HIPHOP chemogenomics database

YMR293C / HER2

Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase

Zygosity: Homozygous strain

fixedexpanded
Profile for YMR293C / HER2

Click on Significant Values for Screen Details

Top fitness defect scores for YMR293C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	13.30	5.3 µM	1.98E-32		133	1.25E-40
2	SGTC_2250	alverine citrate	11.70	130.0 µM	2.05E-25		3	1.06E-31
3	SGTC_310	1273-0058	11.00	1.1 µM	7.70E-23	mitochondrial stress	28	2.00E-28
4	SGTC_173	1273-0061	10.70	2.7 µM	1.49E-21	mitochondrial stress	35	8.64E-27
5	SGTC_2488	5268135	9.40	45.7 µM	3.16E-17		10	2.71E-21
6	SGTC_275	trichlorophene	8.04	5.7 µM	4.01E-13	mitochondrial stress	76	4.34E-16
7	SGTC_2526	patulin	6.67	37.6 µM	1.37E-9		20	1.28E-11
8	SGTC_1627	st003713	6.38	25.6 µM	6.22E-9	calcium & mitochondrial duress	24	8.65E-11
9	SGTC_2826	7992541	6.28	19.5 µM	1.07E-8		2	1.71E-10
10	SGTC_2821	7996764	5.88	71.4 µM	7.49E-8		6	2.00E-9
11	SGTC_63	0099-0242	5.33	26.7 µM	9.52E-7	mitochondrial stress	45	4.90E-8
12	SGTC_2737	bleomycin	4.99	30.5 nM	4.10E-6	Golgi	55	3.07E-7
13	SGTC_2367	9070478	4.85	135.4 µM	7.29E-6	cell wall	20	6.31E-7
14	SGTC_2486	5283202	4.77	22.4 µM	9.71E-6		25	9.04E-7
15	SGTC_2818	7996756	4.71	13.0 µM	1.25E-5		9	1.24E-6
16	SGTC_2996	9066192	4.46	71.4 µM	3.24E-5		21	4.10E-6
17	SGTC_778	3456-2434	4.43	196.0 µM	3.63E-5	mitochondrial response to ROS	61	4.71E-6
18	SGTC_2232	chlorophetanol	4.39	41.5 µM	4.14E-5	TRP & mitochondrial translation	104	5.56E-6
19	SGTC_520	3584-0023	4.39	682.0 µM	4.20E-5		18	5.67E-6
20	SGTC_3101	9120531	4.33	49.5 µM	5.16E-5		23	7.32E-6

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.479	4.61E-191	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.459	1.82E-174	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.446	1.10E-163	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.443	1.06E-160	YNL184C_p	YNL184C_p	hom	Protein of unknown function; expressed at both mRNA and protein levels
0.431	1.44E-151	YGR171C	MSM1	hom	Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p
0.427	1.20E-148	YNL177C	MRPL22	hom	Mitochondrial ribosomal protein of the large subunit
0.425	4.04E-147	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.423	2.02E-145	YMR193W	MRPL24	hom	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.420	3.91E-143	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.415	6.73E-140	YER077C_p	YER077C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.414	2.89E-139	YDR462W	MRPL28	hom	Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.414	1.29E-138	YDR296W	MHR1	hom	Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.409	2.18E-135	YKL170W	MRPL38	hom	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.408	1.37E-134	YOL095C	HMI1	hom	Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD
0.408	5.04E-134	YMR098C	ATP25	hom	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene