YMR310C_p

Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR310C / YMR310C

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.51|P-value:4.34E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:-3.68|P-value:3.19E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.68|P-value:2.41E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:4.93|P-value:1.58E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:5.83|P-value:1.87E-8 ID:SGTC_94|Compound:0334-0113|FD-Score:6.35|P-value:1.02E-9 ID:SGTC_114|Compound:0364-0001|FD-Score:4.30|P-value:2.31E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.45|P-value:5.40E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.31|P-value:2.54E-7 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.83|P-value:1.87E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.38|P-value:6.79E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.72|P-value:2.71E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-7.90|P-value:7.88E-14 ID:SGTC_538|Compound:2922-0838|FD-Score:4.55|P-value:8.40E-6 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.89|P-value:1.49E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.04|P-value:6.46E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.35|P-value:7.42E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.55|P-value:4.81E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.20|P-value:3.44E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:-4.44|P-value:1.83E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:3.48|P-value:4.85E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.60|P-value:3.16E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.52|P-value:9.59E-6 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.04|P-value:6.59E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.91|P-value:1.18E-8 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.45|P-value:5.40E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.69|P-value:2.99E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-10.20|P-value:4.96E-22 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.79|P-value:4.15E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.91|P-value:1.37E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.42|P-value:5.81E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.71|P-value:2.16E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.51|P-value:4.32E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.30|P-value:8.67E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.66|P-value:2.61E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.29|P-value:8.90E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.78|P-value:1.73E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.43|P-value:7.36E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.62|P-value:3.92E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.93|P-value:9.68E-5 ID:SGTC_2295|Compound:7971645|FD-Score:-6.19|P-value:3.80E-9 ID:SGTC_2318|Compound:6029776|FD-Score:8.30|P-value:2.53E-15 ID:SGTC_2326|Compound:6164455|FD-Score:-5.42|P-value:2.18E-7 ID:SGTC_2411|Compound:st077133|FD-Score:4.34|P-value:1.98E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.25|P-value:2.87E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.47|P-value:6.42E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.45|P-value:1.84E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.82|P-value:3.53E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.37|P-value:6.97E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-4.28|P-value:3.48E-5 ID:SGTC_2813|Compound:7971799|FD-Score:4.86|P-value:2.15E-6 ID:SGTC_3007|Compound:9078383|FD-Score:4.53|P-value:9.19E-6 ID:SGTC_3224|Compound:9130643|FD-Score:4.38|P-value:1.70E-5 ID:SGTC_6|Compound:0844-0013|FD-Score:3.51|P-value:4.34E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:-3.68|P-value:3.19E-4 ID:SGTC_18|Compound:0111-0177|FD-Score:3.68|P-value:2.41E-4 ID:SGTC_21|Compound:0849-0113|FD-Score:4.93|P-value:1.58E-6 ID:SGTC_75|Compound:0159-0059|FD-Score:5.83|P-value:1.87E-8 ID:SGTC_94|Compound:0334-0113|FD-Score:6.35|P-value:1.02E-9 ID:SGTC_114|Compound:0364-0001|FD-Score:4.30|P-value:2.31E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:3.45|P-value:5.40E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:5.31|P-value:2.54E-7 ID:SGTC_313|Compound:3474-0040|FD-Score:-3.83|P-value:1.87E-4 ID:SGTC_369|Compound:0957-0393|FD-Score:3.38|P-value:6.79E-4 ID:SGTC_433|Compound:pimozide|FD-Score:-3.72|P-value:2.71E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:-7.90|P-value:7.88E-14 ID:SGTC_538|Compound:2922-0838|FD-Score:4.55|P-value:8.40E-6 ID:SGTC_570|Compound:0987-0065|FD-Score:-3.89|P-value:1.49E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:4.04|P-value:6.46E-5 ID:SGTC_785|Compound:1270-0111|FD-Score:3.35|P-value:7.42E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:-3.55|P-value:4.81E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:4.20|P-value:3.44E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:-4.44|P-value:1.83E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:3.48|P-value:4.85E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:3.60|P-value:3.16E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:4.52|P-value:9.59E-6 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.04|P-value:6.59E-5 ID:SGTC_1118|Compound:chelidonine|FD-Score:5.91|P-value:1.18E-8 ID:SGTC_1119|Compound:parthenolide|FD-Score:3.45|P-value:5.40E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:-3.69|P-value:2.99E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:-10.20|P-value:4.96E-22 ID:SGTC_1131|Compound:3454-3128|FD-Score:-4.79|P-value:4.15E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-3.91|P-value:1.37E-4 ID:SGTC_1186|Compound:1319-0216|FD-Score:3.42|P-value:5.81E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.71|P-value:2.16E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.51|P-value:4.32E-4 ID:SGTC_1248|Compound:0469-0687|FD-Score:3.30|P-value:8.67E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:3.66|P-value:2.61E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.29|P-value:8.90E-4 ID:SGTC_1375|Compound:2910-0797|FD-Score:3.78|P-value:1.73E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.43|P-value:7.36E-4 ID:SGTC_1716|Compound:st033144|FD-Score:-3.62|P-value:3.92E-4 ID:SGTC_2114|Compound:5491910|FD-Score:3.93|P-value:9.68E-5 ID:SGTC_2295|Compound:7971645|FD-Score:-6.19|P-value:3.80E-9 ID:SGTC_2318|Compound:6029776|FD-Score:8.30|P-value:2.53E-15 ID:SGTC_2326|Compound:6164455|FD-Score:-5.42|P-value:2.18E-7 ID:SGTC_2411|Compound:st077133|FD-Score:4.34|P-value:1.98E-5 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.25|P-value:2.87E-5 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.47|P-value:6.42E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:-5.45|P-value:1.84E-7 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:-4.82|P-value:3.53E-6 ID:SGTC_2628|Compound:lathosterol|FD-Score:3.37|P-value:6.97E-4 ID:SGTC_2808|Compound:7946468|FD-Score:-4.28|P-value:3.48E-5 ID:SGTC_2813|Compound:7971799|FD-Score:4.86|P-value:2.15E-6 ID:SGTC_3007|Compound:9078383|FD-Score:4.53|P-value:9.19E-6 ID:SGTC_3224|Compound:9130643|FD-Score:4.38|P-value:1.70E-5

Top fitness defect scores for YMR310C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2318 6029776 8.30 164.0 µM 2.53E-15 1 5.17E-17
2 SGTC_94 0334-0113 6.35 514.8 µM 1.02E-9 3 1.08E-10
3 SGTC_1118 chelidonine 5.91 707.5 nM 1.18E-8 1 1.69E-9
4 SGTC_75 0159-0059 5.83 199.0 µM 1.87E-8 fatty acid desaturase (OLE1) 5 2.83E-9
5 SGTC_165 k038-0023 5.31 64.4 µM 2.54E-7 ubiquinone biosynthesis & proteasome 37 5.34E-8
6 SGTC_21 0849-0113 4.93 23.0 µM 1.58E-6 12 4.13E-7
7 SGTC_2813 7971799 4.86 71.4 µM 2.15E-6 10 5.85E-7
8 SGTC_538 2922-0838 4.55 53.3 µM 8.40E-6 Golgi 20 2.70E-6
9 SGTC_3007 9078383 4.53 71.4 µM 9.19E-6 8 2.99E-6
10 SGTC_1095 3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran 4.52 15.5 µM 9.59E-6 14 3.13E-6
11 SGTC_3224 9130643 4.38 49.5 µM 1.70E-5 RPP1 & pyrimidine depletion 17 5.95E-6
12 SGTC_2411 st077133 4.34 39.9 µM 1.98E-5 RNA pol III & RNase P/MRP 20 7.07E-6
13 SGTC_114 0364-0001 4.30 490.3 µM 2.31E-5 38 8.39E-6
14 SGTC_2555 cholic acid 4.25 100.0 µM 2.87E-5 14 1.07E-5
15 SGTC_972 1319-0219 4.20 195.0 µM 3.44E-5 18 1.31E-5
16 SGTC_773 4358-1457 4.04 44.6 µM 6.46E-5 41 2.65E-5
17 SGTC_1105 epirubicin 4.04 18.1 µM 6.59E-5 anthracycline transcription coupled DNA repair 19 2.71E-5
18 SGTC_2114 5491910 3.93 81.2 µM 9.68E-5 13 4.17E-5
19 SGTC_1375 2910-0797 3.78 186.0 µM 1.73E-4 31 7.97E-5
20 SGTC_1192 1488-0095 3.71 21.4 µM 2.16E-4 19 1.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.114 3.11E-11 YDR471W RPL27B hom Ribosomal 60S subunit protein L27B; homologous to mammalian ribosomal protein L27, no bacterial homolog; RPL27B has a paralog, RPL27A, that arose from the whole genome duplication
0.105 1.01E-9 YOL061W PRS5 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase; synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; forms cytoplasmic foci upon DNA replication stress
0.104 1.49E-9 YDR447C RPS17B hom Ribosomal protein 51 (rp51) of the small (40s) subunit; homologous to mammalian ribosomal protein S17, no bacterial homolog; RPS17B has a paralog, RPS17A, that arose from the whole genome duplication; protein abundance increases in response to DNA replication stress
0.100 6.38E-9 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.100 6.91E-9 YLR365W_d YLR365W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
0.095 3.50E-8 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.089 2.57E-7 YOR164C GET4 hom Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20
0.083 1.31E-6 YOR083W WHI5 hom Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1
0.082 1.92E-6 YDR428C BNA7 hom Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine
0.082 1.94E-6 YCR090C_p YCR090C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene
0.082 2.18E-6 YPR126C_d YPR126C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.079 4.18E-6 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.078 6.59E-6 YMR016C SOK2 hom Nuclear protein that negatively regulates pseudohyphal differentiation; plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; SOK2 has a paralog, PHD1, that arose from the whole genome duplication
0.077 7.49E-6 YKL147C_d YKL147C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3
0.077 8.58E-6 YLR046C_p YLR046C_p hom Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance