YMR299C / DYN3

Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR299C / DYN3

Click on Significant Values for Screen Details ID:SGTC_113|Compound:0099-0221|FD-Score:3.25|P-value:5.06E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.37|P-value:2.63E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:3.82|P-value:5.53E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.56|P-value:1.59E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.40|P-value:4.53E-11 ID:SGTC_140|Compound:0062-0056|FD-Score:7.89|P-value:6.80E-16 ID:SGTC_176|Compound:1486-1328|FD-Score:4.29|P-value:7.13E-6 ID:SGTC_379|Compound:3970-0972|FD-Score:3.99|P-value:2.71E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:3.19|P-value:6.29E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:4.76|P-value:7.32E-7 ID:SGTC_443|Compound:clozapine|FD-Score:-3.27|P-value:4.50E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.30|P-value:4.24E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.30|P-value:4.16E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.96|P-value:3.09E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.55|P-value:1.64E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.56|P-value:1.56E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.20|P-value:5.75E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:7.84|P-value:9.82E-16 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.38|P-value:4.65E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:3.12|P-value:8.02E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:5.14|P-value:9.44E-8 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.15|P-value:7.13E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:-3.06|P-value:9.54E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:4.32|P-value:6.16E-6 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-3.16|P-value:6.73E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.37|P-value:3.19E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.84|P-value:5.10E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.42|P-value:2.62E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.41|P-value:2.80E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.62|P-value:1.26E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.43|P-value:3.68E-6 ID:SGTC_1715|Compound:st032160|FD-Score:-3.26|P-value:4.80E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.50|P-value:1.96E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.54|P-value:1.69E-4 ID:SGTC_2020|Compound:4017018|FD-Score:5.45|P-value:1.74E-8 ID:SGTC_2023|Compound:5144124|FD-Score:5.16|P-value:8.68E-8 ID:SGTC_2024|Compound:5144227|FD-Score:3.09|P-value:8.85E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.48|P-value:2.07E-4 ID:SGTC_2136|Compound:5328288|FD-Score:4.38|P-value:4.55E-6 ID:SGTC_2246|Compound:7293507|FD-Score:4.70|P-value:9.57E-7 ID:SGTC_2280|Compound:7785178|FD-Score:-3.55|P-value:1.57E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.08|P-value:8.98E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.22|P-value:5.54E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.19|P-value:1.08E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.55|P-value:1.93E-6 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.37|P-value:3.27E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.29|P-value:7.12E-6 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.90|P-value:3.94E-5 ID:SGTC_2825|Compound:7998094|FD-Score:6.08|P-value:3.72E-10 ID:SGTC_2893|Compound:9048488|FD-Score:3.45|P-value:2.42E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.87|P-value:4.43E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.71|P-value:8.48E-5 ID:SGTC_2971|Compound:9092186|FD-Score:5.14|P-value:9.42E-8 ID:SGTC_2973|Compound:9094665|FD-Score:3.37|P-value:3.28E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.38|P-value:3.08E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.57|P-value:1.51E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.24|P-value:5.07E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.97|P-value:2.94E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.38|P-value:3.11E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.25|P-value:5.06E-4 ID:SGTC_117|Compound:lucigenin|FD-Score:5.37|P-value:2.63E-8 ID:SGTC_119|Compound:0121-0043|FD-Score:3.82|P-value:5.53E-5 ID:SGTC_136|Compound:0097-0015|FD-Score:3.56|P-value:1.59E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.40|P-value:4.53E-11 ID:SGTC_140|Compound:0062-0056|FD-Score:7.89|P-value:6.80E-16 ID:SGTC_176|Compound:1486-1328|FD-Score:4.29|P-value:7.13E-6 ID:SGTC_379|Compound:3970-0972|FD-Score:3.99|P-value:2.71E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:3.19|P-value:6.29E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:4.76|P-value:7.32E-7 ID:SGTC_443|Compound:clozapine|FD-Score:-3.27|P-value:4.50E-4 ID:SGTC_553|Compound:k007-0256|FD-Score:3.30|P-value:4.24E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:3.30|P-value:4.16E-4 ID:SGTC_680|Compound:0417-1641|FD-Score:3.96|P-value:3.09E-5 ID:SGTC_701|Compound:4424-0219|FD-Score:3.55|P-value:1.64E-4 ID:SGTC_857|Compound:0438-0306|FD-Score:3.56|P-value:1.56E-4 ID:SGTC_997|Compound:3996-0078|FD-Score:-3.20|P-value:5.75E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:7.84|P-value:9.82E-16 ID:SGTC_1045|Compound:1348-1485|FD-Score:4.38|P-value:4.65E-6 ID:SGTC_1074|Compound:carmofur|FD-Score:3.12|P-value:8.02E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:5.14|P-value:9.44E-8 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.15|P-value:7.13E-4 ID:SGTC_1215|Compound:3852-0577|FD-Score:-3.06|P-value:9.54E-4 ID:SGTC_1295|Compound:1013-0063|FD-Score:4.32|P-value:6.16E-6 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-3.16|P-value:6.73E-4 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.37|P-value:3.19E-4 ID:SGTC_1393|Compound:3470-5649|FD-Score:3.84|P-value:5.10E-5 ID:SGTC_1452|Compound:4194-0072|FD-Score:-3.42|P-value:2.62E-4 ID:SGTC_1542|Compound:7-hydroxy-3'-methoxyflavone|FD-Score:3.41|P-value:2.80E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.62|P-value:1.26E-4 ID:SGTC_1611|Compound:st001856|FD-Score:4.43|P-value:3.68E-6 ID:SGTC_1715|Compound:st032160|FD-Score:-3.26|P-value:4.80E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.50|P-value:1.96E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.54|P-value:1.69E-4 ID:SGTC_2020|Compound:4017018|FD-Score:5.45|P-value:1.74E-8 ID:SGTC_2023|Compound:5144124|FD-Score:5.16|P-value:8.68E-8 ID:SGTC_2024|Compound:5144227|FD-Score:3.09|P-value:8.85E-4 ID:SGTC_2058|Compound:5236698|FD-Score:-3.48|P-value:2.07E-4 ID:SGTC_2136|Compound:5328288|FD-Score:4.38|P-value:4.55E-6 ID:SGTC_2246|Compound:7293507|FD-Score:4.70|P-value:9.57E-7 ID:SGTC_2280|Compound:7785178|FD-Score:-3.55|P-value:1.57E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.08|P-value:8.98E-4 ID:SGTC_2549|Compound:cedrol|FD-Score:3.22|P-value:5.54E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-4.19|P-value:1.08E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-4.55|P-value:1.93E-6 ID:SGTC_2685|Compound:mycophenolic acid|FD-Score:3.37|P-value:3.27E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:4.29|P-value:7.12E-6 ID:SGTC_2770|Compound:toltrazuril|FD-Score:3.90|P-value:3.94E-5 ID:SGTC_2825|Compound:7998094|FD-Score:6.08|P-value:3.72E-10 ID:SGTC_2893|Compound:9048488|FD-Score:3.45|P-value:2.42E-4 ID:SGTC_2923|Compound:7992654|FD-Score:3.87|P-value:4.43E-5 ID:SGTC_2969|Compound:9091408|FD-Score:3.71|P-value:8.48E-5 ID:SGTC_2971|Compound:9092186|FD-Score:5.14|P-value:9.42E-8 ID:SGTC_2973|Compound:9094665|FD-Score:3.37|P-value:3.28E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.38|P-value:3.08E-4 ID:SGTC_3031|Compound:9088762|FD-Score:3.57|P-value:1.51E-4 ID:SGTC_3131|Compound:9127911|FD-Score:-3.24|P-value:5.07E-4 ID:SGTC_3174|Compound:9107204|FD-Score:3.97|P-value:2.94E-5 ID:SGTC_3205|Compound:9113483|FD-Score:3.38|P-value:3.11E-4

Top fitness defect scores for YMR299C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_140 0062-0056 7.89 502.5 µM 6.80E-16 1 1.55E-15
2 SGTC_998 3996-0085 7.84 177.0 µM 9.82E-16 1 2.21E-15
3 SGTC_138 0850-0259 6.40 40.9 µM 4.53E-11 cell wall 95 7.78E-11
4 SGTC_2825 7998094 6.08 58.4 µM 3.72E-10 fatty acid desaturase (OLE1) 9 6.06E-10
5 SGTC_2020 4017018 5.45 200.0 µM 1.74E-8 2 2.57E-8
6 SGTC_117 lucigenin 5.37 22.1 µM 2.63E-8 redox potentiating 51 3.85E-8
7 SGTC_2023 5144124 5.16 124.0 µM 8.68E-8 7 1.23E-7
8 SGTC_2971 9092186 5.14 9.9 µM 9.42E-8 ergosterol biosynthesis 11 1.34E-7
9 SGTC_1155 4088-0394 5.14 48.2 µM 9.44E-8 4 1.34E-7
10 SGTC_385 1494-0393 4.76 12.4 µM 7.32E-7 7 9.88E-7
11 SGTC_2246 7293507 4.70 91.6 µM 9.57E-7 19 1.28E-6
12 SGTC_1611 st001856 4.43 99.4 µM 3.68E-6 9 4.77E-6
13 SGTC_2136 5328288 4.38 199.3 µM 4.55E-6 14 5.87E-6
14 SGTC_1045 1348-1485 4.38 165.0 µM 4.65E-6 17 6.00E-6
15 SGTC_1295 1013-0063 4.32 9.8 µM 6.16E-6 3 7.90E-6
16 SGTC_2750 bromebric acid 4.29 70.2 µM 7.12E-6 19 9.09E-6
17 SGTC_176 1486-1328 4.29 72.8 µM 7.13E-6 44 9.10E-6
18 SGTC_379 3970-0972 3.99 5.9 µM 2.71E-5 tubulin folding & SWR complex 37 3.35E-5
19 SGTC_3174 9107204 3.97 49.5 µM 2.94E-5 ERG2 32 3.62E-5
20 SGTC_680 0417-1641 3.96 114.0 µM 3.09E-5 RPP1 & pyrimidine depletion 12 3.81E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.119 4.51E-12 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
0.111 9.80E-11 YKL048C ELM1 hom Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases, such as Kin4p; forms part of the bud neck ring
0.108 3.69E-10 YHR140W_p YHR140W_p hom Putative integral membrane protein of unknown function
0.106 6.90E-10 YDR149C_d YDR149C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth
0.098 1.29E-8 YEL003W GIM4 hom Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it
0.095 4.00E-8 YKL132C RMA1 hom Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.094 4.77E-8 YLR150W STM1 hom Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure; protein abundance increases in response to DNA replication stress; serves as a ribosome preservation factor both during quiescence and recovery
0.091 1.19E-7 YCR102C_p YCR102C_p hom Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family
0.090 2.06E-7 YNL016W PUB1 hom Poly (A)+ RNA-binding protein; abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; protein abundance increases in response to DNA replication stress
0.089 2.11E-7 YDR540C IRC4 hom Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
0.086 5.89E-7 YHR181W SVP26 hom Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
0.085 7.38E-7 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.084 1.26E-6 YMR273C ZDS1 hom Protein with a role in regulating Swe1p-dependent polarized growth; involved in maintaining Cdc55p in the cytoplasm where it promotes mitotic entry; involved in mitotic exit through Cdc14p regulation; interacts with silencing proteins at telomeres; has a role in Bcy1p localization; implicated in mRNA nuclear export; ZDS1 has a paralog, ZDS2, that arose from the whole genome duplication
0.083 1.33E-6 YLL021W SPA2 hom Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate
0.079 4.16E-6 YMR294W JNM1 hom Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B