YMR303C / ADH2

Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR303C / ADH2

Click on Significant Values for Screen Details ID:SGTC_21|Compound:0849-0113|FD-Score:3.67|P-value:1.30E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.43|P-value:3.27E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.73|P-value:1.22E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.94|P-value:5.24E-5 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.95|P-value:5.09E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.41|P-value:3.96E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.35|P-value:4.93E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.56|P-value:2.35E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.17|P-value:8.09E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.46|P-value:3.37E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.55|P-value:2.41E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:4.43|P-value:5.37E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:5.09|P-value:2.16E-7 ID:SGTC_711|Compound:k292-0785|FD-Score:3.25|P-value:6.14E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:4.55|P-value:3.10E-6 ID:SGTC_796|Compound:1234-0020|FD-Score:3.14|P-value:8.95E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:5.11|P-value:1.92E-7 ID:SGTC_956|Compound:1185-0240|FD-Score:3.29|P-value:5.33E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.27|P-value:5.62E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.25|P-value:6.11E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.29|P-value:1.03E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:5.15|P-value:1.62E-7 ID:SGTC_1412|Compound:3909-8563|FD-Score:-3.43|P-value:3.69E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.47|P-value:2.80E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.46|P-value:4.63E-6 ID:SGTC_2331|Compound:7980721|FD-Score:4.24|P-value:1.28E-5 ID:SGTC_2333|Compound:9017922|FD-Score:-3.48|P-value:3.13E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-3.29|P-value:6.08E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.16|P-value:1.76E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-5.11|P-value:2.39E-7 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.29|P-value:5.25E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.18|P-value:7.66E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.79|P-value:9.61E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-3.69|P-value:1.42E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-3.29|P-value:6.04E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.50|P-value:2.48E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:3.67|P-value:1.30E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:3.43|P-value:3.27E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:-3.73|P-value:1.22E-4 ID:SGTC_109|Compound:0132-0036|FD-Score:-3.94|P-value:5.24E-5 ID:SGTC_110|Compound:0850-0284|FD-Score:-3.95|P-value:5.09E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:-3.41|P-value:3.96E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:-3.35|P-value:4.93E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:-3.56|P-value:2.35E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:3.17|P-value:8.09E-4 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.46|P-value:3.37E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.55|P-value:2.41E-4 ID:SGTC_531|Compound:3788-1495|FD-Score:4.43|P-value:5.37E-6 ID:SGTC_696|Compound:1560-0013|FD-Score:5.09|P-value:2.16E-7 ID:SGTC_711|Compound:k292-0785|FD-Score:3.25|P-value:6.14E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:4.55|P-value:3.10E-6 ID:SGTC_796|Compound:1234-0020|FD-Score:3.14|P-value:8.95E-4 ID:SGTC_935|Compound:2996-0153|FD-Score:5.11|P-value:1.92E-7 ID:SGTC_956|Compound:1185-0240|FD-Score:3.29|P-value:5.33E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.27|P-value:5.62E-4 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.25|P-value:6.11E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.29|P-value:1.03E-5 ID:SGTC_1404|Compound:3909-7820|FD-Score:5.15|P-value:1.62E-7 ID:SGTC_1412|Compound:3909-8563|FD-Score:-3.43|P-value:3.69E-4 ID:SGTC_2296|Compound:7971656|FD-Score:3.47|P-value:2.80E-4 ID:SGTC_2320|Compound:7373003|FD-Score:4.46|P-value:4.63E-6 ID:SGTC_2331|Compound:7980721|FD-Score:4.24|P-value:1.28E-5 ID:SGTC_2333|Compound:9017922|FD-Score:-3.48|P-value:3.13E-4 ID:SGTC_2479|Compound:5617353|FD-Score:-3.29|P-value:6.08E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:4.16|P-value:1.76E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-5.11|P-value:2.39E-7 ID:SGTC_2776|Compound:terbinafine|FD-Score:3.29|P-value:5.25E-4 ID:SGTC_2926|Compound:9010726|FD-Score:3.18|P-value:7.66E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.79|P-value:9.61E-5 ID:SGTC_2948|Compound:9070189|FD-Score:-3.69|P-value:1.42E-4 ID:SGTC_3087|Compound:9117406|FD-Score:-3.29|P-value:6.04E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.50|P-value:2.48E-4

Top fitness defect scores for YMR303C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1404 3909-7820 5.15 48.3 µM 1.62E-7 60S ribosome export 4 1.32E-7
2 SGTC_935 2996-0153 5.11 430.0 µM 1.92E-7 PDR1 7 1.58E-7
3 SGTC_696 1560-0013 5.09 611.0 µM 2.16E-7 9 1.78E-7
4 SGTC_793 0488-0545 4.55 106.0 µM 3.10E-6 9 2.68E-6
5 SGTC_2320 7373003 4.46 200.0 µM 4.63E-6 15 4.03E-6
6 SGTC_531 3788-1495 4.43 174.0 µM 5.37E-6 unfolded protein response 15 4.69E-6
7 SGTC_1377 2944-0135 4.29 198.0 µM 1.03E-5 calcium & mitochondrial duress 28 9.04E-6
8 SGTC_2331 7980721 4.24 200.0 µM 1.28E-5 22 1.13E-5
9 SGTC_2594 a-mangostin 4.16 100.0 µM 1.76E-5 26 1.57E-5
10 SGTC_21 0849-0113 3.67 23.0 µM 1.30E-4 39 1.20E-4
11 SGTC_3254 9136651 3.50 49.5 µM 2.48E-4 DNA damage response 37 2.31E-4
12 SGTC_2296 7971656 3.47 126.5 µM 2.80E-4 64 2.62E-4
13 SGTC_73 0327-0325 3.43 16.2 µM 3.27E-4 DNA damage response 70 3.06E-4
14 SGTC_2776 terbinafine 3.29 19.9 µM 5.25E-4 cell wall signaling 85 4.94E-4
15 SGTC_956 1185-0240 3.29 191.0 µM 5.33E-4 44 5.02E-4
16 SGTC_1099 5-nonyloxytryptamine 3.27 2.9 µM 5.62E-4 45 5.30E-4
17 SGTC_1337 1486-1011 3.25 40.3 µM 6.11E-4 40 5.77E-4
18 SGTC_711 k292-0785 3.25 179.0 µM 6.14E-4 DNA intercalators 46 5.80E-4
19 SGTC_2926 9010726 3.18 65.2 µM 7.66E-4 58 7.26E-4
20 SGTC_136 0097-0015 3.17 404.5 µM 8.09E-4 60S ribosome export 52 7.67E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.17E-10 YLR099C ICT1 hom Lysophosphatidic acid acyltransferase; responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress; ICT1 has a paralog, ECM18, that arose from the whole genome duplication
0.104 1.68E-9 YNR070W_p PDR18_p hom Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.090 1.67E-7 YFR055W_p IRC7_p hom Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner
0.087 4.17E-7 YLR176C RFX1 hom Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
0.086 6.34E-7 YCL032W STE50 hom Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction
0.082 2.07E-6 YDL109C_p YDL109C_p hom Putative lipase; involved in lipid metabolism; not an essential gene; YDL109C has a paralog, ROG1, that arose from the whole genome duplication
0.081 2.77E-6 YEL013W VAC8 hom Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions
0.080 3.40E-6 YIL085C KTR7 hom Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; KTR7 has a paralog, KTR5, that arose from the whole genome duplication
0.078 6.44E-6 YDR311W TFB1 het Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators
0.078 6.56E-6 YNR027W BUD17 hom Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK)
0.075 1.29E-5 YMR215W GAS3 hom Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation
0.074 1.57E-5 YJL158C CIS3 hom Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
0.074 1.77E-5 YLL050C COF1 het Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes
0.073 2.31E-5 YDR369C XRS2 hom Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
0.073 2.37E-5 YOL023W IFM1 hom Mitochondrial translation initiation factor 2