YMR309C / NIP1

eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR309C / NIP1

Click on Significant Values for Screen Details ID:SGTC_104|Compound:0074-0074|FD-Score:3.49|P-value:8.80E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.72|P-value:4.34E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.61|P-value:6.09E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.57|P-value:4.89E-9 ID:SGTC_490|Compound:phenamil|FD-Score:-4.09|P-value:1.93E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:6.02|P-value:4.08E-8 ID:SGTC_537|Compound:1334-0398|FD-Score:3.69|P-value:4.68E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.83|P-value:4.39E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.79|P-value:5.01E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-4.11|P-value:1.78E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.80|P-value:3.35E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:4.33|P-value:5.49E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:-4.04|P-value:2.22E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.94|P-value:2.09E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.59|P-value:6.49E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.53|P-value:2.61E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:-5.72|P-value:3.02E-7 ID:SGTC_1225|Compound:1216-0074|FD-Score:-8.54|P-value:3.86E-14 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.94|P-value:2.11E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:5.99|P-value:4.84E-8 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.96|P-value:2.00E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-5.40|P-value:1.26E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.19|P-value:1.86E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.90|P-value:2.39E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-5.73|P-value:2.94E-7 ID:SGTC_1326|Compound:1431-2094|FD-Score:-4.34|P-value:8.01E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.84|P-value:2.92E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.69|P-value:6.83E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-3.69|P-value:6.77E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.91|P-value:3.42E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.92|P-value:2.27E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.59|P-value:2.04E-5 ID:SGTC_2009|Compound:4012297|FD-Score:4.00|P-value:1.70E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.97|P-value:1.91E-4 ID:SGTC_2194|Compound:5927483|FD-Score:4.07|P-value:1.34E-4 ID:SGTC_2197|Compound:6588183|FD-Score:-4.13|P-value:1.65E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.71|P-value:4.52E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.19|P-value:1.36E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-4.26|P-value:1.08E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-3.64|P-value:7.89E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.48|P-value:3.15E-5 ID:SGTC_2331|Compound:7980721|FD-Score:4.52|P-value:2.67E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.81|P-value:4.72E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.58|P-value:9.49E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.85|P-value:7.44E-6 ID:SGTC_2838|Compound:9002687|FD-Score:3.48|P-value:9.04E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.79|P-value:4.98E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.84|P-value:2.90E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.45|P-value:9.92E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-3.99|P-value:2.69E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-5.28|P-value:2.13E-6 ID:SGTC_2949|Compound:9072542|FD-Score:-3.63|P-value:8.33E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.85|P-value:7.53E-6 ID:SGTC_2980|Compound:9014342|FD-Score:-6.60|P-value:4.11E-9 ID:SGTC_2993|Compound:9054257|FD-Score:3.50|P-value:8.61E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-3.63|P-value:8.32E-4 ID:SGTC_3103|Compound:9120822|FD-Score:4.19|P-value:8.97E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-4.53|P-value:4.00E-5 ID:SGTC_3195|Compound:9113082|FD-Score:-3.74|P-value:5.88E-4 ID:SGTC_3287|Compound:9117173|FD-Score:-6.10|P-value:5.17E-8 ID:SGTC_3329|Compound:9141233|FD-Score:-3.80|P-value:4.89E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.49|P-value:8.80E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:3.72|P-value:4.34E-4 ID:SGTC_188|Compound:3229-0966|FD-Score:3.61|P-value:6.09E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-6.57|P-value:4.89E-9 ID:SGTC_490|Compound:phenamil|FD-Score:-4.09|P-value:1.93E-4 ID:SGTC_516|Compound:3992-2719|FD-Score:6.02|P-value:4.08E-8 ID:SGTC_537|Compound:1334-0398|FD-Score:3.69|P-value:4.68E-4 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.83|P-value:4.39E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-3.79|P-value:5.01E-4 ID:SGTC_676|Compound:falcarinol|FD-Score:-4.11|P-value:1.78E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.80|P-value:3.35E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:4.33|P-value:5.49E-5 ID:SGTC_852|Compound:0418-0143|FD-Score:-4.04|P-value:2.22E-4 ID:SGTC_859|Compound:0439-0102|FD-Score:3.94|P-value:2.09E-4 ID:SGTC_894|Compound:0960-0238|FD-Score:3.59|P-value:6.49E-4 ID:SGTC_1177|Compound:0983-0204|FD-Score:4.53|P-value:2.61E-5 ID:SGTC_1217|Compound:1183-1422|FD-Score:-5.72|P-value:3.02E-7 ID:SGTC_1225|Compound:1216-0074|FD-Score:-8.54|P-value:3.86E-14 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.94|P-value:2.11E-4 ID:SGTC_1233|Compound:0325-0408|FD-Score:5.99|P-value:4.84E-8 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.96|P-value:2.00E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:-5.40|P-value:1.26E-6 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.19|P-value:1.86E-6 ID:SGTC_1266|Compound:0828-0227|FD-Score:3.90|P-value:2.39E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:-5.73|P-value:2.94E-7 ID:SGTC_1326|Compound:1431-2094|FD-Score:-4.34|P-value:8.01E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:3.84|P-value:2.92E-4 ID:SGTC_1619|Compound:st003326|FD-Score:-3.69|P-value:6.83E-4 ID:SGTC_1655|Compound:st012546|FD-Score:-3.69|P-value:6.77E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.91|P-value:3.42E-4 ID:SGTC_1863|Compound:st057641|FD-Score:3.92|P-value:2.27E-4 ID:SGTC_1935|Compound:st074532|FD-Score:4.59|P-value:2.04E-5 ID:SGTC_2009|Compound:4012297|FD-Score:4.00|P-value:1.70E-4 ID:SGTC_2166|Compound:5933061|FD-Score:3.97|P-value:1.91E-4 ID:SGTC_2194|Compound:5927483|FD-Score:4.07|P-value:1.34E-4 ID:SGTC_2197|Compound:6588183|FD-Score:-4.13|P-value:1.65E-4 ID:SGTC_2200|Compound:6600604|FD-Score:3.71|P-value:4.52E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.19|P-value:1.36E-4 ID:SGTC_2246|Compound:7293507|FD-Score:-4.26|P-value:1.08E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-3.64|P-value:7.89E-4 ID:SGTC_2307|Compound:7538926|FD-Score:4.48|P-value:3.15E-5 ID:SGTC_2331|Compound:7980721|FD-Score:4.52|P-value:2.67E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-3.81|P-value:4.72E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.58|P-value:9.49E-4 ID:SGTC_2812|Compound:7970281|FD-Score:4.85|P-value:7.44E-6 ID:SGTC_2838|Compound:9002687|FD-Score:3.48|P-value:9.04E-4 ID:SGTC_2846|Compound:9008642|FD-Score:-3.79|P-value:4.98E-4 ID:SGTC_2856|Compound:9022925|FD-Score:3.84|P-value:2.90E-4 ID:SGTC_2870|Compound:9038528|FD-Score:3.45|P-value:9.92E-4 ID:SGTC_2877|Compound:9040724|FD-Score:-3.99|P-value:2.69E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-5.28|P-value:2.13E-6 ID:SGTC_2949|Compound:9072542|FD-Score:-3.63|P-value:8.33E-4 ID:SGTC_2951|Compound:9072950|FD-Score:4.85|P-value:7.53E-6 ID:SGTC_2980|Compound:9014342|FD-Score:-6.60|P-value:4.11E-9 ID:SGTC_2993|Compound:9054257|FD-Score:3.50|P-value:8.61E-4 ID:SGTC_3000|Compound:9075062|FD-Score:-3.63|P-value:8.32E-4 ID:SGTC_3103|Compound:9120822|FD-Score:4.19|P-value:8.97E-5 ID:SGTC_3152|Compound:9099253|FD-Score:-4.53|P-value:4.00E-5 ID:SGTC_3195|Compound:9113082|FD-Score:-3.74|P-value:5.88E-4 ID:SGTC_3287|Compound:9117173|FD-Score:-6.10|P-value:5.17E-8 ID:SGTC_3329|Compound:9141233|FD-Score:-3.80|P-value:4.89E-4

Top fitness defect scores for YMR309C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_516 3992-2719 6.02 87.3 µM 4.08E-8 3 8.48E-10 2.27
2 SGTC_1233 0325-0408 5.99 14.2 µM 4.84E-8 1 1.05E-9 1.16
3 SGTC_1258 0671-0043 5.19 57.1 µM 1.86E-6 3 1.06E-7 0.99
4 SGTC_2812 7970281 4.85 58.4 µM 7.44E-6 4 6.09E-7 0.51
5 SGTC_2951 9072950 4.85 58.1 µM 7.53E-6 ERG2 2 6.18E-7 0.29
6 SGTC_1935 st074532 4.59 41.6 µM 2.04E-5 4 2.17E-6 0.42
7 SGTC_1177 0983-0204 4.53 23.6 µM 2.61E-5 5 2.96E-6 0.45
8 SGTC_2331 7980721 4.52 200.0 µM 2.67E-5 9 3.04E-6 0.18
9 SGTC_2307 7538926 4.48 6.3 µM 3.15E-5 17 3.75E-6 0.02
10 SGTC_847 0342-0274 4.33 5.5 µM 5.49E-5 3 7.52E-6 0.54
11 SGTC_3103 9120822 4.19 49.5 µM 8.97E-5 7 1.39E-5 0.38
12 SGTC_2194 5927483 4.07 104.5 µM 1.34E-4 7 2.30E-5 0.13
13 SGTC_2009 4012297 4.00 12.1 µM 1.70E-4 cell wall signaling 8 3.11E-5 0.02
14 SGTC_2166 5933061 3.97 31.5 µM 1.91E-4 tubulin folding & SWR complex 2 3.60E-5 0.14
15 SGTC_1236 0330-0013 3.96 258.0 µM 2.00E-4 1 3.80E-5 0.53
16 SGTC_859 0439-0102 3.94 54.6 µM 2.09E-4 redox potentiating 10 4.03E-5 0.01
17 SGTC_1228 0124-0032 3.94 52.5 µM 2.11E-4 3 4.07E-5 0.15
18 SGTC_1863 st057641 3.92 20.1 µM 2.27E-4 4 4.48E-5 0.32
19 SGTC_1266 0828-0227 3.90 32.9 µM 2.39E-4 11 4.75E-5 0.02
20 SGTC_2856 9022925 3.84 19.5 µM 2.90E-4 3 6.05E-5 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.160 1.38E-20 YOL040C RPS15 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15 and bacterial S19
0.151 1.86E-18 YJR123W RPS5 het Protein component of the small (40S) ribosomal subunit; least basic of non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; homologous to mammalian ribosomal protein S5 and bacterial S7
0.127 1.85E-13 YDR429C TIF35 het eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation
0.116 1.63E-11 YDR064W RPS13 het Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S13 and bacterial S15
0.114 3.11E-11 YNL178W RPS3 het Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3
0.105 1.22E-9 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.104 1.55E-9 YLR009W RLP24 het Essential protein required for ribosomal large subunit biogenesis; associated with pre-60S ribosomal subunits; stimulates the ATPase activity of Afg2p, which is required for release of Rlp24p from the pre-60S particle; has similarity to Rpl24Ap and Rpl24Bp
0.102 3.61E-9 YPL237W SUI3 het Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding
0.101 4.56E-9 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.099 1.09E-8 YJL143W TIM17 het Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex
0.095 3.18E-8 YPL238C_d YPL238C_d het Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
0.093 6.40E-8 YBR190W_d YBR190W_d het Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W
0.089 2.28E-7 YMR146C TIF34 het eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation
0.088 3.34E-7 YOR157C PUP1 het Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z
0.088 3.83E-7 YOR146W_d YOR146W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C