HIPHOP chemogenomics database
YMR298W / LIP1 
Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YMR298W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.205 | 4.24E-33 | YOR304W | ISW2 | hom | ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth |
| 0.145 | 2.96E-17 | YML006C | GIS4 | hom | CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway |
| 0.122 | 1.25E-12 | YJR116W_p | TDA4_p | hom | Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele |
| 0.111 | 1.14E-10 | YPR179C | HDA3 | hom | Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p |
| 0.108 | 3.19E-10 | YGR047C | TFC4 | het | One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 |
| 0.108 | 3.56E-10 | YGL094C | PAN2 | hom | Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes |
| 0.107 | 4.97E-10 | YDR295C | HDA2 | hom | Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance |
| 0.105 | 1.15E-9 | YKL008C | LAC1 | hom | Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p |
| 0.101 | 4.52E-9 | YOL065C | INP54 | hom | Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins |
| 0.101 | 4.81E-9 | YER085C_p | YER085C_p | hom | Putative protein of unknown function |
| 0.096 | 2.72E-8 | YHR065C | RRP3 | het | Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity |
| 0.088 | 2.98E-7 | YMR135W-A_d | YMR135W-A_d | hom | Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
| 0.087 | 4.69E-7 | YGR116W | SPT6 | het | Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within the coding region |
| 0.086 | 5.72E-7 | YNL140C_p | YNL140C_p | hom | Protein of unknown function; expressed at both mRNA and protein levels; partially overlaps THO2/YNL139C |
| 0.084 | 9.91E-7 | YOR363C | PIP2 | hom | Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes; PIP2 has a paralog, OAF1, that arose from the whole genome duplication |