YMR313C / TGL3

Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation

Zygosity: Homozygous strain
fixedexpanded
Profile for YMR313C / TGL3

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:3.22|P-value:4.48E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-4.08|P-value:1.26E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:-5.43|P-value:9.94E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:5.59|P-value:4.16E-9 ID:SGTC_229|Compound:benomyl|FD-Score:5.02|P-value:1.13E-7 ID:SGTC_319|Compound:1348-1596|FD-Score:5.34|P-value:1.78E-8 ID:SGTC_336|Compound:4111-0029|FD-Score:5.93|P-value:4.79E-10 ID:SGTC_687|Compound:k029-0044|FD-Score:3.55|P-value:1.26E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.33|P-value:2.96E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.40|P-value:2.33E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.10|P-value:6.87E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.13|P-value:6.08E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.82|P-value:3.87E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.76|P-value:5.04E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:4.73|P-value:5.34E-7 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.08|P-value:7.40E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.34|P-value:2.85E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.84|P-value:3.73E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.03|P-value:1.61E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.19|P-value:5.07E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.88|P-value:3.11E-5 ID:SGTC_1640|Compound:st009078|FD-Score:4.06|P-value:1.40E-5 ID:SGTC_1720|Compound:st037298|FD-Score:3.08|P-value:7.53E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.46|P-value:1.76E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.17|P-value:5.42E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.22|P-value:4.59E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.19|P-value:5.12E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.15|P-value:5.74E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.56|P-value:1.16E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.25|P-value:5.74E-6 ID:SGTC_2083|Compound:5306046|FD-Score:3.61|P-value:9.87E-5 ID:SGTC_2099|Compound:5377090|FD-Score:-3.15|P-value:5.66E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.14|P-value:5.98E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.79|P-value:4.58E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.25|P-value:4.00E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.61|P-value:9.96E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.24|P-value:4.23E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.04|P-value:8.73E-4 ID:SGTC_2829|Compound:7992743|FD-Score:5.83|P-value:9.33E-10 ID:SGTC_2833|Compound:9001315|FD-Score:-3.62|P-value:8.94E-5 ID:SGTC_2843|Compound:9000894|FD-Score:3.19|P-value:4.98E-4 ID:SGTC_2950|Compound:9072895|FD-Score:7.34|P-value:1.85E-14 ID:SGTC_3028|Compound:9087778|FD-Score:-3.02|P-value:9.10E-4 ID:SGTC_3069|Compound:9117009|FD-Score:5.18|P-value:4.50E-8 ID:SGTC_3096|Compound:9117468|FD-Score:3.26|P-value:3.85E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.25|P-value:4.10E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.05|P-value:8.37E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:3.22|P-value:4.48E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:-4.08|P-value:1.26E-5 ID:SGTC_134|Compound:0269-0018|FD-Score:-5.43|P-value:9.94E-9 ID:SGTC_142|Compound:0335-0849|FD-Score:5.59|P-value:4.16E-9 ID:SGTC_229|Compound:benomyl|FD-Score:5.02|P-value:1.13E-7 ID:SGTC_319|Compound:1348-1596|FD-Score:5.34|P-value:1.78E-8 ID:SGTC_336|Compound:4111-0029|FD-Score:5.93|P-value:4.79E-10 ID:SGTC_687|Compound:k029-0044|FD-Score:3.55|P-value:1.26E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.33|P-value:2.96E-4 ID:SGTC_766|Compound:1391-0721|FD-Score:3.40|P-value:2.33E-4 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.10|P-value:6.87E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:-3.13|P-value:6.08E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:-3.82|P-value:3.87E-5 ID:SGTC_1057|Compound:3448-5381|FD-Score:-3.76|P-value:5.04E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:4.73|P-value:5.34E-7 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.08|P-value:7.40E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.34|P-value:2.85E-4 ID:SGTC_1505|Compound:k297-0037|FD-Score:3.84|P-value:3.73E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:4.03|P-value:1.61E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:3.19|P-value:5.07E-4 ID:SGTC_1637|Compound:st007924|FD-Score:3.88|P-value:3.11E-5 ID:SGTC_1640|Compound:st009078|FD-Score:4.06|P-value:1.40E-5 ID:SGTC_1720|Compound:st037298|FD-Score:3.08|P-value:7.53E-4 ID:SGTC_1747|Compound:st037496|FD-Score:-3.46|P-value:1.76E-4 ID:SGTC_1807|Compound:st050092|FD-Score:3.17|P-value:5.42E-4 ID:SGTC_1827|Compound:berberine|FD-Score:3.22|P-value:4.59E-4 ID:SGTC_1894|Compound:3',6'-dihydroxyflavone|FD-Score:3.19|P-value:5.12E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.15|P-value:5.74E-4 ID:SGTC_1910|Compound:st062352|FD-Score:-3.56|P-value:1.16E-4 ID:SGTC_1999|Compound:st074831|FD-Score:4.25|P-value:5.74E-6 ID:SGTC_2083|Compound:5306046|FD-Score:3.61|P-value:9.87E-5 ID:SGTC_2099|Compound:5377090|FD-Score:-3.15|P-value:5.66E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.14|P-value:5.98E-4 ID:SGTC_2433|Compound:5607874|FD-Score:3.79|P-value:4.58E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.25|P-value:4.00E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.61|P-value:9.96E-5 ID:SGTC_2604|Compound:4'-hydroxychalcone|FD-Score:3.24|P-value:4.23E-4 ID:SGTC_2640|Compound:pentamidine|FD-Score:3.04|P-value:8.73E-4 ID:SGTC_2829|Compound:7992743|FD-Score:5.83|P-value:9.33E-10 ID:SGTC_2833|Compound:9001315|FD-Score:-3.62|P-value:8.94E-5 ID:SGTC_2843|Compound:9000894|FD-Score:3.19|P-value:4.98E-4 ID:SGTC_2950|Compound:9072895|FD-Score:7.34|P-value:1.85E-14 ID:SGTC_3028|Compound:9087778|FD-Score:-3.02|P-value:9.10E-4 ID:SGTC_3069|Compound:9117009|FD-Score:5.18|P-value:4.50E-8 ID:SGTC_3096|Compound:9117468|FD-Score:3.26|P-value:3.85E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.25|P-value:4.10E-4 ID:SGTC_3270|Compound:9137563|FD-Score:3.05|P-value:8.37E-4

Top fitness defect scores for YMR313C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2950 9072895 7.34 21.5 µM 1.85E-14 3 1.07E-13
2 SGTC_336 4111-0029 5.93 111.0 µM 4.79E-10 2 1.52E-9
3 SGTC_2829 7992743 5.83 58.4 µM 9.33E-10 7 2.84E-9
4 SGTC_142 0335-0849 5.59 62.7 µM 4.16E-9 ubiquinone biosynthesis & proteasome 70 1.16E-8
5 SGTC_319 1348-1596 5.34 45.5 µM 1.78E-8 RSC & ERG11 3 4.56E-8
6 SGTC_3069 9117009 5.18 49.5 µM 4.50E-8 60S ribosome export 4 1.09E-7
7 SGTC_229 benomyl 5.02 22.9 µM 1.13E-7 tubulin folding & SWR complex 21 2.60E-7
8 SGTC_1117 retinoic acid 4.73 1.1 µM 5.34E-7 8 1.12E-6
9 SGTC_1999 st074831 4.25 12.5 µM 5.74E-6 plasma membrane duress 22 1.05E-5
10 SGTC_1640 st009078 4.06 66.4 µM 1.40E-5 7 2.43E-5
11 SGTC_1544 7-methoxy-4-methylcoumarin 4.03 105.0 µM 1.61E-5 16 2.76E-5
12 SGTC_1637 st007924 3.88 17.4 µM 3.11E-5 20 5.14E-5
13 SGTC_1505 k297-0037 3.84 20.6 µM 3.73E-5 20 6.11E-5
14 SGTC_2433 5607874 3.79 27.8 µM 4.58E-5 20 7.40E-5
15 SGTC_2083 5306046 3.61 65.9 µM 9.87E-5 38 1.53E-4
16 SGTC_2586 curcumin 3.61 80.0 µM 9.96E-5 iron homeostasis 70 1.54E-4
17 SGTC_687 k029-0044 3.55 34.9 µM 1.26E-4 PDR1 29 1.93E-4
18 SGTC_766 1391-0721 3.40 126.0 µM 2.33E-4 36 3.43E-4
19 SGTC_1161 k007-0610 3.34 110.0 µM 2.85E-4 ERAD & cell cycle 149 4.16E-4
20 SGTC_756 0508-1999 3.33 28.3 µM 2.96E-4 RPP1 & pyrimidine depletion 53 4.30E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 8.94E-17 YGL041C-B_p YGL041C-B_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.113 5.53E-11 YNL311C SKP2 hom F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments
0.107 4.74E-10 YBR185C MBA1 hom Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane
0.105 8.85E-10 YMR020W FMS1 hom Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis
0.104 1.56E-9 YDR251W PAM1 hom Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
0.104 1.72E-9 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.104 1.77E-9 YPL162C_p YPL162C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology
0.096 2.57E-8 YKL218C SRY1 hom 3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity
0.093 6.10E-8 YMR129W POM152 hom Glycoprotein subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NUP210
0.086 5.88E-7 YGR121W-A_p YGR121W-A_p hom Putative protein of unknown function
0.084 1.05E-6 YPL144W POC4 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.081 2.77E-6 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.080 3.24E-6 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.080 3.30E-6 YHR086W NAM8 hom RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces the meiotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function
0.078 6.61E-6 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene