YMR289W / ABZ2

Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR289W / ABZ2

Click on Significant Values for Screen Details ID:SGTC_44|Compound:0929-0055|FD-Score:3.77|P-value:1.41E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.89|P-value:9.09E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.69|P-value:3.15E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:5.62|P-value:3.02E-8 ID:SGTC_144|Compound:4161-2749|FD-Score:9.17|P-value:4.55E-19 ID:SGTC_145|Compound:3737-0113|FD-Score:11.90|P-value:7.98E-31 ID:SGTC_166|Compound:k072-0058|FD-Score:5.22|P-value:2.47E-7 ID:SGTC_202|Compound:3594-0513|FD-Score:3.23|P-value:9.58E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.39|P-value:1.20E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.69|P-value:1.89E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.66|P-value:2.15E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.92|P-value:8.07E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:8.78|P-value:1.22E-17 ID:SGTC_264|Compound:promethazine|FD-Score:20.10|P-value:7.37E-84 ID:SGTC_277|Compound:nystatin|FD-Score:3.49|P-value:3.98E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:4.63|P-value:4.09E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.41|P-value:5.09E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.55|P-value:3.18E-4 ID:SGTC_470|Compound:aa-861|FD-Score:4.54|P-value:6.19E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.89|P-value:1.24E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:3.68|P-value:2.02E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.20|P-value:2.63E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.41|P-value:4.71E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.19|P-value:2.71E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.68|P-value:1.79E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:5.28|P-value:1.86E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.15|P-value:3.58E-7 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.55|P-value:3.13E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.73|P-value:1.66E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:5.04|P-value:6.05E-7 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.99|P-value:6.21E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:5.65|P-value:2.66E-8 ID:SGTC_1515|Compound:3460-0031|FD-Score:5.16|P-value:3.31E-7 ID:SGTC_1519|Compound:esterone|FD-Score:6.17|P-value:1.38E-9 ID:SGTC_1529|Compound:apigenin|FD-Score:4.26|P-value:2.09E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.63|P-value:2.42E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.79|P-value:1.30E-4 ID:SGTC_1612|Compound:st002233|FD-Score:5.96|P-value:4.61E-9 ID:SGTC_1613|Compound:st002381|FD-Score:5.07|P-value:5.27E-7 ID:SGTC_1614|Compound:st002383|FD-Score:3.78|P-value:1.39E-4 ID:SGTC_1615|Compound:st002656|FD-Score:4.30|P-value:1.75E-5 ID:SGTC_1652|Compound:st011932|FD-Score:-4.39|P-value:1.05E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.17|P-value:3.18E-7 ID:SGTC_1984|Compound:st072354|FD-Score:4.46|P-value:8.85E-6 ID:SGTC_1998|Compound:st075797|FD-Score:-3.55|P-value:2.90E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.63|P-value:2.41E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-3.48|P-value:3.68E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-4.97|P-value:7.65E-7 ID:SGTC_2335|Compound:9018011|FD-Score:-3.84|P-value:1.01E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.78|P-value:1.23E-4 ID:SGTC_2442|Compound:5158906|FD-Score:4.09|P-value:4.10E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.42|P-value:4.91E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.55|P-value:5.77E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.51|P-value:3.32E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.77|P-value:1.40E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.62|P-value:2.43E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-3.21|P-value:9.23E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.31|P-value:7.18E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-4.03|P-value:4.72E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-4.34|P-value:1.29E-5 ID:SGTC_2968|Compound:9090663|FD-Score:-3.20|P-value:9.62E-4 ID:SGTC_3040|Compound:9091894|FD-Score:5.16|P-value:3.29E-7 ID:SGTC_3048|Compound:9093155|FD-Score:-3.57|P-value:2.71E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.28|P-value:8.05E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-5.35|P-value:1.13E-7 ID:SGTC_3123|Compound:9126162|FD-Score:3.64|P-value:2.33E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.84|P-value:9.98E-5 ID:SGTC_3159|Compound:9100096|FD-Score:4.28|P-value:1.88E-5 ID:SGTC_3310|Compound:9130229|FD-Score:4.93|P-value:1.04E-6 ID:SGTC_44|Compound:0929-0055|FD-Score:3.77|P-value:1.41E-4 ID:SGTC_62|Compound:0180-0423|FD-Score:3.89|P-value:9.09E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:4.69|P-value:3.15E-6 ID:SGTC_143|Compound:4032-1194|FD-Score:5.62|P-value:3.02E-8 ID:SGTC_144|Compound:4161-2749|FD-Score:9.17|P-value:4.55E-19 ID:SGTC_145|Compound:3737-0113|FD-Score:11.90|P-value:7.98E-31 ID:SGTC_166|Compound:k072-0058|FD-Score:5.22|P-value:2.47E-7 ID:SGTC_202|Compound:3594-0513|FD-Score:3.23|P-value:9.58E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:4.39|P-value:1.20E-5 ID:SGTC_230|Compound:MPP+|FD-Score:3.69|P-value:1.89E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:3.66|P-value:2.15E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.92|P-value:8.07E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:8.78|P-value:1.22E-17 ID:SGTC_264|Compound:promethazine|FD-Score:20.10|P-value:7.37E-84 ID:SGTC_277|Compound:nystatin|FD-Score:3.49|P-value:3.98E-4 ID:SGTC_323|Compound:4013-0906|FD-Score:4.63|P-value:4.09E-6 ID:SGTC_407|Compound:eburnamonine|FD-Score:3.41|P-value:5.09E-4 ID:SGTC_427|Compound:1354-0053|FD-Score:3.55|P-value:3.18E-4 ID:SGTC_470|Compound:aa-861|FD-Score:4.54|P-value:6.19E-6 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.89|P-value:1.24E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:3.68|P-value:2.02E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:4.20|P-value:2.63E-5 ID:SGTC_1059|Compound:3448-6867|FD-Score:-3.41|P-value:4.71E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.19|P-value:2.71E-5 ID:SGTC_1247|Compound:0448-0043|FD-Score:-3.68|P-value:1.79E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:5.28|P-value:1.86E-7 ID:SGTC_1468|Compound:k284-1086|FD-Score:5.15|P-value:3.58E-7 ID:SGTC_1475|Compound:4092-1048|FD-Score:3.55|P-value:3.13E-4 ID:SGTC_1484|Compound:3473-2379|FD-Score:3.73|P-value:1.66E-4 ID:SGTC_1487|Compound:3970-0795|FD-Score:5.04|P-value:6.05E-7 ID:SGTC_1493|Compound:4348-0038|FD-Score:3.99|P-value:6.21E-5 ID:SGTC_1494|Compound:4358-1428|FD-Score:5.65|P-value:2.66E-8 ID:SGTC_1515|Compound:3460-0031|FD-Score:5.16|P-value:3.31E-7 ID:SGTC_1519|Compound:esterone|FD-Score:6.17|P-value:1.38E-9 ID:SGTC_1529|Compound:apigenin|FD-Score:4.26|P-value:2.09E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.63|P-value:2.42E-4 ID:SGTC_1609|Compound:st001574|FD-Score:3.79|P-value:1.30E-4 ID:SGTC_1612|Compound:st002233|FD-Score:5.96|P-value:4.61E-9 ID:SGTC_1613|Compound:st002381|FD-Score:5.07|P-value:5.27E-7 ID:SGTC_1614|Compound:st002383|FD-Score:3.78|P-value:1.39E-4 ID:SGTC_1615|Compound:st002656|FD-Score:4.30|P-value:1.75E-5 ID:SGTC_1652|Compound:st011932|FD-Score:-4.39|P-value:1.05E-5 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:5.17|P-value:3.18E-7 ID:SGTC_1984|Compound:st072354|FD-Score:4.46|P-value:8.85E-6 ID:SGTC_1998|Compound:st075797|FD-Score:-3.55|P-value:2.90E-4 ID:SGTC_2071|Compound:5230951|FD-Score:3.63|P-value:2.41E-4 ID:SGTC_2175|Compound:5807670|FD-Score:-3.48|P-value:3.68E-4 ID:SGTC_2331|Compound:7980721|FD-Score:-4.97|P-value:7.65E-7 ID:SGTC_2335|Compound:9018011|FD-Score:-3.84|P-value:1.01E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-3.78|P-value:1.23E-4 ID:SGTC_2442|Compound:5158906|FD-Score:4.09|P-value:4.10E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.42|P-value:4.91E-4 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:4.55|P-value:5.77E-6 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.51|P-value:3.32E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:3.77|P-value:1.40E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:3.62|P-value:2.43E-4 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:-3.21|P-value:9.23E-4 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:3.31|P-value:7.18E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-4.03|P-value:4.72E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-4.34|P-value:1.29E-5 ID:SGTC_2968|Compound:9090663|FD-Score:-3.20|P-value:9.62E-4 ID:SGTC_3040|Compound:9091894|FD-Score:5.16|P-value:3.29E-7 ID:SGTC_3048|Compound:9093155|FD-Score:-3.57|P-value:2.71E-4 ID:SGTC_3066|Compound:9117245|FD-Score:3.28|P-value:8.05E-4 ID:SGTC_3073|Compound:9114972|FD-Score:-5.35|P-value:1.13E-7 ID:SGTC_3123|Compound:9126162|FD-Score:3.64|P-value:2.33E-4 ID:SGTC_3149|Compound:9097855|FD-Score:-3.84|P-value:9.98E-5 ID:SGTC_3159|Compound:9100096|FD-Score:4.28|P-value:1.88E-5 ID:SGTC_3310|Compound:9130229|FD-Score:4.93|P-value:1.04E-6

Top fitness defect scores for YMR289W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_264 promethazine 20.10 12.5 mM 7.37E-84 DNA intercalators 4 7.41E-90
2 SGTC_145 3737-0113 11.90 38.4 µM 7.98E-31 DNA intercalators 4 5.73E-33
3 SGTC_144 4161-2749 9.17 112.4 µM 4.55E-19 DNA intercalators 4 2.34E-20
4 SGTC_257 daunorubicin 8.78 18.5 µM 1.22E-17 anthracycline transcription coupled DNA repair 5 7.96E-19
5 SGTC_1519 esterone 6.17 74.0 µM 1.38E-9 DNA intercalators 4 3.46E-10
6 SGTC_1612 st002233 5.96 45.4 µM 4.61E-9 2 1.26E-9
7 SGTC_1494 4358-1428 5.65 177.0 µM 2.66E-8 7 8.23E-9
8 SGTC_143 4032-1194 5.62 15.7 µM 3.02E-8 21 9.44E-9
9 SGTC_1290 0986-0249 5.28 10.2 µM 1.86E-7 DNA intercalators 8 6.64E-8
10 SGTC_166 k072-0058 5.22 166.4 µM 2.47E-7 DNA intercalators 11 8.97E-8
11 SGTC_1926 methyl fluorone black 5.17 53.6 µM 3.18E-7 DNA intercalators 32 1.18E-7
12 SGTC_3040 9091894 5.16 49.5 µM 3.29E-7 DNA intercalators 10 1.22E-7
13 SGTC_1515 3460-0031 5.16 42.1 µM 3.31E-7 DNA intercalators 4 1.23E-7
14 SGTC_1468 k284-1086 5.15 134.0 µM 3.58E-7 DNA intercalators 11 1.34E-7
15 SGTC_1613 st002381 5.07 52.1 µM 5.27E-7 8 2.03E-7
16 SGTC_1487 3970-0795 5.04 2.8 µM 6.05E-7 DNA intercalators 2 2.35E-7
17 SGTC_3310 9130229 4.93 44.1 µM 1.04E-6 Golgi 8 4.19E-7
18 SGTC_471 1-acyl-paf 4.89 4.0 µM 1.24E-6 DNA intercalators 15 5.06E-7
19 SGTC_77 0828-0286 4.69 12.5 µM 3.15E-6 TSC3-RPN4 16 1.38E-6
20 SGTC_323 4013-0906 4.63 34.3 µM 4.09E-6 ERG2 5 1.82E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.620 0 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.619 0 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.570 2.24E-287 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.506 3.34E-217 YOR133W EFT1 hom Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin; EFT1 has a paralog, EFT2, that arose from the whole genome duplication
0.505 5.11E-216 YDL223C HBT1 hom Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis
0.500 3.29E-211 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.389 1.83E-121 YGR065C VHT1 het High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin
0.388 7.22E-121 YPL157W TGS1 hom Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs
0.385 1.37E-118 YJL025W RRN7 het Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p
0.378 5.03E-114 YEL032W MCM3 het Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex
0.371 2.06E-109 YGL041C_d YGL041C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.358 6.52E-102 YGL200C EMP24 hom Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles
0.344 8.07E-94 YMR262W_p YMR262W_p hom Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene
0.331 4.90E-86 YHR037W PUT2 hom Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism
0.312 1.43E-76 YHR172W SPC97 het Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque