YMR290W-A_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR290W-A / YMR290W-A

Click on Significant Values for Screen Details ID:SGTC_26|Compound:0302-0163|FD-Score:5.45|P-value:2.35E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:5.61|P-value:1.23E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:10.00|P-value:3.37E-17 ID:SGTC_86|Compound:0417-1630|FD-Score:5.25|P-value:5.13E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:6.75|P-value:7.60E-9 ID:SGTC_172|Compound:1112-0046|FD-Score:4.83|P-value:2.38E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:8.65|P-value:2.45E-13 ID:SGTC_199|Compound:4063-0024|FD-Score:3.86|P-value:5.53E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:5.87|P-value:4.12E-7 ID:SGTC_218|Compound:alverine citrate|FD-Score:7.25|P-value:6.41E-10 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.08|P-value:6.88E-12 ID:SGTC_224|Compound:benfluorex|FD-Score:7.96|P-value:1.36E-11 ID:SGTC_247|Compound:mechlorethamine|FD-Score:4.02|P-value:3.45E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.10|P-value:2.69E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.76|P-value:7.47E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.78|P-value:7.02E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:4.61|P-value:5.11E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.93|P-value:6.85E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-4.20|P-value:3.07E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.79|P-value:6.75E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:11.00|P-value:1.90E-20 ID:SGTC_571|Compound:k831-0106|FD-Score:5.07|P-value:1.01E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:3.66|P-value:9.97E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:5.19|P-value:6.48E-6 ID:SGTC_634|Compound:1611-4317|FD-Score:3.97|P-value:4.04E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.67|P-value:9.69E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:4.38|P-value:1.12E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:5.21|P-value:5.97E-6 ID:SGTC_721|Compound:1187-1332|FD-Score:4.70|P-value:3.80E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:5.71|P-value:8.11E-7 ID:SGTC_853|Compound:0419-0306|FD-Score:6.99|P-value:2.42E-9 ID:SGTC_911|Compound:3456-4043|FD-Score:4.50|P-value:7.62E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:4.44|P-value:9.10E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:4.45|P-value:8.97E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.99|P-value:1.36E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:6.05|P-value:1.96E-7 ID:SGTC_1200|Compound:1643-0193|FD-Score:5.60|P-value:1.30E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:5.36|P-value:3.39E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:-5.18|P-value:1.12E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.72|P-value:7.93E-7 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.25|P-value:1.68E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.92|P-value:4.63E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:7.23|P-value:7.14E-10 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.24|P-value:5.34E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.52|P-value:1.11E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:7.50|P-value:1.71E-10 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.96|P-value:6.30E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:6.30|P-value:6.48E-8 ID:SGTC_1435|Compound:4092-0789|FD-Score:5.54|P-value:1.60E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:4.13|P-value:2.48E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.95|P-value:1.56E-5 ID:SGTC_1797|Compound:st048695|FD-Score:7.23|P-value:7.00E-10 ID:SGTC_1898|Compound:st060199|FD-Score:4.09|P-value:2.78E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.67|P-value:9.73E-4 ID:SGTC_2016|Compound:5121758|FD-Score:7.20|P-value:8.09E-10 ID:SGTC_2021|Compound:4019055|FD-Score:3.70|P-value:8.72E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.99|P-value:3.84E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.56|P-value:6.15E-5 ID:SGTC_2124|Compound:5246320|FD-Score:5.91|P-value:3.46E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.73|P-value:8.17E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.16|P-value:2.24E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.14|P-value:2.38E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.73|P-value:8.19E-4 ID:SGTC_2439|Compound:5492030|FD-Score:5.19|P-value:6.47E-6 ID:SGTC_2444|Compound:5485484|FD-Score:4.22|P-value:1.84E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.74|P-value:7.77E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.08|P-value:2.90E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.79|P-value:6.89E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:6.57|P-value:1.81E-8 ID:SGTC_2727|Compound:riluzole|FD-Score:7.80|P-value:3.33E-11 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.94|P-value:4.38E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.84|P-value:5.96E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.33|P-value:1.33E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.92|P-value:7.10E-4 ID:SGTC_2887|Compound:9044784|FD-Score:4.50|P-value:7.58E-5 ID:SGTC_2902|Compound:5787006|FD-Score:7.20|P-value:8.32E-10 ID:SGTC_2938|Compound:9059746|FD-Score:3.92|P-value:4.61E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.59|P-value:5.49E-5 ID:SGTC_2943|Compound:9068529|FD-Score:5.63|P-value:1.15E-6 ID:SGTC_2978|Compound:9011784|FD-Score:3.95|P-value:4.29E-4 ID:SGTC_3011|Compound:9081274|FD-Score:6.23|P-value:8.51E-8 ID:SGTC_3020|Compound:9089140|FD-Score:3.97|P-value:3.99E-4 ID:SGTC_3071|Compound:9117417|FD-Score:7.22|P-value:7.58E-10 ID:SGTC_3081|Compound:9117243|FD-Score:5.46|P-value:2.22E-6 ID:SGTC_3127|Compound:9126946|FD-Score:4.62|P-value:4.98E-5 ID:SGTC_3272|Compound:9137413|FD-Score:4.87|P-value:2.11E-5 ID:SGTC_3275|Compound:9138069|FD-Score:3.75|P-value:7.63E-4 ID:SGTC_3279|Compound:9140807|FD-Score:4.21|P-value:1.91E-4 ID:SGTC_3334|Compound:9142812|FD-Score:5.63|P-value:1.16E-6 ID:SGTC_3346|Compound:9158254|FD-Score:4.45|P-value:8.93E-5 ID:SGTC_3356|Compound:9151811|FD-Score:4.90|P-value:1.89E-5 ID:SGTC_26|Compound:0302-0163|FD-Score:5.45|P-value:2.35E-6 ID:SGTC_54|Compound:0159-0055|FD-Score:5.61|P-value:1.23E-6 ID:SGTC_69|Compound:0096-0274|FD-Score:10.00|P-value:3.37E-17 ID:SGTC_86|Compound:0417-1630|FD-Score:5.25|P-value:5.13E-6 ID:SGTC_103|Compound:0844-0104|FD-Score:6.75|P-value:7.60E-9 ID:SGTC_172|Compound:1112-0046|FD-Score:4.83|P-value:2.38E-5 ID:SGTC_188|Compound:3229-0966|FD-Score:8.65|P-value:2.45E-13 ID:SGTC_199|Compound:4063-0024|FD-Score:3.86|P-value:5.53E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:5.87|P-value:4.12E-7 ID:SGTC_218|Compound:alverine citrate|FD-Score:7.25|P-value:6.41E-10 ID:SGTC_221|Compound:trifluoperazine|FD-Score:8.08|P-value:6.88E-12 ID:SGTC_224|Compound:benfluorex|FD-Score:7.96|P-value:1.36E-11 ID:SGTC_247|Compound:mechlorethamine|FD-Score:4.02|P-value:3.45E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:4.10|P-value:2.69E-4 ID:SGTC_270|Compound:tamoxifen|FD-Score:3.76|P-value:7.47E-4 ID:SGTC_307|Compound:1501-1223|FD-Score:3.78|P-value:7.02E-4 ID:SGTC_384|Compound:k007-0144|FD-Score:4.61|P-value:5.11E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.93|P-value:6.85E-4 ID:SGTC_543|Compound:3844-1095|FD-Score:-4.20|P-value:3.07E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:3.79|P-value:6.75E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:11.00|P-value:1.90E-20 ID:SGTC_571|Compound:k831-0106|FD-Score:5.07|P-value:1.01E-5 ID:SGTC_573|Compound:3702-0553|FD-Score:3.66|P-value:9.97E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:5.19|P-value:6.48E-6 ID:SGTC_634|Compound:1611-4317|FD-Score:3.97|P-value:4.04E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:3.67|P-value:9.69E-4 ID:SGTC_648|Compound:0375-0473|FD-Score:4.38|P-value:1.12E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:5.21|P-value:5.97E-6 ID:SGTC_721|Compound:1187-1332|FD-Score:4.70|P-value:3.80E-5 ID:SGTC_851|Compound:0394-0702|FD-Score:5.71|P-value:8.11E-7 ID:SGTC_853|Compound:0419-0306|FD-Score:6.99|P-value:2.42E-9 ID:SGTC_911|Compound:3456-4043|FD-Score:4.50|P-value:7.62E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:4.44|P-value:9.10E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:4.45|P-value:8.97E-5 ID:SGTC_1098|Compound:clofazimine|FD-Score:4.99|P-value:1.36E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:6.05|P-value:1.96E-7 ID:SGTC_1200|Compound:1643-0193|FD-Score:5.60|P-value:1.30E-6 ID:SGTC_1201|Compound:1889-3372|FD-Score:5.36|P-value:3.39E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:-5.18|P-value:1.12E-5 ID:SGTC_1230|Compound:0170-0365|FD-Score:5.72|P-value:7.93E-7 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.25|P-value:1.68E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.92|P-value:4.63E-4 ID:SGTC_1247|Compound:0448-0043|FD-Score:7.23|P-value:7.14E-10 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.24|P-value:5.34E-6 ID:SGTC_1370|Compound:2001-0092|FD-Score:-4.52|P-value:1.11E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:7.50|P-value:1.71E-10 ID:SGTC_1373|Compound:2887-0003|FD-Score:-3.96|P-value:6.30E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:6.30|P-value:6.48E-8 ID:SGTC_1435|Compound:4092-0789|FD-Score:5.54|P-value:1.60E-6 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:4.13|P-value:2.48E-4 ID:SGTC_1672|Compound:st016598|FD-Score:4.95|P-value:1.56E-5 ID:SGTC_1797|Compound:st048695|FD-Score:7.23|P-value:7.00E-10 ID:SGTC_1898|Compound:st060199|FD-Score:4.09|P-value:2.78E-4 ID:SGTC_1899|Compound:st063254|FD-Score:3.67|P-value:9.73E-4 ID:SGTC_2016|Compound:5121758|FD-Score:7.20|P-value:8.09E-10 ID:SGTC_2021|Compound:4019055|FD-Score:3.70|P-value:8.72E-4 ID:SGTC_2028|Compound:5153890|FD-Score:3.99|P-value:3.84E-4 ID:SGTC_2050|Compound:5263056|FD-Score:4.56|P-value:6.15E-5 ID:SGTC_2124|Compound:5246320|FD-Score:5.91|P-value:3.46E-7 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.73|P-value:8.17E-4 ID:SGTC_2269|Compound:7935389|FD-Score:4.16|P-value:2.24E-4 ID:SGTC_2336|Compound:9001819|FD-Score:4.14|P-value:2.38E-4 ID:SGTC_2341|Compound:7987486|FD-Score:3.73|P-value:8.19E-4 ID:SGTC_2439|Compound:5492030|FD-Score:5.19|P-value:6.47E-6 ID:SGTC_2444|Compound:5485484|FD-Score:4.22|P-value:1.84E-4 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.74|P-value:7.77E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:4.08|P-value:2.90E-4 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:3.79|P-value:6.89E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:6.57|P-value:1.81E-8 ID:SGTC_2727|Compound:riluzole|FD-Score:7.80|P-value:3.33E-11 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.94|P-value:4.38E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:3.84|P-value:5.96E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.33|P-value:1.33E-4 ID:SGTC_2873|Compound:9040596|FD-Score:-3.92|P-value:7.10E-4 ID:SGTC_2887|Compound:9044784|FD-Score:4.50|P-value:7.58E-5 ID:SGTC_2902|Compound:5787006|FD-Score:7.20|P-value:8.32E-10 ID:SGTC_2938|Compound:9059746|FD-Score:3.92|P-value:4.61E-4 ID:SGTC_2941|Compound:9056145|FD-Score:4.59|P-value:5.49E-5 ID:SGTC_2943|Compound:9068529|FD-Score:5.63|P-value:1.15E-6 ID:SGTC_2978|Compound:9011784|FD-Score:3.95|P-value:4.29E-4 ID:SGTC_3011|Compound:9081274|FD-Score:6.23|P-value:8.51E-8 ID:SGTC_3020|Compound:9089140|FD-Score:3.97|P-value:3.99E-4 ID:SGTC_3071|Compound:9117417|FD-Score:7.22|P-value:7.58E-10 ID:SGTC_3081|Compound:9117243|FD-Score:5.46|P-value:2.22E-6 ID:SGTC_3127|Compound:9126946|FD-Score:4.62|P-value:4.98E-5 ID:SGTC_3272|Compound:9137413|FD-Score:4.87|P-value:2.11E-5 ID:SGTC_3275|Compound:9138069|FD-Score:3.75|P-value:7.63E-4 ID:SGTC_3279|Compound:9140807|FD-Score:4.21|P-value:1.91E-4 ID:SGTC_3334|Compound:9142812|FD-Score:5.63|P-value:1.16E-6 ID:SGTC_3346|Compound:9158254|FD-Score:4.45|P-value:8.93E-5 ID:SGTC_3356|Compound:9151811|FD-Score:4.90|P-value:1.89E-5

Top fitness defect scores for YMR290W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_553 k007-0256 11.00 45.7 µM 1.90E-20 heme biosynthesis & mitochondrial translocase 4 1.61E-28 2.74
2 SGTC_69 0096-0274 10.00 206.7 µM 3.37E-17 mitochondrial processes 5 7.64E-24 0.62
3 SGTC_188 3229-0966 8.65 278.5 µM 2.45E-13 1 2.69E-18 1.56
4 SGTC_221 trifluoperazine 8.08 10.3 µM 6.88E-12 NEO1-PIK1 9 3.20E-16 0.21
5 SGTC_224 benfluorex 7.96 43.9 µM 1.36E-11 1 8.49E-16 2.01
6 SGTC_2727 riluzole 7.80 51.8 µM 3.33E-11 mitochondrial processes 2 3.07E-15 1.55
7 SGTC_1371 2421-0008 7.50 32.7 µM 1.71E-10 mitochondrial processes 4 3.20E-14 0.53
8 SGTC_218 alverine citrate 7.25 93.8 µM 6.41E-10 fatty acid desaturase (OLE1) 4 2.11E-13 1.24
9 SGTC_1797 st048695 7.23 56.8 µM 7.00E-10 NEO1 4 2.40E-13 0.49
10 SGTC_1247 0448-0043 7.23 5.8 µM 7.14E-10 ERG2 3 2.46E-13 1.97
11 SGTC_3071 9117417 7.22 49.5 µM 7.58E-10 fatty acid desaturase (OLE1) 3 2.68E-13 2.06
12 SGTC_2016 5121758 7.20 140.0 µM 8.09E-10 redox potentiating 3 2.95E-13 1.03
13 SGTC_2902 5787006 7.20 60.5 µM 8.32E-10 Golgi 1 3.06E-13 2.48
14 SGTC_853 0419-0306 6.99 21.0 µM 2.42E-9 1 1.41E-12 1.93
15 SGTC_103 0844-0104 6.75 51.8 µM 7.60E-9 ERAD & cell cycle 19 7.22E-12 0.30
16 SGTC_2725 haloperidol 6.57 53.2 µM 1.81E-8 plasma membrane duress 5 2.49E-11 0.13
17 SGTC_1381 2324-0066 6.30 62.1 µM 6.48E-8 1 1.53E-10 1.38
18 SGTC_3011 9081274 6.23 71.4 µM 8.51E-8 1 2.26E-10 2.30
19 SGTC_1113 artemisinin 6.05 1.2 µM 1.96E-7 heme biosynthesis & mitochondrial translocase 13 7.41E-10 0.20
20 SGTC_2124 5246320 5.91 200.0 µM 3.46E-7 heme biosynthesis & mitochondrial translocase 15 1.66E-9 0.14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.249 1.03E-48 YMR203W TOM40 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore
0.231 1.04E-41 YGL055W OLE1 het Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
0.223 5.37E-39 YJL204C RCY1 hom F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth
0.193 1.59E-29 YCR052W RSC6 het Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p
0.192 2.53E-29 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.189 2.12E-28 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.174 2.43E-24 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.172 9.19E-24 YDR394W RPT3 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B
0.170 2.97E-23 YCR094W CDC50 hom Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Lem3p; CDC50 has a paralog, YNR048W, that arose from the whole genome duplication
0.168 1.18E-22 YOL144W NOP8 het Nucleolar protein required for 60S ribosomal subunit biogenesis
0.161 6.54E-21 YEL034W HYP2 het Translation elongation factor eIF-5A; may function in translation initiation; structural homolog of bacterial EF-P; undergoes an essential hypusination modification; HYP2 has a paralog, ANB1, that arose from the whole genome duplication
0.158 2.85E-20 YDR427W RPN9 het Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress
0.157 7.51E-20 YOR117W RPT5 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
0.157 7.78E-20 YBL105C PKC1 het Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC)
0.152 1.06E-18 YDL100C GET3 hom Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity; protein abundance increases in response to DNA replication stress