YMR290C / HAS1

ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR290C / HAS1

Click on Significant Values for Screen Details ID:SGTC_19|Compound:0279-0214|FD-Score:2.92|P-value:7.61E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:4.88|P-value:5.12E-8 ID:SGTC_74|Compound:000s-0487|FD-Score:3.00|P-value:5.61E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.57|P-value:4.26E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:3.81|P-value:1.63E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.65|P-value:3.48E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:3.81|P-value:1.69E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:2.91|P-value:7.77E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.07|P-value:4.21E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.61|P-value:4.14E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.06|P-value:4.29E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:2.94|P-value:7.04E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.15|P-value:3.08E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.26|P-value:1.64E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.84|P-value:8.79E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.11|P-value:3.06E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:2.88|P-value:8.66E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.94|P-value:5.97E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.37|P-value:1.20E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.79|P-value:1.87E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:2.94|P-value:6.87E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.08|P-value:3.41E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:2.87|P-value:9.16E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:2.97|P-value:6.30E-4 ID:SGTC_1624|Compound:st003710|FD-Score:2.93|P-value:7.14E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.76|P-value:2.16E-5 ID:SGTC_1727|Compound:st034309|FD-Score:2.93|P-value:7.09E-4 ID:SGTC_1791|Compound:st048313|FD-Score:-3.23|P-value:1.91E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.00|P-value:4.77E-4 ID:SGTC_1828|Compound:st055811|FD-Score:4.48|P-value:5.30E-7 ID:SGTC_1830|Compound:st055982|FD-Score:3.75|P-value:2.25E-5 ID:SGTC_1942|Compound:st076330|FD-Score:-2.84|P-value:8.76E-4 ID:SGTC_1979|Compound:st071809|FD-Score:-2.90|P-value:7.06E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-2.99|P-value:4.93E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-3.15|P-value:2.64E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.19|P-value:2.17E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:6.28|P-value:3.68E-12 ID:SGTC_2414|Compound:st077232|FD-Score:-4.27|P-value:1.31E-6 ID:SGTC_2465|Compound:5809242|FD-Score:-2.88|P-value:7.65E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-2.85|P-value:8.46E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.34|P-value:1.38E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.18|P-value:2.67E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.04|P-value:4.80E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.83|P-value:1.51E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.45|P-value:7.45E-5 ID:SGTC_3312|Compound:9133330|FD-Score:-2.86|P-value:8.25E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-3.38|P-value:1.01E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.09|P-value:3.85E-4 ID:SGTC_19|Compound:0279-0214|FD-Score:2.92|P-value:7.61E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:4.88|P-value:5.12E-8 ID:SGTC_74|Compound:000s-0487|FD-Score:3.00|P-value:5.61E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:-3.57|P-value:4.26E-5 ID:SGTC_172|Compound:1112-0046|FD-Score:3.81|P-value:1.63E-5 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.65|P-value:3.48E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:3.81|P-value:1.69E-5 ID:SGTC_548|Compound:1436-0017|FD-Score:2.91|P-value:7.77E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.07|P-value:4.21E-4 ID:SGTC_598|Compound:3937-0236|FD-Score:3.61|P-value:4.14E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.06|P-value:4.29E-4 ID:SGTC_686|Compound:1319-0111|FD-Score:2.94|P-value:7.04E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:3.15|P-value:3.08E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:-3.26|P-value:1.64E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-2.84|P-value:8.79E-4 ID:SGTC_883|Compound:0850-0245|FD-Score:-3.11|P-value:3.06E-4 ID:SGTC_1047|Compound:2043-3044|FD-Score:2.88|P-value:8.66E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-2.94|P-value:5.97E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.37|P-value:1.20E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.79|P-value:1.87E-5 ID:SGTC_1145|Compound:3546-0597|FD-Score:2.94|P-value:6.87E-4 ID:SGTC_1180|Compound:1193-0155|FD-Score:-3.08|P-value:3.41E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:2.87|P-value:9.16E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:2.97|P-value:6.30E-4 ID:SGTC_1624|Compound:st003710|FD-Score:2.93|P-value:7.14E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.76|P-value:2.16E-5 ID:SGTC_1727|Compound:st034309|FD-Score:2.93|P-value:7.09E-4 ID:SGTC_1791|Compound:st048313|FD-Score:-3.23|P-value:1.91E-4 ID:SGTC_1821|Compound:st053465|FD-Score:-3.00|P-value:4.77E-4 ID:SGTC_1828|Compound:st055811|FD-Score:4.48|P-value:5.30E-7 ID:SGTC_1830|Compound:st055982|FD-Score:3.75|P-value:2.25E-5 ID:SGTC_1942|Compound:st076330|FD-Score:-2.84|P-value:8.76E-4 ID:SGTC_1979|Compound:st071809|FD-Score:-2.90|P-value:7.06E-4 ID:SGTC_2031|Compound:5180455|FD-Score:-2.99|P-value:4.93E-4 ID:SGTC_2163|Compound:5671233|FD-Score:-3.15|P-value:2.64E-4 ID:SGTC_2337|Compound:9009472|FD-Score:-3.19|P-value:2.17E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:6.28|P-value:3.68E-12 ID:SGTC_2414|Compound:st077232|FD-Score:-4.27|P-value:1.31E-6 ID:SGTC_2465|Compound:5809242|FD-Score:-2.88|P-value:7.65E-4 ID:SGTC_2473|Compound:5854593|FD-Score:-2.85|P-value:8.46E-4 ID:SGTC_2625|Compound:euphol|FD-Score:3.34|P-value:1.38E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.18|P-value:2.67E-4 ID:SGTC_2814|Compound:7977482|FD-Score:3.04|P-value:4.80E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.83|P-value:1.51E-5 ID:SGTC_2931|Compound:9014674|FD-Score:-3.45|P-value:7.45E-5 ID:SGTC_3312|Compound:9133330|FD-Score:-2.86|P-value:8.25E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-3.38|P-value:1.01E-4 ID:SGTC_3342|Compound:9147791|FD-Score:3.09|P-value:3.85E-4

Top fitness defect scores for YMR290C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2409 alverine citrate 6.28 64.0 µM 3.68E-12 4 1.72E-10 0.13
2 SGTC_21 0849-0113 4.88 23.0 µM 5.12E-8 4 5.27E-7 0.03
3 SGTC_1828 st055811 4.48 49.0 µM 5.30E-7 1 3.78E-6 0.85
4 SGTC_2894 9048625 3.83 32.5 µM 1.51E-5 11 6.39E-5 0.03
5 SGTC_172 1112-0046 3.81 2.6 µM 1.63E-5 NEO1 11 6.82E-5 0.62
6 SGTC_524 r073-0010 3.81 27.8 µM 1.69E-5 13 7.04E-5 0.02
7 SGTC_1083 didemethylchlorpromazine sulfoxide 3.79 707.4 nM 1.87E-5 redox potentiating 27 7.66E-5 0.16
8 SGTC_1642 st009582 3.76 77.7 µM 2.16E-5 RPP1 & pyrimidine depletion 8 8.66E-5 0.16
9 SGTC_1830 st055982 3.75 50.3 µM 2.25E-5 5 8.96E-5 0.33
10 SGTC_440 fluspirilene 3.65 35.1 µM 3.48E-5 2 1.30E-4 0.14
11 SGTC_598 3937-0236 3.61 20.2 µM 4.14E-5 ERG2 6 1.50E-4 0.03
12 SGTC_1058 3448-5425 3.37 97.3 µM 1.20E-4 17 3.70E-4 0.03
13 SGTC_2625 euphol 3.34 100.0 µM 1.38E-4 13 4.18E-4 0.23
14 SGTC_2758 dehydroepiandrosterone 3.18 69.3 µM 2.67E-4 19 7.29E-4 0.01
15 SGTC_739 1486-1183 3.15 203.0 µM 3.08E-4 8 8.23E-4 0.18
16 SGTC_3342 9147791 3.09 14.5 µM 3.85E-4 6 9.96E-4 0.05
17 SGTC_564 3555-0129 3.07 330.0 µM 4.21E-4 10 0.00107 0.14
18 SGTC_610 4215-0184 3.06 155.0 µM 4.29E-4 exosome 33 0.00109 9.24E-4
19 SGTC_2814 7977482 3.04 43.0 µM 4.80E-4 21 0.00120 0.03
20 SGTC_74 000s-0487 3.00 160.3 µM 5.61E-4 13 0.00137 0.06

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.184 6.26E-27 YPL252C YAH1 het Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin
0.173 4.99E-24 YPL251W_d YPL251W_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C
0.130 5.08E-14 YDR431W_d YDR431W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.123 7.29E-13 YMR326C_d YMR326C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13
0.119 5.04E-12 YBR045C GIP1 hom Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p
0.111 1.37E-10 YER121W_p YER121W_p hom Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy
0.105 1.08E-9 YDR236C FMN1 het Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
0.105 1.23E-9 YIL149C MLP2 hom Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length
0.105 1.25E-9 YJR082C EAF6 hom Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
0.103 2.11E-9 YFR045W_p YFR045W_p hom Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white
0.100 6.98E-9 YDR394W RPT3 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
0.098 1.15E-8 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.098 1.23E-8 YNL224C SQS1 hom Protein that stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles; relocalizes from nucleus to nucleolus upon DNA replication stress
0.094 5.12E-8 YKL211C TRP3 hom Indole-3-glycerol-phosphate synthase; forms bifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p
0.092 9.71E-8 YDR229W IVY1 hom Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase