YMR301C / ATM1

Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR301C / ATM1

Click on Significant Values for Screen Details ID:SGTC_76|Compound:0433-0009|FD-Score:4.69|P-value:5.58E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-7.37|P-value:2.73E-12 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.52|P-value:5.07E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.57|P-value:4.32E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.60|P-value:3.74E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.13|P-value:8.31E-7 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.81|P-value:1.85E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-4.00|P-value:9.31E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.43|P-value:6.57E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.28|P-value:4.10E-7 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.69|P-value:2.78E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-4.47|P-value:1.46E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.95|P-value:1.82E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.81|P-value:1.79E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.80|P-value:1.85E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-4.84|P-value:3.07E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:6.60|P-value:3.22E-10 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.93|P-value:1.15E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.32|P-value:9.25E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.36|P-value:8.29E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.75|P-value:2.27E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.36|P-value:8.17E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.41|P-value:7.01E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.35|P-value:8.58E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.96|P-value:1.26E-8 ID:SGTC_2102|Compound:5377816|FD-Score:3.42|P-value:6.74E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.33|P-value:8.93E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.50|P-value:5.26E-4 ID:SGTC_2326|Compound:6164455|FD-Score:5.55|P-value:1.01E-7 ID:SGTC_2415|Compound:st077333|FD-Score:-3.79|P-value:1.97E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.64|P-value:3.26E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.93|P-value:1.15E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.05|P-value:7.53E-5 ID:SGTC_2839|Compound:9003951|FD-Score:3.41|P-value:7.00E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-3.46|P-value:6.23E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.37|P-value:7.99E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.31|P-value:9.61E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-3.41|P-value:7.28E-4 ID:SGTC_2913|Compound:7966556|FD-Score:5.14|P-value:7.48E-7 ID:SGTC_2993|Compound:9054257|FD-Score:3.40|P-value:7.29E-4 ID:SGTC_3108|Compound:9121785|FD-Score:4.46|P-value:1.50E-5 ID:SGTC_3136|Compound:9095672|FD-Score:3.65|P-value:3.10E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.72|P-value:2.46E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.01|P-value:8.59E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-3.34|P-value:8.93E-4 ID:SGTC_76|Compound:0433-0009|FD-Score:4.69|P-value:5.58E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:-7.37|P-value:2.73E-12 ID:SGTC_342|Compound:k048-0088|FD-Score:-3.52|P-value:5.07E-4 ID:SGTC_355|Compound:1311-2252|FD-Score:-3.57|P-value:4.32E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:3.60|P-value:3.74E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:-5.13|P-value:8.31E-7 ID:SGTC_976|Compound:1348-1067|FD-Score:-3.81|P-value:1.85E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:-4.00|P-value:9.31E-5 ID:SGTC_1100|Compound:amiodarone|FD-Score:3.43|P-value:6.57E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-5.28|P-value:4.10E-7 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.69|P-value:2.78E-4 ID:SGTC_1112|Compound:tnp00069|FD-Score:-4.47|P-value:1.46E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.95|P-value:1.82E-6 ID:SGTC_1250|Compound:0485-0349|FD-Score:3.81|P-value:1.79E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:3.80|P-value:1.85E-4 ID:SGTC_1280|Compound:0880-0253|FD-Score:-4.84|P-value:3.07E-6 ID:SGTC_1287|Compound:0971-0001|FD-Score:6.60|P-value:3.22E-10 ID:SGTC_1317|Compound:1273-0028|FD-Score:3.93|P-value:1.15E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.32|P-value:9.25E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.36|P-value:8.29E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.75|P-value:2.27E-4 ID:SGTC_1795|Compound:st049545|FD-Score:3.36|P-value:8.17E-4 ID:SGTC_1810|Compound:st050138|FD-Score:3.41|P-value:7.01E-4 ID:SGTC_1829|Compound:berberine|FD-Score:3.35|P-value:8.58E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-5.96|P-value:1.26E-8 ID:SGTC_2102|Compound:5377816|FD-Score:3.42|P-value:6.74E-4 ID:SGTC_2260|Compound:7964312|FD-Score:3.33|P-value:8.93E-4 ID:SGTC_2317|Compound:5986382|FD-Score:3.50|P-value:5.26E-4 ID:SGTC_2326|Compound:6164455|FD-Score:5.55|P-value:1.01E-7 ID:SGTC_2415|Compound:st077333|FD-Score:-3.79|P-value:1.97E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:3.64|P-value:3.26E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.93|P-value:1.15E-4 ID:SGTC_2789|Compound:5281112|FD-Score:4.05|P-value:7.53E-5 ID:SGTC_2839|Compound:9003951|FD-Score:3.41|P-value:7.00E-4 ID:SGTC_2861|Compound:9024595|FD-Score:-3.46|P-value:6.23E-4 ID:SGTC_2876|Compound:9059903|FD-Score:3.37|P-value:7.99E-4 ID:SGTC_2894|Compound:9048625|FD-Score:3.31|P-value:9.61E-4 ID:SGTC_2909|Compound:7941780|FD-Score:-3.41|P-value:7.28E-4 ID:SGTC_2913|Compound:7966556|FD-Score:5.14|P-value:7.48E-7 ID:SGTC_2993|Compound:9054257|FD-Score:3.40|P-value:7.29E-4 ID:SGTC_3108|Compound:9121785|FD-Score:4.46|P-value:1.50E-5 ID:SGTC_3136|Compound:9095672|FD-Score:3.65|P-value:3.10E-4 ID:SGTC_3166|Compound:9102297|FD-Score:3.72|P-value:2.46E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.01|P-value:8.59E-5 ID:SGTC_3193|Compound:9111931|FD-Score:-3.34|P-value:8.93E-4

Top fitness defect scores for YMR301C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1287 0971-0001 6.60 34.6 µM 3.22E-10 sphingolipid biosynthesis & PDR1 1 2.04E-11 1.04
2 SGTC_2326 6164455 5.55 177.6 µM 1.01E-7 mitochondrial processes 5 1.42E-8 0.53
3 SGTC_2913 7966556 5.14 36.6 µM 7.48E-7 60S ribosome export 3 1.38E-7 0.61
4 SGTC_1203 3992-3522 4.95 103.0 µM 1.82E-6 6 3.78E-7 0.03
5 SGTC_76 0433-0009 4.69 400.3 µM 5.58E-6 6 1.35E-6 0.53
6 SGTC_3108 9121785 4.46 49.5 µM 1.50E-5 6 4.16E-6 0.36
7 SGTC_2789 5281112 4.05 71.4 µM 7.53E-5 9 2.60E-5 0.06
8 SGTC_3174 9107204 4.01 49.5 µM 8.59E-5 ERG2 1 3.01E-5 0.50
9 SGTC_1317 1273-0028 3.93 910.0 nM 1.15E-4 azole & statin 13 4.19E-5 0.28
10 SGTC_2757 clomiphene 3.93 4.2 µM 1.15E-4 fatty acid desaturase (OLE1) 12 4.19E-5 0.15
11 SGTC_1250 0485-0349 3.81 40.2 µM 1.79E-4 12 6.94E-5 0.02
12 SGTC_1278 0874-0585 3.80 172.0 µM 1.85E-4 5 7.19E-5 0.00
13 SGTC_3166 9102297 3.72 49.5 µM 2.46E-4 Golgi 5 9.93E-5 0.24
14 SGTC_1110 3-hydroxy-3'-methoxyflavone 3.69 1.2 µM 2.78E-4 iron homeostasis 4 1.14E-4 0.12
15 SGTC_3136 9095672 3.65 49.5 µM 3.10E-4 8 1.29E-4 0.19
16 SGTC_2689 tacrolimus 3.64 100.0 µM 3.26E-4 16 1.37E-4 0.07
17 SGTC_688 0527-0193 3.60 473.0 µM 3.74E-4 fatty acid desaturase (OLE1) 5 1.60E-4 0.21
18 SGTC_2317 5986382 3.50 200.0 µM 5.26E-4 8 2.35E-4 0.09
19 SGTC_1100 amiodarone 3.43 5.1 µM 6.57E-4 5 3.02E-4 0.23
20 SGTC_2102 5377816 3.42 72.8 µM 6.74E-4 8 3.11E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 1.30E-17 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.146 2.13E-17 YPR088C SRP54 het Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain
0.144 6.04E-17 YKL024C URA6 het Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)
0.142 1.32E-16 YOR082C_d YOR082C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W
0.142 1.69E-16 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.139 5.34E-16 YBL036C YBL036C hom Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS
0.136 2.99E-15 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.121 1.90E-12 YGL017W ATE1 hom Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway
0.119 4.09E-12 YML064C TEM1 het GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis
0.118 6.67E-12 YGR097W ASK10 hom Component of RNA polymerase II holoenzyme; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; ASK10 has a paralog, RGC1, that arose from the whole genome duplication
0.115 2.71E-11 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.110 1.60E-10 YAL034W-A MTW1 het Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly
0.110 1.69E-10 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.110 1.67E-10 YFR031C SMC2 het Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus
0.109 2.25E-10 YCL035C GRX1 hom Glutathione-dependent disulfide oxidoreductase; hydroperoxide and superoxide-radical responsive, heat-stable, with active site cysteine pair; protects cells from oxidative damage; GRX1 has a paralog, GRX2, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress