YMR304C-A_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR304C-A / YMR304C-A

Click on Significant Values for Screen Details ID:SGTC_372|Compound:0155-0182|FD-Score:-3.66|P-value:6.01E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:2.99|P-value:9.28E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-2.99|P-value:8.07E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.65|P-value:7.33E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.17|P-value:4.18E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.58|P-value:9.13E-7 ID:SGTC_661|Compound:1304-0007|FD-Score:4.57|P-value:9.74E-7 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.01|P-value:7.62E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.14|P-value:5.50E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.14|P-value:5.49E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.19|P-value:4.54E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.38|P-value:1.90E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.45|P-value:1.65E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.28|P-value:3.18E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.06|P-value:1.19E-5 ID:SGTC_1641|Compound:st009299|FD-Score:3.04|P-value:7.78E-4 ID:SGTC_1644|Compound:st010134|FD-Score:4.28|P-value:4.04E-6 ID:SGTC_1651|Compound:st011928|FD-Score:3.02|P-value:8.52E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.59|P-value:7.93E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.23|P-value:3.31E-4 ID:SGTC_1792|Compound:st045773|FD-Score:5.80|P-value:7.37E-10 ID:SGTC_1799|Compound:st045822|FD-Score:5.48|P-value:5.57E-9 ID:SGTC_1973|Compound:st070275|FD-Score:3.00|P-value:9.11E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.03|P-value:8.13E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-4.09|P-value:8.37E-6 ID:SGTC_2259|Compound:7964009|FD-Score:3.89|P-value:2.55E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.97|P-value:1.81E-5 ID:SGTC_2385|Compound:9074692|FD-Score:3.11|P-value:6.04E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.26|P-value:3.54E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.31|P-value:2.86E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.94|P-value:2.06E-5 ID:SGTC_2782|Compound:7736369|FD-Score:-3.58|P-value:8.29E-5 ID:SGTC_2807|Compound:7945238|FD-Score:-2.97|P-value:8.84E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.00|P-value:1.55E-5 ID:SGTC_2826|Compound:7992541|FD-Score:-3.47|P-value:1.32E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.92|P-value:1.50E-7 ID:SGTC_2871|Compound:9038510|FD-Score:3.43|P-value:1.77E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-5.28|P-value:1.49E-8 ID:SGTC_2890|Compound:9046729|FD-Score:-3.10|P-value:5.45E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.28|P-value:4.22E-6 ID:SGTC_3032|Compound:9089427|FD-Score:3.08|P-value:6.83E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.89|P-value:2.19E-5 ID:SGTC_3073|Compound:9114972|FD-Score:2.99|P-value:9.39E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-4.08|P-value:8.81E-6 ID:SGTC_3085|Compound:9117376|FD-Score:3.82|P-value:3.52E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.73|P-value:5.13E-5 ID:SGTC_3129|Compound:9127257|FD-Score:-3.23|P-value:3.43E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.42|P-value:1.62E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.21|P-value:3.65E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.31|P-value:2.86E-4 ID:SGTC_3345|Compound:9148410|FD-Score:4.05|P-value:1.21E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-3.24|P-value:3.29E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-3.66|P-value:6.01E-5 ID:SGTC_403|Compound:arphamenine a|FD-Score:2.99|P-value:9.28E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-2.99|P-value:8.07E-4 ID:SGTC_445|Compound:e6 berbamine|FD-Score:3.65|P-value:7.33E-5 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.17|P-value:4.18E-4 ID:SGTC_504|Compound:lovastatin|FD-Score:4.58|P-value:9.13E-7 ID:SGTC_661|Compound:1304-0007|FD-Score:4.57|P-value:9.74E-7 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.01|P-value:7.62E-4 ID:SGTC_749|Compound:1000-0129|FD-Score:3.14|P-value:5.50E-4 ID:SGTC_912|Compound:3474-0017|FD-Score:3.14|P-value:5.49E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:3.19|P-value:4.54E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:-3.38|P-value:1.90E-4 ID:SGTC_1387|Compound:3342-1166|FD-Score:3.45|P-value:1.65E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.28|P-value:3.18E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:4.06|P-value:1.19E-5 ID:SGTC_1641|Compound:st009299|FD-Score:3.04|P-value:7.78E-4 ID:SGTC_1644|Compound:st010134|FD-Score:4.28|P-value:4.04E-6 ID:SGTC_1651|Compound:st011928|FD-Score:3.02|P-value:8.52E-4 ID:SGTC_1738|Compound:st035555|FD-Score:-3.59|P-value:7.93E-5 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.23|P-value:3.31E-4 ID:SGTC_1792|Compound:st045773|FD-Score:5.80|P-value:7.37E-10 ID:SGTC_1799|Compound:st045822|FD-Score:5.48|P-value:5.57E-9 ID:SGTC_1973|Compound:st070275|FD-Score:3.00|P-value:9.11E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.03|P-value:8.13E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-4.09|P-value:8.37E-6 ID:SGTC_2259|Compound:7964009|FD-Score:3.89|P-value:2.55E-5 ID:SGTC_2350|Compound:9023895|FD-Score:3.97|P-value:1.81E-5 ID:SGTC_2385|Compound:9074692|FD-Score:3.11|P-value:6.04E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.26|P-value:3.54E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.31|P-value:2.86E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.94|P-value:2.06E-5 ID:SGTC_2782|Compound:7736369|FD-Score:-3.58|P-value:8.29E-5 ID:SGTC_2807|Compound:7945238|FD-Score:-2.97|P-value:8.84E-4 ID:SGTC_2821|Compound:7996764|FD-Score:4.00|P-value:1.55E-5 ID:SGTC_2826|Compound:7992541|FD-Score:-3.47|P-value:1.32E-4 ID:SGTC_2827|Compound:7993847|FD-Score:4.92|P-value:1.50E-7 ID:SGTC_2871|Compound:9038510|FD-Score:3.43|P-value:1.77E-4 ID:SGTC_2881|Compound:9058953|FD-Score:-5.28|P-value:1.49E-8 ID:SGTC_2890|Compound:9046729|FD-Score:-3.10|P-value:5.45E-4 ID:SGTC_2988|Compound:9073640|FD-Score:4.28|P-value:4.22E-6 ID:SGTC_3032|Compound:9089427|FD-Score:3.08|P-value:6.83E-4 ID:SGTC_3065|Compound:9113888|FD-Score:-3.89|P-value:2.19E-5 ID:SGTC_3073|Compound:9114972|FD-Score:2.99|P-value:9.39E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-4.08|P-value:8.81E-6 ID:SGTC_3085|Compound:9117376|FD-Score:3.82|P-value:3.52E-5 ID:SGTC_3127|Compound:9126946|FD-Score:3.73|P-value:5.13E-5 ID:SGTC_3129|Compound:9127257|FD-Score:-3.23|P-value:3.43E-4 ID:SGTC_3248|Compound:9135562|FD-Score:-3.42|P-value:1.62E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.21|P-value:3.65E-4 ID:SGTC_3306|Compound:9127676|FD-Score:3.31|P-value:2.86E-4 ID:SGTC_3345|Compound:9148410|FD-Score:4.05|P-value:1.21E-5 ID:SGTC_3348|Compound:9149464|FD-Score:-3.24|P-value:3.29E-4

Top fitness defect scores for YMR304C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1792 st045773 5.80 43.6 µM 7.37E-10 5 3.35E-9
2 SGTC_1799 st045822 5.48 46.1 µM 5.57E-9 2 2.15E-8
3 SGTC_2827 7993847 4.92 71.4 µM 1.50E-7 10 4.42E-7
4 SGTC_504 lovastatin 4.58 124.0 µM 9.13E-7 7 2.33E-6
5 SGTC_661 1304-0007 4.57 33.6 µM 9.74E-7 11 2.48E-6
6 SGTC_1644 st010134 4.28 20.9 µM 4.04E-6 mitochondrial processes 8 9.17E-6
7 SGTC_2988 9073640 4.28 71.4 µM 4.22E-6 16 9.54E-6
8 SGTC_1569 carminic acid 4.06 40.6 µM 1.19E-5 13 2.48E-5
9 SGTC_3345 9148410 4.05 3.6 µM 1.21E-5 7 2.53E-5
10 SGTC_2821 7996764 4.00 71.4 µM 1.55E-5 34 3.16E-5
11 SGTC_2350 9023895 3.97 38.9 µM 1.81E-5 ergosterol biosynthesis 29 3.65E-5
12 SGTC_2780 5215298 3.94 71.4 µM 2.06E-5 38 4.10E-5
13 SGTC_2259 7964009 3.89 200.0 µM 2.55E-5 superoxide 31 5.01E-5
14 SGTC_3085 9117376 3.82 49.5 µM 3.52E-5 12 6.73E-5
15 SGTC_3127 9126946 3.73 49.5 µM 5.13E-5 ERG2 23 9.53E-5
16 SGTC_445 e6 berbamine 3.65 66.0 µM 7.33E-5 NEO1-PIK1 131 1.32E-4
17 SGTC_1387 3342-1166 3.45 1.8 µM 1.65E-4 mitochondrial processes 25 2.79E-4
18 SGTC_2871 9038510 3.43 13.0 µM 1.77E-4 36 2.99E-4
19 SGTC_3306 9127676 3.31 59.8 µM 2.86E-4 47 4.65E-4
20 SGTC_2753 fluvastatin 3.31 17.1 µM 2.86E-4 azole & statin 60 4.65E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.187 6.93E-28 YLL011W SOF1 het Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p
0.120 3.33E-12 YLR123C_d YLR123C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
0.116 1.82E-11 YDR124W_p YDR124W_p hom Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
0.100 6.11E-9 YDL230W PTP1 hom Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation
0.093 6.61E-8 YDL222C FMP45 hom Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C
0.091 1.10E-7 YBR165W UBS1 hom Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity
0.089 2.60E-7 YGR174W-A_p YGR174W-A_p hom Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis
0.084 1.21E-6 YDR109C_p YDR109C_p hom Putative kinase
0.082 2.08E-6 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.081 2.53E-6 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.081 2.81E-6 YKL008C LAC1 hom Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p
0.080 3.71E-6 YLR008C PAM18 het Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p
0.078 6.25E-6 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.078 6.59E-6 YDR111C_p ALT2_p hom Catalytically inactive paralog of ALT1, an alanine transaminase; expression is repressed in the presence of alanine and repression is mediated by Nrg1p
0.077 7.85E-6 YPR131C NAT3 hom Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met