YMR295C

Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR295C / YMR295C

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:3.66|P-value:9.71E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.37|P-value:3.60E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.23|P-value:8.34E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.20|P-value:5.48E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.27|P-value:4.33E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:3.22|P-value:5.13E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.44|P-value:3.17E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:3.86|P-value:4.14E-5 ID:SGTC_406|Compound:estrone|FD-Score:3.19|P-value:5.76E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:4.41|P-value:3.58E-6 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.34|P-value:3.98E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.75|P-value:6.69E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.36|P-value:3.11E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.82|P-value:6.03E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:3.22|P-value:5.10E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-4.07|P-value:2.15E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.00|P-value:2.35E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.16|P-value:6.25E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.11|P-value:1.40E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.25|P-value:4.65E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.06|P-value:1.81E-5 ID:SGTC_1677|Compound:st019204|FD-Score:3.21|P-value:5.28E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-3.39|P-value:3.36E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.12|P-value:1.36E-5 ID:SGTC_2084|Compound:5306078|FD-Score:3.33|P-value:3.45E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.13|P-value:7.06E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.70|P-value:8.13E-5 ID:SGTC_2382|Compound:9035899|FD-Score:3.74|P-value:6.86E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.72|P-value:4.22E-12 ID:SGTC_2918|Compound:7977171|FD-Score:3.89|P-value:3.76E-5 ID:SGTC_2931|Compound:9014674|FD-Score:5.89|P-value:1.11E-9 ID:SGTC_2960|Compound:9079389|FD-Score:3.18|P-value:5.97E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:3.66|P-value:9.71E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-3.37|P-value:3.60E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:4.23|P-value:8.34E-6 ID:SGTC_168|Compound:3970-0862|FD-Score:3.20|P-value:5.48E-4 ID:SGTC_176|Compound:1486-1328|FD-Score:3.27|P-value:4.33E-4 ID:SGTC_199|Compound:4063-0024|FD-Score:3.22|P-value:5.13E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.44|P-value:3.17E-6 ID:SGTC_352|Compound:k048-0007|FD-Score:3.86|P-value:4.14E-5 ID:SGTC_406|Compound:estrone|FD-Score:3.19|P-value:5.76E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:4.41|P-value:3.58E-6 ID:SGTC_554|Compound:4483-2211|FD-Score:-3.34|P-value:3.98E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.75|P-value:6.69E-5 ID:SGTC_799|Compound:1310-0557|FD-Score:3.36|P-value:3.11E-4 ID:SGTC_811|Compound:0416-0114|FD-Score:-3.82|P-value:6.03E-5 ID:SGTC_855|Compound:0428-0020|FD-Score:3.22|P-value:5.10E-4 ID:SGTC_963|Compound:1269-2853|FD-Score:-4.07|P-value:2.15E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:4.00|P-value:2.35E-5 ID:SGTC_1094|Compound:duloxetine|FD-Score:3.16|P-value:6.25E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.11|P-value:1.40E-5 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.25|P-value:4.65E-4 ID:SGTC_1599|Compound:8-chlro-1-tetrahydronorharmanone|FD-Score:4.06|P-value:1.81E-5 ID:SGTC_1677|Compound:st019204|FD-Score:3.21|P-value:5.28E-4 ID:SGTC_1729|Compound:st035615|FD-Score:-3.39|P-value:3.36E-4 ID:SGTC_1824|Compound:st053723|FD-Score:4.12|P-value:1.36E-5 ID:SGTC_2084|Compound:5306078|FD-Score:3.33|P-value:3.45E-4 ID:SGTC_2339|Compound:9000433|FD-Score:3.13|P-value:7.06E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.70|P-value:8.13E-5 ID:SGTC_2382|Compound:9035899|FD-Score:3.74|P-value:6.86E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:6.72|P-value:4.22E-12 ID:SGTC_2918|Compound:7977171|FD-Score:3.89|P-value:3.76E-5 ID:SGTC_2931|Compound:9014674|FD-Score:5.89|P-value:1.11E-9 ID:SGTC_2960|Compound:9079389|FD-Score:3.18|P-value:5.97E-4

Top fitness defect scores for YMR295C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 6.72 100.0 µM 4.22E-12 redox potentiating 140 8.78E-12
2 SGTC_2931 9014674 5.89 55.7 µM 1.11E-9 1 1.99E-9
3 SGTC_255 tunicamycin 4.44 200.5 nM 3.17E-6 unfolded protein response 55 4.58E-6
4 SGTC_440 fluspirilene 4.41 35.1 µM 3.58E-6 7 5.15E-6
5 SGTC_165 k038-0023 4.23 64.4 µM 8.34E-6 ubiquinone biosynthesis & proteasome 67 1.17E-5
6 SGTC_1824 st053723 4.12 68.6 µM 1.36E-5 28 1.89E-5
7 SGTC_1227 3909-8010 4.11 46.6 µM 1.40E-5 13 1.94E-5
8 SGTC_1599 8-chlro-1-tetrahydronorharmanone 4.06 90.6 µM 1.81E-5 34 2.49E-5
9 SGTC_1054 3429-0080 4.00 167.0 µM 2.35E-5 26 3.21E-5
10 SGTC_2918 7977171 3.89 22.1 µM 3.76E-5 31 5.07E-5
11 SGTC_352 k048-0007 3.86 5.1 µM 4.14E-5 ERAD & cell cycle 82 5.56E-5
12 SGTC_580 1123-0028 3.75 41.0 µM 6.69E-5 DNA damage response 46 8.88E-5
13 SGTC_2382 9035899 3.74 200.0 µM 6.86E-5 60S ribosome export 19 9.10E-5
14 SGTC_2346 9031566 3.70 143.8 µM 8.13E-5 Golgi 26 1.07E-4
15 SGTC_64 000l-0018 3.66 272.1 µM 9.71E-5 ubiquinone biosynthesis & proteasome 166 1.27E-4
16 SGTC_799 1310-0557 3.36 151.0 µM 3.11E-4 superoxide 46 3.95E-4
17 SGTC_2084 5306078 3.33 60.6 µM 3.45E-4 40 4.37E-4
18 SGTC_176 1486-1328 3.27 72.8 µM 4.33E-4 95 5.45E-4
19 SGTC_1408 3909-7976 3.25 48.8 µM 4.65E-4 Golgi 48 5.85E-4
20 SGTC_855 0428-0020 3.22 25.0 µM 5.10E-4 Golgi 44 6.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 8.15E-34 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.200 1.27E-31 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.185 3.80E-27 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.177 4.54E-25 YOR049C RSB1 hom Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane
0.176 8.62E-25 YJL169W_d YJL169W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2
0.172 1.19E-23 YML052W SUR7 hom Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants
0.168 1.02E-22 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.160 8.86E-21 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.160 1.03E-20 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.160 1.37E-20 YMR109W MYO5 hom One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization
0.158 4.52E-20 YOR050C_d YOR050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable
0.156 1.15E-19 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.152 6.72E-19 YDL194W SNF3 hom Plasma membrane low glucose sensor, regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; SNF3 has a paralog, RGT2, that arose from the whole genome duplication
0.150 2.46E-18 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.148 6.73E-18 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p