YMR314W / PRE5

Alpha 6 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YMR314W / PRE5

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:4.27|P-value:1.86E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.56|P-value:2.96E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:21.80|P-value:1.16E-97 ID:SGTC_86|Compound:0417-1630|FD-Score:4.81|P-value:1.76E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:3.72|P-value:1.64E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:6.71|P-value:5.24E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:3.71|P-value:1.69E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.08|P-value:4.13E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.33|P-value:6.55E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:6.10|P-value:2.07E-9 ID:SGTC_165|Compound:k038-0023|FD-Score:6.40|P-value:3.66E-10 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.59|P-value:3.05E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.11|P-value:4.32E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:8.03|P-value:5.30E-15 ID:SGTC_200|Compound:k038-0079|FD-Score:3.54|P-value:3.11E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.90|P-value:8.51E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:6.01|P-value:3.54E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:4.88|P-value:1.26E-6 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.67|P-value:2.28E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.09|P-value:4.68E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:4.90|P-value:1.15E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:3.81|P-value:1.20E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.83|P-value:1.08E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.75|P-value:2.75E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.32|P-value:7.81E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.39|P-value:1.01E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:4.04|P-value:4.89E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.65|P-value:3.74E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:5.20|P-value:2.67E-7 ID:SGTC_541|Compound:4513-1321|FD-Score:-4.24|P-value:2.53E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.71|P-value:3.35E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.55|P-value:6.98E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.46|P-value:4.79E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.39|P-value:5.24E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:3.61|P-value:2.46E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.31|P-value:6.96E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.50|P-value:3.59E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.60|P-value:5.45E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:3.81|P-value:1.18E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.39|P-value:6.17E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-5.60|P-value:4.26E-8 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.70|P-value:3.52E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-6.36|P-value:5.88E-10 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.26|P-value:8.28E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:6.06|P-value:2.59E-9 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.04|P-value:4.78E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:-5.00|P-value:8.90E-7 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.80|P-value:2.23E-6 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.34|P-value:7.13E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.02|P-value:5.35E-5 ID:SGTC_1454|Compound:4239-0054|FD-Score:5.21|P-value:2.52E-7 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.60|P-value:2.53E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.87|P-value:1.08E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.67|P-value:2.29E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:14.10|P-value:2.88E-42 ID:SGTC_1712|Compound:st032288|FD-Score:7.90|P-value:1.40E-14 ID:SGTC_1713|Compound:st033146|FD-Score:3.53|P-value:3.25E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.75|P-value:1.71E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.50|P-value:8.69E-6 ID:SGTC_1786|Compound:berberine|FD-Score:3.44|P-value:4.53E-4 ID:SGTC_1814|Compound:st052110|FD-Score:4.07|P-value:4.27E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:6.78|P-value:3.24E-11 ID:SGTC_1912|Compound:st060209|FD-Score:3.96|P-value:6.64E-5 ID:SGTC_1968|Compound:st069590|FD-Score:3.76|P-value:1.41E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.68|P-value:2.24E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.62|P-value:2.71E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-3.28|P-value:8.86E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-4.72|P-value:3.22E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.11|P-value:4.24E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.67|P-value:6.63E-11 ID:SGTC_2250|Compound:alverine citrate|FD-Score:10.90|P-value:6.02E-26 ID:SGTC_2331|Compound:7980721|FD-Score:3.73|P-value:1.57E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-4.82|P-value:2.08E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.60|P-value:2.95E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-5.45|P-value:9.33E-8 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.76|P-value:1.43E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.34|P-value:7.20E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-6.01|P-value:4.47E-9 ID:SGTC_2581|Compound:avocatin a|FD-Score:-9.50|P-value:4.45E-20 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.19|P-value:3.17E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.44|P-value:5.18E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-5.63|P-value:3.60E-8 ID:SGTC_2623|Compound:humulene|FD-Score:-3.79|P-value:1.49E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.37|P-value:1.42E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.18|P-value:2.93E-7 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-4.41|P-value:1.28E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.72|P-value:1.92E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.56|P-value:2.98E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.94|P-value:7.08E-5 ID:SGTC_2799|Compound:7812892|FD-Score:-4.44|P-value:1.11E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-4.13|P-value:4.06E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-4.02|P-value:6.16E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-4.43|P-value:1.17E-5 ID:SGTC_3018|Compound:9082602|FD-Score:5.22|P-value:2.45E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-5.14|P-value:4.43E-7 ID:SGTC_3142|Compound:9086498|FD-Score:4.39|P-value:1.15E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.54|P-value:3.15E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.27|P-value:1.86E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.56|P-value:2.96E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:21.80|P-value:1.16E-97 ID:SGTC_86|Compound:0417-1630|FD-Score:4.81|P-value:1.76E-6 ID:SGTC_122|Compound:0236-0016|FD-Score:3.72|P-value:1.64E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:6.71|P-value:5.24E-11 ID:SGTC_138|Compound:0850-0259|FD-Score:3.71|P-value:1.69E-4 ID:SGTC_142|Compound:0335-0849|FD-Score:4.08|P-value:4.13E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:3.33|P-value:6.55E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:6.10|P-value:2.07E-9 ID:SGTC_165|Compound:k038-0023|FD-Score:6.40|P-value:3.66E-10 ID:SGTC_171|Compound:k064-0041|FD-Score:-3.59|P-value:3.05E-4 ID:SGTC_173|Compound:1273-0061|FD-Score:-4.11|P-value:4.32E-5 ID:SGTC_187|Compound:1488-2104|FD-Score:8.03|P-value:5.30E-15 ID:SGTC_200|Compound:k038-0079|FD-Score:3.54|P-value:3.11E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:3.90|P-value:8.51E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:6.01|P-value:3.54E-9 ID:SGTC_268|Compound:camptothecin|FD-Score:4.88|P-value:1.26E-6 ID:SGTC_293|Compound:4049-0273|FD-Score:-3.67|P-value:2.28E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:5.09|P-value:4.68E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:4.90|P-value:1.15E-6 ID:SGTC_314|Compound:1671-0008|FD-Score:3.81|P-value:1.20E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.83|P-value:1.08E-4 ID:SGTC_372|Compound:0155-0182|FD-Score:-4.75|P-value:2.75E-6 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.32|P-value:7.81E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:5.39|P-value:1.01E-7 ID:SGTC_515|Compound:4092-1064|FD-Score:4.04|P-value:4.89E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:4.65|P-value:3.74E-6 ID:SGTC_539|Compound:4859-0462|FD-Score:5.20|P-value:2.67E-7 ID:SGTC_541|Compound:4513-1321|FD-Score:-4.24|P-value:2.53E-5 ID:SGTC_547|Compound:1120-0019|FD-Score:-4.71|P-value:3.35E-6 ID:SGTC_778|Compound:3456-2434|FD-Score:-4.55|P-value:6.98E-6 ID:SGTC_795|Compound:0685-0265|FD-Score:-3.46|P-value:4.79E-4 ID:SGTC_819|Compound:1013-0258|FD-Score:3.39|P-value:5.24E-4 ID:SGTC_837|Compound:0091-0265|FD-Score:3.61|P-value:2.46E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.31|P-value:6.96E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.50|P-value:3.59E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:-4.60|P-value:5.45E-6 ID:SGTC_912|Compound:3474-0017|FD-Score:3.81|P-value:1.18E-4 ID:SGTC_1175|Compound:0741-0056|FD-Score:-3.39|P-value:6.17E-4 ID:SGTC_1182|Compound:1222-0449|FD-Score:-5.60|P-value:4.26E-8 ID:SGTC_1204|Compound:4049-0315|FD-Score:-4.70|P-value:3.52E-6 ID:SGTC_1240|Compound:0356-0016|FD-Score:-6.36|P-value:5.88E-10 ID:SGTC_1257|Compound:0669-0121|FD-Score:3.26|P-value:8.28E-4 ID:SGTC_1266|Compound:0828-0227|FD-Score:6.06|P-value:2.59E-9 ID:SGTC_1346|Compound:1488-2224|FD-Score:4.04|P-value:4.78E-5 ID:SGTC_1347|Compound:1493-0251|FD-Score:-5.00|P-value:8.90E-7 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.80|P-value:2.23E-6 ID:SGTC_1393|Compound:3470-5649|FD-Score:-3.34|P-value:7.13E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.02|P-value:5.35E-5 ID:SGTC_1454|Compound:4239-0054|FD-Score:5.21|P-value:2.52E-7 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.60|P-value:2.53E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.87|P-value:1.08E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-3.67|P-value:2.29E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:14.10|P-value:2.88E-42 ID:SGTC_1712|Compound:st032288|FD-Score:7.90|P-value:1.40E-14 ID:SGTC_1713|Compound:st033146|FD-Score:3.53|P-value:3.25E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.75|P-value:1.71E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-4.50|P-value:8.69E-6 ID:SGTC_1786|Compound:berberine|FD-Score:3.44|P-value:4.53E-4 ID:SGTC_1814|Compound:st052110|FD-Score:4.07|P-value:4.27E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:6.78|P-value:3.24E-11 ID:SGTC_1912|Compound:st060209|FD-Score:3.96|P-value:6.64E-5 ID:SGTC_1968|Compound:st069590|FD-Score:3.76|P-value:1.41E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.68|P-value:2.24E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.62|P-value:2.71E-4 ID:SGTC_2086|Compound:5274770|FD-Score:-3.28|P-value:8.86E-4 ID:SGTC_2183|Compound:6420625|FD-Score:-4.72|P-value:3.22E-6 ID:SGTC_2233|Compound:sulbentine|FD-Score:-4.11|P-value:4.24E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:6.67|P-value:6.63E-11 ID:SGTC_2250|Compound:alverine citrate|FD-Score:10.90|P-value:6.02E-26 ID:SGTC_2331|Compound:7980721|FD-Score:3.73|P-value:1.57E-4 ID:SGTC_2344|Compound:7990960|FD-Score:-4.82|P-value:2.08E-6 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.60|P-value:2.95E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:-5.45|P-value:9.33E-8 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.76|P-value:1.43E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-3.34|P-value:7.20E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-6.01|P-value:4.47E-9 ID:SGTC_2581|Compound:avocatin a|FD-Score:-9.50|P-value:4.45E-20 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.19|P-value:3.17E-5 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-3.44|P-value:5.18E-4 ID:SGTC_2600|Compound:tangeritin|FD-Score:-5.63|P-value:3.60E-8 ID:SGTC_2623|Compound:humulene|FD-Score:-3.79|P-value:1.49E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:-5.37|P-value:1.42E-7 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.18|P-value:2.93E-7 ID:SGTC_2659|Compound:sanguinarine|FD-Score:-4.41|P-value:1.28E-5 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.72|P-value:1.92E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.56|P-value:2.98E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.94|P-value:7.08E-5 ID:SGTC_2799|Compound:7812892|FD-Score:-4.44|P-value:1.11E-5 ID:SGTC_2925|Compound:9010536|FD-Score:-4.13|P-value:4.06E-5 ID:SGTC_2965|Compound:9082772|FD-Score:-4.02|P-value:6.16E-5 ID:SGTC_2993|Compound:9054257|FD-Score:-4.43|P-value:1.17E-5 ID:SGTC_3018|Compound:9082602|FD-Score:5.22|P-value:2.45E-7 ID:SGTC_3062|Compound:9077494|FD-Score:-5.14|P-value:4.43E-7 ID:SGTC_3142|Compound:9086498|FD-Score:4.39|P-value:1.15E-5 ID:SGTC_3197|Compound:9113331|FD-Score:3.54|P-value:3.15E-4

Top fitness defect scores for YMR314W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_64 000l-0018 21.80 272.1 µM 1.16E-97 ubiquinone biosynthesis & proteasome 2 1.38E-105 2.27
2 SGTC_1597 7-benzyloxygramine 14.10 47.5 µM 2.88E-42 calcium & mitochondrial duress 10 1.46E-45 0.55
3 SGTC_2250 alverine citrate 10.90 130.0 µM 6.02E-26 8 6.85E-28 1.29
4 SGTC_187 1488-2104 8.03 32.7 µM 5.30E-15 calcium & mitochondrial duress 2 4.74E-16 1.51
5 SGTC_1712 st032288 7.90 53.4 µM 1.40E-14 calcium & mitochondrial duress 8 1.35E-15 0.24
6 SGTC_1880 MG-132 6.78 525.0 µM 3.24E-11 5 5.85E-12 0.02
7 SGTC_137 0438-0332 6.71 85.4 µM 5.24E-11 ubiquinone biosynthesis & proteasome 18 9.83E-12 0.82
8 SGTC_2249 haloperidol 6.67 116.4 µM 6.63E-11 ergosterol depletion effects on membrane 11 1.27E-11 0.04
9 SGTC_165 k038-0023 6.40 64.4 µM 3.66E-10 ubiquinone biosynthesis & proteasome 7 8.02E-11 0.13
10 SGTC_161 4065-0411 6.10 162.2 µM 2.07E-9 6 5.21E-10 0.32
11 SGTC_1266 0828-0227 6.06 32.9 µM 2.59E-9 3 6.63E-10 0.88
12 SGTC_216 k038-0035 6.01 28.4 µM 3.54E-9 ubiquinone biosynthesis & proteasome 4 9.31E-10 0.22
13 SGTC_467 ro 31-8220 5.39 72.8 µM 1.01E-7 calcium & mitochondrial duress 9 3.47E-8 0.35
14 SGTC_3018 9082602 5.22 49.5 µM 2.45E-7 3 8.99E-8 0.68
15 SGTC_1454 4239-0054 5.21 42.6 µM 2.52E-7 2 9.28E-8 0.62
16 SGTC_539 4859-0462 5.20 2.5 µM 2.67E-7 RNA pol III & RNase P/MRP 11 9.86E-8 0.16
17 SGTC_2658 polymyxin b sulfate 5.18 77.0 µM 2.93E-7 NEO1 8 1.09E-7 0.48
18 SGTC_294 k038-0071 5.09 157.0 µM 4.68E-7 ubiquinone biosynthesis & proteasome 10 1.81E-7 0.94
19 SGTC_312 4092-0653 4.90 6.8 µM 1.15E-6 ergosterol depletion effects on membrane 21 4.75E-7 0.00
20 SGTC_268 camptothecin 4.88 39.6 µM 1.26E-6 DNA damage response 32 5.26E-7 0.19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.581 4.21E-302 YER094C PUP3 het Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10
0.527 1.06E-238 YOL038W PRE6 het Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress
0.516 2.54E-227 YFR050C PRE4 het Beta 7 subunit of the 20S proteasome
0.493 8.04E-205 YML092C PRE8 het Alpha 2 subunit of the 20S proteasome
0.485 1.65E-197 YOR362C PRE10 het Alpha 7 subunit of the 20S proteasome; protein abundance increases in response to DNA replication stress
0.482 4.99E-195 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.445 4.84E-163 YER012W PRE1 het Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
0.442 1.11E-159 YBL041W PRE7 het Beta 6 subunit of the 20S proteasome
0.434 7.54E-154 YGR253C PUP2 het Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta
0.394 1.32E-124 YLR021W IRC25 hom Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions
0.339 8.05E-91 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.332 2.91E-87 YJL001W PRE3 het Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides
0.295 2.52E-68 YPR103W PRE2 het Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome
0.290 1.13E-65 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.286 6.72E-64 YJL165C HAL5 hom Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters; HAL5 has a paralog, KKQ8, that arose from the whole genome duplication