YMR286W / MRPL33

Mitochondrial ribosomal protein of the large subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR286W / MRPL33

Click on Significant Values for Screen Details ID:SGTC_59|Compound:0330-0160|FD-Score:5.84|P-value:8.45E-9 ID:SGTC_63|Compound:0099-0242|FD-Score:4.81|P-value:1.62E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.06|P-value:4.26E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:3.41|P-value:4.76E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.36|P-value:1.24E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.98|P-value:7.37E-7 ID:SGTC_144|Compound:4161-2749|FD-Score:5.48|P-value:6.06E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:5.70|P-value:1.81E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.49|P-value:9.55E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:4.19|P-value:2.50E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:31.50|P-value:7.87E-202 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.48|P-value:6.05E-8 ID:SGTC_279|Compound:1273-0055|FD-Score:3.68|P-value:1.80E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.44|P-value:5.38E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.40|P-value:6.29E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.82|P-value:2.28E-11 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.51|P-value:4.29E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.60|P-value:2.44E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:10.10|P-value:9.44E-23 ID:SGTC_496|Compound:calpeptin|FD-Score:3.44|P-value:4.22E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.76|P-value:1.31E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.27|P-value:7.46E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.04|P-value:6.06E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.82|P-value:1.41E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.43|P-value:4.37E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.48|P-value:3.73E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:5.51|P-value:4.99E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:6.71|P-value:4.65E-11 ID:SGTC_933|Compound:2914-0560|FD-Score:3.28|P-value:7.30E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.86|P-value:7.41E-9 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.79|P-value:1.20E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.02|P-value:5.98E-7 ID:SGTC_1422|Compound:4031-0024|FD-Score:-3.33|P-value:7.78E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.21|P-value:9.05E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.01|P-value:5.12E-5 ID:SGTC_1635|Compound:st007035|FD-Score:5.00|P-value:6.79E-7 ID:SGTC_1668|Compound:st014914|FD-Score:3.34|P-value:5.86E-4 ID:SGTC_1732|Compound:st034308|FD-Score:4.15|P-value:2.97E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.59|P-value:3.38E-8 ID:SGTC_2081|Compound:5214970|FD-Score:3.39|P-value:5.07E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.79|P-value:2.93E-14 ID:SGTC_2460|Compound:5552655|FD-Score:7.82|P-value:2.39E-14 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.48|P-value:3.70E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.46|P-value:3.89E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.59|P-value:3.25E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-3.58|P-value:3.36E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.97|P-value:1.12E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.75|P-value:1.80E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.21|P-value:9.17E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.36|P-value:7.18E-4 ID:SGTC_3004|Compound:9076122|FD-Score:-3.31|P-value:8.48E-4 ID:SGTC_3211|Compound:9128781|FD-Score:11.60|P-value:2.69E-29 ID:SGTC_3274|Compound:9138298|FD-Score:3.41|P-value:4.65E-4 ID:SGTC_59|Compound:0330-0160|FD-Score:5.84|P-value:8.45E-9 ID:SGTC_63|Compound:0099-0242|FD-Score:4.81|P-value:1.62E-6 ID:SGTC_70|Compound:0141-0289|FD-Score:4.06|P-value:4.26E-5 ID:SGTC_131|Compound:0141-0277|FD-Score:3.41|P-value:4.76E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:4.36|P-value:1.24E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:4.98|P-value:7.37E-7 ID:SGTC_144|Compound:4161-2749|FD-Score:5.48|P-value:6.06E-8 ID:SGTC_145|Compound:3737-0113|FD-Score:5.70|P-value:1.81E-8 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.49|P-value:9.55E-6 ID:SGTC_184|Compound:1494-0393|FD-Score:4.19|P-value:2.50E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:31.50|P-value:7.87E-202 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.48|P-value:6.05E-8 ID:SGTC_279|Compound:1273-0055|FD-Score:3.68|P-value:1.80E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.44|P-value:5.38E-4 ID:SGTC_309|Compound:k408-0051|FD-Score:-3.40|P-value:6.29E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:6.82|P-value:2.28E-11 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.51|P-value:4.29E-4 ID:SGTC_365|Compound:0121-0052|FD-Score:3.60|P-value:2.44E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:10.10|P-value:9.44E-23 ID:SGTC_496|Compound:calpeptin|FD-Score:3.44|P-value:4.22E-4 ID:SGTC_503|Compound:tyrphostin 8|FD-Score:3.76|P-value:1.31E-4 ID:SGTC_530|Compound:4358-1714|FD-Score:3.27|P-value:7.46E-4 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.04|P-value:6.06E-5 ID:SGTC_562|Compound:3772-2733|FD-Score:-3.82|P-value:1.41E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:3.43|P-value:4.37E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:3.48|P-value:3.73E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:5.51|P-value:4.99E-8 ID:SGTC_908|Compound:3448-7491|FD-Score:6.71|P-value:4.65E-11 ID:SGTC_933|Compound:2914-0560|FD-Score:3.28|P-value:7.30E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:5.86|P-value:7.41E-9 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.79|P-value:1.20E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:5.02|P-value:5.98E-7 ID:SGTC_1422|Compound:4031-0024|FD-Score:-3.33|P-value:7.78E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.21|P-value:9.05E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.01|P-value:5.12E-5 ID:SGTC_1635|Compound:st007035|FD-Score:5.00|P-value:6.79E-7 ID:SGTC_1668|Compound:st014914|FD-Score:3.34|P-value:5.86E-4 ID:SGTC_1732|Compound:st034308|FD-Score:4.15|P-value:2.97E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.59|P-value:3.38E-8 ID:SGTC_2081|Compound:5214970|FD-Score:3.39|P-value:5.07E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.79|P-value:2.93E-14 ID:SGTC_2460|Compound:5552655|FD-Score:7.82|P-value:2.39E-14 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:3.48|P-value:3.70E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.46|P-value:3.89E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.59|P-value:3.25E-4 ID:SGTC_2710|Compound:st078562|FD-Score:-3.58|P-value:3.36E-4 ID:SGTC_2777|Compound:climbazole|FD-Score:-4.97|P-value:1.12E-6 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.75|P-value:1.80E-4 ID:SGTC_2852|Compound:9023854|FD-Score:3.21|P-value:9.17E-4 ID:SGTC_2867|Compound:9039098|FD-Score:-3.36|P-value:7.18E-4 ID:SGTC_3004|Compound:9076122|FD-Score:-3.31|P-value:8.48E-4 ID:SGTC_3211|Compound:9128781|FD-Score:11.60|P-value:2.69E-29 ID:SGTC_3274|Compound:9138298|FD-Score:3.41|P-value:4.65E-4

Top fitness defect scores for YMR286W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 31.50 5.3 µM 7.87E-202 11 2.17E-218
2 SGTC_3211 9128781 11.60 49.5 µM 2.69E-29 4 1.91E-31
3 SGTC_386 1509-0011 10.10 3.1 µM 9.44E-23 44 2.28E-24
4 SGTC_2460 5552655 7.82 174.2 µM 2.39E-14 amide catabolism 5 2.72E-15
5 SGTC_2250 alverine citrate 7.79 130.0 µM 2.93E-14 22 3.39E-15
6 SGTC_310 1273-0058 6.82 1.1 µM 2.28E-11 mitochondrial stress 122 4.45E-12
7 SGTC_908 3448-7491 6.71 47.7 µM 4.65E-11 mitochondrial stress 33 9.60E-12
8 SGTC_1188 1403-0014 5.86 4.6 µM 7.41E-9 mitochondrial stress 17 2.27E-9
9 SGTC_59 0330-0160 5.84 1.3 µM 8.45E-9 40 2.61E-9
10 SGTC_145 3737-0113 5.70 38.4 µM 1.81E-8 DNA intercalators 30 5.92E-9
11 SGTC_1926 methyl fluorone black 5.59 53.6 µM 3.38E-8 DNA intercalators 24 1.16E-8
12 SGTC_852 0418-0143 5.51 439.0 µM 4.99E-8 calcium & mitochondrial duress 33 1.76E-8
13 SGTC_275 trichlorophene 5.48 5.7 µM 6.05E-8 mitochondrial stress 139 2.17E-8
14 SGTC_144 4161-2749 5.48 112.4 µM 6.06E-8 DNA intercalators 7 2.17E-8
15 SGTC_1371 2421-0008 5.02 32.7 µM 5.98E-7 mitochondrial processes 14 2.55E-7
16 SGTC_1635 st007035 5.00 42.4 µM 6.79E-7 169 2.92E-7
17 SGTC_143 4032-1194 4.98 15.7 µM 7.37E-7 31 3.19E-7
18 SGTC_63 0099-0242 4.81 26.7 µM 1.62E-6 mitochondrial stress 63 7.44E-7
19 SGTC_134 0269-0018 4.36 6.9 µM 1.24E-5 116 6.60E-6
20 SGTC_184 1494-0393 4.19 24.7 µM 2.50E-5 51 1.40E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.675 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.618 0 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.618 0 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.603 0 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.595 2.55E-320 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase
0.593 6.23E-318 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.591 5.61E-315 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.588 3.36E-310 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.578 2.26E-298 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.573 1.09E-291 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.569 2.63E-286 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.564 1.00E-279 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.561 3.81E-277 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.557 7.18E-273 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.550 2.47E-264 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme