YMR287C / DSS1

3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR287C / DSS1

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:6.57|P-value:8.14E-9 ID:SGTC_19|Compound:0279-0214|FD-Score:5.31|P-value:2.36E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.66|P-value:2.94E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:6.87|P-value:1.75E-9 ID:SGTC_66|Compound:0109-0187|FD-Score:3.94|P-value:3.37E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:6.80|P-value:2.47E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:5.80|P-value:3.00E-7 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.50|P-value:1.54E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:16.60|P-value:5.47E-46 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.79|P-value:6.63E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:26.40|P-value:7.41E-114 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.98|P-value:1.33E-7 ID:SGTC_283|Compound:0987-0079|FD-Score:4.48|P-value:5.60E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:13.50|P-value:4.49E-31 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.69|P-value:3.48E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-7.56|P-value:6.48E-11 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.90|P-value:1.61E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:3.95|P-value:3.20E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.81|P-value:5.06E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.96|P-value:3.16E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.62|P-value:8.85E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:5.78|P-value:3.28E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:8.11|P-value:1.67E-12 ID:SGTC_876|Compound:0720-0963|FD-Score:4.13|P-value:1.80E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.28|P-value:1.12E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.69|P-value:7.17E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.36|P-value:8.52E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.81|P-value:5.01E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.03|P-value:3.21E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.80|P-value:5.18E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.74|P-value:7.68E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.32|P-value:9.69E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.18|P-value:5.52E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:5.68|P-value:5.00E-7 ID:SGTC_1963|Compound:st076565|FD-Score:3.63|P-value:8.43E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.70|P-value:4.54E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-4.11|P-value:2.52E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.29|P-value:1.06E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-5.49|P-value:1.57E-6 ID:SGTC_2485|Compound:5633444|FD-Score:-3.66|P-value:9.85E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.43|P-value:8.73E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.92|P-value:3.51E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.66|P-value:9.73E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:-4.69|P-value:3.46E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:-4.47|P-value:7.52E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-5.92|P-value:2.48E-7 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.82|P-value:4.87E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.84|P-value:4.59E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-8.35|P-value:5.91E-13 ID:SGTC_3140|Compound:9094243|FD-Score:3.65|P-value:8.08E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.70|P-value:8.84E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:6.57|P-value:8.14E-9 ID:SGTC_19|Compound:0279-0214|FD-Score:5.31|P-value:2.36E-6 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.66|P-value:2.94E-5 ID:SGTC_63|Compound:0099-0242|FD-Score:6.87|P-value:1.75E-9 ID:SGTC_66|Compound:0109-0187|FD-Score:3.94|P-value:3.37E-4 ID:SGTC_68|Compound:0986-0284|FD-Score:6.80|P-value:2.47E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:5.80|P-value:3.00E-7 ID:SGTC_151|Compound:3013-0144|FD-Score:-5.50|P-value:1.54E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:16.60|P-value:5.47E-46 ID:SGTC_178|Compound:4092-0806|FD-Score:-3.79|P-value:6.63E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:26.40|P-value:7.41E-114 ID:SGTC_275|Compound:trichlorophene|FD-Score:5.98|P-value:1.33E-7 ID:SGTC_283|Compound:0987-0079|FD-Score:4.48|P-value:5.60E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:13.50|P-value:4.49E-31 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.69|P-value:3.48E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-7.56|P-value:6.48E-11 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.90|P-value:1.61E-5 ID:SGTC_532|Compound:1548-0774|FD-Score:3.95|P-value:3.20E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.81|P-value:5.06E-4 ID:SGTC_630|Compound:4356-0227|FD-Score:3.96|P-value:3.16E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.62|P-value:8.85E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:5.78|P-value:3.28E-7 ID:SGTC_832|Compound:4083-0019|FD-Score:8.11|P-value:1.67E-12 ID:SGTC_876|Compound:0720-0963|FD-Score:4.13|P-value:1.80E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:4.28|P-value:1.12E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.69|P-value:7.17E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:4.36|P-value:8.52E-5 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.81|P-value:5.01E-4 ID:SGTC_1556|Compound:plumbagin|FD-Score:-4.03|P-value:3.21E-4 ID:SGTC_1623|Compound:st003709|FD-Score:3.80|P-value:5.18E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.74|P-value:7.68E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.32|P-value:9.69E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.18|P-value:5.52E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:5.68|P-value:5.00E-7 ID:SGTC_1963|Compound:st076565|FD-Score:3.63|P-value:8.43E-4 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:5.70|P-value:4.54E-7 ID:SGTC_2021|Compound:4019055|FD-Score:-4.11|P-value:2.52E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.29|P-value:1.06E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-5.49|P-value:1.57E-6 ID:SGTC_2485|Compound:5633444|FD-Score:-3.66|P-value:9.85E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-4.43|P-value:8.73E-5 ID:SGTC_2533|Compound:agelasine|FD-Score:3.92|P-value:3.51E-4 ID:SGTC_2534|Compound:helenine|FD-Score:-3.66|P-value:9.73E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:-4.69|P-value:3.46E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:-4.47|P-value:7.52E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:-5.92|P-value:2.48E-7 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:3.82|P-value:4.87E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.84|P-value:4.59E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-8.35|P-value:5.91E-13 ID:SGTC_3140|Compound:9094243|FD-Score:3.65|P-value:8.08E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-3.70|P-value:8.84E-4

Top fitness defect scores for YMR287C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 26.40 5.3 µM 7.41E-114 27 1.84E-154
2 SGTC_173 1273-0061 16.60 2.7 µM 5.47E-46 mitochondrial stress 5 7.34E-62
3 SGTC_310 1273-0058 13.50 1.1 µM 4.49E-31 mitochondrial stress 16 1.52E-41
4 SGTC_832 4083-0019 8.11 164.0 µM 1.67E-12 translation 8 2.63E-16
5 SGTC_63 0099-0242 6.87 26.7 µM 1.75E-9 mitochondrial stress 19 3.23E-12
6 SGTC_68 0986-0284 6.80 82.8 µM 2.47E-9 12 5.12E-12
7 SGTC_10 0279-0212 6.57 42.6 µM 8.14E-9 TRP & mitochondrial translation 22 2.57E-11
8 SGTC_275 trichlorophene 5.98 5.7 µM 1.33E-7 mitochondrial stress 122 1.12E-9
9 SGTC_70 0141-0289 5.80 43.3 µM 3.00E-7 mitochondrial stress 88 3.33E-9
10 SGTC_831 k061-1017 5.78 217.0 µM 3.28E-7 translation 13 3.76E-9
11 SGTC_1965 Pectolinarigenin 5.70 58.4 µM 4.54E-7 RPP1 & pyrimidine depletion 1 5.82E-9
12 SGTC_1955 wogonin 5.68 32.4 µM 5.00E-7 5 6.63E-9
13 SGTC_19 0279-0214 5.31 38.4 µM 2.36E-6 TRP & mitochondrial translation 16 5.33E-8
14 SGTC_28 pentachloropyridine N-oxide 4.66 1.6 µM 2.94E-5 TSC3-RPN4 38 1.58E-6
15 SGTC_283 0987-0079 4.48 11.7 µM 5.60E-5 13 3.74E-6
16 SGTC_1154 4088-0362 4.36 150.0 µM 8.52E-5 12 6.55E-6
17 SGTC_1742 st038235 4.32 28.9 µM 9.69E-5 mitochondrial stress 102 7.78E-6
18 SGTC_2250 alverine citrate 4.29 130.0 µM 1.06E-4 134 8.76E-6
19 SGTC_879 0831-1030 4.28 162.0 µM 1.12E-4 35 9.45E-6
20 SGTC_876 0720-0963 4.13 56.8 µM 1.80E-4 11 1.78E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.561 1.69E-276 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.561 4.40E-276 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.536 1.40E-247 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.534 3.09E-245 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.525 3.05E-236 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.519 4.11E-230 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.516 3.85E-227 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.515 1.14E-225 YMR072W ABF2 hom Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation
0.511 8.82E-222 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.510 1.52E-220 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.507 8.03E-217 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene
0.504 6.04E-215 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.504 1.27E-214 YDR268W MSW1 hom Mitochondrial tryptophanyl-tRNA synthetase
0.502 2.12E-212 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.501 8.87E-212 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress