YMR307W / GAS1

Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR307W / GAS1

Click on Significant Values for Screen Details ID:SGTC_114|Compound:0364-0001|FD-Score:6.18|P-value:6.69E-10 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.68|P-value:1.28E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-4.27|P-value:1.14E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.56|P-value:2.55E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.17|P-value:9.80E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.73|P-value:1.31E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.19|P-value:7.63E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.28|P-value:6.76E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:4.56|P-value:4.10E-6 ID:SGTC_590|Compound:k048-0076|FD-Score:3.19|P-value:9.19E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.27|P-value:7.09E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.47|P-value:3.48E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.21|P-value:1.93E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.39|P-value:4.70E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:5.09|P-value:3.04E-7 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.01|P-value:4.37E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:3.96|P-value:5.44E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:3.86|P-value:8.02E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.40|P-value:3.61E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.18|P-value:1.95E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.55|P-value:2.65E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-5.61|P-value:1.37E-8 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.43|P-value:4.01E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.35|P-value:5.42E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-3.59|P-value:1.81E-4 ID:SGTC_1831|Compound:st055328|FD-Score:5.43|P-value:5.13E-8 ID:SGTC_1834|Compound:st055981|FD-Score:3.34|P-value:5.55E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.08|P-value:3.28E-7 ID:SGTC_2014|Compound:4013930|FD-Score:-4.26|P-value:1.17E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.07|P-value:3.48E-5 ID:SGTC_2043|Compound:5101342|FD-Score:3.92|P-value:6.21E-5 ID:SGTC_2141|Compound:5621638|FD-Score:3.57|P-value:2.46E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.59|P-value:2.27E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.54|P-value:2.68E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.62|P-value:1.61E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.56|P-value:2.54E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.20|P-value:7.35E-4 ID:SGTC_2278|Compound:7948257|FD-Score:-3.26|P-value:5.92E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.44|P-value:3.92E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.35|P-value:5.28E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.21|P-value:8.72E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.53|P-value:2.83E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.31|P-value:6.12E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.41|P-value:4.29E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.28|P-value:1.42E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.36|P-value:1.01E-5 ID:SGTC_2413|Compound:inermin|FD-Score:4.53|P-value:4.51E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-4.77|P-value:1.10E-6 ID:SGTC_2444|Compound:5485484|FD-Score:4.25|P-value:1.61E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.28|P-value:6.73E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.82|P-value:9.47E-5 ID:SGTC_2795|Compound:7780010|FD-Score:4.46|P-value:6.43E-6 ID:SGTC_2912|Compound:7964298|FD-Score:3.41|P-value:4.30E-4 ID:SGTC_2966|Compound:9084041|FD-Score:5.05|P-value:3.69E-7 ID:SGTC_2970|Compound:9090938|FD-Score:4.52|P-value:4.71E-6 ID:SGTC_3002|Compound:9075603|FD-Score:4.40|P-value:8.20E-6 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.36|P-value:4.14E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.29|P-value:5.29E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-4.26|P-value:1.16E-5 ID:SGTC_3173|Compound:9105693|FD-Score:6.65|P-value:3.38E-11 ID:SGTC_3197|Compound:9113331|FD-Score:3.74|P-value:1.27E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.38|P-value:4.79E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.30|P-value:6.32E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:6.18|P-value:6.69E-10 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.68|P-value:1.28E-4 ID:SGTC_123|Compound:0083-0120|FD-Score:-4.27|P-value:1.14E-5 ID:SGTC_232|Compound:clozapine|FD-Score:3.56|P-value:2.55E-4 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.17|P-value:9.80E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:3.73|P-value:1.31E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.19|P-value:7.63E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.28|P-value:6.76E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:4.56|P-value:4.10E-6 ID:SGTC_590|Compound:k048-0076|FD-Score:3.19|P-value:9.19E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:3.27|P-value:7.09E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:3.47|P-value:3.48E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:4.21|P-value:1.93E-5 ID:SGTC_868|Compound:0527-0199|FD-Score:3.39|P-value:4.70E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:5.09|P-value:3.04E-7 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.01|P-value:4.37E-5 ID:SGTC_956|Compound:1185-0240|FD-Score:3.96|P-value:5.44E-5 ID:SGTC_957|Compound:1187-1561|FD-Score:3.86|P-value:8.02E-5 ID:SGTC_994|Compound:3910-0338|FD-Score:-3.40|P-value:3.61E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:5.18|P-value:1.95E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:3.55|P-value:2.65E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:-5.61|P-value:1.37E-8 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.43|P-value:4.01E-4 ID:SGTC_1806|Compound:st050005|FD-Score:3.35|P-value:5.42E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-3.59|P-value:1.81E-4 ID:SGTC_1831|Compound:st055328|FD-Score:5.43|P-value:5.13E-8 ID:SGTC_1834|Compound:st055981|FD-Score:3.34|P-value:5.55E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.08|P-value:3.28E-7 ID:SGTC_2014|Compound:4013930|FD-Score:-4.26|P-value:1.17E-5 ID:SGTC_2018|Compound:5133068|FD-Score:4.07|P-value:3.48E-5 ID:SGTC_2043|Compound:5101342|FD-Score:3.92|P-value:6.21E-5 ID:SGTC_2141|Compound:5621638|FD-Score:3.57|P-value:2.46E-4 ID:SGTC_2206|Compound:7254556|FD-Score:3.59|P-value:2.27E-4 ID:SGTC_2254|Compound:7938975|FD-Score:3.54|P-value:2.68E-4 ID:SGTC_2261|Compound:9010538|FD-Score:-3.62|P-value:1.61E-4 ID:SGTC_2266|Compound:7929956|FD-Score:3.56|P-value:2.54E-4 ID:SGTC_2277|Compound:7947813|FD-Score:-3.20|P-value:7.35E-4 ID:SGTC_2278|Compound:7948257|FD-Score:-3.26|P-value:5.92E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.44|P-value:3.92E-4 ID:SGTC_2319|Compound:6033012|FD-Score:3.35|P-value:5.28E-4 ID:SGTC_2320|Compound:7373003|FD-Score:3.21|P-value:8.72E-4 ID:SGTC_2330|Compound:7979373|FD-Score:3.53|P-value:2.83E-4 ID:SGTC_2331|Compound:7980721|FD-Score:3.31|P-value:6.12E-4 ID:SGTC_2332|Compound:7982454|FD-Score:3.41|P-value:4.29E-4 ID:SGTC_2381|Compound:9035592|FD-Score:4.28|P-value:1.42E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:4.36|P-value:1.01E-5 ID:SGTC_2413|Compound:inermin|FD-Score:4.53|P-value:4.51E-6 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:-4.77|P-value:1.10E-6 ID:SGTC_2444|Compound:5485484|FD-Score:4.25|P-value:1.61E-5 ID:SGTC_2472|Compound:5377652|FD-Score:3.28|P-value:6.73E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:3.82|P-value:9.47E-5 ID:SGTC_2795|Compound:7780010|FD-Score:4.46|P-value:6.43E-6 ID:SGTC_2912|Compound:7964298|FD-Score:3.41|P-value:4.30E-4 ID:SGTC_2966|Compound:9084041|FD-Score:5.05|P-value:3.69E-7 ID:SGTC_2970|Compound:9090938|FD-Score:4.52|P-value:4.71E-6 ID:SGTC_3002|Compound:9075603|FD-Score:4.40|P-value:8.20E-6 ID:SGTC_3061|Compound:glucosamine|FD-Score:-3.36|P-value:4.14E-4 ID:SGTC_3081|Compound:9117243|FD-Score:-3.29|P-value:5.29E-4 ID:SGTC_3134|Compound:9127454|FD-Score:-4.26|P-value:1.16E-5 ID:SGTC_3173|Compound:9105693|FD-Score:6.65|P-value:3.38E-11 ID:SGTC_3197|Compound:9113331|FD-Score:3.74|P-value:1.27E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.38|P-value:4.79E-4 ID:SGTC_3274|Compound:9138298|FD-Score:3.30|P-value:6.32E-4

Top fitness defect scores for YMR307W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3173 9105693 6.65 49.5 µM 3.38E-11 2 1.45E-11
2 SGTC_114 0364-0001 6.18 490.3 µM 6.69E-10 10 3.16E-10
3 SGTC_1831 st055328 5.43 12.0 µM 5.13E-8 heme biosynthesis & mitochondrial translocase 9 2.81E-8
4 SGTC_1240 0356-0016 5.18 42.1 µM 1.95E-7 mitochondrial response to ROS 14 1.12E-7
5 SGTC_891 0929-0073 5.09 133.0 µM 3.04E-7 5 1.77E-7
6 SGTC_1873 rapamycin 5.08 2.0 nM 3.28E-7 48 1.92E-7
7 SGTC_2966 9084041 5.05 48.0 µM 3.69E-7 13 2.16E-7
8 SGTC_589 1227-0070 4.56 34.1 µM 4.10E-6 18 2.61E-6
9 SGTC_2413 inermin 4.53 26.1 µM 4.51E-6 40 2.88E-6
10 SGTC_2970 9090938 4.52 41.9 µM 4.71E-6 RNA processing & uracil transport 22 3.02E-6
11 SGTC_2795 7780010 4.46 54.5 µM 6.43E-6 15 4.17E-6
12 SGTC_3002 9075603 4.40 71.4 µM 8.20E-6 10 5.35E-6
13 SGTC_2406 ethylparaben 4.36 405.7 µM 1.01E-5 22 6.62E-6
14 SGTC_2381 9035592 4.28 200.0 µM 1.42E-5 12 9.44E-6
15 SGTC_2444 5485484 4.25 36.4 µM 1.61E-5 29 1.08E-5
16 SGTC_770 0389-1121 4.21 67.2 µM 1.93E-5 RPP1 & pyrimidine depletion 21 1.30E-5
17 SGTC_2018 5133068 4.07 143.0 µM 3.48E-5 20 2.39E-5
18 SGTC_915 methyl methanesulfonate (MMS) 4.01 110.0 mM 4.37E-5 DNA damage response 39 3.03E-5
19 SGTC_956 1185-0240 3.96 191.0 µM 5.44E-5 23 3.80E-5
20 SGTC_2043 5101342 3.92 149.0 µM 6.21E-5 SWF1 & branched chain AA biosynthesis 20 4.35E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.113 6.38E-11 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.113 6.42E-11 YPL256C CLN2 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
0.092 8.42E-8 YDL072C YET3 hom Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
0.089 2.34E-7 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
0.088 3.53E-7 YCL052C PBN1 het Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X
0.082 2.04E-6 YGL062W PYC1 hom Pyruvate carboxylase isoform; cytoplasmic enzyme that converts pyruvate to oxaloacetate; differentially regulated than isoform Pyc2p; mutations in the human homolog are associated with lactic acidosis; PYC1 has a paralog, PYC2, that arose from the whole genome duplication
0.080 3.67E-6 YOL056W GPM3 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.080 3.81E-6 YKL007W CAP1 hom Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p); capping protein (CP) binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches; protein increases in abundance and relocalizes from bud neck to plasma membrane upon DNA replication stress
0.076 1.09E-5 YOL109W ZEO1 hom Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria
0.075 1.31E-5 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.073 2.27E-5 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.073 2.38E-5 YKR053C YSR3 hom Dihydrosphingosine 1-phosphate phosphatase; membrane protein involved in sphingolipid metabolism; YSR3 has a paralog, LCB3, that arose from the whole genome duplication
0.070 4.46E-5 YOL087C DUF1 hom Ubiquitin-binding protein of unknown function; contains one WD40 repeat in a beta-propeller fold; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; homolog of human WDR48/UAF1, which is involved in regulating the Fanconi anemia pathway; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid
0.070 4.63E-5 YOL145C CTR9 hom Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to maintain SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats
0.069 5.92E-5 YPR093C ASR1 hom Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein