YMR292W / GOT1

Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR292W / GOT1

Click on Significant Values for Screen Details ID:SGTC_105|Compound:0111-0055|FD-Score:-4.35|P-value:1.88E-6 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.02|P-value:6.95E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-6.83|P-value:1.82E-13 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.23|P-value:3.11E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.40|P-value:1.32E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.96|P-value:7.42E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.43|P-value:1.37E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.31|P-value:1.91E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.22|P-value:3.21E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.47|P-value:9.88E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:3.59|P-value:5.94E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.01|P-value:6.16E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:2.91|P-value:9.08E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.00|P-value:6.37E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.12|P-value:4.71E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.63|P-value:4.92E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.02|P-value:5.96E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.30|P-value:2.04E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.93|P-value:1.30E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.18|P-value:3.86E-6 ID:SGTC_1369|Compound:1866-0067|FD-Score:2.98|P-value:6.97E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-3.37|P-value:1.74E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.82|P-value:2.14E-5 ID:SGTC_1675|Compound:st018485|FD-Score:2.90|P-value:9.28E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.52|P-value:8.16E-5 ID:SGTC_1896|Compound:st058441|FD-Score:-2.97|P-value:8.14E-4 ID:SGTC_1898|Compound:st060199|FD-Score:4.08|P-value:6.16E-6 ID:SGTC_2069|Compound:5228469|FD-Score:3.51|P-value:8.26E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:5.00|P-value:4.38E-8 ID:SGTC_2161|Compound:5662504|FD-Score:3.11|P-value:4.32E-4 ID:SGTC_2185|Compound:6113692|FD-Score:2.94|P-value:8.17E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.16|P-value:3.55E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.18|P-value:3.20E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-4.12|P-value:6.09E-6 ID:SGTC_2426|Compound:5582046|FD-Score:7.12|P-value:1.38E-14 ID:SGTC_2431|Compound:5490079|FD-Score:2.90|P-value:9.27E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.11|P-value:5.48E-6 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.83|P-value:2.45E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.38|P-value:1.70E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.57|P-value:6.59E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:-5.12|P-value:2.69E-8 ID:SGTC_2610|Compound:ononetin|FD-Score:-5.18|P-value:1.84E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.04|P-value:7.55E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.25|P-value:2.80E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.19|P-value:3.54E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.97|P-value:1.04E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.68|P-value:4.78E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:6.62|P-value:7.43E-13 ID:SGTC_2805|Compound:7950783|FD-Score:3.15|P-value:3.70E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.90|P-value:1.49E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-3.16|P-value:4.01E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.49|P-value:9.13E-5 ID:SGTC_2975|Compound:9084847|FD-Score:3.59|P-value:5.91E-5 ID:SGTC_3164|Compound:9100705|FD-Score:2.91|P-value:9.09E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.10|P-value:4.49E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.68|P-value:3.96E-5 ID:SGTC_3221|Compound:9128209|FD-Score:-2.94|P-value:9.18E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.34|P-value:1.74E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.85|P-value:1.83E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:-4.35|P-value:1.88E-6 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.02|P-value:6.95E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:-6.83|P-value:1.82E-13 ID:SGTC_141|Compound:0443-0274|FD-Score:-3.23|P-value:3.11E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:3.40|P-value:1.32E-4 ID:SGTC_261|Compound:5-fluorouridine|FD-Score:2.96|P-value:7.42E-4 ID:SGTC_422|Compound:cantharidin|FD-Score:-3.43|P-value:1.37E-4 ID:SGTC_438|Compound:sphingosine|FD-Score:3.31|P-value:1.91E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:-3.22|P-value:3.21E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:3.47|P-value:9.88E-5 ID:SGTC_606|Compound:k015-0008|FD-Score:3.59|P-value:5.94E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:3.01|P-value:6.16E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:2.91|P-value:9.08E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:3.00|P-value:6.37E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.12|P-value:4.71E-4 ID:SGTC_986|Compound:1493-0483|FD-Score:3.63|P-value:4.92E-5 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.02|P-value:5.96E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.30|P-value:2.04E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.93|P-value:1.30E-5 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.18|P-value:3.86E-6 ID:SGTC_1369|Compound:1866-0067|FD-Score:2.98|P-value:6.97E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:-3.37|P-value:1.74E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.82|P-value:2.14E-5 ID:SGTC_1675|Compound:st018485|FD-Score:2.90|P-value:9.28E-4 ID:SGTC_1720|Compound:st037298|FD-Score:3.52|P-value:8.16E-5 ID:SGTC_1896|Compound:st058441|FD-Score:-2.97|P-value:8.14E-4 ID:SGTC_1898|Compound:st060199|FD-Score:4.08|P-value:6.16E-6 ID:SGTC_2069|Compound:5228469|FD-Score:3.51|P-value:8.26E-5 ID:SGTC_2131|Compound:toluylene red|FD-Score:5.00|P-value:4.38E-8 ID:SGTC_2161|Compound:5662504|FD-Score:3.11|P-value:4.32E-4 ID:SGTC_2185|Compound:6113692|FD-Score:2.94|P-value:8.17E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:3.16|P-value:3.55E-4 ID:SGTC_2391|Compound:6285546|FD-Score:3.18|P-value:3.20E-4 ID:SGTC_2422|Compound:chlorphenesin carbamate|FD-Score:-4.12|P-value:6.09E-6 ID:SGTC_2426|Compound:5582046|FD-Score:7.12|P-value:1.38E-14 ID:SGTC_2431|Compound:5490079|FD-Score:2.90|P-value:9.27E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.11|P-value:5.48E-6 ID:SGTC_2490|Compound:carminic acid|FD-Score:-3.83|P-value:2.45E-5 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.38|P-value:1.70E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.57|P-value:6.59E-5 ID:SGTC_2507|Compound:purpurin|FD-Score:-5.12|P-value:2.69E-8 ID:SGTC_2610|Compound:ononetin|FD-Score:-5.18|P-value:1.84E-8 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.04|P-value:7.55E-6 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.25|P-value:2.80E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.19|P-value:3.54E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:3.97|P-value:1.04E-5 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-3.68|P-value:4.78E-5 ID:SGTC_2753|Compound:fluvastatin|FD-Score:6.62|P-value:7.43E-13 ID:SGTC_2805|Compound:7950783|FD-Score:3.15|P-value:3.70E-4 ID:SGTC_2863|Compound:9028737|FD-Score:3.90|P-value:1.49E-5 ID:SGTC_2937|Compound:9044753|FD-Score:-3.16|P-value:4.01E-4 ID:SGTC_2951|Compound:9072950|FD-Score:3.49|P-value:9.13E-5 ID:SGTC_2975|Compound:9084847|FD-Score:3.59|P-value:5.91E-5 ID:SGTC_3164|Compound:9100705|FD-Score:2.91|P-value:9.09E-4 ID:SGTC_3213|Compound:9129884|FD-Score:3.10|P-value:4.49E-4 ID:SGTC_3215|Compound:9129942|FD-Score:3.68|P-value:3.96E-5 ID:SGTC_3221|Compound:9128209|FD-Score:-2.94|P-value:9.18E-4 ID:SGTC_3249|Compound:9135183|FD-Score:3.34|P-value:1.74E-4 ID:SGTC_3253|Compound:9135987|FD-Score:3.85|P-value:1.83E-5

Top fitness defect scores for YMR292W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2426 5582046 7.12 32.2 µM 1.38E-14 4 5.51E-13
2 SGTC_2753 fluvastatin 6.62 17.1 µM 7.43E-13 azole & statin 5 1.83E-11
3 SGTC_2131 toluylene red 5.00 5.3 µM 4.38E-8 60S ribosome export 4 2.88E-7
4 SGTC_1246 0422-0085 4.18 105.0 µM 3.86E-6 25 1.48E-5
5 SGTC_2472 5377652 4.11 49.4 µM 5.48E-6 TRP & mitochondrial translation 50 2.02E-5
6 SGTC_1898 st060199 4.08 18.6 µM 6.16E-6 13 2.24E-5
7 SGTC_2612 dictamnine 4.04 15.5 µM 7.55E-6 RNA pol III & RNase P/MRP 42 2.68E-5
8 SGTC_2627 acetyl isogambogic acid 3.97 100.0 µM 1.04E-5 TSC3-RPN4 42 3.54E-5
9 SGTC_1155 4088-0394 3.93 48.2 µM 1.30E-5 29 4.33E-5
10 SGTC_2863 9028737 3.90 58.4 µM 1.49E-5 5 4.88E-5
11 SGTC_3253 9135987 3.85 49.5 µM 1.83E-5 60S ribosome export 15 5.83E-5
12 SGTC_1634 st006576 3.82 41.0 µM 2.14E-5 TSC3-RPN4 22 6.71E-5
13 SGTC_3215 9129942 3.68 49.5 µM 3.96E-5 12 1.15E-4
14 SGTC_986 1493-0483 3.63 84.0 µM 4.92E-5 18 1.40E-4
15 SGTC_2975 9084847 3.59 53.7 µM 5.91E-5 34 1.64E-4
16 SGTC_606 k015-0008 3.59 38.6 µM 5.94E-5 25 1.65E-4
17 SGTC_2501 sodium tetradecyl sulfate 3.57 13.4 µM 6.59E-5 46 1.81E-4
18 SGTC_1720 st037298 3.52 9.5 µM 8.16E-5 52 2.18E-4
19 SGTC_2069 5228469 3.51 200.0 µM 8.26E-5 24 2.20E-4
20 SGTC_2951 9072950 3.49 58.1 µM 9.13E-5 ERG2 35 2.41E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 4.79E-11 YGR280C PXR1 het Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain
0.107 4.54E-10 YLR361C-A_p YLR361C-A_p hom Putative protein of unknown function
0.102 2.84E-9 YML047C PRM6 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family
0.100 6.84E-9 YNL044W YIP3 hom Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p
0.100 7.72E-9 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.091 1.42E-7 YML075C HMG1 hom HMG-CoA reductase; catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to the nuclear envelope; overproduction induces the formation of karmellae; forms foci at the nuclear periphery upon DNA replication stress
0.088 3.52E-7 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.084 1.05E-6 YJL162C JJJ2 hom Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
0.084 1.23E-6 YGR082W TOM20 het Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins
0.084 1.23E-6 YMR155W_p YMR155W_p hom Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
0.084 1.24E-6 YNL313C EMW1 het Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress
0.083 1.48E-6 YPL200W CSM4 hom Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements
0.083 1.73E-6 YDR336W_p YDR336W_p hom Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene
0.082 2.14E-6 YFL047W RGD2 hom GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.081 2.77E-6 YKL182W FAS1 het Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities