YMR293C / HER2

Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR293C / HER2

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.56|P-value:6.82E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.07|P-value:1.30E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.03|P-value:1.51E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.33|P-value:9.52E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:4.29|P-value:6.14E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.05|P-value:1.40E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.71|P-value:1.99E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:10.70|P-value:1.49E-21 ID:SGTC_211|Compound:3455-0679|FD-Score:3.49|P-value:8.62E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:13.30|P-value:1.98E-32 ID:SGTC_268|Compound:camptothecin|FD-Score:-4.03|P-value:2.27E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.04|P-value:4.01E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:11.00|P-value:7.70E-23 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.15|P-value:1.52E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.89|P-value:3.55E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.39|P-value:4.20E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.84|P-value:4.17E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.54|P-value:7.33E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:3.90|P-value:2.31E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.43|P-value:3.63E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:4.07|P-value:1.32E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.98|P-value:2.72E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.30|P-value:5.82E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.66|P-value:7.33E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.98|P-value:1.75E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:-5.64|P-value:4.08E-7 ID:SGTC_1174|Compound:0739-0097|FD-Score:-4.57|P-value:3.38E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.63|P-value:5.59E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:-3.91|P-value:3.34E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.07|P-value:2.01E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.71|P-value:4.27E-4 ID:SGTC_1627|Compound:st003713|FD-Score:6.38|P-value:6.22E-9 ID:SGTC_1707|Compound:st032323|FD-Score:-3.80|P-value:4.83E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.47|P-value:8.95E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.63|P-value:7.99E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-10.00|P-value:7.71E-19 ID:SGTC_2025|Compound:5147754|FD-Score:4.15|P-value:9.81E-5 ID:SGTC_2041|Compound:5107442|FD-Score:3.75|P-value:3.77E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.39|P-value:4.14E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.64|P-value:7.89E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:11.70|P-value:2.05E-25 ID:SGTC_2283|Compound:7944793|FD-Score:3.52|P-value:7.74E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.85|P-value:7.29E-6 ID:SGTC_2368|Compound:9071271|FD-Score:3.47|P-value:8.93E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-5.62|P-value:4.45E-7 ID:SGTC_2483|Compound:5729050|FD-Score:3.90|P-value:2.35E-4 ID:SGTC_2486|Compound:5283202|FD-Score:4.77|P-value:9.71E-6 ID:SGTC_2488|Compound:5268135|FD-Score:9.40|P-value:3.16E-17 ID:SGTC_2526|Compound:patulin|FD-Score:6.67|P-value:1.37E-9 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.52|P-value:7.83E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.62|P-value:5.73E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.52|P-value:7.71E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.27|P-value:6.59E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.99|P-value:4.10E-6 ID:SGTC_2818|Compound:7996756|FD-Score:4.71|P-value:1.25E-5 ID:SGTC_2820|Compound:7989630|FD-Score:-3.71|P-value:6.42E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.88|P-value:7.49E-8 ID:SGTC_2826|Compound:7992541|FD-Score:6.28|P-value:1.07E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-4.66|P-value:2.43E-5 ID:SGTC_2983|Compound:9022671|FD-Score:4.27|P-value:6.45E-5 ID:SGTC_2996|Compound:9066192|FD-Score:4.46|P-value:3.24E-5 ID:SGTC_3052|Compound:9092717|FD-Score:4.15|P-value:1.01E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-5.79|P-value:2.05E-7 ID:SGTC_3101|Compound:9120531|FD-Score:4.33|P-value:5.16E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.60|P-value:6.02E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-4.11|P-value:1.74E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.92|P-value:2.16E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.56|P-value:6.82E-4 ID:SGTC_46|Compound:0329-0187a|FD-Score:4.07|P-value:1.30E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.03|P-value:1.51E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:5.33|P-value:9.52E-7 ID:SGTC_68|Compound:0986-0284|FD-Score:4.29|P-value:6.14E-5 ID:SGTC_119|Compound:0121-0043|FD-Score:4.05|P-value:1.40E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.71|P-value:1.99E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:10.70|P-value:1.49E-21 ID:SGTC_211|Compound:3455-0679|FD-Score:3.49|P-value:8.62E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:13.30|P-value:1.98E-32 ID:SGTC_268|Compound:camptothecin|FD-Score:-4.03|P-value:2.27E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:8.04|P-value:4.01E-13 ID:SGTC_310|Compound:1273-0058|FD-Score:11.00|P-value:7.70E-23 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.15|P-value:1.52E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:-3.89|P-value:3.55E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:4.39|P-value:4.20E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:-3.84|P-value:4.17E-4 ID:SGTC_614|Compound:0462-0418|FD-Score:3.54|P-value:7.33E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:3.90|P-value:2.31E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:4.43|P-value:3.63E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:4.07|P-value:1.32E-4 ID:SGTC_785|Compound:1270-0111|FD-Score:-3.98|P-value:2.72E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:4.30|P-value:5.82E-5 ID:SGTC_1026|Compound:k007-1105|FD-Score:-3.66|P-value:7.33E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.98|P-value:1.75E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:-5.64|P-value:4.08E-7 ID:SGTC_1174|Compound:0739-0097|FD-Score:-4.57|P-value:3.38E-5 ID:SGTC_1231|Compound:0242-0792|FD-Score:3.63|P-value:5.59E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:-3.91|P-value:3.34E-4 ID:SGTC_1310|Compound:1188-0297|FD-Score:-4.07|P-value:2.01E-4 ID:SGTC_1614|Compound:st002383|FD-Score:3.71|P-value:4.27E-4 ID:SGTC_1627|Compound:st003713|FD-Score:6.38|P-value:6.22E-9 ID:SGTC_1707|Compound:st032323|FD-Score:-3.80|P-value:4.83E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.47|P-value:8.95E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.63|P-value:7.99E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-10.00|P-value:7.71E-19 ID:SGTC_2025|Compound:5147754|FD-Score:4.15|P-value:9.81E-5 ID:SGTC_2041|Compound:5107442|FD-Score:3.75|P-value:3.77E-4 ID:SGTC_2232|Compound:chlorophetanol|FD-Score:4.39|P-value:4.14E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.64|P-value:7.89E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:11.70|P-value:2.05E-25 ID:SGTC_2283|Compound:7944793|FD-Score:3.52|P-value:7.74E-4 ID:SGTC_2367|Compound:9070478|FD-Score:4.85|P-value:7.29E-6 ID:SGTC_2368|Compound:9071271|FD-Score:3.47|P-value:8.93E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-5.62|P-value:4.45E-7 ID:SGTC_2483|Compound:5729050|FD-Score:3.90|P-value:2.35E-4 ID:SGTC_2486|Compound:5283202|FD-Score:4.77|P-value:9.71E-6 ID:SGTC_2488|Compound:5268135|FD-Score:9.40|P-value:3.16E-17 ID:SGTC_2526|Compound:patulin|FD-Score:6.67|P-value:1.37E-9 ID:SGTC_2571|Compound:chrysanthemic acid|FD-Score:3.52|P-value:7.83E-4 ID:SGTC_2638|Compound:epoxomicin|FD-Score:3.62|P-value:5.73E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.52|P-value:7.71E-4 ID:SGTC_2727|Compound:riluzole|FD-Score:4.27|P-value:6.59E-5 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.99|P-value:4.10E-6 ID:SGTC_2818|Compound:7996756|FD-Score:4.71|P-value:1.25E-5 ID:SGTC_2820|Compound:7989630|FD-Score:-3.71|P-value:6.42E-4 ID:SGTC_2821|Compound:7996764|FD-Score:5.88|P-value:7.49E-8 ID:SGTC_2826|Compound:7992541|FD-Score:6.28|P-value:1.07E-8 ID:SGTC_2896|Compound:9052656|FD-Score:-4.66|P-value:2.43E-5 ID:SGTC_2983|Compound:9022671|FD-Score:4.27|P-value:6.45E-5 ID:SGTC_2996|Compound:9066192|FD-Score:4.46|P-value:3.24E-5 ID:SGTC_3052|Compound:9092717|FD-Score:4.15|P-value:1.01E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-5.79|P-value:2.05E-7 ID:SGTC_3101|Compound:9120531|FD-Score:4.33|P-value:5.16E-5 ID:SGTC_3152|Compound:9099253|FD-Score:3.60|P-value:6.02E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-4.11|P-value:1.74E-4 ID:SGTC_3277|Compound:9138724|FD-Score:3.92|P-value:2.16E-4

Top fitness defect scores for YMR293C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 13.30 5.3 µM 1.98E-32 133 1.25E-40
2 SGTC_2250 alverine citrate 11.70 130.0 µM 2.05E-25 3 1.06E-31
3 SGTC_310 1273-0058 11.00 1.1 µM 7.70E-23 mitochondrial stress 28 2.00E-28
4 SGTC_173 1273-0061 10.70 2.7 µM 1.49E-21 mitochondrial stress 35 8.64E-27
5 SGTC_2488 5268135 9.40 45.7 µM 3.16E-17 10 2.71E-21
6 SGTC_275 trichlorophene 8.04 5.7 µM 4.01E-13 mitochondrial stress 76 4.34E-16
7 SGTC_2526 patulin 6.67 37.6 µM 1.37E-9 20 1.28E-11
8 SGTC_1627 st003713 6.38 25.6 µM 6.22E-9 calcium & mitochondrial duress 24 8.65E-11
9 SGTC_2826 7992541 6.28 19.5 µM 1.07E-8 2 1.71E-10
10 SGTC_2821 7996764 5.88 71.4 µM 7.49E-8 6 2.00E-9
11 SGTC_63 0099-0242 5.33 26.7 µM 9.52E-7 mitochondrial stress 45 4.90E-8
12 SGTC_2737 bleomycin 4.99 30.5 nM 4.10E-6 Golgi 55 3.07E-7
13 SGTC_2367 9070478 4.85 135.4 µM 7.29E-6 cell wall 20 6.31E-7
14 SGTC_2486 5283202 4.77 22.4 µM 9.71E-6 25 9.04E-7
15 SGTC_2818 7996756 4.71 13.0 µM 1.25E-5 9 1.24E-6
16 SGTC_2996 9066192 4.46 71.4 µM 3.24E-5 21 4.10E-6
17 SGTC_778 3456-2434 4.43 196.0 µM 3.63E-5 mitochondrial response to ROS 61 4.71E-6
18 SGTC_2232 chlorophetanol 4.39 41.5 µM 4.14E-5 TRP & mitochondrial translation 104 5.56E-6
19 SGTC_520 3584-0023 4.39 682.0 µM 4.20E-5 18 5.67E-6
20 SGTC_3101 9120531 4.33 49.5 µM 5.16E-5 23 7.32E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.479 4.61E-191 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.459 1.82E-174 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.446 1.10E-163 YER050C RSM18 hom Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.443 1.06E-160 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.431 1.44E-151 YGR171C MSM1 hom Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.427 1.20E-148 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.425 4.04E-147 YGR102C GTF1 hom Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.423 2.02E-145 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.420 3.91E-143 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.415 6.73E-140 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.414 2.89E-139 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.414 1.29E-138 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.409 2.18E-135 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.408 1.37E-134 YOL095C HMI1 hom Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.408 5.04E-134 YMR098C ATP25 hom Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene