HIPHOP chemogenomics database

YMR308C / PSE1

Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p

Zygosity: Heterozygous strain

fixedexpanded
Profile for YMR308C / PSE1

Click on Significant Values for Screen Details

Top fitness defect scores for YMR308C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2568	diosmetin	7.98	100.0 µM	1.42E-19		1	7.35E-16	2.63
2	SGTC_393	acivicin	6.04	6.2 µM	4.75E-12		4	7.73E-10	0.91
3	SGTC_299	1273-0059	5.37	1.4 µM	6.54E-10		4	3.97E-8	0.59
4	SGTC_335	4077-0256	5.21	27.6 µM	1.97E-9		2	9.60E-8	0.06
5	SGTC_2959	9079155	5.08	11.0 µM	4.54E-9		4	1.87E-7	0.02
6	SGTC_293	4049-0273	5.04	38.5 µM	5.86E-9		1	2.29E-7	0.81
7	SGTC_2471	5466956	4.77	24.8 µM	3.27E-8	mitochondrial processes	11	9.06E-7	0.48
8	SGTC_302	1094-0063	4.68	18.9 µM	5.85E-8		11	1.44E-6	0.06
9	SGTC_315	k915-0449	4.53	187.0 µM	1.46E-7		6	3.00E-6	0.43
10	SGTC_2716	st080858	3.61	38.6 µM	2.04E-5	60S ribosome export	3	1.55E-4	0.12
11	SGTC_933	2914-0560	3.58	114.0 µM	2.33E-5		9	1.73E-4	0.02
12	SGTC_2475	5812728	3.57	15.0 µM	2.48E-5	mitochondrial processes	19	1.82E-4	0.09
13	SGTC_212	3807-4682	3.52	38.8 µM	3.14E-5	tubulin folding & SWR complex	31	2.19E-4	0.12
14	SGTC_300	r073-0011	3.45	5.0 µM	4.31E-5		4	2.83E-4	0.15
15	SGTC_2411	st077133	3.25	39.9 µM	1.07E-4	RNA pol III & RNase P/MRP	29	5.84E-4	0.02
16	SGTC_1996	st072960	3.10	66.8 µM	2.01E-4		7	9.71E-4	0.01
17	SGTC_774	k060-0086	3.09	136.0 µM	2.07E-4		14	9.91E-4	0.02
18	SGTC_1746	st038117	3.09	42.0 µM	2.09E-4		12	0.00100	0.07
19	SGTC_310	1273-0058	3.07	1.1 µM	2.30E-4	mitochondrial stress	3	0.00108	0.10
20	SGTC_3067	9117431	3.01	49.5 µM	2.95E-4		25	0.00132	0.04

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.226	3.47E-40	YLR223C	IFH1	het	Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing
0.186	1.70E-27	YER067C-A_d	YER067C-A_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W
0.173	5.96E-24	YNL149C	PGA2	het	Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect
0.160	9.32E-21	YLR205C	HMX1	hom	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.158	2.63E-20	YDL174C	DLD1	hom	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane
0.158	3.92E-20	YBR118W	TEF2	hom	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus; TEF2 has a paralog, TEF1, that arose from the whole genome duplication
0.151	1.36E-18	YKL196C	YKT6	het	Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus
0.148	5.81E-18	YLR023C	IZH3	hom	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity
0.147	1.06E-17	YDL007W	RPT2	het	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.143	7.47E-17	YDR478W	SNM1	het	Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.143	8.93E-17	YDL060W	TSR1	het	Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.142	1.48E-16	YJR103W	URA8	hom	Minor CTP synthase isozyme (see also URA7); catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis; capable of forming cytoplasmic filaments termed cytoophidium, especially during conditions of glucose depletion; URA8 has a paralog, URA7, that arose from the whole genome duplication
0.142	1.64E-16	YBR089W_d	YBR089W_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30
0.138	1.23E-15	YGL081W_p	YGL081W_p	hom	Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis
0.137	1.37E-15	YLR438C-A	LSM3	het	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein increases in abundance and relocalizes from nucleus to cytoplasmic foci upon DNA replication stress