YMR306W / FKS3

Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR306W / FKS3

Click on Significant Values for Screen Details ID:SGTC_84|Compound:0443-0269|FD-Score:-3.50|P-value:4.63E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:-5.07|P-value:7.94E-7 ID:SGTC_91|Compound:0417-1751|FD-Score:-5.27|P-value:3.08E-7 ID:SGTC_97|Compound:0535-0701|FD-Score:6.32|P-value:1.09E-9 ID:SGTC_100|Compound:0086-0128|FD-Score:3.58|P-value:3.55E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.42|P-value:6.14E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:4.01|P-value:7.31E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:4.80|P-value:2.84E-6 ID:SGTC_330|Compound:1488-0319|FD-Score:3.37|P-value:7.09E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:4.63|P-value:5.86E-6 ID:SGTC_336|Compound:4111-0029|FD-Score:4.33|P-value:2.08E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.58|P-value:3.53E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.15|P-value:4.32E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.57|P-value:7.56E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:3.41|P-value:6.35E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.63|P-value:3.00E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.69|P-value:4.51E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.41|P-value:6.34E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.73|P-value:2.12E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:-4.53|P-value:9.16E-6 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.88|P-value:1.21E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.89|P-value:1.15E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.98|P-value:8.17E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.88|P-value:1.22E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.58|P-value:7.20E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.33|P-value:8.04E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.35|P-value:7.72E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.48|P-value:4.96E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.41|P-value:1.49E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-3.38|P-value:6.84E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.59|P-value:3.40E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.98|P-value:8.34E-5 ID:SGTC_2202|Compound:7226349|FD-Score:3.31|P-value:8.67E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.27|P-value:9.91E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.75|P-value:1.97E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.61|P-value:3.18E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.40|P-value:6.43E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-3.71|P-value:2.24E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.60|P-value:3.27E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.49|P-value:4.83E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.61|P-value:3.16E-4 ID:SGTC_2943|Compound:9068529|FD-Score:5.58|P-value:6.47E-8 ID:SGTC_2980|Compound:9014342|FD-Score:-4.31|P-value:2.23E-5 ID:SGTC_3137|Compound:9097352|FD-Score:3.43|P-value:5.97E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.49|P-value:4.74E-4 ID:SGTC_3332|Compound:9141069|FD-Score:7.30|P-value:2.42E-12 ID:SGTC_84|Compound:0443-0269|FD-Score:-3.50|P-value:4.63E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:-5.07|P-value:7.94E-7 ID:SGTC_91|Compound:0417-1751|FD-Score:-5.27|P-value:3.08E-7 ID:SGTC_97|Compound:0535-0701|FD-Score:6.32|P-value:1.09E-9 ID:SGTC_100|Compound:0086-0128|FD-Score:3.58|P-value:3.55E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:-3.42|P-value:6.14E-4 ID:SGTC_235|Compound:0330-0087|FD-Score:4.01|P-value:7.31E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:4.80|P-value:2.84E-6 ID:SGTC_330|Compound:1488-0319|FD-Score:3.37|P-value:7.09E-4 ID:SGTC_334|Compound:1502-1024|FD-Score:4.63|P-value:5.86E-6 ID:SGTC_336|Compound:4111-0029|FD-Score:4.33|P-value:2.08E-5 ID:SGTC_500|Compound:h-89|FD-Score:3.58|P-value:3.53E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:4.15|P-value:4.32E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.57|P-value:7.56E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:3.41|P-value:6.35E-4 ID:SGTC_1099|Compound:5-nonyloxytryptamine|FD-Score:3.63|P-value:3.00E-4 ID:SGTC_1147|Compound:3809-1045|FD-Score:4.69|P-value:4.51E-6 ID:SGTC_1165|Compound:k072-0275|FD-Score:3.41|P-value:6.34E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:3.73|P-value:2.12E-4 ID:SGTC_1181|Compound:1222-0449|FD-Score:-4.53|P-value:9.16E-6 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.88|P-value:1.21E-4 ID:SGTC_1302|Compound:1159-0335|FD-Score:3.89|P-value:1.15E-4 ID:SGTC_1333|Compound:1482-0047|FD-Score:3.98|P-value:8.17E-5 ID:SGTC_1337|Compound:1486-1011|FD-Score:3.88|P-value:1.22E-4 ID:SGTC_1341|Compound:1486-1360|FD-Score:4.58|P-value:7.20E-6 ID:SGTC_1596|Compound:piperlongumine|FD-Score:3.33|P-value:8.04E-4 ID:SGTC_1674|Compound:st016616|FD-Score:3.35|P-value:7.72E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.48|P-value:4.96E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.41|P-value:1.49E-5 ID:SGTC_1732|Compound:st034308|FD-Score:-3.38|P-value:6.84E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-3.59|P-value:3.40E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:3.98|P-value:8.34E-5 ID:SGTC_2202|Compound:7226349|FD-Score:3.31|P-value:8.67E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.27|P-value:9.91E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:3.75|P-value:1.97E-4 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:-3.61|P-value:3.18E-4 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.40|P-value:6.43E-4 ID:SGTC_2800|Compound:7887935|FD-Score:-3.71|P-value:2.24E-4 ID:SGTC_2836|Compound:9010338|FD-Score:3.60|P-value:3.27E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.49|P-value:4.83E-4 ID:SGTC_2916|Compound:7875993|FD-Score:3.61|P-value:3.16E-4 ID:SGTC_2943|Compound:9068529|FD-Score:5.58|P-value:6.47E-8 ID:SGTC_2980|Compound:9014342|FD-Score:-4.31|P-value:2.23E-5 ID:SGTC_3137|Compound:9097352|FD-Score:3.43|P-value:5.97E-4 ID:SGTC_3291|Compound:9121177|FD-Score:-3.49|P-value:4.74E-4 ID:SGTC_3332|Compound:9141069|FD-Score:7.30|P-value:2.42E-12

Top fitness defect scores for YMR306W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3332 9141069 7.30 11.2 µM 2.42E-12 1 1.40E-13
2 SGTC_97 0535-0701 6.32 19.1 µM 1.09E-9 60S ribosome export 4 1.27E-10
3 SGTC_2943 9068529 5.58 45.3 µM 6.47E-8 4 1.20E-8
4 SGTC_323 4013-0906 4.80 34.3 µM 2.84E-6 ERG2 4 8.07E-7
5 SGTC_1147 3809-1045 4.69 12.3 µM 4.51E-6 9 1.35E-6
6 SGTC_334 1502-1024 4.63 68.5 µM 5.86E-6 4 1.81E-6
7 SGTC_1341 1486-1360 4.58 280.0 µM 7.20E-6 11 2.27E-6
8 SGTC_528 3492-0019 4.57 172.0 µM 7.56E-6 calcium & mitochondrial duress 177 2.40E-6
9 SGTC_1729 st035615 4.41 46.0 µM 1.49E-5 23 5.11E-6
10 SGTC_336 4111-0029 4.33 111.0 µM 2.08E-5 7 7.40E-6
11 SGTC_505 gw-5074 4.15 63.9 µM 4.32E-5 53 1.66E-5
12 SGTC_235 0330-0087 4.01 5.0 mM 7.31E-5 TSC3-RPN4 18 2.99E-5
13 SGTC_1333 1482-0047 3.98 286.0 µM 8.17E-5 16 3.38E-5
14 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 3.98 49.5 µM 8.34E-5 21 3.46E-5
15 SGTC_1302 1159-0335 3.89 255.0 µM 1.15E-4 19 4.95E-5
16 SGTC_1289 0976-0073 3.88 69.1 µM 1.21E-4 14 5.22E-5
17 SGTC_1337 1486-1011 3.88 40.3 µM 1.22E-4 16 5.29E-5
18 SGTC_2417 cerulenin 3.75 830.0 nM 1.97E-4 36 9.00E-5
19 SGTC_1168 k815-0004 3.73 80.5 µM 2.12E-4 DNA damage response 22 9.77E-5
20 SGTC_1099 5-nonyloxytryptamine 3.63 2.9 µM 3.00E-4 26 1.43E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.123 9.67E-13 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.094 4.78E-8 YGL089C MF(ALPHA)2 hom Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
0.091 1.39E-7 YIL041W GVP36 hom BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis
0.088 3.63E-7 YKL096W-A CWP2 hom Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
0.083 1.64E-6 YKL140W TGL1 hom Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes
0.080 3.50E-6 YPL169C MEX67 het Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP
0.080 3.67E-6 YER078C ICP55 hom Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family
0.075 1.36E-5 YDR045C RPC11 het RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS
0.074 1.95E-5 YDR093W DNF2 hom Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase
0.074 1.96E-5 YCR027C RHB1 hom Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins
0.072 3.17E-5 YNL071W LAT1 hom Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA
0.072 3.26E-5 YPR108W RPN7 het Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits
0.071 3.88E-5 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.069 6.87E-5 YMR244C-A COA6 hom Protein involved in cytochrome c oxidase assembly; also required for efficient formation of respiratory supercomplexes comprised of Complexes III and IV; localizes to the mitochondrial intermembrane space; has a human homolog; transcription is induced in response to the DNA-damaging agent MMS; protein abundance increases in response to DNA replication stress
0.068 7.35E-5 YJL164C TPK1 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; regulates Whi3p; partially redundant with Tpk2p and Tpk3p; TPK1 has a paralog, TPK3, that arose from the whole genome duplication