YMR294W / JNM1

Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR294W / JNM1

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:4.40|P-value:4.71E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:4.03|P-value:1.75E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:9.35|P-value:3.83E-17 ID:SGTC_121|Compound:0557-0495|FD-Score:4.56|P-value:2.57E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:3.95|P-value:2.27E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:15.60|P-value:1.13E-44 ID:SGTC_160|Compound:3453-0671|FD-Score:7.84|P-value:1.44E-12 ID:SGTC_162|Compound:k030-0015|FD-Score:5.09|P-value:3.00E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.76|P-value:4.27E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:-4.49|P-value:2.56E-5 ID:SGTC_223|Compound:busulfan|FD-Score:3.63|P-value:6.43E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.75|P-value:4.38E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:6.53|P-value:3.09E-9 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:6.80|P-value:6.94E-10 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.11|P-value:1.32E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.06|P-value:1.59E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.27|P-value:7.57E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:4.25|P-value:8.11E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.67|P-value:5.71E-4 ID:SGTC_456|Compound:gingerol|FD-Score:6.03|P-value:4.01E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:6.32|P-value:9.11E-9 ID:SGTC_528|Compound:3492-0019|FD-Score:8.83|P-value:1.79E-15 ID:SGTC_571|Compound:k831-0106|FD-Score:3.74|P-value:4.54E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.96|P-value:5.31E-6 ID:SGTC_598|Compound:3937-0236|FD-Score:5.48|P-value:5.41E-7 ID:SGTC_608|Compound:k048-0125|FD-Score:4.81|P-value:9.59E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:4.21|P-value:9.29E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:-3.83|P-value:2.69E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.62|P-value:6.60E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.68|P-value:5.47E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.74|P-value:4.51E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.79|P-value:1.03E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.10|P-value:1.38E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.02|P-value:1.79E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.16|P-value:1.12E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.95|P-value:2.30E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:5.30|P-value:1.21E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:3.55|P-value:8.39E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.68|P-value:5.56E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.02|P-value:1.78E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.55|P-value:8.31E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.28|P-value:7.14E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.80|P-value:1.01E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.56|P-value:8.00E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.51|P-value:9.38E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.01|P-value:4.30E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.01|P-value:1.88E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.78|P-value:8.26E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.69|P-value:4.28E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.47|P-value:8.49E-4 ID:SGTC_1647|Compound:st011722|FD-Score:5.38|P-value:8.70E-7 ID:SGTC_1657|Compound:st012939|FD-Score:4.92|P-value:6.05E-6 ID:SGTC_1719|Compound:st032227|FD-Score:5.02|P-value:4.00E-6 ID:SGTC_1767|Compound:st044992|FD-Score:3.65|P-value:6.15E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.77|P-value:1.13E-5 ID:SGTC_1934|Compound:st074720|FD-Score:5.10|P-value:2.89E-6 ID:SGTC_1937|Compound:st074714|FD-Score:3.80|P-value:3.77E-4 ID:SGTC_2017|Compound:5132927|FD-Score:7.10|P-value:1.31E-10 ID:SGTC_2023|Compound:5144124|FD-Score:4.29|P-value:7.06E-5 ID:SGTC_2128|Compound:5255449|FD-Score:3.89|P-value:2.77E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.11|P-value:1.32E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.57|P-value:2.47E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.82|P-value:3.57E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.81|P-value:3.58E-4 ID:SGTC_2424|Compound:5537928|FD-Score:5.25|P-value:1.53E-6 ID:SGTC_2511|Compound:berberine|FD-Score:3.55|P-value:8.19E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.06|P-value:1.55E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:10.00|P-value:2.08E-19 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.80|P-value:3.00E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.77|P-value:1.44E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:5.03|P-value:3.95E-6 ID:SGTC_2906|Compound:7926292|FD-Score:5.45|P-value:6.17E-7 ID:SGTC_2940|Compound:9060638|FD-Score:4.26|P-value:7.91E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-4.06|P-value:1.26E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.59|P-value:7.31E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.93|P-value:6.53E-8 ID:SGTC_3178|Compound:9107506|FD-Score:-3.59|P-value:5.83E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-4.01|P-value:1.46E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.66|P-value:4.77E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-4.34|P-value:4.57E-5 ID:SGTC_3311|Compound:9131146|FD-Score:5.30|P-value:1.23E-6 ID:SGTC_35|Compound:0133-0054|FD-Score:4.40|P-value:4.71E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:4.03|P-value:1.75E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:9.35|P-value:3.83E-17 ID:SGTC_121|Compound:0557-0495|FD-Score:4.56|P-value:2.57E-5 ID:SGTC_128|Compound:0906-2981|FD-Score:3.95|P-value:2.27E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:15.60|P-value:1.13E-44 ID:SGTC_160|Compound:3453-0671|FD-Score:7.84|P-value:1.44E-12 ID:SGTC_162|Compound:k030-0015|FD-Score:5.09|P-value:3.00E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:3.76|P-value:4.27E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:-4.49|P-value:2.56E-5 ID:SGTC_223|Compound:busulfan|FD-Score:3.63|P-value:6.43E-4 ID:SGTC_232|Compound:clozapine|FD-Score:3.75|P-value:4.38E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:6.53|P-value:3.09E-9 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:6.80|P-value:6.94E-10 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:4.11|P-value:1.32E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:4.06|P-value:1.59E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.27|P-value:7.57E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:4.25|P-value:8.11E-5 ID:SGTC_346|Compound:4513-0042|FD-Score:3.67|P-value:5.71E-4 ID:SGTC_456|Compound:gingerol|FD-Score:6.03|P-value:4.01E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:6.32|P-value:9.11E-9 ID:SGTC_528|Compound:3492-0019|FD-Score:8.83|P-value:1.79E-15 ID:SGTC_571|Compound:k831-0106|FD-Score:3.74|P-value:4.54E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:4.96|P-value:5.31E-6 ID:SGTC_598|Compound:3937-0236|FD-Score:5.48|P-value:5.41E-7 ID:SGTC_608|Compound:k048-0125|FD-Score:4.81|P-value:9.59E-6 ID:SGTC_623|Compound:k072-0108|FD-Score:4.21|P-value:9.29E-5 ID:SGTC_715|Compound:0868-0130|FD-Score:-3.83|P-value:2.69E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.62|P-value:6.60E-4 ID:SGTC_839|Compound:0122-0028|FD-Score:3.68|P-value:5.47E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:3.74|P-value:4.51E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.79|P-value:1.03E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:4.10|P-value:1.38E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:4.02|P-value:1.79E-4 ID:SGTC_994|Compound:3910-0338|FD-Score:4.16|P-value:1.12E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:3.95|P-value:2.30E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:5.30|P-value:1.21E-6 ID:SGTC_1101|Compound:ebselen|FD-Score:3.55|P-value:8.39E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.68|P-value:5.56E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.02|P-value:1.78E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.55|P-value:8.31E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:4.28|P-value:7.14E-5 ID:SGTC_1326|Compound:1431-2094|FD-Score:4.80|P-value:1.01E-5 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.56|P-value:8.00E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:3.51|P-value:9.38E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.01|P-value:4.30E-6 ID:SGTC_1454|Compound:4239-0054|FD-Score:4.01|P-value:1.88E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-4.78|P-value:8.26E-6 ID:SGTC_1463|Compound:k081-0032|FD-Score:-3.69|P-value:4.28E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:-3.47|P-value:8.49E-4 ID:SGTC_1647|Compound:st011722|FD-Score:5.38|P-value:8.70E-7 ID:SGTC_1657|Compound:st012939|FD-Score:4.92|P-value:6.05E-6 ID:SGTC_1719|Compound:st032227|FD-Score:5.02|P-value:4.00E-6 ID:SGTC_1767|Compound:st044992|FD-Score:3.65|P-value:6.15E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.77|P-value:1.13E-5 ID:SGTC_1934|Compound:st074720|FD-Score:5.10|P-value:2.89E-6 ID:SGTC_1937|Compound:st074714|FD-Score:3.80|P-value:3.77E-4 ID:SGTC_2017|Compound:5132927|FD-Score:7.10|P-value:1.31E-10 ID:SGTC_2023|Compound:5144124|FD-Score:4.29|P-value:7.06E-5 ID:SGTC_2128|Compound:5255449|FD-Score:3.89|P-value:2.77E-4 ID:SGTC_2191|Compound:5911152|FD-Score:4.11|P-value:1.32E-4 ID:SGTC_2286|Compound:7945697|FD-Score:4.57|P-value:2.47E-5 ID:SGTC_2339|Compound:9000433|FD-Score:3.82|P-value:3.57E-4 ID:SGTC_2368|Compound:9071271|FD-Score:3.81|P-value:3.58E-4 ID:SGTC_2424|Compound:5537928|FD-Score:5.25|P-value:1.53E-6 ID:SGTC_2511|Compound:berberine|FD-Score:3.55|P-value:8.19E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.06|P-value:1.55E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:10.00|P-value:2.08E-19 ID:SGTC_2608|Compound:thymoquinone|FD-Score:-3.80|P-value:3.00E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:5.77|P-value:1.44E-7 ID:SGTC_2764|Compound:methyldopa|FD-Score:5.03|P-value:3.95E-6 ID:SGTC_2906|Compound:7926292|FD-Score:5.45|P-value:6.17E-7 ID:SGTC_2940|Compound:9060638|FD-Score:4.26|P-value:7.91E-5 ID:SGTC_2960|Compound:9079389|FD-Score:-4.06|P-value:1.26E-4 ID:SGTC_2962|Compound:9082311|FD-Score:3.59|P-value:7.31E-4 ID:SGTC_2968|Compound:9090663|FD-Score:5.93|P-value:6.53E-8 ID:SGTC_3178|Compound:9107506|FD-Score:-3.59|P-value:5.83E-4 ID:SGTC_3190|Compound:9110366|FD-Score:-4.01|P-value:1.46E-4 ID:SGTC_3199|Compound:9111318|FD-Score:-3.66|P-value:4.77E-4 ID:SGTC_3210|Compound:9128157|FD-Score:-4.34|P-value:4.57E-5 ID:SGTC_3311|Compound:9131146|FD-Score:5.30|P-value:1.23E-6

Top fitness defect scores for YMR294W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 15.60 40.9 µM 1.13E-44 cell wall 16 1.75E-55
2 SGTC_2584 androsterone 10.00 48.7 µM 2.08E-19 cell wall 16 6.57E-24
3 SGTC_58 0957-0393 9.35 9.0 µM 3.83E-17 cell wall 93 4.44E-21
4 SGTC_528 3492-0019 8.83 172.0 µM 1.79E-15 calcium & mitochondrial duress 58 5.42E-19
5 SGTC_160 3453-0671 7.84 289.7 µM 1.44E-12 5 2.32E-15
6 SGTC_2017 5132927 7.10 60.6 µM 1.31E-10 1 6.46E-13
7 SGTC_240 5hr heat shock (37°C) + Streptovitacin 6.80 300.0 µM 6.94E-10 heat shock/prefoldin 12 5.17E-12
8 SGTC_237 nikkomycin 6.53 200.0 µM 3.09E-9 RSC complex & mRNA processing 3 3.34E-11
9 SGTC_514 4466-0038 6.32 2.6 nM 9.11E-9 cell wall 67 1.29E-10
10 SGTC_456 gingerol 6.03 170.0 µM 4.01E-8 3 8.18E-10
11 SGTC_2968 9090663 5.93 33.4 µM 6.53E-8 7 1.50E-9
12 SGTC_2612 dictamnine 5.77 15.5 µM 1.44E-7 RNA pol III & RNase P/MRP 13 4.03E-9
13 SGTC_598 3937-0236 5.48 20.2 µM 5.41E-7 ERG2 11 2.10E-8
14 SGTC_2906 7926292 5.45 26.4 µM 6.17E-7 9 2.47E-8
15 SGTC_1647 st011722 5.38 22.4 µM 8.70E-7 3 3.79E-8
16 SGTC_1073 triclabendazole 5.30 3.1 µM 1.21E-6 11 5.72E-8
17 SGTC_3311 9131146 5.30 2.9 µM 1.23E-6 cell wall 78 5.86E-8
18 SGTC_2424 5537928 5.25 59.2 µM 1.53E-6 11 7.66E-8
19 SGTC_1934 st074720 5.10 32.6 µM 2.89E-6 25 1.69E-7
20 SGTC_162 k030-0015 5.09 37.8 µM 3.00E-6 iron homeostasis 10 1.78E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.324 5.70E-83 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.309 2.22E-75 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.308 8.33E-75 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.290 6.11E-66 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.288 7.18E-65 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.284 2.18E-63 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.283 1.05E-62 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.275 3.91E-59 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.272 5.51E-58 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.261 2.49E-53 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.259 9.35E-53 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.258 2.55E-52 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.258 2.75E-52 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.257 8.11E-52 YJL080C SCP160 hom Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins
0.256 1.58E-51 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event