YMR284W / YKU70

Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR284W / YKU70

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:-3.17|P-value:4.17E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.50|P-value:8.64E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:3.00|P-value:6.39E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.13|P-value:4.72E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:5.31|P-value:6.71E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.27|P-value:2.86E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.06|P-value:6.27E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.17|P-value:5.31E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:5.13|P-value:2.04E-8 ID:SGTC_360|Compound:0957-0399|FD-Score:3.44|P-value:1.13E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.42|P-value:1.21E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.26|P-value:2.34E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-2.98|P-value:8.60E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.03|P-value:5.67E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-2.99|P-value:8.26E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.07|P-value:6.06E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.34|P-value:1.69E-6 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.39|P-value:1.34E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:5.30|P-value:7.27E-9 ID:SGTC_1115|Compound:galangin|FD-Score:3.05|P-value:5.23E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.13|P-value:4.89E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.11|P-value:5.16E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.44|P-value:1.11E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.09|P-value:4.50E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.27|P-value:2.21E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.01|P-value:7.60E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.15|P-value:3.59E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:2.95|P-value:7.71E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.13|P-value:3.90E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.72|P-value:3.28E-5 ID:SGTC_1658|Compound:st012944|FD-Score:5.25|P-value:9.65E-9 ID:SGTC_1763|Compound:st044482|FD-Score:-2.99|P-value:8.12E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-4.85|P-value:1.48E-7 ID:SGTC_1834|Compound:st055981|FD-Score:5.35|P-value:5.19E-9 ID:SGTC_1847|Compound:st056231|FD-Score:3.46|P-value:1.03E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.69|P-value:3.79E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.15|P-value:3.51E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.20|P-value:2.95E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.76|P-value:3.57E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.39|P-value:1.34E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.87|P-value:9.21E-8 ID:SGTC_2483|Compound:5729050|FD-Score:-3.08|P-value:5.90E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.76|P-value:2.69E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.00|P-value:6.40E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-4.06|P-value:8.84E-6 ID:SGTC_2784|Compound:7567673|FD-Score:2.95|P-value:7.71E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-4.28|P-value:3.12E-6 ID:SGTC_2963|Compound:9082507|FD-Score:2.95|P-value:7.49E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.79|P-value:1.48E-7 ID:SGTC_3002|Compound:9075603|FD-Score:-3.59|P-value:7.61E-5 ID:SGTC_3008|Compound:9078912|FD-Score:4.59|P-value:4.48E-7 ID:SGTC_3010|Compound:9080089|FD-Score:7.18|P-value:8.55E-15 ID:SGTC_3108|Compound:9121785|FD-Score:-2.97|P-value:8.93E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.42|P-value:1.23E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-2.99|P-value:8.33E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.10|P-value:4.27E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.03|P-value:5.69E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:-3.17|P-value:4.17E-4 ID:SGTC_39|Compound:0986-0283|FD-Score:3.50|P-value:8.64E-5 ID:SGTC_41|Compound:0478-0632|FD-Score:3.00|P-value:6.39E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:4.13|P-value:4.72E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:5.31|P-value:6.71E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.27|P-value:2.86E-4 ID:SGTC_157|Compound:1348-1695|FD-Score:-3.06|P-value:6.27E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.17|P-value:5.31E-6 ID:SGTC_268|Compound:camptothecin|FD-Score:5.13|P-value:2.04E-8 ID:SGTC_360|Compound:0957-0399|FD-Score:3.44|P-value:1.13E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:3.44|P-value:1.09E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:3.42|P-value:1.21E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.26|P-value:2.34E-4 ID:SGTC_765|Compound:1319-0117|FD-Score:-2.98|P-value:8.60E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.03|P-value:5.67E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:-2.99|P-value:8.26E-4 ID:SGTC_956|Compound:1185-0240|FD-Score:-3.07|P-value:6.06E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:4.34|P-value:1.69E-6 ID:SGTC_1075|Compound:aripiprazole|FD-Score:3.39|P-value:1.34E-4 ID:SGTC_1079|Compound:idarubicin|FD-Score:5.30|P-value:7.27E-9 ID:SGTC_1115|Compound:galangin|FD-Score:3.05|P-value:5.23E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:-3.13|P-value:4.89E-4 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.11|P-value:5.16E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.44|P-value:1.11E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.09|P-value:4.50E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.27|P-value:2.21E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.01|P-value:7.60E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:3.15|P-value:3.59E-4 ID:SGTC_1515|Compound:3460-0031|FD-Score:2.95|P-value:7.71E-4 ID:SGTC_1522|Compound:st012842|FD-Score:3.13|P-value:3.90E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.72|P-value:3.28E-5 ID:SGTC_1658|Compound:st012944|FD-Score:5.25|P-value:9.65E-9 ID:SGTC_1763|Compound:st044482|FD-Score:-2.99|P-value:8.12E-4 ID:SGTC_1766|Compound:st045414|FD-Score:-4.85|P-value:1.48E-7 ID:SGTC_1834|Compound:st055981|FD-Score:5.35|P-value:5.19E-9 ID:SGTC_1847|Compound:st056231|FD-Score:3.46|P-value:1.03E-4 ID:SGTC_1908|Compound:st060353|FD-Score:3.69|P-value:3.79E-5 ID:SGTC_2321|Compound:7390090|FD-Score:3.15|P-value:3.51E-4 ID:SGTC_2340|Compound:7987427|FD-Score:3.20|P-value:2.95E-4 ID:SGTC_2404|Compound:5161160|FD-Score:-3.76|P-value:3.57E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.39|P-value:1.34E-4 ID:SGTC_2415|Compound:st077333|FD-Score:4.87|P-value:9.21E-8 ID:SGTC_2483|Compound:5729050|FD-Score:-3.08|P-value:5.90E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:3.76|P-value:2.69E-5 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:3.00|P-value:6.40E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-4.06|P-value:8.84E-6 ID:SGTC_2784|Compound:7567673|FD-Score:2.95|P-value:7.71E-4 ID:SGTC_2952|Compound:9073731|FD-Score:-4.28|P-value:3.12E-6 ID:SGTC_2963|Compound:9082507|FD-Score:2.95|P-value:7.49E-4 ID:SGTC_2998|Compound:9066762|FD-Score:4.79|P-value:1.48E-7 ID:SGTC_3002|Compound:9075603|FD-Score:-3.59|P-value:7.61E-5 ID:SGTC_3008|Compound:9078912|FD-Score:4.59|P-value:4.48E-7 ID:SGTC_3010|Compound:9080089|FD-Score:7.18|P-value:8.55E-15 ID:SGTC_3108|Compound:9121785|FD-Score:-2.97|P-value:8.93E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.42|P-value:1.23E-4 ID:SGTC_3280|Compound:9140961|FD-Score:-2.99|P-value:8.33E-4 ID:SGTC_3282|Compound:9108498|FD-Score:3.10|P-value:4.27E-4 ID:SGTC_3320|Compound:9137005|FD-Score:3.03|P-value:5.69E-4

Top fitness defect scores for YMR284W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3010 9080089 7.18 71.4 µM 8.55E-15 2 3.53E-13
2 SGTC_1834 st055981 5.35 52.8 µM 5.19E-9 RPP1 & pyrimidine depletion 10 4.42E-8
3 SGTC_58 0957-0393 5.31 9.0 µM 6.71E-9 cell wall 254 5.54E-8
4 SGTC_1079 idarubicin 5.30 2.4 µM 7.27E-9 DNA damage response 10 5.95E-8
5 SGTC_1658 st012944 5.25 20.0 µM 9.65E-9 iron homeostasis 42 7.63E-8
6 SGTC_268 camptothecin 5.13 39.6 µM 2.04E-8 DNA damage response 44 1.48E-7
7 SGTC_2415 st077333 4.87 57.7 µM 9.21E-8 21 5.57E-7
8 SGTC_2998 9066762 4.79 71.4 µM 1.48E-7 RPP1 & pyrimidine depletion 10 8.47E-7
9 SGTC_3008 9078912 4.59 71.4 µM 4.48E-7 5 2.25E-6
10 SGTC_965 1291-5240 4.34 308.0 µM 1.69E-6 23 7.26E-6
11 SGTC_42 0133-0086 4.13 60.6 µM 4.72E-6 27 1.80E-5
12 SGTC_2619 obliquin 3.76 87.9 µM 2.69E-5 cell wall 154 8.33E-5
13 SGTC_1657 st012939 3.72 43.4 µM 3.28E-5 15 9.92E-5
14 SGTC_1908 st060353 3.69 56.5 µM 3.79E-5 RPP1 & pyrimidine depletion 46 1.13E-4
15 SGTC_39 0986-0283 3.50 58.4 µM 8.64E-5 calcium & mitochondrial duress 52 2.33E-4
16 SGTC_1847 st056231 3.46 15.0 µM 1.03E-4 50 2.73E-4
17 SGTC_368 fentichlor 3.44 4.6 µM 1.09E-4 40 2.87E-4
18 SGTC_1134 3477-0009 3.44 42.5 µM 1.11E-4 64 2.91E-4
19 SGTC_360 0957-0399 3.44 1.0 µM 1.13E-4 cell wall 69 2.96E-4
20 SGTC_372 0155-0182 3.42 15.9 µM 1.21E-4 mitochondrial response to ROS 45 3.15E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 3.39E-22 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.149 4.75E-18 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.140 3.50E-16 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.134 7.68E-15 YCR043C_p YCR043C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene
0.130 4.45E-14 YMR152W YIM1 hom Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress
0.129 7.31E-14 YDR075W PPH3 hom Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes
0.126 2.13E-13 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.125 4.30E-13 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.123 7.83E-13 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.121 1.77E-12 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.119 5.10E-12 YDL174C DLD1 hom D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.118 6.32E-12 YGR058W PEF1 hom Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2; binds to Sec31p and modulates COPII coat assembly
0.118 8.41E-12 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.117 1.02E-11 YIL160C POT1 hom 3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids
0.115 2.63E-11 YBR292C_d YBR292C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene