YMR311C / GLC8

Regulatory subunit of protein phosphatase 1 (Glc7p); involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR311C / GLC8

Click on Significant Values for Screen Details ID:SGTC_117|Compound:lucigenin|FD-Score:3.21|P-value:9.84E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.09|P-value:4.04E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.83|P-value:1.12E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.85|P-value:1.05E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:5.26|P-value:1.89E-7 ID:SGTC_446|Compound:go6976|FD-Score:4.77|P-value:2.06E-6 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.40|P-value:4.60E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.60|P-value:2.63E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.56|P-value:3.06E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.46|P-value:4.29E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.60|P-value:2.57E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.79|P-value:1.92E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.56|P-value:5.54E-6 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.62|P-value:2.44E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.88|P-value:9.09E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.60|P-value:2.65E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.59|P-value:4.72E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.54|P-value:3.29E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.23|P-value:2.22E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.50|P-value:3.68E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.01|P-value:5.60E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.77|P-value:1.38E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.45|P-value:4.50E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.44|P-value:4.61E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.32|P-value:6.89E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.85|P-value:1.46E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.44|P-value:4.56E-4 ID:SGTC_2015|Compound:5119600|FD-Score:4.05|P-value:4.69E-5 ID:SGTC_2020|Compound:4017018|FD-Score:6.00|P-value:3.42E-9 ID:SGTC_2026|Compound:5148700|FD-Score:-3.18|P-value:9.88E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.96|P-value:6.83E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:4.73|P-value:2.52E-6 ID:SGTC_2049|Compound:5262831|FD-Score:6.07|P-value:2.30E-9 ID:SGTC_2095|Compound:5432005|FD-Score:3.30|P-value:7.49E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.22|P-value:9.51E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.80|P-value:1.23E-4 ID:SGTC_2307|Compound:7538926|FD-Score:6.01|P-value:3.33E-9 ID:SGTC_2394|Compound:5221648|FD-Score:-3.56|P-value:2.69E-4 ID:SGTC_2488|Compound:5268135|FD-Score:5.20|P-value:2.64E-7 ID:SGTC_2515|Compound:chrysin|FD-Score:3.33|P-value:6.67E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:7.42|P-value:3.75E-13 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.22|P-value:2.35E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-4.73|P-value:2.12E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:5.17|P-value:3.03E-7 ID:SGTC_2623|Compound:humulene|FD-Score:-3.48|P-value:3.48E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.45|P-value:3.89E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.89|P-value:8.92E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.00|P-value:5.02E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:5.79|P-value:1.13E-8 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.26|P-value:8.43E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.92|P-value:8.02E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.62|P-value:2.39E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.32|P-value:6.95E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.54|P-value:5.84E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-3.24|P-value:8.04E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.13|P-value:3.44E-5 ID:SGTC_2943|Compound:9068529|FD-Score:5.26|P-value:1.94E-7 ID:SGTC_3026|Compound:9090633|FD-Score:3.57|P-value:2.92E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.71|P-value:1.75E-4 ID:SGTC_3249|Compound:9135183|FD-Score:4.02|P-value:5.36E-5 ID:SGTC_117|Compound:lucigenin|FD-Score:3.21|P-value:9.84E-4 ID:SGTC_159|Compound:3970-0959|FD-Score:4.09|P-value:4.04E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:3.83|P-value:1.12E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:3.85|P-value:1.05E-4 ID:SGTC_377|Compound:3970-0964|FD-Score:5.26|P-value:1.89E-7 ID:SGTC_446|Compound:go6976|FD-Score:4.77|P-value:2.06E-6 ID:SGTC_532|Compound:1548-0774|FD-Score:-3.40|P-value:4.60E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:3.60|P-value:2.63E-4 ID:SGTC_667|Compound:1498-1044|FD-Score:3.56|P-value:3.06E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.46|P-value:4.29E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.60|P-value:2.57E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:4.79|P-value:1.92E-6 ID:SGTC_1029|Compound:k015-0030|FD-Score:4.56|P-value:5.54E-6 ID:SGTC_1091|Compound:telmisartan|FD-Score:3.62|P-value:2.44E-4 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.88|P-value:9.09E-5 ID:SGTC_1183|Compound:1254-0324|FD-Score:3.60|P-value:2.65E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:4.59|P-value:4.72E-6 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.54|P-value:3.29E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:4.23|P-value:2.22E-5 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.50|P-value:3.68E-4 ID:SGTC_1390|Compound:3413-2614|FD-Score:4.01|P-value:5.60E-5 ID:SGTC_1403|Compound:3909-7815|FD-Score:3.77|P-value:1.38E-4 ID:SGTC_1404|Compound:3909-7820|FD-Score:3.45|P-value:4.50E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:3.44|P-value:4.61E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.32|P-value:6.89E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.85|P-value:1.46E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:3.44|P-value:4.56E-4 ID:SGTC_2015|Compound:5119600|FD-Score:4.05|P-value:4.69E-5 ID:SGTC_2020|Compound:4017018|FD-Score:6.00|P-value:3.42E-9 ID:SGTC_2026|Compound:5148700|FD-Score:-3.18|P-value:9.88E-4 ID:SGTC_2027|Compound:5150920|FD-Score:3.96|P-value:6.83E-5 ID:SGTC_2039|Compound:Aminomethylbenzodioxan|FD-Score:4.73|P-value:2.52E-6 ID:SGTC_2049|Compound:5262831|FD-Score:6.07|P-value:2.30E-9 ID:SGTC_2095|Compound:5432005|FD-Score:3.30|P-value:7.49E-4 ID:SGTC_2113|Compound:5491891|FD-Score:3.22|P-value:9.51E-4 ID:SGTC_2282|Compound:7944268|FD-Score:3.80|P-value:1.23E-4 ID:SGTC_2307|Compound:7538926|FD-Score:6.01|P-value:3.33E-9 ID:SGTC_2394|Compound:5221648|FD-Score:-3.56|P-value:2.69E-4 ID:SGTC_2488|Compound:5268135|FD-Score:5.20|P-value:2.64E-7 ID:SGTC_2515|Compound:chrysin|FD-Score:3.33|P-value:6.67E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:7.42|P-value:3.75E-13 ID:SGTC_2555|Compound:cholic acid|FD-Score:4.22|P-value:2.35E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-4.73|P-value:2.12E-6 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:5.17|P-value:3.03E-7 ID:SGTC_2623|Compound:humulene|FD-Score:-3.48|P-value:3.48E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-3.45|P-value:3.89E-4 ID:SGTC_2646|Compound:retinol|FD-Score:3.89|P-value:8.92E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-4.00|P-value:5.02E-5 ID:SGTC_2663|Compound:amphotericin b|FD-Score:5.79|P-value:1.13E-8 ID:SGTC_2670|Compound:beta-carotene|FD-Score:3.26|P-value:8.43E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.92|P-value:8.02E-5 ID:SGTC_2765|Compound:myclobutanil|FD-Score:3.62|P-value:2.39E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.32|P-value:6.95E-4 ID:SGTC_2844|Compound:9010103|FD-Score:4.54|P-value:5.84E-6 ID:SGTC_2845|Compound:9003024|FD-Score:-3.24|P-value:8.04E-4 ID:SGTC_2908|Compound:7930301|FD-Score:4.13|P-value:3.44E-5 ID:SGTC_2943|Compound:9068529|FD-Score:5.26|P-value:1.94E-7 ID:SGTC_3026|Compound:9090633|FD-Score:3.57|P-value:2.92E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.71|P-value:1.75E-4 ID:SGTC_3249|Compound:9135183|FD-Score:4.02|P-value:5.36E-5

Top fitness defect scores for YMR311C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2544 sphondin 7.42 68.5 µM 3.75E-13 RNA pol III & RNase P/MRP 3 5.80E-14
2 SGTC_2049 5262831 6.07 67.2 µM 2.30E-9 5 6.41E-10
3 SGTC_2307 7538926 6.01 6.3 µM 3.33E-9 9 9.50E-10
4 SGTC_2020 4017018 6.00 200.0 µM 3.42E-9 1 9.79E-10
5 SGTC_2663 amphotericin b 5.79 100.0 µM 1.13E-8 1 3.50E-9
6 SGTC_377 3970-0964 5.26 33.1 µM 1.89E-7 23 7.09E-8
7 SGTC_2943 9068529 5.26 45.3 µM 1.94E-7 5 7.29E-8
8 SGTC_2488 5268135 5.20 45.7 µM 2.64E-7 24 1.01E-7
9 SGTC_2562 3',7'-dimethoxyflavone 5.17 64.9 µM 3.03E-7 9 1.17E-7
10 SGTC_1508 1080-0625 4.85 72.9 µM 1.46E-6 6 6.29E-7
11 SGTC_1024 4507-0395 4.79 26.0 µM 1.92E-6 TSC3-RPN4 13 8.41E-7
12 SGTC_446 go6976 4.77 132.0 µM 2.06E-6 6 9.07E-7
13 SGTC_2039 Aminomethylbenzodioxan 4.73 200.0 µM 2.52E-6 1 1.13E-6
14 SGTC_1239 0337-0584 4.59 35.4 µM 4.72E-6 unfolded protein response 36 2.20E-6
15 SGTC_1029 k015-0030 4.56 64.7 µM 5.54E-6 15 2.61E-6
16 SGTC_2844 9010103 4.54 26.0 µM 5.84E-6 16 2.76E-6
17 SGTC_1339 1486-1321 4.23 22.7 µM 2.22E-5 ERG2 15 1.14E-5
18 SGTC_2555 cholic acid 4.22 100.0 µM 2.35E-5 15 1.22E-5
19 SGTC_2908 7930301 4.13 100.0 µM 3.44E-5 23 1.83E-5
20 SGTC_159 3970-0959 4.09 50.0 µM 4.04E-5 69 2.17E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.61E-15 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.128 8.33E-14 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.122 1.50E-12 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.121 1.75E-12 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.119 3.88E-12 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.113 4.71E-11 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.113 5.09E-11 YKL087C CYT2 hom Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1
0.113 5.32E-11 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.113 6.00E-11 YKL208W CBT1 hom Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p
0.113 6.52E-11 YOR065W CYT1 hom Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
0.108 2.92E-10 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.108 3.88E-10 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.108 4.12E-10 YOR293C-A_p YOR293C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.107 6.09E-10 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.106 6.68E-10 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER