondrial duress 85 2.43E-14
7 SGTC_1758 st042942 6.88 75.2 µM 1.89E-9 1 3.03E-12
8 SGTC_1856 st057054 6.13 55.7 µM 7.68E-8 7 4.52E-10
9 SGTC_2288 7946289 5.94 167.3 µM 1.79E-7 5 1.42E-9
10 SGTC_502 l-744,832 5.90 89.3 µM 2.18E-7 calcium & mitochondrial duress 11 1.85E-9
11 SGTC_1624 st003710 5.81 6.2 µM 3.21E-7 calcium & mitochondrial duress 14 3.11E-9
12 SGTC_2854 9024559 5.58 71.4 µM 8.82E-7 7 1.22E-8
13 SGTC_1765 st044815 5.43 90.4 µM 1.68E-6 6 2.89E-8
14 SGTC_87 0100-0052 5.42 35.5 µM 1.72E-6 43 2.99E-8
15 SGTC_990 3985-0011 5.39 41.3 µM 1.96E-6 amide catabolism 5 3.58E-8
16 SGTC_2232 chlorophetanol 5.35 41.5 µM 2.26E-6 TRP & mitochondrial translation 64 4.32E-8
17 SGTC_2345 9052315 5.26 157.4 µM 3.33E-6 7 7.30E-8
18 SGTC_1623 st003709 4.96 20.3 µM 1.09E-5 calcium & mitochondrial duress 33 3.60E-7
19 SGTC_1742 st038235 4.89 28.9 µM 1.42E-5 mitochondrial stress 83 5.16E-7
20 SGTC_2290 7904846 4.83 200.0 µM 1.75E-5 10 6.80E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.478 9.36E-191 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.473 7.94E-187 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.457 1.98E-172 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.452 1.66E-168 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.449 3.46E-166 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.445 4.80E-163 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.439 2.19E-158 YEL050C RML2 hom Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
0.439 4.67E-158 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.439 5.69E-158 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.435 4.15E-155 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.425 8.99E-147 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.425 3.19E-147 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.420 9.51E-144 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.417 9.74E-142 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.417 2.93E-141 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss